DE69634360T2 - Methoden zur erhöhung der produktion von viralen impstoffen in zellkultur durch unterdrückung von interferon - Google Patents
Methoden zur erhöhung der produktion von viralen impstoffen in zellkultur durch unterdrückung von interferon Download PDFInfo
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- DE69634360T2 DE69634360T2 DE69634360T DE69634360T DE69634360T2 DE 69634360 T2 DE69634360 T2 DE 69634360T2 DE 69634360 T DE69634360 T DE 69634360T DE 69634360 T DE69634360 T DE 69634360T DE 69634360 T2 DE69634360 T2 DE 69634360T2
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C12N15/67—General methods for enhancing the expression
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- C12N2710/16641—Use of virus, viral particle or viral elements as a vector
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US262195P | 1995-08-22 | 1995-08-22 | |
| US2621P | 1995-08-22 | ||
| PCT/US1996/013745 WO1997008292A1 (en) | 1995-08-22 | 1996-08-22 | Methods for enhancing the production of viral vaccines in cell culture by interferon suppression |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69634360D1 DE69634360D1 (de) | 2005-03-24 |
| DE69634360T2 true DE69634360T2 (de) | 2005-12-29 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69634360T Expired - Lifetime DE69634360T2 (de) | 1995-08-22 | 1996-08-22 | Methoden zur erhöhung der produktion von viralen impstoffen in zellkultur durch unterdrückung von interferon |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US5840565A (https=) |
| EP (2) | EP0846174A4 (https=) |
| JP (2) | JP3432519B2 (https=) |
| CN (1) | CN1161469C (https=) |
| AT (1) | ATE289348T1 (https=) |
| AU (2) | AU707130B2 (https=) |
| BR (1) | BR9610550A (https=) |
| CA (2) | CA2229405C (https=) |
| DE (1) | DE69634360T2 (https=) |
| WO (2) | WO1997008324A1 (https=) |
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| US6855519B2 (en) * | 1995-08-22 | 2005-02-15 | The Regents Of The University Of California | Methods for enhancing the production of interferon in cell culture |
| US5840565A (en) * | 1995-08-22 | 1998-11-24 | The Regents Of The University Of California | Methods for enhancing the production of viral vaccines in PKR-deficient cell culture |
| US6740519B1 (en) | 1997-11-03 | 2004-05-25 | Mount Sinai School Of Medicine | Immortalized, homozygous stat1-deficient mammalian cell lines and their uses |
| KR100637937B1 (ko) * | 1998-06-12 | 2006-10-23 | 마운트 시나이 스쿨 오브 메디신 오브 뉴욕 유니버시티 | 변형된 인터페론 길항물질을 보유하고, 백신 및 약제로사용되는 약독화된 네거티브 가닥 바이러스 |
| US6762038B1 (en) | 1998-09-09 | 2004-07-13 | The Cleveland Clinic Foundation | Mutant cell lines and methods for producing enhanced levels of recombinant proteins |
| CA2376487A1 (en) * | 1999-06-15 | 2000-12-21 | Allan S. Lau | Methods for enhancing the production of cytokines in cell culture |
| EP1067179A1 (en) * | 1999-07-09 | 2001-01-10 | Pierre Fabre Medicament | Method to select attenuated paramyxoviridae useful for vaccines and therapeutics |
| AU7126000A (en) * | 1999-09-08 | 2001-04-10 | Genetrol Biotherapeutics, Inc. | High level cytokine production with enhanced cell viability |
| US20010031859A1 (en) * | 1999-09-08 | 2001-10-18 | Lau Allan S. | High level cytokine production with enhanced cell viability |
| WO2001077394A1 (en) | 2000-04-10 | 2001-10-18 | Mount Sinai School Of Medicine Of New York University | Screening methods for identifying viral proteins with interferon antagonizing functions and potential antiviral agents |
| IL136232A0 (en) * | 2000-05-18 | 2001-05-20 | Bar Ilan University Res Author | Measurements of enzymatic activity in a single, individual cell in population |
| US6660471B2 (en) * | 2000-08-04 | 2003-12-09 | Chiron Corporation | Enhanced replication of HCV RNA |
| US20020150541A1 (en) * | 2000-09-12 | 2002-10-17 | Gene Trol Biotherapeutics, Inc. | Compositions comprising mixtures of therapeutic proteins and methods of producing the same |
| AU2001290855A1 (en) | 2000-09-14 | 2002-03-26 | Genetrol Biotherapeutics, Inc. | Method and cell composition for screening compounds for anti-inflammatory activity |
| US20020115212A1 (en) * | 2000-12-19 | 2002-08-22 | Browning Laura A. | Enchanced PKR expression and cytokine production |
| DE10104094C1 (de) * | 2001-01-31 | 2002-07-25 | Angelika Vallbracht-Flehmig | Verfahren zur Erhöhung der Virusvermehrung und Virusausbeute in Zellkulturen, durch Blockade der RNaseL-Aktivierung |
| WO2003035824A1 (en) * | 2001-10-25 | 2003-05-01 | Bar-Ilan University | Interactive transparent individual cells biochip processor |
| IL154677A0 (en) | 2003-02-27 | 2003-09-17 | Univ Bar Ilan | A method and apparatus for manipulating an individual cell |
