KR960701632A - 맥관형성의 억제를 위한 방법 및 조성물(method and compositions for in-hibition of angiogenesis) - Google Patents
맥관형성의 억제를 위한 방법 및 조성물(method and compositions for in-hibition of angiogenesis)Info
- Publication number
- KR960701632A KR960701632A KR1019950703700A KR19950703700A KR960701632A KR 960701632 A KR960701632 A KR 960701632A KR 1019950703700 A KR1019950703700 A KR 1019950703700A KR 19950703700 A KR19950703700 A KR 19950703700A KR 960701632 A KR960701632 A KR 960701632A
- Authority
- KR
- South Korea
- Prior art keywords
- disease
- sarcoma
- hibition
- angiogenesis
- compositions
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2504693A | 1993-03-01 | 1993-03-01 | |
US08/025046 | 1993-03-01 | ||
US08/168817 | 1993-12-15 | ||
US08/168,817 US5629327A (en) | 1993-03-01 | 1993-12-15 | Methods and compositions for inhibition of angiogenesis |
PCT/US1994/001971 WO1994020085A1 (en) | 1993-03-01 | 1994-02-24 | Methods and compositions for inhibition of angiogenesis |
Publications (2)
Publication Number | Publication Date |
---|---|
KR960701632A true KR960701632A (ko) | 1996-03-28 |
KR100506043B1 KR100506043B1 (ko) | 2005-11-08 |
Family
ID=26699202
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019950703700A KR100506043B1 (ko) | 1993-03-01 | 1994-02-24 | 맥관형성을억제하기위한조성물 |
Country Status (20)
Country | Link |
---|---|
US (18) | US5629327A (ko) |
EP (4) | EP1245229A3 (ko) |
JP (4) | JPH08507767A (ko) |
KR (1) | KR100506043B1 (ko) |
AT (2) | ATE304356T1 (ko) |
AU (1) | AU676722B2 (ko) |
BR (1) | BR9400764A (ko) |
CA (3) | CA2157288C (ko) |
CO (1) | CO4230017A1 (ko) |
DE (3) | DE122008000044I2 (ko) |
DK (2) | DK1264597T3 (ko) |
ES (2) | ES2245711T3 (ko) |
FR (1) | FR08C0036I2 (ko) |
HK (1) | HK1052865A1 (ko) |
LU (1) | LU91471I2 (ko) |
NL (1) | NL300358I2 (ko) |
NZ (4) | NZ262676A (ko) |
PE (1) | PE10095A1 (ko) |
PT (1) | PT688211E (ko) |
WO (1) | WO1994020085A1 (ko) |
Families Citing this family (290)
Publication number | Priority date | Publication date | Assignee | Title |
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US6582959B2 (en) | 1991-03-29 | 2003-06-24 | Genentech, Inc. | Antibodies to vascular endothelial cell growth factor |
US5629327A (en) * | 1993-03-01 | 1997-05-13 | Childrens Hospital Medical Center Corp. | Methods and compositions for inhibition of angiogenesis |
US6114355A (en) * | 1993-03-01 | 2000-09-05 | D'amato; Robert | Methods and compositions for inhibition of angiogenesis |
US8143283B1 (en) * | 1993-03-01 | 2012-03-27 | The Children's Medical Center Corporation | Methods for treating blood-born tumors with thalidomide |
US6228879B1 (en) * | 1997-10-16 | 2001-05-08 | The Children's Medical Center | Methods and compositions for inhibition of angiogenesis |
US20040248799A1 (en) * | 1993-05-27 | 2004-12-09 | Holaday John W. | Compositions and methods for treating cancer and hyperproliferative disorders |
US6805865B1 (en) | 1993-05-27 | 2004-10-19 | Entremed, Inc. | Compositions and methods for treating cancer and hyperproliferative disorders |
DE4422237A1 (de) * | 1994-06-24 | 1996-01-04 | Gruenenthal Gmbh | Verwendung von Lactamverbindungen als pharmazeutische Wirkstoffe |
US6429221B1 (en) * | 1994-12-30 | 2002-08-06 | Celgene Corporation | Substituted imides |
US6358735B1 (en) | 1995-06-30 | 2002-03-19 | University Of Kansas Medical Center | Method for inhibiting angiogenesis and tumors with the isolated NC1 α3 chain monomer of type IV collagen |
US6440729B1 (en) | 1995-06-30 | 2002-08-27 | University Of Kansas Medical Center | Treating angiogenesis-mediated diseases with the α2 monomer of type IV collagen |
US6518281B2 (en) * | 1995-08-29 | 2003-02-11 | Celgene Corporation | Immunotherapeutic agents |
