ATE84515T1 - Antikrebsverbindungen. - Google Patents

Antikrebsverbindungen.

Info

Publication number
ATE84515T1
ATE84515T1 AT88301440T AT88301440T ATE84515T1 AT E84515 T1 ATE84515 T1 AT E84515T1 AT 88301440 T AT88301440 T AT 88301440T AT 88301440 T AT88301440 T AT 88301440T AT E84515 T1 ATE84515 T1 AT E84515T1
Authority
AT
Austria
Prior art keywords
substituted
chem
formula
cancer
links
Prior art date
Application number
AT88301440T
Other languages
English (en)
Inventor
Bernt Borretzen
Rolf Olaf Larsen
John Michael Dornish
Reidar Oftebro
Erik Olai Pettersen
Original Assignee
Norsk Hydro As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norsk Hydro As filed Critical Norsk Hydro As
Application granted granted Critical
Publication of ATE84515T1 publication Critical patent/ATE84515T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/39—Heterocyclic compounds having sulfur as a ring hetero atom having oxygen in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
AT88301440T 1987-03-11 1988-02-19 Antikrebsverbindungen. ATE84515T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878705780A GB8705780D0 (en) 1987-03-11 1987-03-11 Anticancer compounds
EP88301440A EP0283139B1 (de) 1987-03-11 1988-02-19 Antikrebsverbindungen

Publications (1)

Publication Number Publication Date
ATE84515T1 true ATE84515T1 (de) 1993-01-15

Family

ID=10613770

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88301440T ATE84515T1 (de) 1987-03-11 1988-02-19 Antikrebsverbindungen.

Country Status (12)

Country Link
US (1) US4874780A (de)
EP (1) EP0283139B1 (de)
JP (1) JP2769492B2 (de)
AT (1) ATE84515T1 (de)
AU (1) AU612348B2 (de)
CA (1) CA1327038C (de)
DE (1) DE3877386T2 (de)
DK (1) DK173244B1 (de)
ES (1) ES2043807T3 (de)
GB (1) GB8705780D0 (de)
HK (1) HK68697A (de)
NO (1) NO171631C (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5032610A (en) * 1988-11-21 1991-07-16 Norsk Hydro As Activity against carcinoma and method for the treatment of carcinoma
GB9026114D0 (en) * 1990-11-30 1991-01-16 Norsk Hydro As New compounds
GB9026080D0 (en) * 1990-11-30 1991-01-16 Norsk Hydro As Pharmaceutical compositions
HU208084B (en) * 1991-10-31 1993-08-30 Hyd Kutato Fejlesztoe Kft Process for producing compositions suitable for curing tumorous diseases
GB9201275D0 (en) * 1992-01-21 1992-03-11 Norsk Hydro As New compounds
GB9201274D0 (en) * 1992-01-21 1992-03-11 Norsk Hydro As New compounds
GB9400047D0 (en) * 1994-01-04 1994-03-02 Norsk Hydro As Pharmaceutical compositions
ES2293638T3 (es) * 1994-03-25 2008-03-16 Isotechnika, Inc. Mejora de la eficacia de farmacos por deuteracion.
US6334997B1 (en) 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
DE4417865A1 (de) * 1994-05-20 1995-11-23 Behringwerke Ag Kombination von Tumornekrose-induzierenden Substanzen mit Substanzen, die durch Nekrosen aktiviert werden, zur selektiven Tumortherapie
DE4427690A1 (de) * 1994-08-04 1996-02-08 Bogdahn Ulrich Prof Deuterium enthaltende pharmazeutische Zusammensetzung als Zytostatikum oder Tumor-Therapeutikum
NO309305B1 (no) * 1999-02-19 2001-01-15 Norsk Hydro As Anvendelse av benzaldehydderivater ved fremstilling av farmasöytiske preparater for forebygging og/eller behandling av kreft, samt visse nye benzaldehydderivater
US9713330B1 (en) 2013-03-15 2017-07-25 Deuteria Agrochemicals, Llc Deuterium-enriched aldehydes
US9023336B2 (en) * 2013-03-15 2015-05-05 Deuterra Agrochemicals, LLC Deuterium-enriched aldehydes
CN116726183A (zh) 2015-08-03 2023-09-12 Enb治疗公司 用于治疗与etbr激活相关的癌症的组合物和方法
EP3713571A4 (de) 2018-01-12 2021-08-25 ENB Therapeutics, Inc. Deuterierte verbindungen, zusammensetzungen und verfahren zur behandlung von mit etbr-aktivierung assoziiertem krebs
CN108383697B (zh) * 2018-02-12 2021-11-19 中山大学 一种以卤甲基化合物为原料制备氘代醛的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52108027A (en) * 1976-03-09 1977-09-10 Rikagaku Kenkyusho Anticarcinogen
GB1582666A (en) * 1976-08-24 1981-01-14 Rikagaku Kenkyusho Treatment of malignant conditions with mandelic acid or derivatives thereof
US4146651A (en) * 1977-05-20 1979-03-27 Canada Packers Limited Acetals and ketals of ascorbic acid and anti-nitrosamine compositions and methods using same
US4297289A (en) * 1980-07-17 1981-10-27 Wisconsin Alumni Research Foundation Vitamin D compounds isotopically substituted at carbon 6 and process for their preparation
US4423236A (en) * 1980-08-14 1983-12-27 National Foundation For Cancer Research, Inc. 5,6,-0-Isoalkylidene ascorbic acid derivatives
JPS60139619A (ja) * 1983-12-27 1985-07-24 Mutsuyuki Kochi Ｏ−ベンジリデン−アスコルビン酸又はその塩よりなる抗腫瘍剤

Also Published As

Publication number Publication date
DE3877386D1 (de) 1993-02-25
DK129788D0 (da) 1988-03-10
EP0283139B1 (de) 1993-01-13
DE3877386T2 (de) 1993-08-12
AU612348B2 (en) 1991-07-11
JP2769492B2 (ja) 1998-06-25
US4874780A (en) 1989-10-17
HK68697A (en) 1997-05-30
DK173244B1 (da) 2000-05-22
NO880964L (no) 1988-09-12
EP0283139A2 (de) 1988-09-21
DK129788A (da) 1988-09-12
AU1233188A (en) 1988-09-15
JPS63250341A (ja) 1988-10-18
NO171631B (no) 1993-01-04
NO880964D0 (no) 1988-03-04
GB8705780D0 (en) 1987-04-15
ES2043807T3 (es) 1994-01-01
NO171631C (no) 1993-04-14
EP0283139A3 (en) 1989-01-18
CA1327038C (en) 1994-02-15

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee