DE69428403D1 - Verfahren zur Herstellung von Azetidinverbindungen und Ausgangsverbindungen dafür - Google Patents
Verfahren zur Herstellung von Azetidinverbindungen und Ausgangsverbindungen dafürInfo
- Publication number
- DE69428403D1 DE69428403D1 DE69428403T DE69428403T DE69428403D1 DE 69428403 D1 DE69428403 D1 DE 69428403D1 DE 69428403 T DE69428403 T DE 69428403T DE 69428403 T DE69428403 T DE 69428403T DE 69428403 D1 DE69428403 D1 DE 69428403D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- preparation
- therefor
- azetidine
- starting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001539 azetidines Chemical class 0.000 title 1
- 239000007858 starting material Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
- C07D265/22—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
- C07D477/04—Preparation by forming the ring or condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15189993 | 1993-06-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69428403D1 true DE69428403D1 (de) | 2001-10-31 |
DE69428403T2 DE69428403T2 (de) | 2002-06-20 |
Family
ID=15528629
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69428403T Expired - Lifetime DE69428403T2 (de) | 1993-06-23 | 1994-06-23 | Verfahren zur Herstellung von Azetidinverbindungen und Ausgangsverbindungen dafür |
Country Status (3)
Country | Link |
---|---|
US (2) | US5550229A (de) |
EP (1) | EP0635488B1 (de) |
DE (1) | DE69428403T2 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5731431A (en) * | 1991-12-26 | 1998-03-24 | Nippon Soda Co., Ltd. | Process for preparing 4-substituted azetidinone derivatives |
US5631365A (en) | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
JPH09143156A (ja) * | 1995-11-17 | 1997-06-03 | Tanabe Seiyaku Co Ltd | アセトキシアゼチジノン誘導体の製法及びその合成中間体 |
JP3450193B2 (ja) * | 1998-07-24 | 2003-09-22 | 高砂香料工業株式会社 | 4−置換アゼチジノン誘導体の製造方法 |
AU4343500A (en) * | 1999-04-16 | 2000-11-02 | Schering Corporation | Use of azetidinone compounds |
US7235543B2 (en) | 2003-03-07 | 2007-06-26 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
JP4589919B2 (ja) | 2003-03-07 | 2010-12-01 | シェーリング コーポレイション | 高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用 |
US7667076B2 (en) * | 2005-09-14 | 2010-02-23 | Regents Of The University Of California | Amide forming chemical ligation |
US8841444B2 (en) * | 2008-07-30 | 2014-09-23 | Ranbaxy Laboratories Limited | Process for the preparation of carbapenem compounds |
CA2774715C (en) | 2009-07-27 | 2018-04-03 | Gilead Sciences, Inc. | Fused heterocyclic compounds as ion channel modulators |
WO2011048583A1 (en) | 2009-10-23 | 2011-04-28 | Ranbaxy Laboratories Limited | Process for the preparation of carbapenem compounds |
NZ604478A (en) | 2010-07-02 | 2014-12-24 | Gilead Sciences Inc | Fused heterocyclic compounds as ion channel modulators |
EA028156B9 (ru) | 2011-05-10 | 2018-01-31 | Джилид Сайэнс, Инк. | Конденсированные гетероциклические соединения в качестве модуляторов ионных каналов |
TWI478908B (zh) | 2011-07-01 | 2015-04-01 | Gilead Sciences Inc | 作為離子通道調節劑之稠合雜環化合物 |
NO3175985T3 (de) | 2011-07-01 | 2018-04-28 | ||
CN102367239B (zh) * | 2011-07-20 | 2015-10-28 | 沈阳药科大学 | 2-芳基-2,3-二氢-4h-1,3-苯并噻嗪-4-酮衍生物及其用途 |
CN102977134A (zh) * | 2012-12-13 | 2013-03-20 | 凯莱英医药集团(天津)股份有限公司 | 碳青霉烯中间体β-甲基-ADC-8的制备方法 |
WO2017132321A1 (en) | 2016-01-29 | 2017-08-03 | The Johns Hopkins University | Novel inhibitors of bacterial growth |
CN111440102B (zh) * | 2020-04-26 | 2022-02-15 | 大连凯飞化学股份有限公司 | 一种二硫代二苯甲酰胺类化合物的制备方法 |
Family Cites Families (35)
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AU433549B2 (en) * | 1968-10-10 | 1973-03-09 | Chhom Gyogyszer Es Vegyeszeti Termeker Ciara N | New 4 quinazoline derivatives and process forthe preparation thereof |
US4194047A (en) * | 1975-11-21 | 1980-03-18 | Merck & Co., Inc. | Substituted N-methylene derivatives of thienamycin |
EP0010348A1 (de) * | 1978-09-12 | 1980-04-30 | Imperial Chemical Industries Plc | Heterocyclische Trichlormethyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
US4640915A (en) * | 1982-03-29 | 1987-02-03 | Fujisawa Pharmaceutical Co., Ltd. | 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives |
JPS6019764A (ja) * | 1983-07-13 | 1985-01-31 | Sankyo Co Ltd | アゼチジノン誘導体の製造法 |
JPS60202886A (ja) * | 1984-03-27 | 1985-10-14 | Sankyo Co Ltd | 1―置換カルバペネム―3―カルボン酸誘導体 |
JPS615081A (ja) * | 1984-06-18 | 1986-01-10 | Sankyo Co Ltd | 1−置換カルバペネム−3−カルボン酸誘導体の製造法 |
DK270685A (da) * | 1984-06-29 | 1985-12-30 | Hoffmann La Roche | Carbapenemderivater |
ES8800215A1 (es) * | 1985-03-29 | 1987-10-16 | Merck & Co Inc | Un procedimiento enantioselectivo para la preparacion de intermedios para los antibioticos de 1-b-metil-carbapenem |
JPS61275267A (ja) * | 1985-03-29 | 1986-12-05 | メルク エンド カムパニ− インコ−ポレ−テツド | 1−β−メチルカルバペネム抗生物質中間体の鏡像異性選択的製造方法 |
EP0213610A1 (de) * | 1985-08-31 | 1987-03-11 | Lederle (Japan) Ltd. | Azetidin-2-on-Derivate und Verfahren zu ihrer Herstellung |
JPS62158277A (ja) * | 1986-01-07 | 1987-07-14 | Sumitomo Pharmaceut Co Ltd | β−ラクタム誘導体 |
JPS62252785A (ja) * | 1986-01-08 | 1987-11-04 | Sankyo Co Ltd | 4−置換β−ラクタム化合物 |
JPS62169781A (ja) * | 1986-01-21 | 1987-07-25 | Sankyo Co Ltd | β−ラクタム化合物 |
JP2789190B2 (ja) * | 1986-01-27 | 1998-08-20 | 住友製薬株式会社 | 新規なβ−ラクタム誘導体およびその製造法 |
GB8607921D0 (en) * | 1986-04-01 | 1986-05-08 | Fujisawa Pharmaceutical Co | 3,4-disubstituted-2-azetidinone derivatives |
JPH0759581B2 (ja) * | 1986-09-05 | 1995-06-28 | 日本レダリ−株式会社 | (1r)−1−メチルカルバペネム−3−カルボン酸誘導体 |
JPS6363680A (ja) * | 1986-09-05 | 1988-03-22 | Nippon Redarii Kk | (1r)−1−メチルカルバペネム−3−カルボン酸誘導体 |
