ATE289348T1 - Methoden zur erhöhung der produktion von viralen impstoffen in zellkultur durch unterdrückung von interferon - Google Patents
Methoden zur erhöhung der produktion von viralen impstoffen in zellkultur durch unterdrückung von interferonInfo
- Publication number
- ATE289348T1 ATE289348T1 AT96929066T AT96929066T ATE289348T1 AT E289348 T1 ATE289348 T1 AT E289348T1 AT 96929066 T AT96929066 T AT 96929066T AT 96929066 T AT96929066 T AT 96929066T AT E289348 T1 ATE289348 T1 AT E289348T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- cell culture
- synthetase
- cell cultures
- vaccine production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16641—Use of virus, viral particle or viral elements as a vector
- C12N2710/16643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32051—Methods of production or purification of viral material
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US262195P | 1995-08-22 | 1995-08-22 | |
PCT/US1996/013745 WO1997008292A1 (en) | 1995-08-22 | 1996-08-22 | Methods for enhancing the production of viral vaccines in cell culture by interferon suppression |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE289348T1 true ATE289348T1 (de) | 2005-03-15 |
Family
ID=21701659
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96929066T ATE289348T1 (de) | 1995-08-22 | 1996-08-22 | Methoden zur erhöhung der produktion von viralen impstoffen in zellkultur durch unterdrückung von interferon |
Country Status (10)
Country | Link |
---|---|
US (6) | US5840565A (de) |
EP (2) | EP0846160B1 (de) |
JP (2) | JP3432519B2 (de) |
CN (1) | CN1161469C (de) |
AT (1) | ATE289348T1 (de) |
AU (2) | AU6857696A (de) |
BR (1) | BR9610550A (de) |
CA (2) | CA2229163C (de) |
DE (1) | DE69634360T2 (de) |
WO (2) | WO1997008324A1 (de) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6855519B2 (en) * | 1995-08-22 | 2005-02-15 | The Regents Of The University Of California | Methods for enhancing the production of interferon in cell culture |
US5840565A (en) * | 1995-08-22 | 1998-11-24 | The Regents Of The University Of California | Methods for enhancing the production of viral vaccines in PKR-deficient cell culture |
US6740519B1 (en) * | 1997-11-03 | 2004-05-25 | Mount Sinai School Of Medicine | Immortalized, homozygous stat1-deficient mammalian cell lines and their uses |
DK1086207T3 (da) * | 1998-06-12 | 2007-05-29 | Sinai School Medicine | Hidtil ukendte fremgangsmåder og inteferon-deficiente substrater til opformering af vira |
US6762038B1 (en) * | 1998-09-09 | 2004-07-13 | The Cleveland Clinic Foundation | Mutant cell lines and methods for producing enhanced levels of recombinant proteins |
EP1255848A2 (de) * | 1999-06-15 | 2002-11-13 | Genetrol Biotherapeutics | Methode zur erhöhung der produktion von zytokinen in zellkultur |
EP1067179A1 (de) * | 1999-07-09 | 2001-01-10 | Pierre Fabre Medicament | Verfahren zur Selektion von attenuierten Paramyxoviridae verwenbare als Impstoffen und Therapeutika |
AU7126000A (en) * | 1999-09-08 | 2001-04-10 | Genetrol Biotherapeutics, Inc. | High level cytokine production with enhanced cell viability |
US20010031859A1 (en) * | 1999-09-08 | 2001-10-18 | Lau Allan S. | High level cytokine production with enhanced cell viability |
AU2001257001A1 (en) | 2000-04-10 | 2001-10-23 | Mount Sinai School Of Medicine Of New York University | Screening methods for identifying viral proteins with interferon antagonizing functions and potential antiviral agents |
IL136232A0 (en) * | 2000-05-18 | 2001-05-20 | Bar Ilan University Res Author | Measurements of enzymatic activity in a single, individual cell in population |
