ITRM950273A0 - Antagonisti di interluchina-6 umana del tutto incapaci di formare un legame con gp 130, e loro uso per la preparazione di composizioni farmaceutiche. - Google Patents

Antagonisti di interluchina-6 umana del tutto incapaci di formare un legame con gp 130, e loro uso per la preparazione di composizioni farmaceutiche.

Info

Publication number
ITRM950273A0
ITRM950273A0 ITRM950273A ITRM950273A ITRM950273A0 IT RM950273 A0 ITRM950273 A0 IT RM950273A0 IT RM950273 A ITRM950273 A IT RM950273A IT RM950273 A ITRM950273 A IT RM950273A IT RM950273 A0 ITRM950273 A0 IT RM950273A0
Authority
IT
Italy
Prior art keywords
interluchin
antagonists
bind
human
preparation
Prior art date
Application number
ITRM950273A
Other languages
English (en)
Inventor
Gennaro Ciliberto
Rocco Savino
Original Assignee
Angeletti P Ist Richerche Bio
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angeletti P Ist Richerche Bio filed Critical Angeletti P Ist Richerche Bio
Publication of ITRM950273A0 publication Critical patent/ITRM950273A0/it
Priority to IT95RM000273A priority Critical patent/IT1276555B1/it
Priority to CA002218372A priority patent/CA2218372C/en
Priority to PCT/IT1996/000084 priority patent/WO1996034104A1/en
Priority to ES96912205T priority patent/ES2191096T3/es
Priority to PT96912205T priority patent/PT822986E/pt
Priority to DE69626387T priority patent/DE69626387T2/de
Priority to DK96912205T priority patent/DK0822986T3/da
Priority to AT96912205T priority patent/ATE233320T1/de
Priority to JP53233396A priority patent/JP3373856B2/ja
Priority to US08/945,529 priority patent/US5972902A/en
Priority to EP96912205A priority patent/EP0822986B1/en
Publication of ITRM950273A1 publication Critical patent/ITRM950273A1/it
Application granted granted Critical
Publication of IT1276555B1 publication Critical patent/IT1276555B1/it
Priority to JP2002259481A priority patent/JP2003153691A/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT95RM000273A 1995-04-28 1995-04-28 Antagonisti di interluchina-6 umana del tutto incapaci di formare un legame con gp 130, e loro uso per la preparazione di composizioni IT1276555B1 (it)

Priority Applications (12)

Application Number Priority Date Filing Date Title
IT95RM000273A IT1276555B1 (it) 1995-04-28 1995-04-28 Antagonisti di interluchina-6 umana del tutto incapaci di formare un legame con gp 130, e loro uso per la preparazione di composizioni
DK96912205T DK0822986T3 (da) 1995-04-28 1996-04-26 Antagonister af human interleukin-6, der er fuldstændig ude af stand til at binde GP 130, og deres anvendelse til fremstilling af farmaceutiske forbindelser
JP53233396A JP3373856B2 (ja) 1995-04-28 1996-04-26 Ｇｐ１３０に全く結合することができないヒトインターロイキン−６の拮抗薬、および医薬化合物の製造におけるそれらの使用
ES96912205T ES2191096T3 (es) 1995-04-28 1996-04-26 Antagonistas de la interleucina-6 humana que es completamente incapaz de unir gp130, y su uso en la preparacion de compuestos farmaceuticos.
PT96912205T PT822986E (pt) 1995-04-28 1996-04-26 Antagonistas da interleucina 6 humana totalmente incapazes de se ligarem a gp130 e sua utilizacao para a preparacao de compostos farmaceuticos
DE69626387T DE69626387T2 (de) 1995-04-28 1996-04-26 Antagonisten von humanem interleukin-6, welche zur bindung mit gp 130 unfähig sind und ihre verwendung in der herstellung von pharmazeutische zusammensetzungen
CA002218372A CA2218372C (en) 1995-04-28 1996-04-26 Antagonists of human interleukin-6 that are totally incapable of binding gp 130, and their use in the preparation of pharmaceutical compounds
AT96912205T ATE233320T1 (de) 1995-04-28 1996-04-26 Antagonisten von humanem interleukin-6, welche zur bindung mit gp 130 unfähig sind und ihre verwendung in der herstellung von pharmazeutische zusammensetzungen
PCT/IT1996/000084 WO1996034104A1 (en) 1995-04-28 1996-04-26 Antagonists of human interleukin-6 that are totally incapable of binding gp 130, and their use in the preparation of pharmaceutical compounds
US08/945,529 US5972902A (en) 1995-04-28 1996-04-26 DNA encoding human IL-6 receptor antagonist and protein encoded thereby
EP96912205A EP0822986B1 (en) 1995-04-28 1996-04-26 Antagonists of human interleukin-6 that are totally incapable of binding gp 130, and their use in the preparation of pharmaceutical compounds
JP2002259481A JP2003153691A (ja) 1995-04-28 2002-09-05 Ｇｐ１３０に全く結合することができないヒトインターロイキン−６の拮抗薬をコードする組換えｄｎａ分子、および医薬化合物の製造におけるそれらの使用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95RM000273A IT1276555B1 (it) 1995-04-28 1995-04-28 Antagonisti di interluchina-6 umana del tutto incapaci di formare un legame con gp 130, e loro uso per la preparazione di composizioni

