YU48073B - Postupak za dobijanje heterocikličnih jedinjenja - Google Patents
Postupak za dobijanje heterocikličnih jedinjenjaInfo
- Publication number
- YU48073B YU48073B YU169990A YU169990A YU48073B YU 48073 B YU48073 B YU 48073B YU 169990 A YU169990 A YU 169990A YU 169990 A YU169990 A YU 169990A YU 48073 B YU48073 B YU 48073B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- group
- compound
- hydrogen atom
- atom
- protecting group
- Prior art date
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 11
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 8
- 125000006239 protecting group Chemical group 0.000 abstract 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 6
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000000468 ketone group Chemical group 0.000 abstract 3
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 125000004005 formimidoyl group Chemical group [H]\N=C(/[H])* 0.000 abstract 2
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 2
- 238000000926 separation method Methods 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 101100533888 Hypocrea jecorina (strain QM6a) sor4 gene Proteins 0.000 abstract 1
- 101100533877 Hypocrea jecorina (strain QM6a) sor8 gene Proteins 0.000 abstract 1
- 241000282553 Macaca Species 0.000 abstract 1
- 238000010934 O-alkylation reaction Methods 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-N phosphine group Chemical group P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
Postupak za dobijanje heterociklicnih jedinjenja opste formule (I) u kojoj: R1 pretstavlja vodonikov atom ili hidroksilnu zastitnu grupu; R2 pretstavlja vodonikov atom ili karboksilnu zastitnu grupu; i R3 pretstavlja vodonikov atom, hidroksilnu grupu, hidrok-simetil grupu, C1-3alkil grupu ili grupu XR4 u kojoj X pretstavlja atom kiseonika ili grupu S(O)n u kojoj je n nula ili ceo broj 1 ili 2 i R4 pretstavlja C1-5alkil, C3-7cikloalkil ili fenil grupu, ili kada je X atom kiseonika ili sumpora tada R4 moze takodje pretstavljati grupu AlkNR5R6 gde Alk pretstavlja C2-6 pravi ili racvasti alkilenski niz, i R5 i R6 svaki nezavisno pretstavlja vodonikov atom ili C1-4alkil grupu ili R5 pretstavlja formil, acetil ili iminometil grupu a R6 pretstavlja vodonikov atom ili R5 i R6 zajedno sa azotovim atomom za koji su vezani formiraju pirolidino ili piperidino prsten, ili R3 pretstavlja grupu (CH2)mNR7R8 gde je m nula ili jedan i R7i R8 nezavisno svaki pretstavlja vodonikov atom ili C1-4 alkil grupu ili R7 pretstavlja formil, acetil ili iminometil grupu a R8 pretstavlja vodonikov atom, ili R3 i ugljenikov atom za koji je vezan pretstavljaju keto grupu ili njen ketalni derivat; i njihovih soli (ukljucujuci interne soli gde to odgovara), metabolicki labilne estre i solvate, naznacen time, sto obuhvata makoju od faza: (I) ciklizaciju jedinjenje formule (II): (u kojoj je R1a zastitna grupa za hidroksil, R2a je zastitna grupa za karboksil i R3a je kao sto je definisano za R3 ili je grupa koja se u nju moze prevesti, i Y je atom kiseonika ili fosfinska grupa, (II) oksidacija jedinjenja (I) u kojem je R2 zastitna grupa za karboksil a R3 je grupa SR4 tako da se dobiva jedinjenje (I) u kojem je R3 grupa SOR4, (III) hidroliza jedinjenja (I) u kojem je R2 zastitna grupa za karboksil a R3 zajedno sa ugljenikovim atomom za koji je vezana pretstavlja ketalnu grupu, tako da se dobiva jedinjenje (I) u kojem R3 zajedno sa ugljenikovim