DE3877386T2 - Antikrebsverbindungen. - Google Patents

Antikrebsverbindungen.

Info

Publication number
DE3877386T2
DE3877386T2 DE8888301440T DE3877386T DE3877386T2 DE 3877386 T2 DE3877386 T2 DE 3877386T2 DE 8888301440 T DE8888301440 T DE 8888301440T DE 3877386 T DE3877386 T DE 3877386T DE 3877386 T2 DE3877386 T2 DE 3877386T2
Authority
DE
Germany
Prior art keywords
substituted
chem
formula
cancer
links
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888301440T
Other languages
English (en)
Other versions
DE3877386D1 (de
Inventor
Bernt Borretzen
Rolf Olaf Larsen
John Michael Dornish
Reidar Oftebro
Erik Olai Pettersen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Norsk Hydro ASA
Original Assignee
Norsk Hydro ASA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norsk Hydro ASA filed Critical Norsk Hydro ASA
Publication of DE3877386D1 publication Critical patent/DE3877386D1/de
Application granted granted Critical
Publication of DE3877386T2 publication Critical patent/DE3877386T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/39—Heterocyclic compounds having sulfur as a ring hetero atom having oxygen in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
DE8888301440T 1987-03-11 1988-02-19 Antikrebsverbindungen. Expired - Fee Related DE3877386T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878705780A GB8705780D0 (en) 1987-03-11 1987-03-11 Anticancer compounds

Publications (2)

Publication Number Publication Date
DE3877386D1 DE3877386D1 (de) 1993-02-25
DE3877386T2 true DE3877386T2 (de) 1993-08-12

Family

ID=10613770

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888301440T Expired - Fee Related DE3877386T2 (de) 1987-03-11 1988-02-19 Antikrebsverbindungen.

Country Status (12)

Country Link
US (1) US4874780A (de)
EP (1) EP0283139B1 (de)
JP (1) JP2769492B2 (de)
AT (1) ATE84515T1 (de)
AU (1) AU612348B2 (de)
CA (1) CA1327038C (de)
DE (1) DE3877386T2 (de)
DK (1) DK173244B1 (de)
ES (1) ES2043807T3 (de)
GB (1) GB8705780D0 (de)
HK (1) HK68697A (de)
NO (1) NO171631C (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5032610A (en) * 1988-11-21 1991-07-16 Norsk Hydro As Activity against carcinoma and method for the treatment of carcinoma
GB9026114D0 (en) * 1990-11-30 1991-01-16 Norsk Hydro As New compounds
GB9026080D0 (en) * 1990-11-30 1991-01-16 Norsk Hydro As Pharmaceutical compositions
HU208084B (en) * 1991-10-31 1993-08-30 Hyd Kutato Fejlesztoe Kft Process for producing compositions suitable for curing tumorous diseases
GB9201274D0 (en) * 1992-01-21 1992-03-11 Norsk Hydro As New compounds
GB9201275D0 (en) * 1992-01-21 1992-03-11 Norsk Hydro As New compounds
GB9400047D0 (en) * 1994-01-04 1994-03-02 Norsk Hydro As Pharmaceutical compositions
US6334997B1 (en) * 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
AU707748B2 (en) * 1994-03-25 1999-07-22 Isotechnika Inc. Enhancement of the efficacy of drugs by deuteration
DE4417865A1 (de) * 1994-05-20 1995-11-23 Behringwerke Ag Kombination von Tumornekrose-induzierenden Substanzen mit Substanzen, die durch Nekrosen aktiviert werden, zur selektiven Tumortherapie
DE4427690A1 (de) * 1994-08-04 1996-02-08 Bogdahn Ulrich Prof Deuterium enthaltende pharmazeutische Zusammensetzung als Zytostatikum oder Tumor-Therapeutikum
NO309305B1 (no) * 1999-02-19 2001-01-15 Norsk Hydro As Anvendelse av benzaldehydderivater ved fremstilling av farmasöytiske preparater for forebygging og/eller behandling av kreft, samt visse nye benzaldehydderivater
EP2975931A4 (de) * 2013-03-15 2016-11-02 Deuteria Agrochemicals Llc Deuterium-angereicherte aldehyde
US9713330B1 (en) 2013-03-15 2017-07-25 Deuteria Agrochemicals, Llc Deuterium-enriched aldehydes
WO2019140324A1 (en) * 2018-01-12 2019-07-18 Enb Therapeutics, Inc. Deuterated compounds, compositions, and methods for treating cancers associated with etbr activation
CN108383697B (zh) * 2018-02-12 2021-11-19 中山大学 一种以卤甲基化合物为原料制备氘代醛的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52108027A (en) * 1976-03-09 1977-09-10 Rikagaku Kenkyusho Anticarcinogen
GB1582666A (en) * 1976-08-24 1981-01-14 Rikagaku Kenkyusho Treatment of malignant conditions with mandelic acid or derivatives thereof
US4146651A (en) * 1977-05-20 1979-03-27 Canada Packers Limited Acetals and ketals of ascorbic acid and anti-nitrosamine compositions and methods using same
US4297289A (en) * 1980-07-17 1981-10-27 Wisconsin Alumni Research Foundation Vitamin D compounds isotopically substituted at carbon 6 and process for their preparation
US4423236A (en) * 1980-08-14 1983-12-27 National Foundation For Cancer Research, Inc. 5,6,-0-Isoalkylidene ascorbic acid derivatives
JPS60139619A (ja) * 1983-12-27 1985-07-24 Mutsuyuki Kochi Ｏ−ベンジリデン−アスコルビン酸又はその塩よりなる抗腫瘍剤

Also Published As

Publication number Publication date
DK129788A (da) 1988-09-12
US4874780A (en) 1989-10-17
NO880964D0 (no) 1988-03-04
EP0283139A2 (de) 1988-09-21
JPS63250341A (ja) 1988-10-18
CA1327038C (en) 1994-02-15
NO171631B (no) 1993-01-04
EP0283139A3 (en) 1989-01-18
NO171631C (no) 1993-04-14
ES2043807T3 (es) 1994-01-01
DK129788D0 (da) 1988-03-10
AU612348B2 (en) 1991-07-11
DE3877386D1 (de) 1993-02-25
DK173244B1 (da) 2000-05-22
AU1233188A (en) 1988-09-15
ATE84515T1 (de) 1993-01-15
JP2769492B2 (ja) 1998-06-25
NO880964L (no) 1988-09-12
GB8705780D0 (en) 1987-04-15
HK68697A (en) 1997-05-30
EP0283139B1 (de) 1993-01-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee