ES2180932T3 - Derivados de camptotecina y su uso como agentes antitumorales. - Google Patents
Derivados de camptotecina y su uso como agentes antitumorales.Info
- Publication number
- ES2180932T3 ES2180932T3 ES97905057T ES97905057T ES2180932T3 ES 2180932 T3 ES2180932 T3 ES 2180932T3 ES 97905057 T ES97905057 T ES 97905057T ES 97905057 T ES97905057 T ES 97905057T ES 2180932 T3 ES2180932 T3 ES 2180932T3
- Authority
- ES
- Spain
- Prior art keywords
- rent
- hydrogen
- arilo
- linear
- camptotechine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002246 antineoplastic agent Substances 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 2
- HBJUQLMVCIEESP-UHFFFAOYSA-N 2,5-dihydro-1,2,4-oxadiazole Chemical compound C1NC=NO1 HBJUQLMVCIEESP-UHFFFAOYSA-N 0.000 abstract 1
- -1 AMINO Chemical class 0.000 abstract 1
- 125000003147 glycosyl group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Saccharide Compounds (AREA)
Abstract
COMPUESTOS DE FORMULA (I), EN LA QUE: R 1 ES -CN, -CH(CN)R 4 , -CH=C(CN)-R 4 , -CH 2 -CH(CN)-R 4 , C(=NOH)-NH 2 , C(=NH)-NH 2 , -CH=C(NO 2 )-R 4 , CH(CN)-R 5 , -CH(CH 2 NO 2 )-R 5 ; 5 TETRAZOLILO, 2 - (4,5 - DIHIDROOXAZOLILO), 1,2,4 - OXADIAZOLIN 3 - IL - 5 - ONA; R 2 ES HIDROGENO; R 3 ES HIDROGENO, OR 6 ; R 4 ES HIDROGENO, ALQUILO C 1 -C 6 LINEAL O RAMIFICADO, CN, COOR 7 ; R 5 ES HIDROGENO, OR 8; R 6 ES HIDROGENO, ALQUILO (C 1 -C 6 ) LINEAL O RAMIFICADO, ARILO (C 6 -C 12 ), ALQUILO (C 1 -C 4 ) ALCOXI (C 1 -C 4 ) ALQUILO (C 1 C 4 ); A LQUILO (C 1 -C 4 ) ARILO (C 6 C 12 ), ARILO (C6 -C 12 ) ACILO (C 2 -C 4 ), AMINOALQUIL (C 1 -C 4 ), AMINOACILO (C 2 -C 4 ), GLICOSILO; R SUB,7 ES HIDROGENO, ALQUILO (C 1 -C 6 ) LINEAL O RAMI FICADO, ARILO (C 6 -C 12 ) ALQUILO (C 1-C 4 ), ALCOXI (C 1 -C 4 ) ALQUILO (C 1 -C 4 ), ALQUILO (C 1 -C 4 ) ARILO (C 6 C 12 ); R 8 TI ENE LOS MISMOS SIGNIFICADOS DE R 6 , INDEPENDIENTEMENTE DEL ULTIMO. ESTOS COMPUESTOS SON ACTIVOS COMO INHIBIDORES DE LA TOPOISOMERASA I Y SEPUEDEN UTILIZAR COMO FARMACOS ANTITUMORALES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT96MI000338A IT1282673B1 (it) | 1996-02-23 | 1996-02-23 | Derivati della camptotecina e loro uso come agenti antitumorali |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2180932T3 true ES2180932T3 (es) | 2003-02-16 |
Family
ID=11373368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES97905057T Expired - Lifetime ES2180932T3 (es) | 1996-02-23 | 1997-02-19 | Derivados de camptotecina y su uso como agentes antitumorales. |
Country Status (22)
Country | Link |
---|---|
US (2) | US6130227A (es) |
EP (1) | EP0885230B1 (es) |
JP (1) | JP4171527B2 (es) |
KR (1) | KR100497906B1 (es) |
CN (1) | CN1107677C (es) |
AT (1) | ATE221071T1 (es) |
AU (1) | AU718361B2 (es) |
BR (1) | BR9707622B1 (es) |
CZ (1) | CZ289268B6 (es) |
DE (1) | DE69714220T2 (es) |
DK (1) | DK0885230T3 (es) |
EE (1) | EE03529B1 (es) |
ES (1) | ES2180932T3 (es) |
HU (1) | HUP9900987A3 (es) |
IL (1) | IL125856A (es) |
IT (1) | IT1282673B1 (es) |
NZ (1) | NZ331126A (es) |
PT (1) | PT885230E (es) |
RU (1) | RU2165935C2 (es) |
SK (1) | SK283217B6 (es) |
UA (1) | UA49005C2 (es) |
WO (1) | WO1997031003A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000000238A1 (en) * | 1998-06-26 | 2000-01-06 | Quanam Medical Corporation | Topoisomerase inhibitors for prevention of restenosis |
ATE216998T1 (de) * | 1999-03-09 | 2002-05-15 | Sigma Tau Ind Farmaceuti | Camptothecin-derivate mit antitumor-wirkung |
US7105492B2 (en) * | 1999-03-09 | 2006-09-12 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Camptothecin derivatives having antitumor activity |