US6346510B1 (en) | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
JP3263598B2 (ja) * | 1995-11-01 | 2002-03-04 | 有限会社ドット | 経鼻吸収用生理活性ペプチド組成物 |
US5798368A (en) * | 1996-08-22 | 1998-08-25 | Celgene Corporation | Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels |
HU228769B1 (en) * | 1996-07-24 | 2013-05-28 | Celgene Corp | Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha |
US6281230B1 (en) | 1996-07-24 | 2001-08-28 | Celgene Corporation | Isoindolines, method of use, and pharmaceutical compositions |
PT925294E (pt) * | 1996-07-24 | 2003-04-30 | Celgene Corp | 2-(2,6-dioxopiperidin-3-il)-ftalimidas e -1-oxoisoindolinas substituidas e metodo de reducao dos niveis de tnf-alfa |
US5635517B1 (en) * | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
EP2859895A1 (en) * | 1996-07-24 | 2015-04-15 | Celgene Corporation | Substituted 2-(2,6-dioxopiperidin-3-yl)-phthalimides and 1-oxoisoindolines and method of reducing TNF alpha levels |
US5955496A (en) * | 1996-08-13 | 1999-09-21 | The Regents Of The University Of California | Dihydroxy-oxy-eicosadienoates |
EP1586322B1 (en) * | 1996-11-05 | 2008-08-20 | The Children's Medical Center Corporation | Compositions comprising thalodimide and dexamethasone for the treatment of cancer& x9; |
US5858991A (en) * | 1997-01-29 | 1999-01-12 | Vanderbilt University | Facilitation of wound healing with CM101/GBS toxin |
US6670337B1 (en) | 1998-01-29 | 2003-12-30 | Yeda Reaearch And Development Co., Ltd. | Facilitation of wound healing with CM101/GBS toxin |
US5981508A (en) * | 1997-01-29 | 1999-11-09 | Vanderbilt University | Facilitation of repair of neural injury with CM101/GBS toxin |
US6028060A (en) * | 1997-01-29 | 2000-02-22 | Vanderbilt University | Treatment of chronic inflammatory diseases with CM101/GBS toxin |
US6593291B1 (en) | 1997-02-06 | 2003-07-15 | Entremed, Inc. | Compositions and methods of use of ligands that bind components of the blood coagulation/clotting pathway for the treatment of cancer and angiogenic-based disease |
US5994388A (en) * | 1997-03-18 | 1999-11-30 | The Children's Medical Center Corporation | Cytochalasin and isoindolinone derivatives as inhibitors of angiogenesis |
AU6578298A (en) | 1997-03-21 | 1998-10-20 | President And Fellows Of Harvard College | Antisense inhibition of angiogenin expression |
US6174695B1 (en) | 1997-08-12 | 2001-01-16 | The Regents Of The University Of California | Epoxide hydrolase inhibitor methods |
AU8918898A (en) | 1997-08-25 | 1999-03-16 | Harold Brem | Prevention of adhesions and excessive scar formation using angiogenesis inhibi tors |
US5955476A (en) * | 1997-11-18 | 1999-09-21 | Celgene Corporation | Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels |
ATE327228T1 (de) * | 1997-11-18 | 2006-06-15 | Celgene Corp | Substituierte 2-(2,6-dioxo-3-fluoropiperidine-3- yl)-isoindoline und ihre verwendung zum reduzieren des tnf-alpha spiegels |
TR200101501T2 (tr) * | 1998-03-16 | 2002-06-21 | Celgene Corporation | 2-(2,6-dioksopiperidin-3-il)izoindolin türevleri, bunların hazırlanması ve enflamatuar sitokinlerin inhibitörleri olarak kullanımı. |
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- 1994-02-24 DE DE122008000044C patent/DE122008000044I2/de active Active
- 1994-02-24 CA CA002157288A patent/CA2157288C/en not_active Expired - Lifetime
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- 1994-02-24 AU AU62486/94A patent/AU676722B2/en not_active Expired
- 1994-02-24 EP EP02012280A patent/EP1245229A3/en not_active Withdrawn
- 1994-02-24 DK DK02011928T patent/DK1264597T3/da active
- 1994-02-24 DE DE69430796T patent/DE69430796T2/de not_active Expired - Lifetime