ATE318893T1 (de) * | 2000-08-04 | 2006-03-15 | Chiron Corp | Verbesserte replikation von hcv rna |
US20020150541A1 (en) * | 2000-09-12 | 2002-10-17 | Gene Trol Biotherapeutics, Inc. | Compositions comprising mixtures of therapeutic proteins and methods of producing the same |
WO2002022786A1 (en) | 2000-09-14 | 2002-03-21 | Genetrol Biotherapeutics, Inc. | Method and cell composition for screening compounds for anti-inflammatory activity |
JP2005500816A (ja) * | 2000-12-19 | 2005-01-13 | ジーントロール バイオセラピューティクス, インコーポレイテッド | サイトカイン産生を増加するための増大したpkr発現を有する細胞 |
DE10104094C1 (de) * | 2001-01-31 | 2002-07-25 | Angelika Vallbracht-Flehmig | Verfahren zur Erhöhung der Virusvermehrung und Virusausbeute in Zellkulturen, durch Blockade der RNaseL-Aktivierung |
WO2003035824A1 (en) * | 2001-10-25 | 2003-05-01 | Bar-Ilan University | Interactive transparent individual cells biochip processor |
IL154677A0 (en) * | 2003-02-27 | 2003-09-17 | Univ Bar Ilan | A method and apparatus for manipulating an individual cell |
US9200245B2 (en) | 2003-06-26 | 2015-12-01 | Seng Enterprises Ltd. | Multiwell plate |
US7888110B2 (en) | 2003-06-26 | 2011-02-15 | Seng Enterprises Ltd. | Pico liter well holding device and method of making the same |
US8597597B2 (en) | 2003-06-26 | 2013-12-03 | Seng Enterprises Ltd. | Picoliter well holding device and method of making the same |
WO2004113492A1 (en) * | 2003-06-26 | 2004-12-29 | Molecular Cytomics Ltd. | Improved materials for constructing cell-chips, cell-chip covers, cell-chip coats, processed cell-chips and uses thereof |
US7982751B2 (en) * | 2003-07-11 | 2011-07-19 | The University Of North Carolina | Methods and systems for controlling a computer using a video image and for combining the video image with a computer desktop |
EP1666059A4 (de) * | 2003-08-11 | 2008-08-27 | Univ Osaka Res Found | Neue vakzine mit einem adjuvans zur auslösung von schleimhautimmunität |
US20050064524A1 (en) * | 2003-08-11 | 2005-03-24 | Mordechai Deutsch | Population of cells utilizable for substance detection and methods and devices using same |
NZ603105A (en) * | 2003-10-23 | 2014-08-29 | Kineta Two Llc | Detection of mutations in a gene associated with resistance to viral infection, oasi |
KR20060116825A (ko) * | 2003-10-23 | 2006-11-15 | 일루미겐 바이오사이언시스, 인코포레이티드 | 바이러스 감염에 대한 저항성과 관련된 유전자인oas1에서의 돌연변이의 검출 |
WO2005074650A2 (en) | 2004-02-02 | 2005-08-18 | Ambrx, Inc. | Modified human four helical bundle polypeptides and their uses |
WO2005074893A1 (en) * | 2004-02-03 | 2005-08-18 | Chemagis Ltd. | Stable amorphous forms of montelukast sodium |
EP1718738A2 (de) * | 2004-02-23 | 2006-11-08 | Crucell Holland B.V. | Verfahren zur reinigung von viren |
EP3332803B1 (de) | 2004-06-01 | 2021-09-08 | Icahn School of Medicine at Mount Sinai | Genetisch veränderter schweineinfluenzavirus und verwendungen davon |
WO2006003664A1 (en) * | 2004-07-07 | 2006-01-12 | Seng Enterprises Ltd. | Method and device for identifying an image of a well in an image of a well-bearing component |
US7403647B2 (en) * | 2004-09-13 | 2008-07-22 | Seng Enterprises Ltd. | Method for identifying an image of a well in an image of a well-bearing component |
EP1781404A2 (de) * | 2004-08-25 | 2007-05-09 | Seng Enterprises Limited | Verfahren und vorrichtung zur isolierung von zellen |
US20060051369A1 (en) * | 2004-08-27 | 2006-03-09 | Taylor Deborah R | ADAR1 antiviral pathway |
US20080107683A1 (en) * | 2004-11-30 | 2008-05-08 | David Hone | Bacterial Packaging Strains Useful for Generation and Production of Recombinant Double-Stranded RNA Nucleocapsids and Uses Thereof |
