DE69434490T2 - Zusammenstellungen zur Krebsbehandlung - Google Patents

Zusammenstellungen zur Krebsbehandlung Download PDF

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Publication number
DE69434490T2
DE69434490T2 DE69434490T DE69434490T DE69434490T2 DE 69434490 T2 DE69434490 T2 DE 69434490T2 DE 69434490 T DE69434490 T DE 69434490T DE 69434490 T DE69434490 T DE 69434490T DE 69434490 T2 DE69434490 T2 DE 69434490T2
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Germany
Prior art keywords
angiogenesis
disease
thalidomide
medicament
use according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69434490T
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German (de)
English (en)
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DE69434490D1 (de
Inventor
Robert D'amato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Childrens Medical Center Corp
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Childrens Medical Center Corp
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26699202&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69434490(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Childrens Medical Center Corp filed Critical Childrens Medical Center Corp
Publication of DE69434490D1 publication Critical patent/DE69434490D1/de
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Publication of DE69434490T2 publication Critical patent/DE69434490T2/de
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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DE69434490T 1993-03-01 1994-02-24 Zusammenstellungen zur Krebsbehandlung Expired - Lifetime DE69434490T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2504693A 1993-03-01 1993-03-01
US25046 1993-03-01
US08/168,817 US5629327A (en) 1993-03-01 1993-12-15 Methods and compositions for inhibition of angiogenesis
US168817 1993-12-15

Publications (2)

Publication Number Publication Date
DE69434490D1 DE69434490D1 (de) 2005-10-20
DE69434490T2 true DE69434490T2 (de) 2006-06-22

Family

ID=26699202

Family Applications (3)

Application Number Title Priority Date Filing Date
DE122008000044C Active DE122008000044I2 (US20020061911A1-20020523-C00002.png) 1993-03-01 1994-02-24
DE69434490T Expired - Lifetime DE69434490T2 (de) 1993-03-01 1994-02-24 Zusammenstellungen zur Krebsbehandlung
DE69430796T Expired - Lifetime DE69430796T2 (de) 1993-03-01 1994-02-24 Thalidomid zur hemmung der angiogenese

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE122008000044C Active DE122008000044I2 (US20020061911A1-20020523-C00002.png) 1993-03-01 1994-02-24

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69430796T Expired - Lifetime DE69430796T2 (de) 1993-03-01 1994-02-24 Thalidomid zur hemmung der angiogenese

Country Status (20)

Country Link
US (18) US5629327A (US20020061911A1-20020523-C00002.png)
EP (4) EP1537870A3 (US20020061911A1-20020523-C00002.png)
JP (4) JPH08507767A (US20020061911A1-20020523-C00002.png)
KR (1) KR100506043B1 (US20020061911A1-20020523-C00002.png)
AT (2) ATE218865T1 (US20020061911A1-20020523-C00002.png)
AU (1) AU676722B2 (US20020061911A1-20020523-C00002.png)
BR (1) BR9400764A (US20020061911A1-20020523-C00002.png)
CA (3) CA2512926C (US20020061911A1-20020523-C00002.png)
CO (1) CO4230017A1 (US20020061911A1-20020523-C00002.png)
DE (3) DE122008000044I2 (US20020061911A1-20020523-C00002.png)
DK (2) DK1264597T3 (US20020061911A1-20020523-C00002.png)
ES (2) ES2245711T3 (US20020061911A1-20020523-C00002.png)
FR (1) FR08C0036I2 (US20020061911A1-20020523-C00002.png)
HK (1) HK1052865A1 (US20020061911A1-20020523-C00002.png)
LU (1) LU91471I2 (US20020061911A1-20020523-C00002.png)
NL (1) NL300358I2 (US20020061911A1-20020523-C00002.png)
NZ (4) NZ535670A (US20020061911A1-20020523-C00002.png)
PE (1) PE10095A1 (US20020061911A1-20020523-C00002.png)
PT (1) PT688211E (US20020061911A1-20020523-C00002.png)
WO (1) WO1994020085A1 (US20020061911A1-20020523-C00002.png)

