DE69634360T2 - Methoden zur erhöhung der produktion von viralen impstoffen in zellkultur durch unterdrückung von interferon - Google Patents

Methoden zur erhöhung der produktion von viralen impstoffen in zellkultur durch unterdrückung von interferon Download PDF

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Publication number
DE69634360T2
DE69634360T2 DE69634360T DE69634360T DE69634360T2 DE 69634360 T2 DE69634360 T2 DE 69634360T2 DE 69634360 T DE69634360 T DE 69634360T DE 69634360 T DE69634360 T DE 69634360T DE 69634360 T2 DE69634360 T2 DE 69634360T2
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virus
cell
pkr
gene
cells
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DE69634360D1 (de
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S. Allan LAU
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University of California
University of California Berkeley
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/555Interferons [IFN]
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    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67General methods for enhancing the expression
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    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18Testing for antimicrobial activity of a material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
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    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16611Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16641Use of virus, viral particle or viral elements as a vector
    • C12N2710/16643Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2770/00011Details
    • C12N2770/32011Picornaviridae
    • C12N2770/32051Methods of production or purification of viral material

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  • Life Sciences & Earth Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
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  • Wood Science & Technology (AREA)
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  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69634360T 1995-08-22 1996-08-22 Methoden zur erhöhung der produktion von viralen impstoffen in zellkultur durch unterdrückung von interferon Expired - Lifetime DE69634360T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US262195P 1995-08-22 1995-08-22
US2621P 1995-08-22
PCT/US1996/013745 WO1997008292A1 (en) 1995-08-22 1996-08-22 Methods for enhancing the production of viral vaccines in cell culture by interferon suppression

Publications (2)

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DE69634360D1 DE69634360D1 (de) 2005-03-24
DE69634360T2 true DE69634360T2 (de) 2005-12-29

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DE69634360T Expired - Lifetime DE69634360T2 (de) 1995-08-22 1996-08-22 Methoden zur erhöhung der produktion von viralen impstoffen in zellkultur durch unterdrückung von interferon

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US (6) US5840565A (https=)
EP (2) EP0846160B1 (https=)
JP (2) JP4267693B2 (https=)
CN (1) CN1161469C (https=)
AT (1) ATE289348T1 (https=)
AU (2) AU707130B2 (https=)
BR (1) BR9610550A (https=)
CA (2) CA2229163C (https=)
DE (1) DE69634360T2 (https=)
WO (2) WO1997008292A1 (https=)

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Publication number Publication date
US6159712A (en) 2000-12-12
JPH11514344A (ja) 1999-12-07
US20010001290A1 (en) 2001-05-17
US20010001709A1 (en) 2001-05-24
US5840565A (en) 1998-11-24
EP0846174A1 (en) 1998-06-10
JP3432519B2 (ja) 2003-08-04
CA2229163A1 (en) 1997-03-06
EP0846160B1 (en) 2005-02-16
US7132271B2 (en) 2006-11-07
DE69634360D1 (de) 2005-03-24
EP0846160A4 (en) 2002-01-02
CA2229405A1 (en) 1997-03-06
US6489144B1 (en) 2002-12-03
MX9801423A (es) 1998-05-31
AU6860896A (en) 1997-03-19
WO1997008324A1 (en) 1997-03-06
CA2229405C (en) 2004-03-02
US20040157310A1 (en) 2004-08-12
EP0846160A1 (en) 1998-06-10
AU6857696A (en) 1997-03-19
CN1200148A (zh) 1998-11-25
US6673591B2 (en) 2004-01-06
JPH11511324A (ja) 1999-10-05
CN1161469C (zh) 2004-08-11
BR9610550A (pt) 1999-07-06
CA2229163C (en) 2011-04-05
EP0846174A4 (en) 2003-02-05
JP4267693B2 (ja) 2009-05-27
WO1997008292A1 (en) 1997-03-06
ATE289348T1 (de) 2005-03-15
AU707130B2 (en) 1999-07-01
US6686190B2 (en) 2004-02-03

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