DE69633947T2 - Zwischenprodukte zur Herstellung von Metallproteinasehemmern - Google Patents

Zwischenprodukte zur Herstellung von Metallproteinasehemmern Download PDF

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Publication number
DE69633947T2
DE69633947T2 DE69633947T DE69633947T DE69633947T2 DE 69633947 T2 DE69633947 T2 DE 69633947T2 DE 69633947 T DE69633947 T DE 69633947T DE 69633947 T DE69633947 T DE 69633947T DE 69633947 T2 DE69633947 T2 DE 69633947T2
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DE
Germany
Prior art keywords
formula
benzenesulfonyl
solution
added
thiazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69633947T
Other languages
German (de)
English (en)
Other versions
DE69633947D1 (de
Inventor
Scott E. Zook
Jr. Raymond Dagnino
Michael E. Deason
Steven L. Bender
Michael J. Melnick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agouron Pharmaceuticals LLC
Original Assignee
Agouron Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharmaceuticals LLC filed Critical Agouron Pharmaceuticals LLC
Application granted granted Critical
Publication of DE69633947D1 publication Critical patent/DE69633947D1/de
Publication of DE69633947T2 publication Critical patent/DE69633947T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/04—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69633947T 1995-12-08 1996-12-05 Zwischenprodukte zur Herstellung von Metallproteinasehemmern Expired - Fee Related DE69633947T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56976695A 1995-12-08 1995-12-08
US569766 1995-12-08

Publications (2)

Publication Number Publication Date
DE69633947D1 DE69633947D1 (de) 2004-12-30
DE69633947T2 true DE69633947T2 (de) 2005-12-01

Family

ID=24276764

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69633947T Expired - Fee Related DE69633947T2 (de) 1995-12-08 1996-12-05 Zwischenprodukte zur Herstellung von Metallproteinasehemmern
DE69626684T Expired - Fee Related DE69626684T2 (de) 1995-12-08 1996-12-05 Metallproteinasehemmer, diesen enthaltende pharmazeutische zusammensetzung und dessen pharmazeutische verwendung und verfahren zu ihrer herstellung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69626684T Expired - Fee Related DE69626684T2 (de) 1995-12-08 1996-12-05 Metallproteinasehemmer, diesen enthaltende pharmazeutische zusammensetzung und dessen pharmazeutische verwendung und verfahren zu ihrer herstellung

Country Status (39)

Country Link
US (1) US6153757A (cg-RX-API-DMAC7.html)
EP (2) EP1095936B1 (cg-RX-API-DMAC7.html)
JP (1) JP2000502330A (cg-RX-API-DMAC7.html)
KR (1) KR19990072009A (cg-RX-API-DMAC7.html)
CN (2) CN1542002A (cg-RX-API-DMAC7.html)
AP (2) AP1288A (cg-RX-API-DMAC7.html)
AT (2) ATE283264T1 (cg-RX-API-DMAC7.html)
AU (1) AU725831C (cg-RX-API-DMAC7.html)
BG (1) BG64279B1 (cg-RX-API-DMAC7.html)
BR (1) BR9611929A (cg-RX-API-DMAC7.html)
CA (1) CA2238306A1 (cg-RX-API-DMAC7.html)
CO (1) CO4790150A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ292942B6 (cg-RX-API-DMAC7.html)
DE (2) DE69633947T2 (cg-RX-API-DMAC7.html)
DK (1) DK0874830T3 (cg-RX-API-DMAC7.html)
EA (1) EA003294B1 (cg-RX-API-DMAC7.html)
ES (2) ES2233275T3 (cg-RX-API-DMAC7.html)
GE (1) GEP20012388B (cg-RX-API-DMAC7.html)
GT (2) GT199700015AA (cg-RX-API-DMAC7.html)
HR (1) HRP970031A2 (cg-RX-API-DMAC7.html)
HU (1) HUP9902092A3 (cg-RX-API-DMAC7.html)
ID (1) ID17624A (cg-RX-API-DMAC7.html)
IL (6) IL138027A (cg-RX-API-DMAC7.html)
MX (1) MX9804457A (cg-RX-API-DMAC7.html)
MY (1) MY117290A (cg-RX-API-DMAC7.html)
NO (1) NO311360B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ325559A (cg-RX-API-DMAC7.html)
OA (1) OA10794A (cg-RX-API-DMAC7.html)
PA (1) PA8431301A1 (cg-RX-API-DMAC7.html)
PE (1) PE69298A1 (cg-RX-API-DMAC7.html)
PL (1) PL327275A1 (cg-RX-API-DMAC7.html)
PT (1) PT874830E (cg-RX-API-DMAC7.html)
SI (1) SI0874830T1 (cg-RX-API-DMAC7.html)
SK (1) SK73898A3 (cg-RX-API-DMAC7.html)
SV (1) SV1997000008A (cg-RX-API-DMAC7.html)
TR (1) TR199800990T2 (cg-RX-API-DMAC7.html)
TW (1) TW546293B (cg-RX-API-DMAC7.html)
WO (1) WO1997020824A1 (cg-RX-API-DMAC7.html)
YU (1) YU21597A (cg-RX-API-DMAC7.html)

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