DE69030147T2 - 10-(1-Hydroxyethyl)-11-oxo-1-azatricyclo[7.2.0.0.3,8]undec-2-en-2-carbonsäure-Derivate - Google Patents

10-(1-Hydroxyethyl)-11-oxo-1-azatricyclo[7.2.0.0.3,8]undec-2-en-2-carbonsäure-Derivate

Info

Publication number
DE69030147T2
DE69030147T2 DE69030147T DE69030147T DE69030147T2 DE 69030147 T2 DE69030147 T2 DE 69030147T2 DE 69030147 T DE69030147 T DE 69030147T DE 69030147 T DE69030147 T DE 69030147T DE 69030147 T2 DE69030147 T2 DE 69030147T2
Authority
DE
Germany
Prior art keywords
group
atom
zero
represent
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69030147T
Other languages
English (en)
Other versions
DE69030147D1 (de
Inventor
Bruno Tamburini
Alcide Perboni
Tino Rossi
Daniele Donati
Daniele Andreotti
Giovanni Gaviraghi
Roberto Carlesso
Claudio Bismara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline SpA
Original Assignee
Glaxo SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898920337A external-priority patent/GB8920337D0/en
Priority claimed from GB909015484A external-priority patent/GB9015484D0/en
Application filed by Glaxo SpA filed Critical Glaxo SpA
Application granted granted Critical
Publication of DE69030147D1 publication Critical patent/DE69030147D1/de
Publication of DE69030147T2 publication Critical patent/DE69030147T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D477/00Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
DE69030147T 1989-09-08 1990-09-07 10-(1-Hydroxyethyl)-11-oxo-1-azatricyclo[7.2.0.0.3,8]undec-2-en-2-carbonsäure-Derivate Expired - Fee Related DE69030147T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898920337A GB8920337D0 (en) 1989-09-08 1989-09-08 Heterocyclic compounds
GB909015484A GB9015484D0 (en) 1990-07-13 1990-07-13 Heterocyclic compounds

Publications (2)

Publication Number Publication Date
DE69030147D1 DE69030147D1 (de) 1997-04-17
DE69030147T2 true DE69030147T2 (de) 1997-07-10

Family

ID=26295887

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69030147T Expired - Fee Related DE69030147T2 (de) 1989-09-08 1990-09-07 10-(1-Hydroxyethyl)-11-oxo-1-azatricyclo[7.2.0.0.3,8]undec-2-en-2-carbonsäure-Derivate
DE69029627T Expired - Fee Related DE69029627T2 (de) 1989-09-08 1990-09-07 4-(1'-Oxocyclohex-2'-yl)azetidin-2-on-Derivate

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69029627T Expired - Fee Related DE69029627T2 (de) 1989-09-08 1990-09-07 4-(1'-Oxocyclohex-2'-yl)azetidin-2-on-Derivate

Country Status (28)

