ES2067468T3 - Secuencia de reaccion de adicion en 1,2-1,4 para dar difenilacetilenos. - Google Patents

Secuencia de reaccion de adicion en 1,2-1,4 para dar difenilacetilenos.

Info

Publication number
ES2067468T3
ES2067468T3 ES88302409T ES88302409T ES2067468T3 ES 2067468 T3 ES2067468 T3 ES 2067468T3 ES 88302409 T ES88302409 T ES 88302409T ES 88302409 T ES88302409 T ES 88302409T ES 2067468 T3 ES2067468 T3 ES 2067468T3
Authority
ES
Spain
Prior art keywords
addition
difenilacetilenos
give
sequence
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88302409T
Other languages
English (en)
Inventor
Dennis Casey Liotta
Cynthia Anne Maryanoff
Vasken Paragamian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
McNeilab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by McNeilab Inc filed Critical McNeilab Inc
Application granted granted Critical
Publication of ES2067468T3 publication Critical patent/ES2067468T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/02—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains containing only carbon and hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/60—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/16—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Luminescent Compositions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Revetment (AREA)
  • Surgical Instruments (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE PRESENTA UN METODO PARA SINTETIZAR UN COMPUESTO FENILICO TRI-SUSTITUIDO (I) USANDO UNA ADICION 1,2 SEGUIDA POR UNA ADICION -1,4 A LA 1,4-BENZOQUINONA (II), SIENDO HIDROXI, ALCOXI O ALCANOXI, AR1 UN GRUPO ORGANICO Y R UN GRUPO ALQUILO SUSTITUIDO O SIN SUSTITUIR.
ES88302409T 1987-03-19 1988-03-18 Secuencia de reaccion de adicion en 1,2-1,4 para dar difenilacetilenos. Expired - Lifetime ES2067468T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/027,762 US4772755A (en) 1987-03-19 1987-03-19 1,2-1,4 addition reaction sequence leading to disubstituted acelylenes

Publications (1)

Publication Number Publication Date
ES2067468T3 true ES2067468T3 (es) 1995-04-01

Family

ID=21839645

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88302409T Expired - Lifetime ES2067468T3 (es) 1987-03-19 1988-03-18 Secuencia de reaccion de adicion en 1,2-1,4 para dar difenilacetilenos.

Country Status (12)

Country Link
US (1) US4772755A (es)
EP (1) EP0283309B1 (es)
JP (1) JPS63264535A (es)
AT (1) ATE118493T1 (es)
AU (1) AU626788B2 (es)
DE (1) DE3853015T2 (es)
DK (1) DK152088A (es)
ES (1) ES2067468T3 (es)
GR (1) GR880100169A (es)
HU (1) HU205338B (es)
NZ (1) NZ223905A (es)
ZA (1) ZA881963B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5420361A (en) * 1992-02-05 1995-05-30 Bio-Technical Resources Formulation of and dehydration of hydroxylated diphenyl acetylenes
FR2700548B1 (fr) * 1993-01-20 1995-03-03 Roussel Uclaf Nouveau procédé de préparation de stéroïdes 16 alpha-méthylés.
US6465664B1 (en) 1999-09-15 2002-10-15 Massachusetts Institute Of Technology Asymmetric 1,4-reductions of and 1,4-additions to enoates and related systems
DE112013002903T5 (de) * 2012-06-12 2015-03-05 Daicel Corporation Lösungsmittel oder Lösungsmittelzusammensetzung für die Herstellung von organischen Transistoren

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3719712A (en) * 1969-09-29 1973-03-06 Merck & Co Inc 2-phenylethynyl-benzyl-amines
US4201638A (en) * 1978-09-25 1980-05-06 Queen's University At Kingston Triple ions of 1,2- and 1,4-dicarbonyl compounds and analogs thereof containing nitrogen and containing two strategic oxygen or nitrogen groups and process for producing same
JPS5910541A (ja) * 1982-07-09 1984-01-20 Takeda Chem Ind Ltd キノン化合物
EP0120341B1 (de) * 1983-03-25 1989-01-25 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zur Herstellung von Pentadienol-Derivaten
US4661635A (en) * 1983-11-21 1987-04-28 Mcneilab, Inc. Aralykyl (arylethynyl)aralkyl amines and their use as vasodilators and antihypertensives
CA1242718A (en) * 1983-11-21 1988-10-04 John R. Carson Acetylene derivatives and methods for the treatment of hypertension and angina
US4652584A (en) * 1984-07-13 1987-03-24 Mcneilab, Inc. Acetylenic phenoxypropanol derivatives and pharmaceutical compositions for the treatment of hypertension
JPS6322547A (ja) * 1986-06-20 1988-01-30 マクニ−ラブ・インコ−ポレ−テツド スチルベン類およびその用途

Also Published As

Publication number Publication date
DE3853015D1 (de) 1995-03-23
AU1323188A (en) 1988-09-22
EP0283309A2 (en) 1988-09-21
AU626788B2 (en) 1992-08-13
DK152088D0 (da) 1988-03-18
HUT48565A (en) 1989-06-28
ATE118493T1 (de) 1995-03-15
JPS63264535A (ja) 1988-11-01
HU205338B (en) 1992-04-28
GR880100169A (el) 1989-01-31
EP0283309B1 (en) 1995-02-15
US4772755A (en) 1988-09-20
EP0283309A3 (en) 1990-06-13
ZA881963B (en) 1989-11-29
DK152088A (da) 1988-09-20
NZ223905A (en) 1992-04-28
DE3853015T2 (de) 1995-06-08

Similar Documents

Publication Publication Date Title
BG61319B1 (bg) Метод за получаване на арилпиперидинкарбиноли
ES2067468T3 (es) Secuencia de reaccion de adicion en 1,2-1,4 para dar difenilacetilenos.
DE68917853T2 (de) Herstellung von 1,4-Diazabicyclo[3.2.2]nonanen.
ES553461A0 (es) Un procedimiento enantioselectivo para la preparacion de intermedios para los antibioticos de 1-b-metil-carbapenem
ES541544A0 (es) Un metodo de preparar bestatinas
EP0206765A3 (en) Process for preparation of rooperol, hypoxoside and derivatives thereof
CA1267906C (en) PROSTAGLANDIN ANALOGS WITH 7-OXABICYCLOHEPTANE SUBSTITUTE
ATE66961T1 (de) Verfahren zur herstellung von penemen.
FI880265A (fi) 1-substituoitujen (S)- ja (R)-2-aminometyylipyrrolidiinien tehokas, stereorakenteen säilyttävä synteesi sekä synteesin välituotteet
PT93593A (pt) Processo de preparacao de cloreto de delfinidina e dos seus intermediarios
ATE127774T1 (de) Verfahren zur herstellung von bicyclo(3.2.0)hept- 2-en-7-onen.
ATE25680T1 (de) Verfahren zur herstellung von 4-amino-5-dialkoxy- methylpyrimidinderivaten.
HUT45011A (en) Process for producing azetidine derivatives
GR3007466T3 (es)
DE3778765D1 (de) Verfahren zur herstellung von antibiotika.
KR860001817A (ko) 페니실린 유도체의 제조방법
ES486995A1 (es) Un procedimiento para la preparacion de una b-lactama
FI863897A (fi) Kemiskt foerfarande.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 283309

Country of ref document: ES