DE69230879T2 - Verwendung von Hepatocyten-Wachstumsfaktoren zur Herstellung eines Vermehrungssystems für Hematopoietische Stammzellen - Google Patents

Verwendung von Hepatocyten-Wachstumsfaktoren zur Herstellung eines Vermehrungssystems für Hematopoietische Stammzellen

Info

Publication number
DE69230879T2
DE69230879T2 DE69230879T DE69230879T DE69230879T2 DE 69230879 T2 DE69230879 T2 DE 69230879T2 DE 69230879 T DE69230879 T DE 69230879T DE 69230879 T DE69230879 T DE 69230879T DE 69230879 T2 DE69230879 T2 DE 69230879T2
Authority
DE
Germany
Prior art keywords
hematopoietic stem
stem cells
proliferating
hepatocyte
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69230879T
Other languages
English (en)
Other versions
DE69230879D1 (de
Inventor
Atsushi Komiyama
Tatsutoshi Nakahata
Tetsuo Kubo
Ryuhei Tanaka
Genji Kawano
Tetsuo Sudo
Emiko Sano
Katsuaki Kojima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Application granted granted Critical
Publication of DE69230879D1 publication Critical patent/DE69230879D1/de
Publication of DE69230879T2 publication Critical patent/DE69230879T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69230879T 1991-07-26 1992-07-24 Verwendung von Hepatocyten-Wachstumsfaktoren zur Herstellung eines Vermehrungssystems für Hematopoietische Stammzellen Expired - Fee Related DE69230879T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP18748191 1991-07-26
JP18747091 1991-07-26
PCT/JP1992/000949 WO1993003061A1 (en) 1991-07-26 1992-07-24 Hematopoietic stem cell multiplier

Publications (2)

Publication Number Publication Date
DE69230879D1 DE69230879D1 (de) 2000-05-11
DE69230879T2 true DE69230879T2 (de) 2000-08-03

Family

ID=26504364

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69230879T Expired - Fee Related DE69230879T2 (de) 1991-07-26 1992-07-24 Verwendung von Hepatocyten-Wachstumsfaktoren zur Herstellung eines Vermehrungssystems für Hematopoietische Stammzellen

Country Status (8)

Country Link
US (1) US6221359B1 (de)
EP (1) EP0550769B1 (de)
JP (1) JP3395181B2 (de)
AT (1) ATE191501T1 (de)
CA (1) CA2092542A1 (de)
DE (1) DE69230879T2 (de)
ES (1) ES2143990T3 (de)
WO (1) WO1993003061A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1271088B (it) * 1994-11-24 1997-05-26 Dompe Spa Uso di fattore di crescita degli epatociti per indurre la proliferazione e differenziazione di cellule emopoietiche
US5728581A (en) * 1995-06-07 1998-03-17 Systemix, Inc. Method of expanding hematopoietic stem cells, reagents and bioreactors for use therein
US5824789A (en) * 1995-06-07 1998-10-20 Systemix, Inc. Human growth factors, nucleotide sequence encoding growth factors, and method of use thereof
US6887477B1 (en) 1998-08-05 2005-05-03 Tomokazu Nagano Method of treating ischemic disease by intramuscular administration of Hepatocyte growth factor
US20060177929A1 (en) * 2003-03-24 2006-08-10 Klug Christopher A Regulation of self-renewal in stem cells
CA2519975C (en) * 2003-04-08 2013-07-02 Yeda Research And Development Co. Ltd Stem cells having increased sensitivity to a chemoattractant and methods of generating and using same
FR2853551B1 (fr) 2003-04-09 2006-08-04 Lab Francais Du Fractionnement Formulation stabilisante pour compositions d'immunoglobulines g sous forme liquide et sous forme lyophilisee
JP4728807B2 (ja) * 2003-09-03 2011-07-20 敏一 中村 ヒト組換えｈｇｆを含有する皮膚潰瘍予防治癒剤
EP1695982B1 (de) 2003-12-16 2013-01-23 Toshikazu Nakamura Glycosylierungsdefizienter hepatocytenwachstumsfaktor
US8003607B2 (en) 2006-04-20 2011-08-23 Kringle Pharma Inc. HGF precursor protein variant and active protein thereof
CN103743906B (zh) * 2013-07-24 2015-05-20 北京大学人民医院 用于测定造血干细胞移植后患者骨髓微环境的试剂盒、系统及方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2564486B2 (ja) * 1986-07-14 1996-12-18 修治 橋本 肝細胞増殖因子
US5362716A (en) * 1989-12-27 1994-11-08 The United States Of America As Represented By The Department Of Health And Human Services Methods for stimulating hematopoietic progenitors using hepatocyte growth factor and lymphokines
JP2634323B2 (ja) * 1990-07-13 1997-07-23 雪印乳業株式会社 Ｔｃｆ‐▲ｉｉ▼のアミノ酸配列をコードするｄｎａを含むプラスミド，形質転換細胞及びこれを用いて生理活性物質を生産する方法

Also Published As

Publication number Publication date
EP0550769B1 (de) 2000-04-05
EP0550769A4 (de) 1994-04-27
EP0550769A1 (de) 1993-07-14
ATE191501T1 (de) 2000-04-15
CA2092542A1 (en) 1993-01-27
DE69230879D1 (de) 2000-05-11
US6221359B1 (en) 2001-04-24
JP3395181B2 (ja) 2003-04-07
ES2143990T3 (es) 2000-06-01
WO1993003061A1 (en) 1993-02-18

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Legal Events

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8339 Ceased/non-payment of the annual fee