JPS6450818A - Prostaglandin f2alpha-inhibitor - Google Patents

Prostaglandin f2alpha-inhibitor

Info

Publication number
JPS6450818A
JPS6450818A JP20521687A JP20521687A JPS6450818A JP S6450818 A JPS6450818 A JP S6450818A JP 20521687 A JP20521687 A JP 20521687A JP 20521687 A JP20521687 A JP 20521687A JP S6450818 A JPS6450818 A JP S6450818A
Authority
JP
Japan
Prior art keywords
compound
formula
methoxy
inhibitor
active component
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP20521687A
Other languages
Japanese (ja)
Inventor
Kiyoshi Kubota
Yoshimitsu Ogawa
Kunio Hosaka
Masao Chin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tsumura and Co
Original Assignee
Tsumura and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tsumura and Co filed Critical Tsumura and Co
Priority to JP20521687A priority Critical patent/JPS6450818A/en
Publication of JPS6450818A publication Critical patent/JPS6450818A/en
Pending legal-status Critical Current

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  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE:To obtain titled inhibitor active to relax the smooth muscle of uterine and effective for the remedy of abdominal pain caused by abortion, premature labor and dysfunction, by using a phthalide derivative which is a component of SENKYU (rhizome or Cnidium officinale) as an active component. CONSTITUTION:The objective agent contains a compound of formula I (R1 is OH or methoxy), e.g. 4-methoxy-3-propylphthalide as an active component. The compound of formula I is administered at a rate of preferably 30-400mg daily in several divided doses. The compound can be produced by converting a compound of formula II into a compound of formula III with an aldehyde in the presence of a base, treating the obtained compound with an acid and, as necessary, further demethylating the product.
JP20521687A 1987-08-20 1987-08-20 Prostaglandin f2alpha-inhibitor Pending JPS6450818A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP20521687A JPS6450818A (en) 1987-08-20 1987-08-20 Prostaglandin f2alpha-inhibitor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP20521687A JPS6450818A (en) 1987-08-20 1987-08-20 Prostaglandin f2alpha-inhibitor

Publications (1)

Publication Number Publication Date
JPS6450818A true JPS6450818A (en) 1989-02-27

Family

ID=16503327

Family Applications (1)

Application Number Title Priority Date Filing Date
JP20521687A Pending JPS6450818A (en) 1987-08-20 1987-08-20 Prostaglandin f2alpha-inhibitor

Country Status (1)

Country Link
JP (1) JPS6450818A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005531524A (en) * 2002-03-28 2005-10-20 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ Thiazolidinecarboxamide derivatives as modulators of prostaglandin F receptors
WO2006125651A3 (en) * 2005-05-24 2007-07-19 Dsm Ip Assets Bv Ligustilide derivatives for the treatment of inflammatory disorders
WO2008017491A1 (en) * 2006-08-11 2008-02-14 Dsm Ip Assets B.V. Ligustilide derivatives for the treatment of disorders of the central nervous system
JP2011256121A (en) * 2010-06-07 2011-12-22 Kao Corp Potential-dependent cation channel inhibitor
US8404690B2 (en) 2003-02-14 2013-03-26 Merck Serono Sa Piperazine-2-carboxamide derivatives

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005531524A (en) * 2002-03-28 2005-10-20 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ Thiazolidinecarboxamide derivatives as modulators of prostaglandin F receptors
US8415480B2 (en) 2002-03-28 2013-04-09 Merck Serono Sa Thiazolidine carboxamide derivatives as modulators of the prostaglandin F receptor
US8404690B2 (en) 2003-02-14 2013-03-26 Merck Serono Sa Piperazine-2-carboxamide derivatives
WO2006125651A3 (en) * 2005-05-24 2007-07-19 Dsm Ip Assets Bv Ligustilide derivatives for the treatment of inflammatory disorders
WO2008017491A1 (en) * 2006-08-11 2008-02-14 Dsm Ip Assets B.V. Ligustilide derivatives for the treatment of disorders of the central nervous system
JP2011256121A (en) * 2010-06-07 2011-12-22 Kao Corp Potential-dependent cation channel inhibitor

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