BR0214701A - Métodos para a preparação de o-desmetilvenlafaxina - Google Patents

Métodos para a preparação de o-desmetilvenlafaxina

Info

Publication number
BR0214701A
BR0214701A BR0214701-7A BR0214701A BR0214701A BR 0214701 A BR0214701 A BR 0214701A BR 0214701 A BR0214701 A BR 0214701A BR 0214701 A BR0214701 A BR 0214701A
Authority
BR
Brazil
Prior art keywords
desmethylvenlafaxine
methods
preparation
desmethylvenlafaxin
preparing
Prior art date
Application number
BR0214701-7A
Other languages
English (en)
Inventor
Beat Theodor Weber
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23309595&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0214701(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BR0214701A publication Critical patent/BR0214701A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

"MéTODOS PARA A PREPARAçãO DE O-DESMETILVENLAFAXINA". A presente invenção fornece um método eficiente de produção da O-desmetilvenlafaxina através da desmetilação da venlafaxina com um ânion de tiolato.
BR0214701-7A 2001-12-04 2002-12-03 Métodos para a preparação de o-desmetilvenlafaxina BR0214701A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33495301P 2001-12-04 2001-12-04
PCT/US2002/038403 WO2003048104A1 (en) 2001-12-04 2002-12-03 Methods for preparing o-desmethylvenlafaxine

Publications (1)

Publication Number Publication Date
BR0214701A true BR0214701A (pt) 2004-08-31

Family

ID=23309595

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0214701-7A BR0214701A (pt) 2001-12-04 2002-12-03 Métodos para a preparação de o-desmetilvenlafaxina

Country Status (29)