- 1994-02-24 ES ES02011928T patent/ES2245711T3/es not_active Expired - Lifetime
- 1994-02-24 NZ NZ336527A patent/NZ336527A/en not_active IP Right Cessation
- 1994-02-24 AT AT02011928T patent/ATE304356T1/de not_active IP Right Cessation
- 1994-02-24 WO PCT/US1994/001971 patent/WO1994020085A1/en active IP Right Grant
- 1994-02-24 EP EP05002523A patent/EP1537870A3/en not_active Withdrawn
- 1994-02-24 EP EP02011928A patent/EP1264597B1/en not_active Revoked
- 1994-02-24 ES ES94909773T patent/ES2174873T3/es not_active Expired - Lifetime
- 1994-02-24 PT PT94909773T patent/PT688211E/pt unknown
- 1994-02-24 KR KR1019950703700A patent/KR100506043B1/ko not_active IP Right Cessation
- 1994-02-24 AT AT94909773T patent/ATE218865T1/de active
- 1994-02-24 NZ NZ535671A patent/NZ535671A/en not_active IP Right Cessation
- 1994-02-24 JP JP6520046A patent/JPH08507767A/ja not_active Withdrawn
- 1994-02-24 DE DE69434490T patent/DE69434490T2/de not_active Expired - Lifetime
- 1994-02-24 NZ NZ535670A patent/NZ535670A/en not_active IP Right Cessation
- 1994-02-24 EP EP94909773A patent/EP0688211B1/en not_active Expired - Lifetime
- 1994-02-24 DK DK94909773T patent/DK0688211T3/da active
- 1994-03-01 BR BR9400764A patent/BR9400764A/pt not_active Application Discontinuation
- 1994-03-01 PE PE1994237564A patent/PE10095A1/es not_active Application Discontinuation
- 1994-03-01 CO CO94008093A patent/CO4230017A1/es unknown
-
1995
- 1995-01-13 US US08/371,987 patent/US5593990A/en not_active Expired - Lifetime
- 1995-06-06 US US08/468,792 patent/US5712291A/en not_active Ceased
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1997
- 1997-08-22 US US08/918,610 patent/US6235756B1/en not_active Expired - Lifetime
- 1997-10-16 US US08/950,673 patent/US6071948A/en not_active Expired - Lifetime
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2000
- 2000-04-07 US US09/545,139 patent/US6469045B1/en not_active Expired - Fee Related
- 2000-11-09 US US09/710,533 patent/US6420414B1/en not_active Expired - Lifetime
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2001
- 2001-02-26 JP JP2001050214A patent/JP4065373B2/ja not_active Expired - Lifetime
- 2001-07-05 US US09/899,318 patent/US20010056113A1/en not_active Abandoned
- 2001-09-28 US US09/966,895 patent/US20020049231A1/en not_active Abandoned
- 2001-10-24 US US10/001,183 patent/US20020119956A1/en not_active Abandoned
- 2001-12-12 US US10/015,252 patent/US20020052398A1/en not_active Abandoned
- 2001-12-19 US US10/026,037 patent/US6977268B2/en not_active Expired - Fee Related
- 2001-12-20 US US10/026,291 patent/US20020061911A1/en not_active Abandoned
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2002
- 2002-06-11 US US10/167,531 patent/US20020161024A1/en not_active Abandoned
- 2002-12-13 US US10/319,389 patent/US20030187024A1/en not_active Abandoned
-
2003
- 2003-01-14 US US10/341,928 patent/US20030176463A1/en not_active Abandoned
- 2003-06-10 HK HK03104072A patent/HK1052865A1/xx not_active IP Right Cessation
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2004
- 2004-07-28 JP JP2004220584A patent/JP2004359693A/ja active Pending
-
2005
- 2005-03-31 US US11/096,155 patent/US7723361B2/en not_active Expired - Fee Related
-
2006
- 2006-09-22 US US11/525,346 patent/US8012996B2/en not_active Expired - Fee Related
-
2007
- 2007-11-07 JP JP2007289175A patent/JP2008088182A/ja active Pending
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2008
- 2008-08-01 FR FR08C0036C patent/FR08C0036I2/fr active Active
- 2008-08-20 LU LU91471C patent/LU91471I2/fr unknown
- 2008-09-01 NL NL300358C patent/NL300358I2/nl unknown
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