DE3632916A1 (de) * | 1986-09-27 | 1988-03-31 | Bayer Ag | Enantiomerenreine 2-azetidinone, verfahren zu ihrer herstellung und ihre verwendung |
JPH0713058B2 (ja) * | 1986-12-29 | 1995-02-15 | 日本レダリ−株式会社 | 4―置換アゼチジノン誘導体の製造方法 |
JPS6425778A (en) * | 1987-04-11 | 1989-01-27 | Lederle Japan Ltd | (1r,5s,6s)-2-((1,2,3-thiadiazolium-4-yl)methyl)thio-6-((r)-1-hydroxyethyl)-1-methyl-carbapenem-3-carboxylate |
JPS63255280A (ja) * | 1987-04-11 | 1988-10-21 | Nippon Redarii Kk | (1r,5s,6s)−2−置換−6−〔(r)−1−ヒドロキシエチル〕−1−メチル−カルバペネム−3−カルボン酸誘導体 |
JPS63255281A (ja) * | 1987-04-11 | 1988-10-21 | Nippon Redarii Kk | (1r,5s,6s)−2−〔(ピラジニウム−2−イル)メチル〕チオ−6−〔(r)−1−ヒドロキシエチル〕−1−メチル−カルバペネム−3−カルボキシレ−ト |
JPS63255282A (ja) * | 1987-04-11 | 1988-10-21 | Nippon Redarii Kk | (1r,5s,6s)−2−〔(チアゾリウム−2−イル)または(イミダゾリウム−2−イル)メチル〕チオ−6−〔(r)−1−ヒドロキシエチル〕−1−メチル−カルバペネム−3−カルボキシレ−ト |
JPS63255284A (ja) * | 1987-04-11 | 1988-10-21 | Nippon Redarii Kk | (1r,5s,6s)−2−〔(置換ピリジニウム−2−イル)メチル〕チオ−6−〔(r)−1−ヒドロキシエチル〕−1−メチル−カルバペネム−3−カルボキシレ−ト |
JPS6425779A (en) * | 1987-04-11 | 1989-01-27 | Lederle Japan Ltd | (1r,5s,6s)-2-substituted-thio-6-((r)-1-hydroxyethyl)-1-methyl -carbapenem-3-carboxylic acid derivative |
JPS63255283A (ja) * | 1987-04-11 | 1988-10-21 | Nippon Redarii Kk | (1r,5s,6s)−2−〔(3−置換イミダゾリニウム−1−イル)アルキル〕チオ−6−〔(r)−1−ヒドロキシエチル〕−1−メチル−カルバペネム−3−カルボキシレ−ト |
JPS63284176A (ja) * | 1987-05-15 | 1988-11-21 | Nippon Redarii Kk | (1r,5r,6s)−6−〔(1r)−1−ヒドロキシエチル〕−1−メチルカルバペネム−3−カルボン酸誘導体の高立体選択的製造方法 |
JPH02788A (ja) * | 1988-01-07 | 1990-01-05 | Fujisawa Pharmaceut Co Ltd | 3,4―ジ置換―2―アゼチジノン誘導体 |
IE66711B1 (en) * | 1988-04-01 | 1996-01-24 | Sankyo Co | 2-(heterocyclylthio) carbapenem derivatives their preparation and their use as antibiotics |
JPH02292269A (ja) * | 1989-05-06 | 1990-12-03 | Lederle Japan Ltd | 活性アミド化合物 |
CA2050255C (en) * | 1990-09-07 | 1997-02-04 | Tameo Iwasaki | 1-methylcarbapenem derivatives and process for preparation thereof |
JP3220985B2 (ja) * | 1991-12-26 | 2001-10-22 | 日本曹達株式会社 | 4−置換アゼチジノン誘導体の製造方法 |
JPH0665195A (ja) * | 1992-08-24 | 1994-03-08 | Banyu Pharmaceut Co Ltd | β−ラクタム誘導体の新規な製造法 |
US5442055A (en) * | 1992-11-13 | 1995-08-15 | Tanabe Seiyaku Co., Ltd. | Azetidinone compound and process for preparation thereof |
-
1994
- 1994-06-21 US US08/262,892 patent/US5550229A/en not_active Expired - Lifetime
- 1994-06-23 EP EP94109711A patent/EP0635488B1/de not_active Expired - Lifetime
- 1994-06-23 DE DE69428403T patent/DE69428403T2/de not_active Expired - Lifetime
-
1995
- 1995-06-05 US US08/462,676 patent/US5703234A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US5550229A (en) | 1996-08-27 |
EP0635488A2 (de) | 1995-01-25 |
EP0635488A3 (de) | 1995-08-23 |
US5703234A (en) | 1997-12-30 |
DE69428403T2 (de) | 2002-06-20 |
EP0635488B1 (de) | 2001-09-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |