ATE429228T1 - Derivate von piperazine-2-carboxamide - Google Patents
Derivate von piperazine-2-carboxamideInfo
- Publication number
- ATE429228T1 ATE429228T1 AT04708776T AT04708776T ATE429228T1 AT E429228 T1 ATE429228 T1 AT E429228T1 AT 04708776 T AT04708776 T AT 04708776T AT 04708776 T AT04708776 T AT 04708776T AT E429228 T1 ATE429228 T1 AT E429228T1
- Authority
- AT
- Austria
- Prior art keywords
- piperazine
- carboxamide
- derivatives
- labor
- dysmenorrhea
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03003422 | 2003-02-14 | ||
| PCT/EP2004/050093 WO2004071390A2 (en) | 2003-02-14 | 2004-02-06 | Piperazine-2-carboxamide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE429228T1 true ATE429228T1 (de) | 2009-05-15 |
Family
ID=32864935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04708776T ATE429228T1 (de) | 2003-02-14 | 2004-02-06 | Derivate von piperazine-2-carboxamide |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8404690B2 (de) |
| EP (1) | EP1592389B1 (de) |
| JP (1) | JP4825664B2 (de) |
| AT (1) | ATE429228T1 (de) |
| AU (1) | AU2004212335A1 (de) |
| CA (1) | CA2513716A1 (de) |
| DE (1) | DE602004020734D1 (de) |
| ES (1) | ES2324535T3 (de) |
| NO (1) | NO20053991L (de) |
| WO (1) | WO2004071390A2 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7629341B2 (en) | 2002-06-12 | 2009-12-08 | Symphony Evolution, Inc. | Human ADAM-10 inhibitors |
| US7754722B2 (en) * | 2002-09-20 | 2010-07-13 | Merck Serono Sa | Piperazine derivatives and methods of use |
| BRPI0412263B1 (pt) | 2003-07-22 | 2019-10-15 | Arena Pharmaceuticals, Inc. | Derivados de diaril e aril heteroaril uréia, uso e composição farmacêutica contendo os mesmos, bem como processo para preparação da dita composição |
| EP1694686A1 (de) | 2003-12-19 | 2006-08-30 | Takeda San Diego, Inc. | Kinaseinhibitoren |
| EP1778669A2 (de) | 2004-08-18 | 2007-05-02 | Takeda San Diego, Inc. | Kinase-inhibitoren |
| ATE479687T1 (de) | 2004-10-15 | 2010-09-15 | Takeda Pharmaceutical | Kinaseinhibitoren |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| US8017612B2 (en) | 2006-04-18 | 2011-09-13 | Japan Tobacco Inc. | Piperazine compound and use thereof as a HCV polymerase inhibitor |
| US7943622B2 (en) | 2006-06-06 | 2011-05-17 | Cornerstone Therapeutics, Inc. | Piperazines, pharmaceutical compositions and methods of use thereof |
| JP5363315B2 (ja) * | 2006-06-06 | 2013-12-11 | コーナーストーン セラピューティクス インコーポレイテッド | 新規ピペラジン、医薬組成物、およびその使用方法 |
| JP2010505962A (ja) | 2006-10-09 | 2010-02-25 | 武田薬品工業株式会社 | キナーゼ阻害剤 |
| WO2009074607A1 (en) | 2007-12-12 | 2009-06-18 | Glaxo Group Limited | Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline |
| WO2009123714A2 (en) | 2008-04-02 | 2009-10-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
| JP6902466B2 (ja) * | 2014-11-07 | 2021-07-14 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | ミオカルディン関連転写因子および血清応答因子（ｍｒｔｆ／ｓｒｆ）媒介性遺伝子転写の阻害剤ならびにその使用方法 |
| EP4119141A1 (de) | 2015-06-12 | 2023-01-18 | Axovant Sciences GmbH | Nelotanserin zur prophylaxe und behandlung von schlafverhaltensstörungen in der rem-phase |
| EP3322415A4 (de) | 2015-07-15 | 2019-03-13 | Axovant Sciences GmbH | Diaryl- und arylheteroaryl-harnstoff-derivate als modulatoren des 5-ht2a-serotoninrezeptors zur prophylaxe und behandlung von halluzinationen im zusammenhang mit einer neurogenerativen erkrankung |
| WO2019104011A1 (en) * | 2017-11-21 | 2019-05-31 | Biomarin Pharmaceutical Inc. | Ceramide galactosyltransferase inhibitors for the treatment of disease |
| WO2020028221A1 (en) * | 2018-07-30 | 2020-02-06 | Biomarin Pharmaceutical Inc. | Ceramide galactosyltransferase inhibitors for the treatment of disease |
| US20220287987A1 (en) * | 2019-08-26 | 2022-09-15 | Societe Des Produits Nestle S.A. | Myo-inositol and the prevention of pprom |
| CN115460934A (zh) * | 2019-08-26 | 2022-12-09 | 雀巢产品有限公司 | 肌醇和早产的预防 |
| WO2023215205A1 (en) * | 2022-05-06 | 2023-11-09 | Merck Sharp & Dohme Llc | Orexin receptor agonists |
| WO2024107615A1 (en) * | 2022-11-17 | 2024-05-23 | Merck Sharp & Dohme Llc | Orexin receptor agonists |
| WO2025132542A1 (en) | 2023-12-19 | 2025-06-26 | Idorsia Pharmaceuticals Ltd | Macrocyclic orexin agonists |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6450818A (en) | 1987-08-20 | 1989-02-27 | Tsumura & Co | Prostaglandin f2alpha-inhibitor |
| US6271201B1 (en) | 1993-07-15 | 2001-08-07 | Board Of Regents, The University Of Texas System | Methods for the selective regulation of placental prostanoids and inhibition of labor using IGF-I |
| TW472047B (en) * | 1994-02-04 | 2002-01-11 | Merck & Co Inc | Process for making HIV protease inhibitors |
| US5612484A (en) * | 1995-05-18 | 1997-03-18 | Merck & Co., Inc. | Process for making HIV protease inhibitors |
| AU725831C (en) * | 1995-12-08 | 2002-10-17 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation |
| ATE299140T1 (de) * | 1998-12-23 | 2005-07-15 | Schering Corp | Farnesyl-protein transferase inhibitoren |
| AU5486600A (en) * | 1999-06-15 | 2001-01-02 | Aventis Pharmaceuticals Products Inc. | Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives |
| US20040082786A1 (en) * | 2000-09-29 | 2004-04-29 | Bing-Yan Zhu | Piperazine based inhibitors of factor xa |
| CA2435510A1 (en) | 2001-01-24 | 2002-08-01 | John W. Regan | Methods for screening for substances which inhibit fp prostanoid receptor interaction with a compound having pgf2.alpha.alphaactivity and methods of treating cancer |
| US7754722B2 (en) | 2002-09-20 | 2010-07-13 | Merck Serono Sa | Piperazine derivatives and methods of use |
-
2004
- 2004-02-06 AT AT04708776T patent/ATE429228T1/de not_active IP Right Cessation
- 2004-02-06 US US10/545,296 patent/US8404690B2/en not_active Expired - Fee Related
- 2004-02-06 DE DE602004020734T patent/DE602004020734D1/de not_active Expired - Lifetime
- 2004-02-06 CA CA002513716A patent/CA2513716A1/en not_active Abandoned
- 2004-02-06 EP EP04708776A patent/EP1592389B1/de not_active Expired - Lifetime
- 2004-02-06 WO PCT/EP2004/050093 patent/WO2004071390A2/en not_active Ceased
- 2004-02-06 ES ES04708776T patent/ES2324535T3/es not_active Expired - Lifetime
- 2004-02-06 JP JP2006502009A patent/JP4825664B2/ja not_active Expired - Fee Related
- 2004-02-06 AU AU2004212335A patent/AU2004212335A1/en not_active Abandoned
-
2005
- 2005-08-26 NO NO20053991A patent/NO20053991L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20070142391A1 (en) | 2007-06-21 |
| CA2513716A1 (en) | 2004-08-26 |
| EP1592389B1 (de) | 2009-04-22 |
| JP4825664B2 (ja) | 2011-11-30 |
| US8404690B2 (en) | 2013-03-26 |
| ES2324535T3 (es) | 2009-08-10 |
| JP2006517566A (ja) | 2006-07-27 |
| AU2004212335A1 (en) | 2004-08-26 |
| WO2004071390A3 (en) | 2004-12-23 |
| EP1592389A2 (de) | 2005-11-09 |
| WO2004071390A2 (en) | 2004-08-26 |
| DE602004020734D1 (de) | 2009-06-04 |
| NO20053991L (no) | 2005-08-26 |
| AU2004212335A8 (en) | 2004-08-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |