DE60228118D1 - Verfahren zur herstellung von o-desmethylvenlafaxin - Google Patents

Verfahren zur herstellung von o-desmethylvenlafaxin

Info

Publication number
DE60228118D1
DE60228118D1 DE60228118T DE60228118T DE60228118D1 DE 60228118 D1 DE60228118 D1 DE 60228118D1 DE 60228118 T DE60228118 T DE 60228118T DE 60228118 T DE60228118 T DE 60228118T DE 60228118 D1 DE60228118 D1 DE 60228118D1
Authority
DE
Germany
Prior art keywords
desmethylvenlafaxine
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60228118T
Other languages
English (en)
Inventor
Beat Theodor Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23309595&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60228118(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth LLC filed Critical Wyeth LLC
Application granted granted Critical
Publication of DE60228118D1 publication Critical patent/DE60228118D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
DE60228118T 2001-12-04 2002-12-03 Verfahren zur herstellung von o-desmethylvenlafaxin Expired - Lifetime DE60228118D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33495301P 2001-12-04 2001-12-04
PCT/US2002/038403 WO2003048104A1 (en) 2001-12-04 2002-12-03 Methods for preparing o-desmethylvenlafaxine

Publications (1)

Publication Number Publication Date
DE60228118D1 true DE60228118D1 (de) 2008-09-18

Family

ID=23309595

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60228118T Expired - Lifetime DE60228118D1 (de) 2001-12-04 2002-12-03 Verfahren zur herstellung von o-desmethylvenlafaxin

Country Status (29)

Country Link
US (4) US6689912B2 (de)
EP (1) EP1451143B9 (de)
JP (1) JP4342312B2 (de)
KR (1) KR100939650B1 (de)
CN (1) CN1319934C (de)
AR (1) AR037622A1 (de)
AT (1) ATE403641T1 (de)
AU (1) AU2002357049B2 (de)
BR (1) BR0214701A (de)
CA (1) CA2466779C (de)
CO (1) CO5580816A2 (de)
DE (1) DE60228118D1 (de)
DK (1) DK1451143T3 (de)
EC (1) ECSP045135A (de)
ES (1) ES2311647T4 (de)
HK (1) HK1065778A1 (de)
HU (1) HUP0402269A3 (de)
IL (3) IL162253A0 (de)
MX (1) MXPA04005309A (de)
NO (1) NO20042680L (de)
NZ (1) NZ533316A (de)
PL (1) PL369299A1 (de)
PT (1) PT1451143E (de)
RU (1) RU2317286C2 (de)
SI (1) SI1451143T1 (de)
TW (1) TWI260982B (de)
UA (1) UA80543C2 (de)
WO (1) WO2003048104A1 (de)
ZA (1) ZA200405250B (de)

Families Citing this family (44)

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US6342533B1 (en) * 1998-12-01 2002-01-29 Sepracor, Inc. Derivatives of (−)-venlafaxine and methods of preparing and using the same
DE60039132D1 (de) * 1999-04-06 2008-07-17 Sepracor Inc O-Desmethylvenlafaxin-Succinat
PT1360169E (pt) * 2001-02-12 2007-10-29 Wyeth Corp Sal succinato de o-desmetil-venlafaxina
UA80543C2 (en) * 2001-12-04 2007-10-10 Wyeth Corp Method for the preparation of o-desmethylvenlafaxine
MX2008000249A (es) * 2005-07-06 2008-03-18 Sepracor Inc Combinaciones de eszopiclona y o-desmetilvenlafaxina y metodos de tratamiento de menopausia y trastornos del estado de animo, ansiedad y cognitivos.
BRPI0619449A2 (pt) * 2005-12-05 2011-03-29 Wyeth Corp processo para a sìntese estereosseletiva de uma (4s ou 4r)-4-benzil-3-[2r ou 2s]-(1-hidroxicicloexil)-(metoxifenil) acetil]-1,3-oxazolidin-2-ona e de um enantiÈmero de uma 2-fenil-2-(1-hidroxicicloalquil) etilamina ou seu sal e compostos
EP1973866A1 (de) * 2005-12-20 2008-10-01 Synthon B.V. Verfahren zur herstellung von desvenlafaxin
MX2007016179A (es) * 2006-04-17 2008-03-11 Teva Pharma Formas cristalinas de o-desmetilvenlafaxina.
EP2007708A1 (de) 2006-04-17 2008-12-31 Teva Pharmaceutical Industries Ltd Substanziell reines o-desmethylvenlafaxin und herstellungsverfahren dafür
WO2008035369A2 (en) * 2006-06-30 2008-03-27 Alembic Limited Novel form of o-desmethyl venlafaxine
US20090137846A1 (en) * 2006-07-26 2009-05-28 Valerie Niddam-Hildesheim Processes for the synthesis of O-Desmethylvenlafaxine
US20080221356A1 (en) * 2006-07-26 2008-09-11 Valerie Niddam-Hildesheim Processes for the synthesis of O-desmethylvenlafaxine
WO2008013995A2 (en) * 2006-07-26 2008-01-31 Teva Pharmaceutical Industries Ltd. Tridesmethylvenlafaxine and processes for the synthesis of o-desmethylvenlafaxine
WO2008013993A2 (en) * 2006-07-26 2008-01-31 Teva Pharmaceutical Industries Ltd. Processes for the synthesis of o-desmethylvenlafaxine
WO2008013994A2 (en) 2006-07-26 2008-01-31 Teva Pharmaceutical Industries Ltd. Processes for the synthesis of o-desmethylvenlafaxine
US20090069601A1 (en) * 2006-07-26 2009-03-12 Valerie Niddam-Hildesheim Processes for the synthesis of O-desmethylvenlafaxine
CA2656161A1 (en) * 2006-07-26 2008-01-31 Teva Pharmaceutical Industries Ltd. Process for the synthesis of o-desmethylvenlafaxine
EP2061750A2 (de) * 2006-08-04 2009-05-27 Medichem, S.A. Verbessertes verfahren zur synthetisierung einer desvenlafaxin-freien base und von salzen oder solvaten daraus
AU2008211711A1 (en) * 2007-01-31 2008-08-07 Generics [Uk] Limited Process for the preparation of O-desmethyl venlafaxine
IN2009DN05509A (de) * 2007-03-14 2010-04-30 Teva Pharma
CA2692738A1 (en) * 2007-07-12 2009-01-15 Dr. Reddy's Laboratories, Ltd. O-desmethylvenlafaxine
WO2009010990A2 (en) * 2007-07-16 2009-01-22 Matrix Laboratories Limited Process for the preparation of o-desmethylvenlafaxine succinate polymorphic forms
WO2009034434A2 (en) * 2007-09-10 2009-03-19 Cadila Pharmaceuticals Limited An improved process for the preparation of o-desmethylvenlafaxine
JP2011500777A (ja) * 2007-10-26 2011-01-06 ジェネリクス・（ユーケー）・リミテッド Ｏ−デスメチルベンラファキシンの製造方法
KR101343027B1 (ko) * 2007-11-26 2013-12-18 테바 파마슈티컬 인더스트리즈 리미티드 Ｏ-데스메틸벤라팍신 푸마레이트의 결정형
WO2009084038A2 (en) * 2007-12-28 2009-07-09 Ind-Swift Laboratories Limited Improved process for the preparation of 0-desmethyl-venlafaxine
CA2717580A1 (en) * 2008-03-06 2009-12-17 Teva Pharmaceutical Industries Ltd. Processes for the preparation of o-desmethylvenlafaxine, free from its dimer impurities
EP2119695A1 (de) 2008-05-16 2009-11-18 Krka Zubereitung von O-Desmethylvenlafaxin-Salzen
EP2119696A1 (de) 2008-05-16 2009-11-18 Krka Zubereitung von O-Desmethylvenlafaxin-Salzen
KR20100132069A (ko) * 2008-06-16 2010-12-16 테바 파마슈티컬 인더스트리즈 리미티드 Ｏ-데스메틸벤라팍신염의 고체 상태
US20100016638A1 (en) * 2008-07-21 2010-01-21 Zdenko Hamersak Method for preparation of o-desmethylvenlafaxine using polythiolates
CN102164886A (zh) * 2008-07-30 2011-08-24 基因里克斯(英国)有限公司 用于制备o-去甲文拉法辛的方法
CZ2008756A3 (cs) 2008-11-27 2010-03-24 Zentiva, A. S. Zpusob prípravy desvenlafaxinu a jeho solí
CZ301820B6 (cs) 2009-02-06 2010-06-30 Zentiva, K.S. Nové soli desvenlafaxinu a zpusob jejich prípravy
CZ2009454A3 (cs) 2009-07-15 2010-11-10 Zentiva, K. S. Zpusob prípravy desvenlafaxinu a jeho solí
AU2010272377A1 (en) 2009-07-16 2012-01-19 Cipla Limited Process for the preparation of O-desmethyl venlafaxine and intermediate for use therein
US20110098506A1 (en) * 2009-10-26 2011-04-28 Intas Pharmaceuticals Limited Method of preparing o-desmethylvenlafaxine
US20110184067A1 (en) * 2010-01-25 2011-07-28 Intas Pharmaceuticals Ltd. O-desmethylvenlafaxine succinate polymorph & process for preparing thereof
KR101409554B1 (ko) 2010-03-29 2014-06-19 플리바 흐르바츠카 디.오.오. Ｏ-데스메틸벤라팍신 푸마레이트의 결정형
CZ303249B6 (cs) 2010-04-06 2012-06-20 Zentiva, K.S. Zpusob výroby 4-(2-(substituovaných)-1-(1-hydroxycyklohexyl)ethyl)fenolu O-demethylací jejich methyletheru pomocí nepáchnoucích aromatických thiolu
EP2394976A1 (de) 2010-06-11 2011-12-14 LEK Pharmaceuticals d.d. Verfahren zur Demethylierung aromatischer Methylether unter Verwendung von 3-Mercaptopropionsäure
WO2018146529A1 (en) 2017-02-09 2018-08-16 R L Finechem Private Limited A process for preparation of1-[2-(dimethylamino)-1-(4-hydroxyphenyl) ethyl]-cyclohexanol and salts thereof
CN109232189B (zh) * 2018-09-25 2021-10-08 杭州盛弗泰新材料科技有限公司 一种高纯度1-羟基芘的制备方法
CN109665966A (zh) * 2018-11-01 2019-04-23 山东蒲济医药科技有限公司 一种琥珀酸去甲文拉法辛化合物的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2741009A1 (de) * 1976-09-22 1978-03-23 Sandoz Ag 4-styryl-4-indolinol-derivate, ihre verwendung und herstellung
US4535186A (en) 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
CA1227304A (en) * 1984-08-01 1987-09-29 Raymond C. Francis Delignification of pulp
GB8902209D0 (en) 1989-02-01 1989-03-22 Wyeth John And Brother Limited Preparation of cyclohexanol derivatives and novel thioamide intermediates
US6342533B1 (en) * 1998-12-01 2002-01-29 Sepracor, Inc. Derivatives of (−)-venlafaxine and methods of preparing and using the same
US6197828B1 (en) * 1998-12-01 2001-03-06 Sepracor, Inc. Derivatives of (+)-venlafaxine and methods of preparing and using the same
DE60039132D1 (de) 1999-04-06 2008-07-17 Sepracor Inc O-Desmethylvenlafaxin-Succinat
WO2000076955A1 (en) 1999-06-15 2000-12-21 American Home Products Corporation Enantiomers of o-desmethyl venlafaxine
US20030171324A1 (en) 2000-07-18 2003-09-11 Shyam Ramakrishnan Regulation of human desc1-like serine protease
PT1360169E (pt) * 2001-02-12 2007-10-29 Wyeth Corp Sal succinato de o-desmetil-venlafaxina
UA80543C2 (en) * 2001-12-04 2007-10-10 Wyeth Corp Method for the preparation of o-desmethylvenlafaxine