Country Link
US (2) US5138048A (de)
EP (2) EP0416953B1 (de)
JP (2) JP3035325B2 (de)
KR (1) KR100188175B1 (de)
AT (2) ATE147394T1 (de)
AU (1) AU632163B2 (de)
CA (1) CA2024880C (de)
CZ (1) CZ285778B6 (de)
DD (1) DD298102A5 (de)
DE (2) DE69030147T2 (de)
DK (1) DK0416953T3 (de)
ES (2) ES2100872T3 (de)
FI (1) FI93450C (de)
GR (1) GR3023647T3 (de)
HR (1) HRP940559B1 (de)
HU (1) HU218222B (de)
IE (1) IE903257A1 (de)
IL (1) IL95609A (de)
MY (1) MY106980A (de)
NO (1) NO175479C (de)
NZ (1) NZ235223A (de)
PL (1) PL166197B1 (de)
PT (1) PT95247B (de)
RU (1) RU2054006C1 (de)
SG (1) SG73399A1 (de)
SI (1) SI9011699A (de)
SK (1) SK435990A3 (de)
YU (1) YU48073B (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU636913B2 (en) * 1989-10-11 1993-05-13 Takeda Chemical Industries Ltd. Tricyclic carbapenem compounds
GB9015485D0 (en) * 1990-07-13 1990-08-29 Glaxo Spa Heterocyclic derivatives
YU48079B (sh) * 1990-08-21 1997-01-08 Glaxo S.P.A. Heterociklična jedinjenja
GB9104833D0 (en) * 1991-03-07 1991-04-17 Glaxo Spa Heterocyclic compounds
AP198A (en) * 1991-03-07 1992-06-30 Glaxo Spa Heterocyclic compounds.
GB9104769D0 (en) * 1991-03-07 1991-04-17 Glaxo Spa Heterocyclic compounds
GB9104832D0 (en) * 1991-03-07 1991-04-17 Glaxo Spa Heterocyclic compounds
GB9104838D0 (en) * 1991-03-07 1991-04-17 Glaxo Spa Heterocyclic compounds
KR920019791A (ko) * 1991-04-05 1992-11-20 우메모또 요시마사 다환성 카르바페넴 화합물, 그의 제조방법 및 용도
TW198035B (de) * 1991-05-29 1993-01-11 Hoechst Ag
GB9218240D0 (en) * 1992-08-27 1992-10-14 Glaxo Spa Heterocyclic compounds
GB9218781D0 (en) * 1992-09-04 1992-10-21 Glaxo Spa Heterocyclic derivatives
GB9305805D0 (en) * 1993-03-20 1993-05-05 Glaxo Spa Chemical process
GB9305853D0 (en) * 1993-03-20 1993-05-05 Glaxo Spa Chemical compounds
GB9305813D0 (en) * 1993-03-20 1993-05-05 Glaxo Spa Chemical process
GB9305806D0 (en) * 1993-03-20 1993-05-05 Glaxo Spa Chemical compounds
US5849907A (en) * 1993-03-20 1998-12-15 Glaxo Wellcome Spa Chemical process
US5372993A (en) * 1993-06-10 1994-12-13 Merck & Co., Inc. Bridged carbapenem compounds, compositions containing such compounds and methods of use
US5374630A (en) * 1993-06-10 1994-12-20 Merck & Co., Inc. Bridged carbapenem antibacterial compounds
US5384317A (en) * 1993-08-02 1995-01-24 Merck & Co., Inc. Bridged biphenyl carbapenem compounds, compositions containing such compounds and methods of use
US5401735A (en) * 1993-08-02 1995-03-28 Merck & Co., Inc. Bridged biphenyl carbapenem antibacterial compounds
GB9323137D0 (en) * 1993-11-10 1994-01-05 Glaxo Spa Chemical compounds
GB9403729D0 (en) * 1994-02-26 1994-04-13 Glaxo Spa Amine derivatives
GB2287709A (en) * 1994-03-26 1995-09-27 Glaxo Spa Silylated azetidinone intermediates
GB9406074D0 (en) * 1994-03-26 1994-05-18 Glaxo Spa Chemical process
US5688786A (en) * 1994-04-01 1997-11-18 Microcide Pharmaceuticals, Inc. β-lactam antibiotics
US5698547A (en) * 1994-04-01 1997-12-16 Microcide Pharmaceuticals, Inc. Cephalosporin antibiotics
GB9516118D0 (en) * 1995-08-05 1995-10-04 Glaxo Spa Chemical process
US6531466B2 (en) 1996-11-14 2003-03-11 Glaxosmithkline Spa Tricyclic carbapenem compounds
GB9623684D0 (en) * 1996-11-14 1997-01-08 Glaxo Wellcome Spa Chemical compounds
JPH10168057A (ja) * 1996-12-12 1998-06-23 Takasago Internatl Corp シクロヘキシルアゼチジノン誘導体の製造法
AU5781498A (en) * 1997-02-10 1998-08-26 Sankyo Company Limited Tricyclic heterocyclic compounds
US5994343A (en) * 1997-10-02 1999-11-30 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
US6207823B1 (en) * 1997-10-23 2001-03-27 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
CA2306632A1 (en) * 1997-10-23 1999-04-29 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions and methods of treatment
US6271222B1 (en) 1998-05-28 2001-08-07 Merck & Co., Inc. Penem antibacterial compounds, compositions and methods of treatment
CN101367817B (zh) * 2007-06-26 2011-01-12 山东轩竹医药科技有限公司 含有环己烯酮甲酰氨基的碳青霉烯化合物
EP2085084A1 (de) * 2008-01-29 2009-08-05 LEK Pharmaceuticals D.D. Verwendung eines Hemmers von Beta-Lactamasen und dessen Kombination mit Beta-Lactam-Antibiotika
EP2135871A1 (de) * 2008-06-18 2009-12-23 LEK Pharmaceuticals D.D. Neuartige Trinemantibiotika und Hemmer von Beta-Lactamasen
PT3621609T (pt) 2017-05-08 2022-08-24 Glaxosmithkline Ip Dev Ltd Sanfetrinem ou um sal ou um éster do mesmo para a sua utilização no tratamento de infeções micobacterianas
KR102471353B1 (ko) * 2020-07-03 2022-11-28 한국공학대학교산학협력단 바이메탈을 이용한 복원 기능을 포함하는 퓨즈