US8038964B2 (en) | 2005-01-25 | 2011-10-18 | Seng Enterprises Ltd. | Device for studying individual cells |
US8137676B2 (en) | 2005-02-15 | 2012-03-20 | Mount Sinai School Of Medicine | Genetically engineered equine influenza virus and uses thereof |
DK1869171T4 (en) * | 2005-04-11 | 2016-01-18 | Crucell Holland Bv | Virus cleaning using ultrafiltration |
UA95446C2 (ru) * | 2005-05-04 | 2011-08-10 | Іллюміджен Байосайєнсіз, Інк. | Мутаци в генах oas1 |
DE102005034043B4 (de) * | 2005-07-18 | 2019-12-12 | Südzucker Aktiengesellschaft Mannheim/Ochsenfurt | Gemisch, enthaltend L-Carnitin und Trehalulose, sowie Produkt enthaltend das Gemisch |
US20070111309A1 (en) * | 2005-10-04 | 2007-05-17 | Daelli Marcelo G | Vero cell line adapted to grow in suspension |
US20070141555A1 (en) * | 2005-10-11 | 2007-06-21 | Mordechai Deutsch | Current damper for the study of cells |
US8288120B2 (en) | 2005-11-03 | 2012-10-16 | Seng Enterprises Ltd. | Method for studying floating, living cells |
US20070196333A1 (en) * | 2006-02-23 | 2007-08-23 | Fu-Yung Lin | Composition comprising mixtures of IFN-alpha subtypes |
US20060223999A1 (en) * | 2006-05-10 | 2006-10-05 | Chemagis Ltd. | Process for preparing montelukast and precursors thereof |
BRPI0810622A2 (pt) | 2007-05-02 | 2020-10-13 | Ambrx, Inc. | polipeptídeos de interferon beta modificados e seus usos |
US9145540B1 (en) | 2007-11-15 | 2015-09-29 | Seng Enterprises Ltd. | Device for the study of living cells |
EP2237887A2 (de) | 2007-12-26 | 2010-10-13 | Seng Enterprises Ltd. | Vorrichtung zur untersuchung von lebenden zellen |
JP5702150B2 (ja) | 2008-02-08 | 2015-04-15 | アンブルックス, インコーポレイテッドAmbrx, Inc. | 修飾されているレプチンポリペプチドおよびそれらの使用 |
EP2133358A1 (de) * | 2008-06-10 | 2009-12-16 | Universitätsklinikum Freiburg | Rifttalfiebervieren-ähnliche Partikel und ihre Verwendung zur Immunisierung und als Testsystem |
CA2733356C (en) * | 2008-08-01 | 2016-06-07 | Gamma Vaccines Pty Limited | Influenza vaccines |
WO2010077986A2 (en) | 2008-12-16 | 2010-07-08 | Baxter International Inc. | Production of viral vaccine |
BR112012026095A2 (pt) | 2010-04-14 | 2015-09-15 | Emd Millipore Corp | métodos de produção de estoques de vírus de alta pureza e altos títulos e métodos de uso dos mesmos. |
WO2012100302A1 (en) | 2011-01-27 | 2012-08-02 | Gamma Vaccines Pty Limited | Combination vaccines |
WO2013182498A1 (en) * | 2012-06-04 | 2013-12-12 | Novartis Ag | Improved safety testing |
JP2016506734A (ja) * | 2013-02-05 | 2016-03-07 | ユニバーシティ・オブ・ジョージア・リサーチ・ファウンデイション・インコーポレイテッド | ウイルス産生用の細胞株及びその使用方法 |
AU2016222962B2 (en) | 2015-02-26 | 2020-05-21 | Boehringer Ingelheim Vetmedica Gmbh | Bivalent swine influenza virus vaccine |
WO2017070167A1 (en) * | 2015-10-20 | 2017-04-27 | The University Of North Carolina At Chapel Hill | Methods and compositions for modified factor ix fusion proteins |
KR102651055B1 (ko) | 2016-03-24 | 2024-03-26 | 삼성디스플레이 주식회사 | 광학 필름 및 디스플레이 장치 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE33164E (en) * | 1979-05-15 | 1990-02-13 | Mobay Corporation | Influenza vaccine production in liquid cell culture |
JPS5754586A (en) * | 1980-09-18 | 1982-04-01 | Ajinomoto Co Inc | Cell strain producing human interferon prolongably, its preparation, and preparation of human interferon using it |
US4579821A (en) * | 1981-11-23 | 1986-04-01 | University Patents, Inc. | Control of DNA sequence transcription |
JPS58209993A (ja) * | 1982-05-31 | 1983-12-07 | Mochida Pharmaceut Co Ltd | インタ−フエロンの産生方法 |
AU572783B2 (en) * | 1982-06-21 | 1988-05-19 | Wellcome Foundation Limited, The | Improvements in or relating to the production of antiviral agents |
US4485038A (en) * | 1982-10-19 | 1984-11-27 | Health Research (Roswell Park Division) | Method for the production and purification of human leukocyte interferon |
US4966843A (en) * | 1982-11-01 | 1990-10-30 | Cetus Corporation | Expression of interferon genes in Chinese hamster ovary cells |
US4745053A (en) * | 1983-07-08 | 1988-05-17 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyojo | Process for producing human interferon and method for assaying the interferon productivity of blood |
JPS6062997A (ja) * | 1983-09-17 | 1985-04-11 | Mochida Pharmaceut Co Ltd | インタ−フエロンの生産方法 |
US5196323A (en) * | 1985-04-27 | 1993-03-23 | Boehringer Ingelheim International Gmbh | Process for preparing and purifying alpha-interferon |
US4732683A (en) * | 1986-12-02 | 1988-03-22 | Biospectrum, Inc. | Purification method for alpha interferon |
ES2110411T3 (es) * | 1989-08-25 | 1998-02-16 | Chiron Corp | Metodos para cultivar el virus de la hepatitis c (hcv) en lineas celulares de linfocitos b o t. |
US5149531A (en) * | 1990-06-27 | 1992-09-22 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Method of using cold-adapted live influenza virus vaccine as an antiviral agent against influenza |
JPH05260981A (ja) * | 1992-03-02 | 1993-10-12 | Massachusetts Inst Of Technol <Mit> | ヘムに調節される真核細胞開始因子2αキナーゼをコードするDNA |
FR2689520B1 (fr) * | 1992-04-03 | 1996-07-19 | Bio Merieux | Procede et milieu de culture pour l'obtention de cellules infectees par un virus associe a la sclerose en plaques. |
US5840565A (en) * | 1995-08-22 | 1998-11-24 | The Regents Of The University Of California | Methods for enhancing the production of viral vaccines in PKR-deficient cell culture |
-
1996
- 1996-08-21 US US08/700,198 patent/US5840565A/en not_active Expired - Lifetime
- 1996-08-22 DE DE69634360T patent/DE69634360T2/de not_active Expired - Lifetime
- 1996-08-22 WO PCT/US1996/013627 patent/WO1997008324A1/en not_active Application Discontinuation
- 1996-08-22 AT AT96929066T patent/ATE289348T1/de active
- 1996-08-22 JP JP51045097A patent/JP3432519B2/ja not_active Expired - Fee Related
- 1996-08-22 EP EP96929066A patent/EP0846160B1/de not_active Expired - Lifetime
- 1996-08-22 CN CNB961977515A patent/CN1161469C/zh not_active Expired - Fee Related
- 1996-08-22 JP JP51050897A patent/JP4267693B2/ja not_active Expired - Lifetime
- 1996-08-22 AU AU68576/96A patent/AU6857696A/en not_active Abandoned
- 1996-08-22 WO PCT/US1996/013745 patent/WO1997008292A1/en active IP Right Grant
- 1996-08-22 EP EP96929017A patent/EP0846174A4/de not_active Withdrawn
- 1996-08-22 BR BR9610550A patent/BR9610550A/pt not_active Application Discontinuation
- 1996-08-22 CA CA2229163A patent/CA2229163C/en not_active Expired - Lifetime
- 1996-08-22 AU AU68608/96A patent/AU707130B2/en not_active Expired
- 1996-08-22 CA CA002229405A patent/CA2229405C/en not_active Expired - Fee Related
-
1999
- 1999-11-19 US US09/444,224 patent/US6159712A/en not_active Expired - Fee Related
-
2000
- 2000-06-12 US US09/591,813 patent/US6489144B1/en not_active Expired - Fee Related
- 2000-12-13 US US09/736,748 patent/US6673591B2/en not_active Expired - Fee Related
- 2000-12-13 US US09/737,126 patent/US6686190B2/en not_active Expired - Lifetime
-
2003
- 2003-11-24 US US10/722,349 patent/US7132271B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP4267693B2 (ja) | 2009-05-27 |
US6159712A (en) | 2000-12-12 |
US20010001290A1 (en) | 2001-05-17 |
CN1161469C (zh) | 2004-08-11 |
BR9610550A (pt) | 1999-07-06 |
DE69634360D1 (de) | 2005-03-24 |
US6686190B2 (en) | 2004-02-03 |
AU6857696A (en) | 1997-03-19 |
US20010001709A1 (en) | 2001-05-24 |