Also Published As

Publication number Publication date
IL162253A0 (en) 2005-11-20
ES2311647T3 (es) 2009-02-16
HUP0402269A2 (hu) 2005-02-28
SI1451143T1 (sl) 2008-12-31
HK1065778A1 (en) 2005-03-04
TW200301102A (en) 2003-07-01
AU2002357049A1 (en) 2003-06-17
JP2005511681A (ja) 2005-04-28
MXPA04005309A (es) 2004-09-13
RU2317286C2 (ru) 2008-02-20
BR0214701A (pt) 2004-08-31
EP1451143B1 (de) 2008-08-06
NZ533316A (en) 2005-12-23
CN1625546A (zh) 2005-06-08
NO20042680L (no) 2004-06-25
IL194034A (en) 2010-12-30
JP4342312B2 (ja) 2009-10-14
PL369299A1 (en) 2005-04-18
DK1451143T3 (da) 2008-11-10
EP1451143B9 (de) 2009-08-12
TWI260982B (en) 2006-09-01
US20090018365A1 (en) 2009-01-15
AU2002357049B2 (en) 2009-07-16
WO2003048104A1 (en) 2003-06-12
US6689912B2 (en) 2004-02-10
US20070225525A1 (en) 2007-09-27
US7435854B2 (en) 2008-10-14
ECSP045135A (es) 2004-07-23
EP1451143A1 (de) 2004-09-01
US20040158101A1 (en) 2004-08-12
PT1451143E (pt) 2008-10-21
CA2466779A1 (en) 2003-06-12
CA2466779C (en) 2013-11-19
AR037622A1 (es) 2004-11-17
ES2311647T4 (es) 2009-11-10
HUP0402269A3 (en) 2010-06-28
RU2004120284A (ru) 2005-04-10
ATE403641T1 (de) 2008-08-15
US20030105358A1 (en) 2003-06-05
UA80543C2 (en) 2007-10-10
CO5580816A2 (es) 2005-11-30
IL162253A (en) 2009-02-11
ZA200405250B (en) 2005-12-28
KR20050044671A (ko) 2005-05-12
KR100939650B1 (ko) 2010-02-05
CN1319934C (zh) 2007-06-06

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