AR025587A1 (es) | 1999-09-13 | 2002-12-04 | Hoffmann La Roche | Formulaciones en dispersion que contienen inhibidores de lipasa |
AU2002258787A1 (en) * | 2001-04-11 | 2002-10-28 | Emerald Biostructures, Inc. | Screening methods for identifying ligands |
US7067666B2 (en) * | 2003-06-27 | 2006-06-27 | Research Triangle Institute | 7-substituted camptothecin and camptothecin analogs and methods for producing the same |
ITRM20030344A1 (it) * | 2003-07-14 | 2005-01-15 | Ist Naz Stud Cura Dei Tumori | 7-n-poliamminoalchil(ossi)imminometilcamptotecine recanti gruppi protettivi. |
BRPI0620209A2 (pt) | 2005-12-21 | 2011-11-01 | Sigma Tau Ind Famaceutiche Riunite S P A | tratamento de tumores resistentes a fármacos |
WO2007095389A2 (en) * | 2006-02-17 | 2007-08-23 | Novacea, Inc. | Treatment of hyperproliferative diseases with camptothecine n-oxide and analogs |
CN101033230B (zh) | 2006-03-10 | 2010-12-08 | 中国科学院上海药物研究所 | 一类喜树碱衍生物及其应用 |
ITMI20061474A1 (it) * | 2006-07-26 | 2008-01-27 | Indena Spa | Derivati della camptotecina ad attivita antitumorale |
CN102731516B (zh) * | 2011-04-07 | 2014-07-02 | 宁波天衡药业股份有限公司 | 一类具有抗肿瘤活性的喜树碱衍生物 |
CN104774209B (zh) * | 2014-01-15 | 2018-06-19 | 上海海和药物研究开发有限公司 | 一种9-烯丙基喜树碱衍生物的合成方法 |
WO2023030364A1 (zh) * | 2021-09-01 | 2023-03-09 | 上海弼领生物技术有限公司 | 一种喜树碱类化合物、其制备方法和用途 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4399282A (en) * | 1979-07-10 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives |
JPS58154582A (ja) * | 1982-03-10 | 1983-09-14 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体およびその製造法 |
US5726181A (en) * | 1995-06-05 | 1998-03-10 | Bionumerik Pharmaceuticals, Inc. | Formulations and compositions of poorly water soluble camptothecin derivatives |
WO1998007727A1 (en) * | 1996-08-19 | 1998-02-26 | Bionumerik Pharmaceuticals, Inc. | Highly lipophilic camptothecin derivatives |
-
1996
- 1996-02-23 IT IT96MI000338A patent/IT1282673B1/it active IP Right Grant
-
1997
- 1997-02-19 NZ NZ331126A patent/NZ331126A/en not_active IP Right Cessation
- 1997-02-19 WO PCT/EP1997/000786 patent/WO1997031003A1/en not_active Application Discontinuation
- 1997-02-19 UA UA98084449A patent/UA49005C2/uk unknown
- 1997-02-19 JP JP52979197A patent/JP4171527B2/ja not_active Expired - Fee Related
- 1997-02-19 RU RU98117449/04A patent/RU2165935C2/ru not_active IP Right Cessation
- 1997-02-19 DE DE69714220T patent/DE69714220T2/de not_active Expired - Lifetime
- 1997-02-19 CZ CZ19982652A patent/CZ289268B6/cs not_active IP Right Cessation
- 1997-02-19 EP EP97905057A patent/EP0885230B1/en not_active Expired - Lifetime
- 1997-02-19 PT PT97905057T patent/PT885230E/pt unknown
- 1997-02-19 IL IL12585697A patent/IL125856A/xx not_active IP Right Cessation
- 1997-02-19 BR BRPI9707622-8A patent/BR9707622B1/pt not_active IP Right Cessation
- 1997-02-19 SK SK1127-98A patent/SK283217B6/sk not_active IP Right Cessation
- 1997-02-19 EE EE9800259A patent/EE03529B1/xx not_active IP Right Cessation
- 1997-02-19 CN CN97192493A patent/CN1107677C/zh not_active Expired - Fee Related
- 1997-02-19 AT AT97905057T patent/ATE221071T1/de not_active IP Right Cessation
- 1997-02-19 KR KR1019980706498A patent/KR100497906B1/ko not_active IP Right Cessation
- 1997-02-19 AU AU18753/97A patent/AU718361B2/en not_active Ceased
- 1997-02-19 ES ES97905057T patent/ES2180932T3/es not_active Expired - Lifetime
- 1997-02-19 DK DK97905057T patent/DK0885230T3/da active
- 1997-02-19 US US09/125,512 patent/US6130227A/en not_active Expired - Fee Related
- 1997-02-19 HU HU9900987A patent/HUP9900987A3/hu unknown
-
2000
- 2000-08-22 US US09/643,256 patent/US6306868B1/en not_active Expired - Fee Related
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