ES8800215A1 - Un procedimiento enantioselectivo para la preparacion de intermedios para los antibioticos de 1-b-metil-carbapenem - Google Patents

Un procedimiento enantioselectivo para la preparacion de intermedios para los antibioticos de 1-b-metil-carbapenem

Info

Publication number
ES8800215A1
ES8800215A1 ES553461A ES553461A ES8800215A1 ES 8800215 A1 ES8800215 A1 ES 8800215A1 ES 553461 A ES553461 A ES 553461A ES 553461 A ES553461 A ES 553461A ES 8800215 A1 ES8800215 A1 ES 8800215A1
Authority
ES
Spain
Prior art keywords
compound
alkyl
chem
beta
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES553461A
Other languages
English (en)
Other versions
ES553461A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES553461A0 publication Critical patent/ES553461A0/es
Publication of ES8800215A1 publication Critical patent/ES8800215A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO ENANTIOSELECTIVO PARA LA PREPARACION DE INTERMEDIOS PARA ANTIBIOTICOS DE 1-BETA-METIL-CARBOPENEM. COMPRENDE: A) HACER REACCIONAR A UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN PRESENCIA DE UN CATALIZADOR DE LEWIS Y DE UNA BASE ORGANICA Y ENTRE 0 Y 25GC, PARA FORMAR UN COMPUESTO DE FORMULA (IV); Y B) HIDROLIZAR A (IV) EN CONDICIONES BASICAS Y ENTRE 0 Y 25GC, PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO: L, UN GRUPO SALIENTE; R ELEVADO A 1, (A) O ALCOXI DE C 1 A 4, R ELEVADO A 2 Y R ELEVADO A 9, H Y OTROS; R ELEVADO A 3, H O UN GRUPO PROTECTOR; R ELEVADO A 4, R ELEVADO A 5 Y R ELEVADO A 6, H; (A), ARILO DE C 6 A 10 Y OTROS; R ELEVADO A 8, UN GRUPO PROTECTOR DE ENOL FACILMENTE ESCINDIBLE; X ELEVADO A 1 Y X ELEVADO A 2, O O S; Y A, ALQUILO DE C 1 A 4. *FORMULA*
ES553461A 1985-03-29 1986-03-26 Un procedimiento enantioselectivo para la preparacion de intermedios para los antibioticos de 1-b-metil-carbapenem Expired ES8800215A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71734285A 1985-03-29 1985-03-29
US71774685A 1985-03-29 1985-03-29
US71774285A 1985-03-29 1985-03-29

Publications (2)

Publication Number Publication Date
ES553461A0 ES553461A0 (es) 1987-10-16
ES8800215A1 true ES8800215A1 (es) 1987-10-16

Family

ID=27418970

Family Applications (1)

Application Number Title Priority Date Filing Date
ES553461A Expired ES8800215A1 (es) 1985-03-29 1986-03-26 Un procedimiento enantioselectivo para la preparacion de intermedios para los antibioticos de 1-b-metil-carbapenem

Country Status (8)

Country Link
EP (1) EP0197432B1 (es)
JP (2) JPH05320159A (es)
AT (1) ATE107278T1 (es)
CA (3) CA1276156C (es)
DE (1) DE3689911D1 (es)
DK (1) DK141786A (es)
ES (1) ES8800215A1 (es)
IE (1) IE860840L (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3650023T2 (de) * 1985-12-28 1994-11-24 Sumitomo Pharma Beta-Lactamverbindungen und deren Herstellung.
US5231179A (en) * 1986-01-27 1993-07-27 Sumitomo Pharmaceuticals Company, Limited Heterocyclic compounds and their production
JP2789190B2 (ja) * 1986-01-27 1998-08-20 住友製薬株式会社 新規なβ−ラクタム誘導体およびその製造法
GB8607921D0 (en) * 1986-04-01 1986-05-08 Fujisawa Pharmaceutical Co 3,4-disubstituted-2-azetidinone derivatives
DE3767004D1 (de) * 1986-04-07 1991-02-07 Merck & Co Inc Verfahren zur herstellung von 1-betamethylcarbapenem-antibiotikum-zwischenprodukten.
US5550229A (en) * 1993-06-23 1996-08-27 Tanabe Seiyaku Co., Ltd. Alkylation process for preparing azetidinone compound and starting compound therefor
DE69405922T2 (de) * 1993-06-30 1998-01-29 Nippon Soda Co Verfahren zur Herstellung von 4-substituierten Azetidinon-Derivaten
JP3450193B2 (ja) * 1998-07-24 2003-09-22 高砂香料工業株式会社 ４−置換アゼチジノン誘導体の製造方法
CN113817299B (zh) * 2021-08-18 2022-12-13 安徽建筑大学 一种具有离子和化学双重交联结构的pla基共混复合材料及其制备方法
CN113970500B (zh) * 2021-10-27 2023-08-29 北京新风航天装备有限公司 一种油污固废含油率快速测定方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2399118A (en) 1942-02-13 1946-04-23 Mallinckrodt Chemical Works 2-oxazolidone compounds and method for preparing the same
US3950357A (en) 1974-11-25 1976-04-13 Merck & Co., Inc. Antibiotics
US4194047A (en) 1975-11-21 1980-03-18 Merck & Co., Inc. Substituted N-methylene derivatives of thienamycin
US4383946A (en) 1980-03-27 1983-05-17 Merck & Co., Inc. Process for the preparation of 1-carbapenems and intermediates via silyl-substituted dithioacetals
ES8404184A1 (es) * 1981-08-03 1984-04-16 Merck & Co Inc Un procedimiento para la prepracion de nuevos derivados de acidos 2-carbamimidoil-1-,carbadestiapen-2-en-3-carboxilados.
JPS6019763A (ja) 1983-07-13 1985-01-31 Sankyo Co Ltd アゼチジノンチオエステル類の製造法

Also Published As

Publication number Publication date
CA1276156C (en) 1990-11-13
CA1319697C (en) 1993-06-29
JPH05320171A (ja) 1993-12-03
ES553461A0 (es) 1987-10-16
DK141786A (da) 1986-09-30
DE3689911D1 (de) 1994-07-21
CA1279649C (en) 1991-01-29
EP0197432A2 (en) 1986-10-15
EP0197432A3 (en) 1987-01-21
DK141786D0 (da) 1986-03-26
ATE107278T1 (de) 1994-07-15
IE860840L (en) 1986-09-29
EP0197432B1 (en) 1994-06-15
JPH05320159A (ja) 1993-12-03

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401