atomom za koji je vezana pretstavlja keto grupu, (IV) redukcija jedinjenja (I) u kojem je R2 karboksilna zastitna grupa a R3 zajedno sa ugljenikovim atomom za koji je vezana pretstavlja keto grupu, tako da se dobiva jedinjenje (I) u kojem je R3 hidroksilna grupa, (v) O-alkilovanje jedinjenja (I) u kojem je R1 zastitna grupa za hidroksil, R2 je zastitna grupa za karboksil i R3 je hidroksilna grupa tako da se dobiva jedinjenje (I) u kojem je R3 alkoksi grupa, i posle toga, ako je potrebno ili ako se zeli, podvrgavanje dobivenog jedinjenja, ili pre ili posle makakvog odvajanja, u stereohemijske izomere, prema jednoj ili vecem broju sledecih operacija: a) konverzija grupe R3a u zeljenu R3 grupu, b) odvajanje jedne ili vise zastitnih grupa, ili c) konverzija jedinjenja u kojem je R2 vodonikov atom ili zastitna grupa za karboksil u odgovarajucu so, metabolicki labilan estar ili solvat. Prijava sadrzi jos 7 zavisnih zahteva.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI9011699A SI9011699A (en) | 1989-09-08 | 1990-09-06 | Heterocyclic compounds |
| HRP-1699/90A HRP940559B1 (en) | 1989-09-08 | 1994-09-16 | Heterocyclic compounds |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898920337A GB8920337D0 (en) | 1989-09-08 | 1989-09-08 | Heterocyclic compounds |
| GB909015484A GB9015484D0 (en) | 1990-07-13 | 1990-07-13 | Heterocyclic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU169990A YU169990A (sh) | 1993-05-28 |
| YU48073B true YU48073B (sh) | 1997-01-08 |
Family
ID=26295887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU169990A YU48073B (sh) | 1989-09-08 | 1990-09-06 | Postupak za dobijanje heterocikličnih jedinjenja |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US5407931A (sh) |
| EP (2) | EP0416953B1 (sh) |
| JP (2) | JP3018442B2 (sh) |
| KR (1) | KR100188175B1 (sh) |
| AT (2) | ATE147394T1 (sh) |
| AU (1) | AU632163B2 (sh) |
| CA (1) | CA2024880C (sh) |
| CZ (1) | CZ435990A3 (sh) |
| DD (1) | DD298102A5 (sh) |
| DE (2) | DE69030147T2 (sh) |
| DK (1) | DK0416953T3 (sh) |
| ES (2) | ES2100872T3 (sh) |
| FI (1) | FI93450C (sh) |
| GR (1) | GR3023647T3 (sh) |
| HR (1) | HRP940559B1 (sh) |
| HU (1) | HU218222B (sh) |
| IE (1) | IE903257A1 (sh) |
| IL (1) | IL95609A (sh) |
| MY (1) | MY106980A (sh) |
| NO (1) | NO175479C (sh) |
| NZ (1) | NZ235223A (sh) |
| PL (1) | PL166197B1 (sh) |
| PT (1) | PT95247B (sh) |
| RU (1) | RU2054006C1 (sh) |
| SG (1) | SG73399A1 (sh) |
| SI (1) | SI9011699A (sh) |
| SK (1) | SK278688B6 (sh) |
| YU (1) | YU48073B (sh) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU636913B2 (en) * | 1989-10-11 | 1993-05-13 | Takeda Chemical Industries Ltd. | Tricyclic carbapenem compounds |
| GB9015485D0 (en) * | 1990-07-13 | 1990-08-29 | Glaxo Spa | Heterocyclic derivatives |
| SI9111427B (sl) * | 1990-08-21 | 2000-10-31 | Glaxo S.P.A. | Heterociklične spojine |
| GB9104833D0 (en) * | 1991-03-07 | 1991-04-17 | Glaxo Spa | Heterocyclic compounds |
| GB9104769D0 (en) * | 1991-03-07 | 1991-04-17 | Glaxo Spa | Heterocyclic compounds |
| AP198A (en) * | 1991-03-07 | 1992-06-30 | Glaxo Spa | Heterocyclic compounds. |
| GB9104838D0 (en) * | 1991-03-07 | 1991-04-17 | Glaxo Spa | Heterocyclic compounds |
| GB9104832D0 (en) * | 1991-03-07 | 1991-04-17 | Glaxo Spa | Heterocyclic compounds |
| EP0507313A1 (en) * | 1991-04-05 | 1992-10-07 | Takeda Chemical Industries, Ltd. | Polycyclic carbapenem compounds, their production and use |
| TW198035B (sh) * | 1991-05-29 | 1993-01-11 | Hoechst Ag | |
| GB9218240D0 (en) * | 1992-08-27 | 1992-10-14 | Glaxo Spa | Heterocyclic compounds |
| GB9218781D0 (en) * | 1992-09-04 | 1992-10-21 | Glaxo Spa | Heterocyclic derivatives |
| GB9305853D0 (en) * | 1993-03-20 | 1993-05-05 | Glaxo Spa | Chemical compounds |
| US5849907A (en) * | 1993-03-20 | 1998-12-15 | Glaxo Wellcome Spa | Chemical process |
| GB9305813D0 (en) * | 1993-03-20 | 1993-05-05 | Glaxo Spa | Chemical process |
| GB9305806D0 (en) * | 1993-03-20 | 1993-05-05 | Glaxo Spa | Chemical compounds |
| GB9305805D0 (en) * | 1993-03-20 | 1993-05-05 | Glaxo Spa | Chemical process |
| US5372993A (en) * | 1993-06-10 | 1994-12-13 | Merck & Co., Inc. | Bridged carbapenem compounds, compositions containing such compounds and methods of use |
| US5374630A (en) * | 1993-06-10 | 1994-12-20 | Merck & Co., Inc. | Bridged carbapenem antibacterial compounds |
| US5401735A (en) * | 1993-08-02 | 1995-03-28 | Merck & Co., Inc. | Bridged biphenyl carbapenem antibacterial compounds |
| US5384317A (en) * | 1993-08-02 | 1995-01-24 | Merck & Co., Inc. | Bridged biphenyl carbapenem compounds, compositions containing such compounds and methods of use |
| GB9323137D0 (en) * | 1993-11-10 | 1994-01-05 | Glaxo Spa | Chemical compounds |
| GB9403729D0 (en) * | 1994-02-26 | 1994-04-13 | Glaxo Spa | Amine derivatives |
| GB2287709A (en) * | 1994-03-26 | 1995-09-27 | Glaxo Spa | Silylated azetidinone intermediates |
| GB9406074D0 (en) * | 1994-03-26 | 1994-05-18 | Glaxo Spa | Chemical process |
| US5688786A (en) * | 1994-04-01 | 1997-11-18 | Microcide Pharmaceuticals, Inc. | β-lactam antibiotics |
| US5698547A (en) * | 1994-04-01 | 1997-12-16 | Microcide Pharmaceuticals, Inc. | Cephalosporin antibiotics |
| GB9516118D0 (en) * | 1995-08-05 | 1995-10-04 | Glaxo Spa | Chemical process |
| GB9623684D0 (en) * | 1996-11-14 | 1997-01-08 | Glaxo Wellcome Spa | Chemical compounds |
| US6531466B2 (en) | 1996-11-14 | 2003-03-11 | Glaxosmithkline Spa | Tricyclic carbapenem compounds |
| JPH10168057A (ja) * | 1996-12-12 | 1998-06-23 | Takasago Internatl Corp | シクロヘキシルアゼチジノン誘導体の製造法 |
| AU5781498A (en) * | 1997-02-10 | 1998-08-26 | Sankyo Company Limited | Tricyclic heterocyclic compounds |
| US5994343A (en) * | 1997-10-02 | 1999-11-30 | Merck & Co., Inc. | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment |
| EP1032384A4 (en) * | 1997-10-23 | 2001-11-21 | Merck & Co Inc | ANTIBACTERIAL COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING CARBAPENEMAS |
| US6207823B1 (en) * | 1997-10-23 | 2001-03-27 | Merck & Co., Inc. | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment |
| US6271222B1 (en) | 1998-05-28 | 2001-08-07 | Merck & Co., Inc. | Penem antibacterial compounds, compositions and methods of treatment |
| CN101367817B (zh) * | 2007-06-26 | 2011-01-12 | 山东轩竹医药科技有限公司 | 含有环己烯酮甲酰氨基的碳青霉烯化合物 |
| EP2085084A1 (en) * | 2008-01-29 | 2009-08-05 | LEK Pharmaceuticals D.D. | Use of inhibitor of beta-lactamases and its combination with beta-lactam antibiotics |
| EP2135871A1 (en) * | 2008-06-18 | 2009-12-23 | LEK Pharmaceuticals D.D. | New trinem antibiotics and inhibitors of beta-lactamases |
| HRP20221212T1 (hr) | 2017-05-08 | 2022-12-09 | Glaxosmithkline Intellectual Property Development Limited | Sanfetrinem ili njegova sol ili esteri za uporabu u liječenju mikobakterijskih infekcija |
| KR102471353B1 (ko) * | 2020-07-03 | 2022-11-28 | 한국공학대학교산학협력단 | 바이메탈을 이용한 복원 기능을 포함하는 퓨즈 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4260627A (en) * | 1978-10-24 | 1981-04-07 | Merck & Co., Inc. | 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids |
| US4600713A (en) * | 1979-12-03 | 1986-07-15 | Merck & Co., Inc. | 1-, 6- and 2-substituted-1-carba-2-penem-3-carboxylic acids |
| US4374849A (en) * | 1981-09-14 | 1983-02-22 | Merck & Co., Inc. | 6-Amidocyclonocardicins |
| US4374848A (en) * | 1981-09-14 | 1983-02-22 | Merck & Co., Inc. | 6-(1-Hydroxyethyl)cyclonocardicin |
| JPS61236785A (ja) * | 1985-04-15 | 1986-10-22 | Sankyo Co Ltd | アゼチジノン誘導体 |
| GB8607921D0 (en) | 1986-04-01 | 1986-05-08 | Fujisawa Pharmaceutical Co | 3,4-disubstituted-2-azetidinone derivatives |
| AU636913B2 (en) * | 1989-10-11 | 1993-05-13 | Takeda Chemical Industries Ltd. | Tricyclic carbapenem compounds |
-
1990
- 1990-09-04 CZ CS904359A patent/CZ435990A3/cs not_active IP Right Cessation
- 1990-09-06 SI SI9011699A patent/SI9011699A/sl unknown
- 1990-09-06 DD DD90343863A patent/DD298102A5/de not_active IP Right Cessation
- 1990-09-06 YU YU169990A patent/YU48073B/sh unknown
- 1990-09-07 AT AT90309847T patent/ATE147394T1/de active
- 1990-09-07 PL PL90286796A patent/PL166197B1/pl unknown
- 1990-09-07 JP JP2235976A patent/JP3018442B2/ja not_active Expired - Lifetime
- 1990-09-07 IL IL9560990A patent/IL95609A/en not_active IP Right Cessation
- 1990-09-07 IE IE325790A patent/IE903257A1/en not_active IP Right Cessation
- 1990-09-07 US US07/578,948 patent/US5407931A/en not_active Expired - Fee Related
- 1990-09-07 FI FI904423A patent/FI93450C/fi not_active IP Right Cessation
- 1990-09-07 ES ES90309848T patent/ES2100872T3/es not_active Expired - Lifetime
- 1990-09-07 DE DE69030147T patent/DE69030147T2/de not_active Expired - Fee Related
- 1990-09-07 US US07/578,949 patent/US5138048A/en not_active Expired - Fee Related
- 1990-09-07 DK DK90309848.1T patent/DK0416953T3/da active
- 1990-09-07 HU HU826/90A patent/HU218222B/hu not_active IP Right Cessation
- 1990-09-07 KR KR1019900014226A patent/KR100188175B1/ko not_active IP Right Cessation
- 1990-09-07 SK SK4359-90A patent/SK278688B6/sk unknown
- 1990-09-07 SG SG1996006269A patent/SG73399A1/en unknown
- 1990-09-07 EP EP90309848A patent/EP0416953B1/en not_active Expired - Lifetime
- 1990-09-07 DE DE69029627T patent/DE69029627T2/de not_active Expired - Fee Related
- 1990-09-07 AU AU62265/90A patent/AU632163B2/en not_active Ceased
- 1990-09-07 JP JP2235975A patent/JP3035325B2/ja not_active Expired - Fee Related
- 1990-09-07 MY MYPI90001540A patent/MY106980A/en unknown
- 1990-09-07 NO NO903914A patent/NO175479C/no unknown
- 1990-09-07 AT AT90309848T patent/ATE150022T1/de not_active IP Right Cessation
- 1990-09-07 CA CA002024880A patent/CA2024880C/en not_active Expired - Fee Related
- 1990-09-07 ES ES90309847T patent/ES2095860T3/es not_active Expired - Lifetime
- 1990-09-07 EP EP90309847A patent/EP0416952B1/en not_active Expired - Lifetime
- 1990-09-07 NZ NZ235223A patent/NZ235223A/xx unknown
- 1990-09-07 PT PT95247A patent/PT95247B/pt not_active IP Right Cessation
-
1992
- 1992-06-04 RU SU5011726/04A patent/RU2054006C1/ru not_active IP Right Cessation
-
1994
- 1994-09-16 HR HRP-1699/90A patent/HRP940559B1/xx not_active IP Right Cessation
-
1997
- 1997-05-09 GR GR970401017T patent/GR3023647T3/el unknown
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