DE69626387T2 - Antagonisten von humanem interleukin-6, welche zur bindung mit gp 130 unfähig sind und ihre verwendung in der herstellung von pharmazeutische zusammensetzungen - Google Patents

Antagonisten von humanem interleukin-6, welche zur bindung mit gp 130 unfähig sind und ihre verwendung in der herstellung von pharmazeutische zusammensetzungen

Info

Publication number
DE69626387T2
DE69626387T2 DE69626387T DE69626387T DE69626387T2 DE 69626387 T2 DE69626387 T2 DE 69626387T2 DE 69626387 T DE69626387 T DE 69626387T DE 69626387 T DE69626387 T DE 69626387T DE 69626387 T2 DE69626387 T2 DE 69626387T2
Authority
DE
Germany
Prior art keywords
interleukin
pct
antagonists
humanem
bind
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69626387T
Other languages
English (en)
Other versions
DE69626387D1 (de
Inventor
Gennaro Ciliberto
Rocco Savino
Giacomo Paonessa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of DE69626387D1 publication Critical patent/DE69626387D1/de
Application granted granted Critical
Publication of DE69626387T2 publication Critical patent/DE69626387T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
DE69626387T 1995-04-28 1996-04-26 Antagonisten von humanem interleukin-6, welche zur bindung mit gp 130 unfähig sind und ihre verwendung in der herstellung von pharmazeutische zusammensetzungen Expired - Fee Related DE69626387T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT95RM000273A IT1276555B1 (it) 1995-04-28 1995-04-28 Antagonisti di interluchina-6 umana del tutto incapaci di formare un legame con gp 130, e loro uso per la preparazione di composizioni
PCT/IT1996/000084 WO1996034104A1 (en) 1995-04-28 1996-04-26 Antagonists of human interleukin-6 that are totally incapable of binding gp 130, and their use in the preparation of pharmaceutical compounds

Publications (2)

Publication Number Publication Date
DE69626387D1 DE69626387D1 (de) 2003-04-03
DE69626387T2 true DE69626387T2 (de) 2003-12-11

Family

ID=11403338

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69626387T Expired - Fee Related DE69626387T2 (de) 1995-04-28 1996-04-26 Antagonisten von humanem interleukin-6, welche zur bindung mit gp 130 unfähig sind und ihre verwendung in der herstellung von pharmazeutische zusammensetzungen

Country Status (11)

Country Link
US (1) US5972902A (de)
EP (1) EP0822986B1 (de)
JP (2) JP3373856B2 (de)
AT (1) ATE233320T1 (de)
CA (1) CA2218372C (de)
DE (1) DE69626387T2 (de)
DK (1) DK0822986T3 (de)
ES (1) ES2191096T3 (de)
IT (1) IT1276555B1 (de)
PT (1) PT822986E (de)
WO (1) WO1996034104A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997017441A1 (fr) * 1995-11-07 1997-05-15 Kaneka Corporation Autoantigenes
DE19704979A1 (de) * 1996-02-07 1997-08-14 Max Delbrueck Centrum Retroviraler Vektor für den Gentransfer eines IL6-Antagonisten in humane hämatopoetische Stammzellen
ES2312184T3 (es) 1997-03-21 2009-02-16 Chugai Seiyaku Kabushiki Kaisha Agentes preventivos terapeuticos para el tratamiento de esclerosis multiple, que contienen anticuerpos anti-receptores de il-6 antagonistas.
IT1291932B1 (it) * 1997-06-20 1999-01-21 Angeletti P Ist Richerche Bio Composizioni farmaceutiche antitumorali capaci anche di ridurre la farmacoresistenza in cellule tumorali, in particolare di carcinoma
ES2241583T3 (es) 2000-03-06 2005-11-01 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Uso de antagonistas de interleuquina 6 para el tratamiento de tumores dependientes de estrogenos.
IL161968A0 (en) * 2001-11-14 2005-11-20 Centocor Inc Anti-il-6 antibodies, compositions, methods and uses
US20050100550A1 (en) * 2003-11-10 2005-05-12 Mohit Trikha Anti-angiogenic uses of IL-6 antagonists
ITRM20050103A1 (it) * 2005-03-10 2006-09-11 Rocco Savino Associazione di antagonisti della interleuchina 6 e farmaci antiproliferativi.
PA8672101A1 (es) 2005-04-29 2006-12-07 Centocor Inc Anticuerpos anti-il-6, composiciones, métodos y usos
US8188235B2 (en) 2008-06-18 2012-05-29 Pfizer Inc. Antibodies to IL-6 and their uses

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994009138A1 (en) * 1992-10-20 1994-04-28 Cetus Oncology Corporation Interleukin-6 receptor antagonists
IT1261787B (it) * 1993-06-23 1996-06-03 Angeletti P Ist Richerche Bio Metodologia per la selezione di superagonisti, antagonisti e super- antagonisti di ormoni del cui complesso recettoriale fa parte gp 130.

Also Published As

Publication number Publication date
PT822986E (pt) 2003-07-31
CA2218372A1 (en) 1996-10-31
IT1276555B1 (it) 1997-11-03
JPH10506538A (ja) 1998-06-30
DE69626387D1 (de) 2003-04-03
EP0822986A1 (de) 1998-02-11
ITRM950273A1 (it) 1996-10-28
CA2218372C (en) 2001-07-31
JP2003153691A (ja) 2003-05-27
ATE233320T1 (de) 2003-03-15
DK0822986T3 (da) 2003-04-28
EP0822986B1 (de) 2003-02-26
US5972902A (en) 1999-10-26
ES2191096T3 (es) 2003-09-01
JP3373856B2 (ja) 2003-02-04
ITRM950273A0 (it) 1995-04-28
WO1996034104A1 (en) 1996-10-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee