JP4267693B2 - インターフェロン抑圧による細胞培養でのウィルスワクチン製造強化方法 - Google Patents

インターフェロン抑圧による細胞培養でのウィルスワクチン製造強化方法 Download PDF

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JP4267693B2
JP4267693B2 JP51050897A JP51050897A JP4267693B2 JP 4267693 B2 JP4267693 B2 JP 4267693B2 JP 51050897 A JP51050897 A JP 51050897A JP 51050897 A JP51050897 A JP 51050897A JP 4267693 B2 JP4267693 B2 JP 4267693B2
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virus
pkr
cells
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JPH11514344A (ja
JPH11514344A5 (https=
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ロウ、アラン、エス．
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University of California
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16641—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32051—Methods of production or purification of viral material

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  • Wood Science & Technology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
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  • Immunology (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP51050897A 1995-08-22 1996-08-22 インターフェロン抑圧による細胞培養でのウィルスワクチン製造強化方法 Expired - Lifetime JP4267693B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US262195P 1995-08-22 1995-08-22
US60/002,621 1995-08-22
PCT/US1996/013745 WO1997008292A1 (en) 1995-08-22 1996-08-22 Methods for enhancing the production of viral vaccines in cell culture by interferon suppression

Publications (3)

Publication Number Publication Date
JPH11514344A JPH11514344A (ja) 1999-12-07
JPH11514344A5 JPH11514344A5 (https=) 2004-09-09
JP4267693B2 true JP4267693B2 (ja) 2009-05-27

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JP51050897A Expired - Lifetime JP4267693B2 (ja) 1995-08-22 1996-08-22 インターフェロン抑圧による細胞培養でのウィルスワクチン製造強化方法
JP51045097A Expired - Fee Related JP3432519B2 (ja) 1995-08-22 1996-08-22 細胞培養でインターフェロン産生を高める方法

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JP51045097A Expired - Fee Related JP3432519B2 (ja) 1995-08-22 1996-08-22 細胞培養でインターフェロン産生を高める方法

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US (6) US5840565A (https=)
EP (2) EP0846160B1 (https=)
JP (2) JP4267693B2 (https=)
CN (1) CN1161469C (https=)
AT (1) ATE289348T1 (https=)
AU (2) AU707130B2 (https=)
BR (1) BR9610550A (https=)
CA (2) CA2229163C (https=)
DE (1) DE69634360T2 (https=)
WO (2) WO1997008292A1 (https=)

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Publication number Publication date
US6159712A (en) 2000-12-12
JPH11514344A (ja) 1999-12-07
US20010001290A1 (en) 2001-05-17
US20010001709A1 (en) 2001-05-24
US5840565A (en) 1998-11-24
EP0846174A1 (en) 1998-06-10
JP3432519B2 (ja) 2003-08-04
CA2229163A1 (en) 1997-03-06
EP0846160B1 (en) 2005-02-16
US7132271B2 (en) 2006-11-07
DE69634360D1 (de) 2005-03-24
EP0846160A4 (en) 2002-01-02
CA2229405A1 (en) 1997-03-06
US6489144B1 (en) 2002-12-03
MX9801423A (es) 1998-05-31
AU6860896A (en) 1997-03-19
WO1997008324A1 (en) 1997-03-06
CA2229405C (en) 2004-03-02
DE69634360T2 (de) 2005-12-29
US20040157310A1 (en) 2004-08-12
EP0846160A1 (en) 1998-06-10
AU6857696A (en) 1997-03-19
CN1200148A (zh) 1998-11-25
US6673591B2 (en) 2004-01-06
JPH11511324A (ja) 1999-10-05
CN1161469C (zh) 2004-08-11
BR9610550A (pt) 1999-07-06
CA2229163C (en) 2011-04-05
EP0846174A4 (en) 2003-02-05
WO1997008292A1 (en) 1997-03-06
ATE289348T1 (de) 2005-03-15
AU707130B2 (en) 1999-07-01
US6686190B2 (en) 2004-02-03

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