Country Link
US (4) US6689912B2 (pt)
EP (1) EP1451143B9 (pt)
JP (1) JP4342312B2 (pt)
KR (1) KR100939650B1 (pt)
CN (1) CN1319934C (pt)
AR (1) AR037622A1 (pt)
AT (1) ATE403641T1 (pt)
AU (1) AU2002357049B2 (pt)
BR (1) BR0214701A (pt)
CA (1) CA2466779C (pt)
CO (1) CO5580816A2 (pt)
DE (1) DE60228118D1 (pt)
DK (1) DK1451143T3 (pt)
EC (1) ECSP045135A (pt)
ES (1) ES2311647T4 (pt)
HK (1) HK1065778A1 (pt)
HU (1) HUP0402269A3 (pt)
IL (3) IL162253A0 (pt)
MX (1) MXPA04005309A (pt)
NO (1) NO20042680L (pt)
NZ (1) NZ533316A (pt)
PL (1) PL369299A1 (pt)
PT (1) PT1451143E (pt)
RU (1) RU2317286C2 (pt)
SI (1) SI1451143T1 (pt)
TW (1) TWI260982B (pt)
UA (1) UA80543C2 (pt)
WO (1) WO2003048104A1 (pt)
ZA (1) ZA200405250B (pt)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6342533B1 (en) 1998-12-01 2002-01-29 Sepracor, Inc. Derivatives of (−)-venlafaxine and methods of preparing and using the same
EP1466889B1 (en) * 1999-04-06 2008-06-04 Sepracor Inc. O-Desmethylvenlafaxine succinate
SI1360169T1 (sl) * 2001-02-12 2007-12-31 Wyeth Corp Sukcinatna sol o-desmetil-venlafaksina
UA80543C2 (en) * 2001-12-04 2007-10-10 Wyeth Corp Method for the preparation of o-desmethylvenlafaxine
US20090111818A1 (en) * 2005-07-06 2009-04-30 Sepracor Inc. Combinations of Eszopiclone and O-Desmethylvenlafaxine, and Methods of Treatment of Menopause and Mood, Anxiety, and Cognitive Disorders
AU2006322057A1 (en) * 2005-12-05 2007-06-14 Wyeth Process for selective synthesis of enantiomers of substituted 1-(2-amino-1-phenyl-ethyl)-cyclohexanols
EP1973866A1 (en) * 2005-12-20 2008-10-01 Synthon B.V. Process for making desvenlafaxine
MX2007016179A (es) 2006-04-17 2008-03-11 Teva Pharma Formas cristalinas de o-desmetilvenlafaxina.
EP2007708A1 (en) 2006-04-17 2008-12-31 Teva Pharmaceutical Industries Ltd Substantially pure o-desmethylvenlafaxine and processes for preparing it
WO2008035369A2 (en) * 2006-06-30 2008-03-27 Alembic Limited Novel form of o-desmethyl venlafaxine
US20090137846A1 (en) * 2006-07-26 2009-05-28 Valerie Niddam-Hildesheim Processes for the synthesis of O-Desmethylvenlafaxine
CA2656167A1 (en) 2006-07-26 2008-01-31 Teva Pharmaceutical Industries Ltd. Processes for the synthesis of o-desmethylvenlafaxine
JP4763788B2 (ja) * 2006-07-26 2011-08-31 テバ ファーマシューティカル インダストリーズ リミティド Ｏ−デスメチルベンラファキシンの合成方法
US20090069601A1 (en) * 2006-07-26 2009-03-12 Valerie Niddam-Hildesheim Processes for the synthesis of O-desmethylvenlafaxine
CA2656285A1 (en) * 2006-07-26 2008-01-31 Teva Pharmaceutical Industries Ltd. Processes for the synthesis of o-desmethylvenlafaxine
KR101019454B1 (ko) * 2006-07-26 2011-03-07 테바 파마슈티컬 인더스트리즈 리미티드 Ｏ-데스메틸벤라팍신의 합성 방법
US20080221356A1 (en) * 2006-07-26 2008-09-11 Valerie Niddam-Hildesheim Processes for the synthesis of O-desmethylvenlafaxine
US20100121108A1 (en) * 2006-08-04 2010-05-13 Medichem, S.A. Process for synthesizing desvenlafaxine free base and salts or solvates thereof
AU2008211711A1 (en) * 2007-01-31 2008-08-07 Generics [Uk] Limited Process for the preparation of O-desmethyl venlafaxine
EP2049465A2 (en) * 2007-03-14 2009-04-22 Teva Pharmaceutical Industries Ltd. Processes for preparing solid states of o-desmethylvenlafaxine succinate
US20100210719A1 (en) * 2007-07-12 2010-08-19 Dr. Reddy's Laboratories Ltd. O-desmethylvenlafaxine
US8329952B2 (en) * 2007-07-16 2012-12-11 Matrix Laboratories Limited Process for the preparation of O-desmethylvenlafaxine succinate polymorphic forms
WO2009034434A2 (en) * 2007-09-10 2009-03-19 Cadila Pharmaceuticals Limited An improved process for the preparation of o-desmethylvenlafaxine
AU2008315740A1 (en) 2007-10-26 2009-04-30 Generics [Uk] Limited Process for preparing O-desmethylvenlafaxine
US8063250B2 (en) * 2007-11-26 2011-11-22 Teva Pharmaceutical Industries, Ltd. Crystal forms of O-desmethylvenlafaxine fumarate
WO2009084038A2 (en) * 2007-12-28 2009-07-09 Ind-Swift Laboratories Limited Improved process for the preparation of 0-desmethyl-venlafaxine
EP2252574A1 (en) * 2008-03-06 2010-11-24 Teva Pharmaceutical Industries Ltd. Processes for the preparation of o-desmethylvenlafaxine, free from its dimer impurities
EP2119695A1 (en) 2008-05-16 2009-11-18 Krka Preparation of O-desmethylvenlafaxine salts
EP2119696A1 (en) 2008-05-16 2009-11-18 Krka Preparation of O-desmethylvenlafaxine salts
KR20100132069A (ko) * 2008-06-16 2010-12-16 테바 파마슈티컬 인더스트리즈 리미티드 Ｏ-데스메틸벤라팍신염의 고체 상태
US20100016638A1 (en) * 2008-07-21 2010-01-21 Zdenko Hamersak Method for preparation of o-desmethylvenlafaxine using polythiolates
WO2010013050A1 (en) * 2008-07-30 2010-02-04 Generics [Uk] Limited Process for the preparation of o-desmethylvenlafaxine
CZ301503B6 (cs) 2008-11-27 2010-03-24 Zentiva, A. S. Zpusob prípravy desvenlafaxinu a jeho solí
CZ301820B6 (cs) 2009-02-06 2010-06-30 Zentiva, K.S. Nové soli desvenlafaxinu a zpusob jejich prípravy
CZ2009454A3 (cs) 2009-07-15 2010-11-10 Zentiva, K. S. Zpusob prípravy desvenlafaxinu a jeho solí
CA2768377A1 (en) 2009-07-16 2011-01-20 Cipla Limited Process for the preparation of o-desmethyl venlafaxine and intermediate for use therein
US20110098506A1 (en) * 2009-10-26 2011-04-28 Intas Pharmaceuticals Limited Method of preparing o-desmethylvenlafaxine
US20110184067A1 (en) * 2010-01-25 2011-07-28 Intas Pharmaceuticals Ltd. O-desmethylvenlafaxine succinate polymorph & process for preparing thereof
EP2539313A2 (en) * 2010-03-29 2013-01-02 Pliva Hrvatska D.O.O. Crystal forms of o-desmethylvenlafaxine fumarate
CZ303249B6 (cs) 2010-04-06 2012-06-20 Zentiva, K.S. Zpusob výroby 4-(2-(substituovaných)-1-(1-hydroxycyklohexyl)ethyl)fenolu O-demethylací jejich methyletheru pomocí nepáchnoucích aromatických thiolu
EP2394976A1 (en) 2010-06-11 2011-12-14 LEK Pharmaceuticals d.d. Process for demethylating aromatic methyl ethers using 3-mercaptopropionic acid
JP6751200B2 (ja) 2017-02-09 2020-09-02 アール エル ファインケム プライベート リミテッド １−［２−（ジメチルアミノ）−１−（４−ヒドロキシフェニル）エチル］−シクロヘキサノール及びその塩の製造方法
CN109232189B (zh) * 2018-09-25 2021-10-08 杭州盛弗泰新材料科技有限公司 一种高纯度1-羟基芘的制备方法
CN109665966A (zh) * 2018-11-01 2019-04-23 山东蒲济医药科技有限公司 一种琥珀酸去甲文拉法辛化合物的制备方法