| EP1654347B1 (en) * | 2003-06-26 | 2014-06-04 | Seng Enterprises Limited | Improved materials for constructing cell-chips, cell-chip covers, cell-chip coats, processed cell-chips and uses thereof |
| US8597597B2 (en) | 2003-06-26 | 2013-12-03 | Seng Enterprises Ltd. | Picoliter well holding device and method of making the same |
| US9200245B2 (en) | 2003-06-26 | 2015-12-01 | Seng Enterprises Ltd. | Multiwell plate |
| US7888110B2 (en) | 2003-06-26 | 2011-02-15 | Seng Enterprises Ltd. | Pico liter well holding device and method of making the same |
| WO2005008626A1 (en) * | 2003-07-11 | 2005-01-27 | University Of North Carolina At Chapel Hill | Methods and systems for controlling a computer using a video image and for combining the video image with a computer desktop |
| US20050064524A1 (en) * | 2003-08-11 | 2005-03-24 | Mordechai Deutsch | Population of cells utilizable for substance detection and methods and devices using same |
| RU2390351C2 (ru) * | 2003-08-11 | 2010-05-27 | Дзе Ресерч Фаундейшн Фо Макробайал Дизизес Оф Осака Юниверсити | Вакцина против вируса гриппа для введения через слизистую и способ предотвращения гриппа |
| JP2007529199A (ja) * | 2003-10-23 | 2007-10-25 | イルミジェン バイオサイエンシーズ， インコーポレイテッド | ウイルス感染に対する抵抗性に関連する遺伝子である、ｏａｓ１における変異の検出 |
| US20050191649A1 (en) * | 2003-10-23 | 2005-09-01 | Illumigen Biosciences, Inc. | Detection of mutations in a gene associated with resistance to viral infection, OAS1 |
| EP2327724A3 (en) | 2004-02-02 | 2011-07-27 | Ambrx, Inc. | Modified human growth hormone polypeptides and their uses |
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1996
- 1996-08-21 US US08/700,198 patent/US5840565A/en not_active Expired - Lifetime
- 1996-08-22 AU AU68608/96A patent/AU707130B2/en not_active Expired
- 1996-08-22 CN CNB961977515A patent/CN1161469C/zh not_active Expired - Fee Related
- 1996-08-22 WO PCT/US1996/013627 patent/WO1997008324A1/en not_active Ceased
- 1996-08-22 AU AU68576/96A patent/AU6857696A/en not_active Abandoned
- 1996-08-22 EP EP96929017A patent/EP0846174A4/en not_active Withdrawn
- 1996-08-22 EP EP96929066A patent/EP0846160B1/en not_active Expired - Lifetime
- 1996-08-22 WO PCT/US1996/013745 patent/WO1997008292A1/en not_active Ceased
- 1996-08-22 BR BR9610550A patent/BR9610550A/pt not_active Application Discontinuation
- 1996-08-22 AT AT96929066T patent/ATE289348T1/de active
- 1996-08-22 JP JP51045097A patent/JP3432519B2/ja not_active Expired - Fee Related
- 1996-08-22 CA CA002229405A patent/CA2229405C/en not_active Expired - Fee Related
- 1996-08-22 DE DE69634360T patent/DE69634360T2/de not_active Expired - Lifetime
- 1996-08-22 CA CA2229163A patent/CA2229163C/en not_active Expired - Lifetime
- 1996-08-22 JP JP51050897A patent/JP4267693B2/ja not_active Expired - Lifetime
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1999
- 1999-11-19 US US09/444,224 patent/US6159712A/en not_active Expired - Fee Related
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2000
- 2000-06-12 US US09/591,813 patent/US6489144B1/en not_active Expired - Fee Related
- 2000-12-13 US US09/737,126 patent/US6686190B2/en not_active Expired - Lifetime
- 2000-12-13 US US09/736,748 patent/US6673591B2/en not_active Expired - Fee Related
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2003
- 2003-11-24 US US10/722,349 patent/US7132271B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0846160B1 (en) | 2005-02-16 |
| AU6860896A (en) | 1997-03-19 |
| JP4267693B2 (ja) | 2009-05-27 |
| US6489144B1 (en) | 2002-12-03 |
| JP3432519B2 (ja) | 2003-08-04 |
| AU6857696A (en) | 1997-03-19 |
| US6686190B2 (en) | 2004-02-03 |
| BR9610550A (pt) | 1999-07-06 |
| CA2229163A1 (en) | 1997-03-06 |
| CN1200148A (zh) | 1998-11-25 |
| US20040157310A1 (en) | 2004-08-12 |
| US20010001709A1 (en) | 2001-05-24 |
| US20010001290A1 (en) | 2001-05-17 |
| AU707130B2 (en) | 1999-07-01 |
| EP0846160A1 (en) | 1998-06-10 |
| JPH11511324A (ja) | 1999-10-05 |
| ATE289348T1 (de) | 2005-03-15 |
| EP0846160A4 (en) | 2002-01-02 |
| US5840565A (en) | 1998-11-24 |
| CN1161469C (zh) | 2004-08-11 |
| EP0846174A4 (en) | 2003-02-05 |
| EP0846174A1 (en) | 1998-06-10 |
| US7132271B2 (en) | 2006-11-07 |
| WO1997008292A1 (en) | 1997-03-06 |
| CA2229405A1 (en) | 1997-03-06 |
| US6159712A (en) | 2000-12-12 |
| JPH11514344A (ja) | 1999-12-07 |
| DE69634360D1 (de) | 2005-03-24 |
| US6673591B2 (en) | 2004-01-06 |
| CA2229163C (en) | 2011-04-05 |
| CA2229405C (en) | 2004-03-02 |
| WO1997008324A1 (en) | 1997-03-06 |
| MX9801423A (es) | 1998-05-31 |
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