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US6228879B1 (en) * 1997-10-16 2001-05-08 The Children's Medical Center Methods and compositions for inhibition of angiogenesis
US6114355A (en) * 1993-03-01 2000-09-05 D'amato; Robert Methods and compositions for inhibition of angiogenesis
US8143283B1 (en) * 1993-03-01 2012-03-27 The Children's Medical Center Corporation Methods for treating blood-born tumors with thalidomide
US5629327A (en) * 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
US20040248799A1 (en) * 1993-05-27 2004-12-09 Holaday John W. Compositions and methods for treating cancer and hyperproliferative disorders
US6805865B1 (en) 1993-05-27 2004-10-19 Entremed, Inc. Compositions and methods for treating cancer and hyperproliferative disorders
DE4422237A1 (de) * 1994-06-24 1996-01-04 Gruenenthal Gmbh Verwendung von Lactamverbindungen als pharmazeutische Wirkstoffe
US6429221B1 (en) * 1994-12-30 2002-08-06 Celgene Corporation Substituted imides
US6440729B1 (en) 1995-06-30 2002-08-27 University Of Kansas Medical Center Treating angiogenesis-mediated diseases with the α2 monomer of type IV collagen
US6358735B1 (en) 1995-06-30 2002-03-19 University Of Kansas Medical Center Method for inhibiting angiogenesis and tumors with the isolated NC1 α3 chain monomer of type IV collagen
US6518281B2 (en) * 1995-08-29 2003-02-11 Celgene Corporation Immunotherapeutic agents
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
JP3263598B2 (ja) * 1995-11-01 2002-03-04 有限会社ドット 経鼻吸収用生理活性ペプチド組成物
US5635517B1 (en) * 1996-07-24 1999-06-29 Celgene Corp Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines
US5798368A (en) * 1996-08-22 1998-08-25 Celgene Corporation Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels
EP2859895A1 (en) * 1996-07-24 2015-04-15 Celgene Corporation Substituted 2-(2,6-dioxopiperidin-3-yl)-phthalimides and 1-oxoisoindolines and method of reducing TNF alpha levels
US6281230B1 (en) 1996-07-24 2001-08-28 Celgene Corporation Isoindolines, method of use, and pharmaceutical compositions
HU228769B1 (en) * 1996-07-24 2013-05-28 Celgene Corp Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
DE69717831T3 (de) * 1996-07-24 2018-08-30 Celgene Corp. Substituierte 2-(2,6-dioxopiperidin-3-yl)-phthalimide und -1-oxoisoindoline und verfahren zur reduzierung des tnf-alpha-spiegels
US5955496A (en) * 1996-08-13 1999-09-21 The Regents Of The University Of California Dihydroxy-oxy-eicosadienoates
ATE493983T1 (de) * 1996-11-05 2011-01-15 Childrens Medical Center Thalidomide und dexamethason für die behandlung von tumors
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BR9400764A (pt) 1994-11-01
NL300358I2 (nl) 2009-06-02
US20020052398A1 (en) 2002-05-02
LU91471I2 (fr) 2008-11-06
FR08C0036I2 (US20020061911A1-20020523-C00002.png) 2009-11-20
JP2008088182A (ja) 2008-04-17
EP0688211A4 (en) 1997-05-21
JP4065373B2 (ja) 2008-03-26
CA2157288A1 (en) 1994-09-15
US6420414B1 (en) 2002-07-16
ES2245711T3 (es) 2006-01-16
US7723361B2 (en) 2010-05-25
US20030187024A1 (en) 2003-10-02
NZ262676A (en) 1999-08-30
JPH08507767A (ja) 1996-08-20
DE122008000044I2 (US20020061911A1-20020523-C00002.png) 2010-12-30
KR960701632A (ko) 1996-03-28
DE69430796D1 (de) 2002-07-18
JP2004359693A (ja) 2004-12-24
US6977268B2 (en) 2005-12-20
ES2174873T3 (es) 2002-11-16
WO1994020085A1 (en) 1994-09-15
EP1245229A2 (en) 2002-10-02
US20020061923A1 (en) 2002-05-23
AU676722B2 (en) 1997-03-20
US6071948A (en) 2000-06-06
CA2342974A1 (en) 1994-09-15
US20010056113A1 (en) 2001-12-27
NZ336527A (en) 2005-01-28
US5712291A (en) 1998-01-27
DE69434490D1 (de) 2005-10-20
US20020161024A1 (en) 2002-10-31
US5593990A (en) 1997-01-14
US20070021464A1 (en) 2007-01-25
EP1264597B1 (en) 2005-09-14
KR100506043B1 (ko) 2005-11-08
EP1264597A3 (en) 2003-03-19
AU676722C (en) 1994-09-26
US20020061911A1 (en) 2002-05-23
PT688211E (pt) 2002-11-29
DE69430796T2 (de) 2003-01-30
DE122008000044I1 (US20020061911A1-20020523-C00002.png) 2009-01-02
EP1537870A2 (en) 2005-06-08
US20030176463A1 (en) 2003-09-18
NL300358I1 (nl) 2008-11-03
ATE304356T1 (de) 2005-09-15
CO4230017A1 (es) 1995-10-19
US6469045B1 (en) 2002-10-22
EP1245229A3 (en) 2004-05-06
US8012996B2 (en) 2011-09-06
EP0688211A1 (en) 1995-12-27
US5629327A (en) 1997-05-13
EP0688211B1 (en) 2002-06-12
US20050215593A1 (en) 2005-09-29
US6235756B1 (en) 2001-05-22
PE10095A1 (es) 1995-04-25
AU6248694A (en) 1994-09-26
EP1537870A3 (en) 2007-12-12
HK1052865A1 (en) 2003-10-03
CA2342974C (en) 2005-08-16
US20020119956A1 (en) 2002-08-29

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