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
US4260627A (en) * 1978-10-24 1981-04-07 Merck & Co., Inc. 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids
US4600713A (en) * 1979-12-03 1986-07-15 Merck & Co., Inc. 1-, 6- and 2-substituted-1-carba-2-penem-3-carboxylic acids
US4374849A (en) * 1981-09-14 1983-02-22 Merck & Co., Inc. 6-Amidocyclonocardicins
US4374848A (en) * 1981-09-14 1983-02-22 Merck & Co., Inc. 6-(1-Hydroxyethyl)cyclonocardicin
JPS61236785A (ja) * 1985-04-15 1986-10-22 Sankyo Co Ltd アゼチジノン誘導体
GB8607921D0 (en) 1986-04-01 1986-05-08 Fujisawa Pharmaceutical Co 3,4-disubstituted-2-azetidinone derivatives
AU636913B2 (en) * 1989-10-11 1993-05-13 Takeda Chemical Industries Ltd. Tricyclic carbapenem compounds

Also Published As

Publication number Publication date
DK0416953T3 (da) 1997-09-01
NO175479C (no) 1994-10-19
NO903914L (no) 1991-03-11
SK278688B6 (sk) 1998-01-14
US5138048A (en) 1992-08-11
CZ435990A3 (cs) 1999-11-17
EP0416952A2 (de) 1991-03-13
KR910006291A (ko) 1991-04-29
FI93450C (fi) 1995-04-10
NO175479B (no) 1994-07-11
PT95247B (pt) 1997-06-30
MY106980A (en) 1995-08-30
JP3035325B2 (ja) 2000-04-24
CA2024880A1 (en) 1991-03-09
KR100188175B1 (ko) 1999-06-01
CZ285778B6 (cs) 1999-11-17
HU218222B (hu) 2000-06-28
DE69029627D1 (de) 1997-02-20
DE69029627T2 (de) 1997-04-24
PT95247A (pt) 1991-06-25
IL95609A (en) 1995-03-30
YU169990A (sh) 1993-05-28
NO903914D0 (no) 1990-09-07
HRP940559B1 (en) 1999-08-31
IE903257A1 (en) 1991-03-13
AU6226590A (en) 1991-03-14
AU632163B2 (en) 1992-12-17
DD298102A5 (de) 1992-02-06
SK435990A3 (en) 1998-01-14
JP3018442B2 (ja) 2000-03-13
PL286796A1 (en) 1991-08-26
HUT56105A (en) 1991-07-29
JPH03169854A (ja) 1991-07-23
SG73399A1 (en) 2000-06-20
US5407931A (en) 1995-04-18
JPH03167187A (ja) 1991-07-19
HRP940559A2 (en) 1997-02-28
CA2024880C (en) 2000-05-30
GR3023647T3 (en) 1997-09-30
ES2095860T3 (es) 1997-03-01
HU905826D0 (en) 1991-03-28
RU2054006C1 (ru) 1996-02-10
EP0416952B1 (de) 1997-01-08
ATE150022T1 (de) 1997-03-15
EP0416953B1 (de) 1997-03-12
YU48073B (sh) 1997-01-08
EP0416953A2 (de) 1991-03-13
FI93450B (fi) 1994-12-30
EP0416953A3 (en) 1992-03-25
FI904423A0 (fi) 1990-09-07
ATE147394T1 (de) 1997-01-15
SI9011699A (en) 1997-10-31
PL166197B1 (pl) 1995-04-28
ES2100872T3 (es) 1997-07-01
EP0416952A3 (en) 1992-03-11
NZ235223A (en) 1992-11-25
DE69030147D1 (de) 1997-04-17

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee