ES8609195A1 - Un nuevo procedimiento para la preparacion de derivados del acido cicloalquilidenmetilfenilacetico. - Google Patents
Un nuevo procedimiento para la preparacion de derivados del acido cicloalquilidenmetilfenilacetico.Info
- Publication number
- ES8609195A1 ES8609195A1 ES545044A ES545044A ES8609195A1 ES 8609195 A1 ES8609195 A1 ES 8609195A1 ES 545044 A ES545044 A ES 545044A ES 545044 A ES545044 A ES 545044A ES 8609195 A1 ES8609195 A1 ES 8609195A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- acid derivatives
- image
- inflammatory
- cycloalkylidenemethylphenylacetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/353—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
NUEVO METODO DE SINTESIS DE DERIVADOS DEL ACIDO CICLOALQUILIDENMETILFENILACETICO. CONSISTENTE EN: A) HACER REACCIONAR UN ACIDO DE BENZALDEHIDO DE FORMULA (II) CON UN DERIVADO DE ENAMINA DE FORMULA (III), EN UN DISOLVENTE SELECCIONADO ENTRE HIDROCARBUROS AROMATICOS, ETERES Y OTROS; CON RELACION MOLAR (III) A (II) DE 1,5:1 A 2,0:1, A TEMPERATURA DE 20 A 60JC, DURANTE 30 MINUTOS A 30 HORAS PARA OBTENER EL COMPUESTO DE FORMULA (IV); Y B) HIDROLIZAR A (IV) CON UN ACIDO O UNA BASDE ELEGIDOS ENTRE: ACIDOS MINERALES O SOLUCIONES ACUOSAS DE HIDROXIDOS DE METALES ALCALINOS; A TEMPERATURA AMBIENTE, DURANTE 20 MINUTOS A 30 HORAS PARA OBTENER EL COMPUESTO DE FORMULA (I). SIENDO: RK F H O UN GRUPO ALQUILO C1-4; N F 1, 2 O 3; Y R2 Y R3 IGUALES O DISTINTOS SON UN GRUPO ALQUILO C1-6. SE UTILIZAN POR SU ACTIVIDAD ANTIINFLAMATORIA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP59142567A JPS6122043A (ja) | 1984-07-10 | 1984-07-10 | シクロアルキリデンメチルフエニル酢酸誘導体の製法 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8609195A1 true ES8609195A1 (es) | 1986-09-01 |
ES545044A0 ES545044A0 (es) | 1986-09-01 |
Family
ID=15318325
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES545044A Expired ES8609195A1 (es) | 1984-07-10 | 1985-07-10 | Un nuevo procedimiento para la preparacion de derivados del acido cicloalquilidenmetilfenilacetico. |
Country Status (8)
Country | Link |
---|---|
US (1) | US4673761A (es) |
EP (1) | EP0169688B1 (es) |
JP (1) | JPS6122043A (es) |
CA (1) | CA1253173A (es) |
DE (1) | DE3565251D1 (es) |
DK (1) | DK161885C (es) |
ES (1) | ES8609195A1 (es) |
MX (1) | MX163402B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6392053B2 (en) * | 1999-12-15 | 2002-05-21 | Bristol-Myers Squibb Company | Process for preparing arylacetylaminothiazoles |
KR100922519B1 (ko) | 2008-11-12 | 2009-10-20 | 대원제약주식회사 | 펠루비프로펜을 함유하는 용출률 및 안정성이 개선된 경구투여용 약제학적 제제 |
CN106699559B (zh) * | 2015-11-12 | 2021-04-06 | 浙江九洲药业股份有限公司 | 一种洛索洛芬钠的制备工艺 |
CN107353195B (zh) * | 2017-06-13 | 2020-10-13 | 迪嘉药业集团有限公司 | 一种洛索洛芬钠开环杂质的制备方法 |
KR20200069617A (ko) | 2018-12-07 | 2020-06-17 | 엠에프씨 주식회사 | 플루비프로펜의 제조방법 |
CN110041191A (zh) * | 2019-04-30 | 2019-07-23 | 湖南九典宏阳制药有限公司 | 一种培比洛芬的纯化方法 |
CN111153791B (zh) * | 2019-12-26 | 2023-03-03 | 湖南九典制药股份有限公司 | 不同粒径培比洛芬的制备方法 |
CN111039782A (zh) * | 2019-12-26 | 2020-04-21 | 湖南九典制药股份有限公司 | 2-[4-[(e)-(2-酮环己烯基)甲基]苯基]丙酸的晶型及其制备方法 |
KR20220039116A (ko) | 2020-09-21 | 2022-03-29 | 엠에프씨 주식회사 | 고순도 펠루비프로펜의 제조방법 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2134197A1 (en) * | 1971-04-26 | 1972-12-08 | Logeais Labor Jacques | 2(4' (dithiane, dithiolane or dithiacycloheptane) phenyl)-acetic - acid derivs - antiinflammatories |
FR2233049A1 (en) * | 1973-06-18 | 1975-01-10 | Logeais Labor Jacques | Phenylacetic acid derivs. - having analgesic and antiinflammatory props. |
JPS5432460A (en) * | 1977-08-16 | 1979-03-09 | Sankyo Co Ltd | Cycloalkylidenemethylphenylacetic acid derivative and their preparation |
DD141422A5 (de) * | 1978-01-27 | 1980-04-30 | Schering Ag | Verfahren zur herstellung von phenylessigsaeure-derivaten |
-
1984
- 1984-07-10 JP JP59142567A patent/JPS6122043A/ja active Granted
-
1985
- 1985-06-28 US US06/750,481 patent/US4673761A/en not_active Expired - Lifetime
- 1985-07-09 DK DK313685A patent/DK161885C/da not_active IP Right Cessation
- 1985-07-10 CA CA000486586A patent/CA1253173A/en not_active Expired
- 1985-07-10 MX MX6899A patent/MX163402B/es unknown
- 1985-07-10 DE DE8585304944T patent/DE3565251D1/de not_active Expired
- 1985-07-10 ES ES545044A patent/ES8609195A1/es not_active Expired
- 1985-07-10 EP EP85304944A patent/EP0169688B1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DK161885C (da) | 1992-02-24 |
US4673761A (en) | 1987-06-16 |
MX163402B (es) | 1992-05-11 |
DE3565251D1 (en) | 1988-11-03 |
DK313685D0 (da) | 1985-07-09 |
EP0169688B1 (en) | 1988-09-28 |
JPH032134B2 (es) | 1991-01-14 |
CA1253173A (en) | 1989-04-25 |
JPS6122043A (ja) | 1986-01-30 |
DK313685A (da) | 1986-01-11 |
ES545044A0 (es) | 1986-09-01 |
DK161885B (da) | 1991-08-26 |
EP0169688A1 (en) | 1986-01-29 |
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