MX2015010017A - Lineas celulares para la produccion de virus y metodos de uso. - Google Patents
Lineas celulares para la produccion de virus y metodos de uso.Info
- Publication number
- MX2015010017A MX2015010017A MX2015010017A MX2015010017A MX2015010017A MX 2015010017 A MX2015010017 A MX 2015010017A MX 2015010017 A MX2015010017 A MX 2015010017A MX 2015010017 A MX2015010017 A MX 2015010017A MX 2015010017 A MX2015010017 A MX 2015010017A
- Authority
- MX
- Mexico
- Prior art keywords
- virus
- altered expression
- methods
- dosing chamber
- shuttle member
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/125—Picornaviridae, e.g. calicivirus
- A61K39/13—Poliovirus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
- C12N2310/141—MicroRNAs, miRNAs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/10—Applications; Uses in screening processes
- C12N2320/12—Applications; Uses in screening processes in functional genomics, i.e. for the determination of gene function
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32051—Methods of production or purification of viral material
- C12N2770/32052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32311—Enterovirus
- C12N2770/32351—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32611—Poliovirus
- C12N2770/32651—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se proporcionan en la presente líneas celulares manipuladas. En algunas modalidades, las células de una línea celular manipulada tienen expresión alterada de un gen y/o expresión alterada de un miARN, en donde la expresión alterada resulta en una producción aumentada o reducida de un virus. Ese virus es un picornavirus, tal como un virus poliomielítico o Enterovirus 71. También se proporcionan en la presente métodos para uso de las células manipuladas para producir virus y métodos para tratar a un sujeto que tiene corre el riesgo de tener una infección viral.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361760895P | 2013-02-05 | 2013-02-05 | |
US201361885357P | 2013-10-01 | 2013-10-01 | |
PCT/US2014/014813 WO2014123967A2 (en) | 2013-02-05 | 2014-02-05 | Cell lines for virus production and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2015010017A true MX2015010017A (es) | 2016-03-04 |
Family
ID=50159542
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015010017A MX2015010017A (es) | 2013-02-05 | 2014-02-05 | Lineas celulares para la produccion de virus y metodos de uso. |
Country Status (12)
Country | Link |
---|---|
US (1) | US10137188B2 (es) |
EP (2) | EP2954055B1 (es) |
JP (1) | JP2016506734A (es) |
KR (1) | KR20150133695A (es) |
CN (2) | CN105121645B (es) |
AU (1) | AU2014215025B2 (es) |
BR (1) | BR112015018493A2 (es) |
CA (1) | CA2899928A1 (es) |
HK (1) | HK1219975A1 (es) |
MX (1) | MX2015010017A (es) |
RU (1) | RU2015137703A (es) |
WO (1) | WO2014123967A2 (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9771586B2 (en) | 2002-11-14 | 2017-09-26 | Thermo Fisher Scientific Inc. | RNAi targeting ZNF205 |
US9719092B2 (en) | 2002-11-14 | 2017-08-01 | Thermo Fisher Scientific Inc. | RNAi targeting CNTD2 |
US9719094B2 (en) | 2002-11-14 | 2017-08-01 | Thermo Fisher Scientific Inc. | RNAi targeting SEC61G |
AU2012333134B2 (en) | 2011-07-22 | 2017-05-25 | John Paul Guilinger | Evaluation and improvement of nuclease cleavage specificity |
US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
US9340800B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | Extended DNA-sensing GRNAS |
US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