Publications (3)

Publication Number Publication Date
ITRM950273A0 true ITRM950273A0 (it) 1995-04-28
ITRM950273A1 ITRM950273A1 (it) 1996-10-28
IT1276555B1 IT1276555B1 (it) 1997-11-03

Family

ID=11403338

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95RM000273A IT1276555B1 (it) 1995-04-28 1995-04-28 Antagonisti di interluchina-6 umana del tutto incapaci di formare un legame con gp 130, e loro uso per la preparazione di composizioni

Country Status (11)

Country Link
US (1) US5972902A (it)
EP (1) EP0822986B1 (it)
JP (2) JP3373856B2 (it)
AT (1) ATE233320T1 (it)
CA (1) CA2218372C (it)
DE (1) DE69626387T2 (it)
DK (1) DK0822986T3 (it)
ES (1) ES2191096T3 (it)
IT (1) IT1276555B1 (it)
PT (1) PT822986E (it)
WO (1) WO1996034104A1 (it)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997017441A1 (fr) * 1995-11-07 1997-05-15 Kaneka Corporation Autoantigenes
WO1997029201A2 (de) * 1996-02-07 1997-08-14 Max-Delbrück-Centrum für Molekulare Medizin Retroviraler vektor für den gentransfer eines il6-antagonisten in humane hämatopoetische stammzellen
JPH10324639A (ja) 1997-03-21 1998-12-08 Chugai Pharmaceut Co Ltd Ｉｌ−６アンタゴニストを有効成分として含有する感作ｔ細胞関与疾患の予防・治療剤
IT1291932B1 (it) * 1997-06-20 1999-01-21 Angeletti P Ist Richerche Bio Composizioni farmaceutiche antitumorali capaci anche di ridurre la farmacoresistenza in cellule tumorali, in particolare di carcinoma
MXPA02008697A (es) 2000-03-06 2003-04-14 Sigma Tau Ind Farmaceuti Uso de antagonistas de interleucina-6 para el tratamiento de enfermedades caracterizadas por altos niveles de aromatasa.
US7291721B2 (en) * 2001-11-14 2007-11-06 Centocor, Inc. Anti-IL-6 antibodies, compositions, methods and uses
US20050100550A1 (en) * 2003-11-10 2005-05-12 Mohit Trikha Anti-angiogenic uses of IL-6 antagonists
ITRM20050103A1 (it) * 2005-03-10 2006-09-11 Rocco Savino Associazione di antagonisti della interleuchina 6 e farmaci antiproliferativi.
PE20061324A1 (es) 2005-04-29 2007-01-15 Centocor Inc Anticuerpos anti-il-6, composiciones, metodos y usos
US8188235B2 (en) * 2008-06-18 2012-05-29 Pfizer Inc. Antibodies to IL-6 and their uses

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0672144A1 (en) * 1992-10-20 1995-09-20 Chiron Corporation Interleukin-6 receptor antagonists
IT1261787B (it) * 1993-06-23 1996-06-03 Angeletti P Ist Richerche Bio Metodologia per la selezione di superagonisti, antagonisti e super- antagonisti di ormoni del cui complesso recettoriale fa parte gp 130.

Also Published As

Publication number Publication date
ES2191096T3 (es) 2003-09-01
IT1276555B1 (it) 1997-11-03
ITRM950273A1 (it) 1996-10-28
PT822986E (pt) 2003-07-31
US5972902A (en) 1999-10-26
JPH10506538A (ja) 1998-06-30
WO1996034104A1 (en) 1996-10-31
DE69626387D1 (de) 2003-04-03
CA2218372C (en) 2001-07-31
JP3373856B2 (ja) 2003-02-04
EP0822986A1 (en) 1998-02-11
DK0822986T3 (da) 2003-04-28
JP2003153691A (ja) 2003-05-27
EP0822986B1 (en) 2003-02-26
CA2218372A1 (en) 1996-10-31
ATE233320T1 (de) 2003-03-15
DE69626387T2 (de) 2003-12-11

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