AU707130B2 (en) | 1999-07-01 |
EP0846160B1 (de) | 2005-02-16 |
CA2229405C (en) | 2004-03-02 |
EP0846160A1 (de) | 1998-06-10 |
CA2229163A1 (en) | 1997-03-06 |
JPH11514344A (ja) | 1999-12-07 |
US20040157310A1 (en) | 2004-08-12 |
CA2229405A1 (en) | 1997-03-06 |
US5840565A (en) | 1998-11-24 |
MX9801423A (es) | 1998-05-31 |
DE69634360T2 (de) | 2005-12-29 |
JP3432519B2 (ja) | 2003-08-04 |
US6673591B2 (en) | 2004-01-06 |
AU6860896A (en) | 1997-03-19 |
EP0846160A4 (de) | 2002-01-02 |
US6489144B1 (en) | 2002-12-03 |
CA2229163C (en) | 2011-04-05 |
US7132271B2 (en) | 2006-11-07 |
WO1997008324A1 (en) | 1997-03-06 |
WO1997008292A1 (en) | 1997-03-06 |
CN1200148A (zh) | 1998-11-25 |
EP0846174A1 (de) | 1998-06-10 |
EP0846174A4 (de) | 2003-02-05 |
JPH11511324A (ja) | 1999-10-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE289348T1 (de) | Methoden zur erhöhung der produktion von viralen impstoffen in zellkultur durch unterdrückung von interferon | |
ATE482267T1 (de) | Tierzellen und verfahren für die replikation von influenza viren | |
ATE466932T1 (de) | Vermehrung von viren in zellkultur | |
FI932678A (fi) | Pao alfavirus baserande dna expressionssystem | |
BRPI0407636A (pt) | meio de cultura de células, linhagem de células animais, métodos para produzir um meio de cultura condicionado, células animais, uma cultura de células animais, vìrus em uma cultura de células animais, ou, de preferência, humanas diplóides dependentes de ancoragem, método para produzir uma vacina, e, população de vìrus | |
ES2156852T3 (es) | Citoquina mamifera, il-11. | |
DE68929115T2 (de) | Verfahren zur Herstellung von menschlichem Serumalbumin in Hefe | |
ATE370229T1 (de) | Ein verstärkter, durch viren vermittelter dna- transfer | |
ATE27463T1 (de) | Verfahren zur in vitro transformation von pflanzenprotoplasten mit plasmid-dns. | |
DE69031791T2 (de) | Verfahren zur HCV-Züchtung in Zell-Linien aus B- oder T-Lymphozyten | |
IL175264A0 (en) | Method for proliferating cardiomyocytes | |
ATE530657T1 (de) | Verfahren zur herstellung von zellinien mit latentem immunschwächevirus | |
ATE366803T1 (de) | Hohe zytokinproduktion mit verbesserte zelllebensfähigkeit | |
Lelievre et al. | Contact inhibition-plasma membranes enzymatic activities in cultured cell lines | |
WO2003027290A1 (fr) | Procede pour conferer ou reguler la fertilite d'un cytoplasme a sterilite male de riz bt au moyen d'un gene de restauration de la fertilite, et procede d'estimation de la presence d'un gene de restauration de la fertilite | |
FR2600079B1 (fr) | Vecteur viral et adn recombinant codant pour la proteine f du virus agent causal du s.i.d.a., culture cellulaire infectee par ce vecteur, procede de preparation de la proteine, proteine obtenue, vaccin et anticorps obtenus | |
DE50011695D1 (de) | Expressionssystem zur Produktion von Proteinen in Pilzen | |
AU6262786A (en) | Growing aids virus in cell lines lacking human class ii histocompatability antigens | |
ATE111527T1 (de) | Herstellung und verwendung einer dna zur erhöhung der ausbeute bei der expression von rekombinanten genen. | |
SE7705701L (sv) | Forfarande for utvinning av eggvita med forminskad nukleinsyrahalt ur mikroorganismer | |
DE69923595D1 (de) | Herstellung von proteinen | |
DE50212759D1 (de) | Medium zur züchtung von tumorzellen | |
WO2002062837A3 (en) | Cells with enhanced pkr expression for increasing cytokine production | |
SU1559700A1 (ru) | Штамм культивируемых клеток почки эмбриона овцы для размножения вирусов | |
AU2002212013A1 (en) | Zipper protein kinase and uses thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 0846160 Country of ref document: EP |