ES2070873T3 - Carbinoloimidazoles antiinflamatorios. - Google Patents

Carbinoloimidazoles antiinflamatorios.

Info

Publication number
ES2070873T3
ES2070873T3 ES89114664T ES89114664T ES2070873T3 ES 2070873 T3 ES2070873 T3 ES 2070873T3 ES 89114664 T ES89114664 T ES 89114664T ES 89114664 T ES89114664 T ES 89114664T ES 2070873 T3 ES2070873 T3 ES 2070873T3
Authority
ES
Spain
Prior art keywords
carbinoloimidazoles
antiinflamatorios
alkyl
carbon atoms
antiinflammatory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89114664T
Other languages
English (en)
Inventor
Douglas Guy Batt
Richard Russell Harris
Richard Scot Greenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
DuPont Merck Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DuPont Merck Pharmaceutical Co filed Critical DuPont Merck Pharmaceutical Co
Application granted granted Critical
Publication of ES2070873T3 publication Critical patent/ES2070873T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

SON PROPORCIONADOS CARBINOLOIMIDAZOLES ANTIINFLAMATORIOS QUE TIENEN LA FOMRULA (I): O UNA SAL FARMACEUTICMANETE ACEPTABLE DEL MISMO, DONDE R1 Y R2 SON INDEPENDIENTEMENTE H, F, CL, BR, CH3, CF3 O S(O)NR3, DONDE N ES 0. 1 O 2 Y R3 ES ALQUIL DE 1 - 4 ATOMOS DE CARBONO; R4 ES H O UN ALQUIL DE 1 - 4 ATOMOS DE CARBONO CON LA SALVEDAD DE QUE R4 ES H CUANDO M ES 2 O 3 Y M ES DE 1 A 3. LOS CARBINOLOIMIDAZOLES SON ADMINISTRADOS PREFERIBLEMENTE COMO COMPOSICIONES ANTIINFLAMATORIAS TOPICAS.
ES89114664T 1988-08-10 1989-08-08 Carbinoloimidazoles antiinflamatorios. Expired - Lifetime ES2070873T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/230,448 US4859693A (en) 1988-08-10 1988-08-10 Antiinflammatory carbinoloimidazoles

Publications (1)

Publication Number Publication Date
ES2070873T3 true ES2070873T3 (es) 1995-06-16

Family

ID=22865262

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89114664T Expired - Lifetime ES2070873T3 (es) 1988-08-10 1989-08-08 Carbinoloimidazoles antiinflamatorios.

Country Status (18)

Country Link
US (1) US4859693A (es)
EP (1) EP0354539B1 (es)
JP (1) JPH0692301B2 (es)
KR (1) KR900002773A (es)
AT (1) ATE120643T1 (es)
AU (1) AU633261B2 (es)
CA (1) CA1336964C (es)
DE (1) DE68922038T2 (es)
DK (1) DK390589A (es)
ES (1) ES2070873T3 (es)
HU (1) HU207794B (es)
IL (1) IL91261A (es)
MX (1) MX166479B (es)
MY (1) MY104099A (es)
NO (1) NO893213L (es)
NZ (1) NZ230247A (es)
PT (1) PT91427B (es)
ZA (1) ZA896121B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5049570A (en) * 1990-01-23 1991-09-17 Du Pont Merck Pharmaceutical Company Pyridylphenyl nitrogen heterocycle-substituted carbinols and derivatives thereof with anti-inflammatory activity

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE44186B1 (en) * 1975-12-03 1981-09-09 Ici Ltd 1,2,4-triazolyl alkanols and their use as pesticides
JPS6048486B2 (ja) * 1976-01-01 1985-10-28 木場 常義 抗リウマチ剤
DE2623129C3 (de) * 1976-05-22 1980-04-10 Nordmark-Werke Gmbh, 2000 Hamburg U-Diphenyl-3-(imidazol-l-yl) -propan-2-ole, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE2732750A1 (de) * 1977-07-20 1979-02-08 Merck Patent Gmbh Basische thioaether und verfahren zu ihrer herstellung
US4413003A (en) * 1977-07-29 1983-11-01 Rohm And Haas Company β-Hydroxyarylethylimidazoles
DE2851116A1 (de) * 1978-11-25 1980-06-12 Bayer Ag Hydroxyethyl-azole, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2851143A1 (de) * 1978-11-25 1980-06-04 Bayer Ag Fluorenyl-azolylmethyl-carbinole, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2912288A1 (de) * 1979-03-28 1980-10-09 Bayer Ag Verfahren zur herstellung von hydroxyethyl-azolen
DE2920375A1 (de) * 1979-05-19 1980-11-20 Bayer Ag Fungizide mittel, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide
US4414210A (en) * 1979-10-02 1983-11-08 Rohm And Haas Company 2-Hydroxyarylethyltriazole fungicides
GB2068228B (en) * 1980-01-24 1984-02-29 Janssen Pharmaceutica Nv Anti-microbial compositions for the topical treatment of acne vulgaris
EP0082340B1 (de) * 1981-11-27 1990-01-03 Ciba-Geigy Ag Mikrobizide Triazolyl-ethyl-äther
US4569935A (en) * 1983-03-17 1986-02-11 University Of Tennessee Research Corp. Topical treatment of psoriasis with imidazole antibiotics
DE3579347D1 (de) * 1984-04-05 1990-10-04 Ici Plc Azolylpropanole.
US4766140A (en) * 1984-06-18 1988-08-23 Eli Lilly And Company Method of inhibiting aromatase
DE102007058724B3 (de) * 2007-12-06 2009-05-14 Fujitsu Siemens Computers Gmbh Datenverarbeitungssystem

Also Published As

Publication number Publication date
DK390589A (da) 1990-02-11
DE68922038D1 (de) 1995-05-11
PT91427B (pt) 1995-05-31
NO893213D0 (no) 1989-08-09
HU207794B (en) 1993-06-28
NO893213L (no) 1990-02-12
MX166479B (es) 1993-01-12
DE68922038T2 (de) 1995-08-03
CA1336964C (en) 1995-09-12
JPH0692301B2 (ja) 1994-11-16
US4859693A (en) 1989-08-22
EP0354539B1 (en) 1995-04-05
EP0354539A3 (en) 1991-11-13
MY104099A (en) 1993-11-30
IL91261A0 (en) 1990-03-19
DK390589D0 (da) 1989-08-09
EP0354539A2 (en) 1990-02-14
NZ230247A (en) 1991-12-23
KR900002773A (ko) 1990-03-23
IL91261A (en) 1994-01-25
ATE120643T1 (de) 1995-04-15
AU3943989A (en) 1990-02-15
ZA896121B (en) 1991-04-24
PT91427A (pt) 1990-03-08
HUT51895A (en) 1990-06-28
JPH0291021A (ja) 1990-03-30
AU633261B2 (en) 1993-01-28

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