JPS6450818A - Prostaglandin f2alpha-inhibitor - Google Patents
Prostaglandin f2alpha-inhibitorInfo
- Publication number
- JPS6450818A JPS6450818A JP20521687A JP20521687A JPS6450818A JP S6450818 A JPS6450818 A JP S6450818A JP 20521687 A JP20521687 A JP 20521687A JP 20521687 A JP20521687 A JP 20521687A JP S6450818 A JPS6450818 A JP S6450818A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- methoxy
- inhibitor
- active component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Furan Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE:To obtain titled inhibitor active to relax the smooth muscle of uterine and effective for the remedy of abdominal pain caused by abortion, premature labor and dysfunction, by using a phthalide derivative which is a component of SENKYU (rhizome or Cnidium officinale) as an active component. CONSTITUTION:The objective agent contains a compound of formula I (R1 is OH or methoxy), e.g. 4-methoxy-3-propylphthalide as an active component. The compound of formula I is administered at a rate of preferably 30-400mg daily in several divided doses. The compound can be produced by converting a compound of formula II into a compound of formula III with an aldehyde in the presence of a base, treating the obtained compound with an acid and, as necessary, further demethylating the product.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20521687A JPS6450818A (en) | 1987-08-20 | 1987-08-20 | Prostaglandin f2alpha-inhibitor |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20521687A JPS6450818A (en) | 1987-08-20 | 1987-08-20 | Prostaglandin f2alpha-inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS6450818A true JPS6450818A (en) | 1989-02-27 |
Family
ID=16503327
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP20521687A Pending JPS6450818A (en) | 1987-08-20 | 1987-08-20 | Prostaglandin f2alpha-inhibitor |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6450818A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005531524A (en) * | 2002-03-28 | 2005-10-20 | アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ | Thiazolidinecarboxamide derivatives as modulators of prostaglandin F receptors |
WO2006125651A3 (en) * | 2005-05-24 | 2007-07-19 | Dsm Ip Assets Bv | Ligustilide derivatives for the treatment of inflammatory disorders |
WO2008017491A1 (en) * | 2006-08-11 | 2008-02-14 | Dsm Ip Assets B.V. | Ligustilide derivatives for the treatment of disorders of the central nervous system |
JP2011256121A (en) * | 2010-06-07 | 2011-12-22 | Kao Corp | Potential-dependent cation channel inhibitor |
US8404690B2 (en) | 2003-02-14 | 2013-03-26 | Merck Serono Sa | Piperazine-2-carboxamide derivatives |
-
1987
- 1987-08-20 JP JP20521687A patent/JPS6450818A/en active Pending
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005531524A (en) * | 2002-03-28 | 2005-10-20 | アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ | Thiazolidinecarboxamide derivatives as modulators of prostaglandin F receptors |
US8415480B2 (en) | 2002-03-28 | 2013-04-09 | Merck Serono Sa | Thiazolidine carboxamide derivatives as modulators of the prostaglandin F receptor |
US8404690B2 (en) | 2003-02-14 | 2013-03-26 | Merck Serono Sa | Piperazine-2-carboxamide derivatives |
WO2006125651A3 (en) * | 2005-05-24 | 2007-07-19 | Dsm Ip Assets Bv | Ligustilide derivatives for the treatment of inflammatory disorders |
WO2008017491A1 (en) * | 2006-08-11 | 2008-02-14 | Dsm Ip Assets B.V. | Ligustilide derivatives for the treatment of disorders of the central nervous system |
JP2011256121A (en) * | 2010-06-07 | 2011-12-22 | Kao Corp | Potential-dependent cation channel inhibitor |
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