US9068179B1 (en) | 2013-12-12 | 2015-06-30 | President And Fellows Of Harvard College | Methods for correcting presenilin point mutations |
AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
WO2016047595A1 (ja) * | 2014-09-22 | 2016-03-31 | 国立研究開発法人科学技術振興機構 | インフルエンザウイルス産生用細胞、及びインフルエンザウイルスの産生方法 |
WO2017007784A1 (en) * | 2015-07-06 | 2017-01-12 | University Of Georgia Research Foundation | Methods and compositions related to increased influenza virus production |
WO2017070632A2 (en) | 2015-10-23 | 2017-04-27 | President And Fellows Of Harvard College | Nucleobase editors and uses thereof |
WO2017083423A1 (en) * | 2015-11-10 | 2017-05-18 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for modulating aav infection |
WO2017088017A1 (en) | 2015-11-24 | 2017-06-01 | Commonwealth Scientific And Industrial Research Organisation | Production of viruses in avian eggs |
EP3380611A4 (en) | 2015-11-24 | 2020-02-12 | Commonwealth Scientific and Industrial Research Organisation | PRODUCTION OF VIRUSES IN A CELL CULTURE |
WO2017177029A1 (en) * | 2016-04-06 | 2017-10-12 | Duke University | Compositions and methods for enhanced gene expression and viral replication |
US11058760B2 (en) | 2016-04-18 | 2021-07-13 | University Of Florida Research Foundation, Incorporated | N-antigenic form poliovirus virus-like particles comprising thermostable mutations |
CA3032699A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harvard College | Adenosine nucleobase editors and uses thereof |
WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
EP3526320A1 (en) | 2016-10-14 | 2019-08-21 | President and Fellows of Harvard College | Aav delivery of nucleobase editors |
US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
EP4008343A3 (en) * | 2017-03-08 | 2022-08-24 | University of Georgia Research Foundation Inc. | Methods and compositions related to increased viral production |
EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
KR102687373B1 (ko) | 2017-03-23 | 2024-07-23 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
FR3067933B1 (fr) * | 2017-06-21 | 2020-07-17 | L'oreal | Modulateurs de l’opsine 3 dans la modulation de la pigmentation de la peau |
EP3658573A1 (en) | 2017-07-28 | 2020-06-03 | President and Fellows of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace) |
EP3668309A4 (en) * | 2017-08-14 | 2021-06-09 | University of Georgia Research Foundation, Inc. | PROTEINS WITH PNEUMOCOCCK CAPSULE DEGRADING ACTIVITY AND METHOD OF USING |
WO2019139645A2 (en) | 2017-08-30 | 2019-07-18 | President And Fellows Of Harvard College | High efficiency base editors comprising gam |
CN111757937A (zh) | 2017-10-16 | 2020-10-09 | 布罗德研究所股份有限公司 | 腺苷碱基编辑器的用途 |
US20210024900A1 (en) * | 2017-11-02 | 2021-01-28 | University Of Georgia Research Foundation, Inc. | Methods and compositions related to increased rotavirus production |
WO2020000464A1 (zh) * | 2018-06-29 | 2020-01-02 | 深圳市博奥康生物科技有限公司 | 一种制备gl-r基因敲除小鼠的方法 |
JP7350859B2 (ja) | 2018-09-07 | 2023-09-26 | ザ プロクター アンド ギャンブル カンパニー | 揮発性組成物ディスペンサ |
WO2020191249A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
EP3953458A1 (en) | 2019-04-12 | 2022-02-16 | Ultragenyx Pharmaceutical Inc. | Engineered producer cell lines and methods of making and using the same |
MX2022014008A (es) | 2020-05-08 | 2023-02-09 | Broad Inst Inc | Métodos y composiciones para la edición simultánea de ambas cadenas de una secuencia de nucleótidos de doble cadena objetivo. |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB240455A (en) | 1924-09-23 | 1926-12-16 | Siegmund Loewe | High frequency thermionic valve |
US5840565A (en) * | 1995-08-22 | 1998-11-24 | The Regents Of The University Of California | Methods for enhancing the production of viral vaccines in PKR-deficient cell culture |
RU2192884C2 (ru) | 2000-11-09 | 2002-11-20 | Государственное учреждение Научно-исследовательский институт клинической иммунологии СО РАМН | Вакцина для стимуляции противоопухолевого иммунитета |
EP1583832B1 (en) * | 2003-01-17 | 2010-12-01 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Inducible small interfering rna (sirna) expression constructs for targeted gene silencing |
CN1548054A (zh) * | 2003-05-08 | 2004-11-24 | 陆爱丽 | 预防或治疗sars冠状病毒的药物 |
US20090280567A1 (en) | 2004-02-06 | 2009-11-12 | Dharmacon, Inc. | Stabilized sirnas as transfection controls and silencing reagents |
EP1933880A4 (en) * | 2005-09-09 | 2009-11-18 | Quark Pharmaceuticals Inc | OLIGORIBONUCLEOTIDES AND METHODS OF USE IN THE TREATMENT OF CARDIOVASCULAR DISEASES |
CN101627121A (zh) * | 2006-12-08 | 2010-01-13 | 奥斯瑞根公司 | 作为治疗干预的靶标的miRNA调控基因和路径 |
US20090232893A1 (en) * | 2007-05-22 | 2009-09-17 | Bader Andreas G | miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION |
US8071378B2 (en) * | 2007-08-06 | 2011-12-06 | Sanford-Burnham Medical Research Institute | ZNF206: regulator of embryonic stem cell self-renewal and pluripotency |
US8188060B2 (en) | 2008-02-11 | 2012-05-29 | Dharmacon, Inc. | Duplex oligonucleotides with enhanced functionality in gene regulation |
US20120039939A1 (en) * | 2008-04-11 | 2012-02-16 | The Johns Hopkins University | Compositions and methods for vaccine and virus production |
SG177655A1 (en) * | 2009-07-16 | 2012-02-28 | Crucell Holland Bv | Production of polio virus at high titers for vaccine production |
-
2014
- 2014-02-05 CN CN201480007578.8A patent/CN105121645B/zh not_active Expired - Fee Related
- 2014-02-05 EP EP14706395.2A patent/EP2954055B1/en not_active Not-in-force
- 2014-02-05 US US14/765,365 patent/US10137188B2/en not_active Expired - Fee Related
- 2014-02-05 BR BR112015018493A patent/BR112015018493A2/pt active Search and Examination
- 2014-02-05 KR KR1020157020862A patent/KR20150133695A/ko not_active Application Discontinuation
- 2014-02-05 AU AU2014215025A patent/AU2014215025B2/en not_active Expired - Fee Related
- 2014-02-05 CN CN201810357652.9A patent/CN108588027A/zh active Pending
- 2014-02-05 CA CA2899928A patent/CA2899928A1/en not_active Abandoned
- 2014-02-05 JP JP2015556249A patent/JP2016506734A/ja active Pending
- 2014-02-05 EP EP18164513.6A patent/EP3372685A3/en not_active Withdrawn
- 2014-02-05 MX MX2015010017A patent/MX2015010017A/es unknown
- 2014-02-05 WO PCT/US2014/014813 patent/WO2014123967A2/en active Application Filing
- 2014-02-05 RU RU2015137703A patent/RU2015137703A/ru not_active Application Discontinuation
-
2016
- 2016-06-07 HK HK16106481.5A patent/HK1219975A1/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
BR112015018493A2 (pt) | 2017-08-22 |
JP2016506734A (ja) | 2016-03-07 |
US20150374812A1 (en) | 2015-12-31 |
EP2954055B1 (en) | 2018-04-11 |
EP3372685A2 (en) | 2018-09-12 |
AU2014215025B2 (en) | 2018-08-30 |
RU2015137703A (ru) | 2017-03-09 |
CN108588027A (zh) | 2018-09-28 |
CN105121645A (zh) | 2015-12-02 |
CA2899928A1 (en) | 2014-08-14 |
CN105121645B (zh) | 2018-05-08 |
WO2014123967A2 (en) | 2014-08-14 |
EP3372685A3 (en) | 2018-10-17 |
HK1219975A1 (zh) | 2017-04-21 |
KR20150133695A (ko) | 2015-11-30 |
AU2014215025A1 (en) | 2015-07-09 |
US20170151322A9 (en) | 2017-06-01 |
RU2015137703A3 (es) | 2018-03-01 |
EP2954055A2 (en) | 2015-12-16 |
US10137188B2 (en) | 2018-11-27 |
WO2014123967A3 (en) | 2014-11-06 |
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