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DE2741009A1 (de) * 1976-09-22 1978-03-23 Sandoz Ag 4-styryl-4-indolinol-derivate, ihre verwendung und herstellung
US4535186A (en) 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
CA1227304A (en) * 1984-08-01 1987-09-29 Raymond C. Francis Delignification of pulp
GB8902209D0 (en) 1989-02-01 1989-03-22 Wyeth John And Brother Limited Preparation of cyclohexanol derivatives and novel thioamide intermediates
US6342533B1 (en) * 1998-12-01 2002-01-29 Sepracor, Inc. Derivatives of (−)-venlafaxine and methods of preparing and using the same
US6197828B1 (en) * 1998-12-01 2001-03-06 Sepracor, Inc. Derivatives of (+)-venlafaxine and methods of preparing and using the same
EP1466889B1 (en) 1999-04-06 2008-06-04 Sepracor Inc. O-Desmethylvenlafaxine succinate
AU5738700A (en) 1999-06-15 2001-01-02 American Home Products Corporation Enantiomers of o-desmethyl venlafaxine
JP2004504026A (ja) 2000-07-18 2004-02-12 バイエル　アクチェンゲゼルシャフト ヒトｄｅｓｃ１様セリンプロテアーゼの調節
SI1360169T1 (sl) * 2001-02-12 2007-12-31 Wyeth Corp Sukcinatna sol o-desmetil-venlafaksina
UA80543C2 (en) 2001-12-04 2007-10-10 Wyeth Corp Method for the preparation of o-desmethylvenlafaxine

Also Published As

Publication number Publication date
US7435854B2 (en) 2008-10-14
PL369299A1 (en) 2005-04-18
HUP0402269A2 (hu) 2005-02-28
IL194034A (en) 2010-12-30
NZ533316A (en) 2005-12-23
ES2311647T4 (es) 2009-11-10
CN1625546A (zh) 2005-06-08
ECSP045135A (es) 2004-07-23
AU2002357049B2 (en) 2009-07-16
WO2003048104A1 (en) 2003-06-12
EP1451143B1 (en) 2008-08-06
US20070225525A1 (en) 2007-09-27
ES2311647T3 (es) 2009-02-16
PT1451143E (pt) 2008-10-21
EP1451143B9 (en) 2009-08-12
JP2005511681A (ja) 2005-04-28
AU2002357049A1 (en) 2003-06-17
US20030105358A1 (en) 2003-06-05
TWI260982B (en) 2006-09-01
SI1451143T1 (sl) 2008-12-31
TW200301102A (en) 2003-07-01
UA80543C2 (en) 2007-10-10
NO20042680L (no) 2004-06-25
HK1065778A1 (en) 2005-03-04
ZA200405250B (en) 2005-12-28
IL162253A0 (en) 2005-11-20
ATE403641T1 (de) 2008-08-15
CN1319934C (zh) 2007-06-06
MXPA04005309A (es) 2004-09-13
US20090018365A1 (en) 2009-01-15
AR037622A1 (es) 2004-11-17
IL162253A (en) 2009-02-11
CO5580816A2 (es) 2005-11-30
HUP0402269A3 (en) 2010-06-28
KR100939650B1 (ko) 2010-02-05
KR20050044671A (ko) 2005-05-12
DE60228118D1 (de) 2008-09-18
US20040158101A1 (en) 2004-08-12
RU2004120284A (ru) 2005-04-10
JP4342312B2 (ja) 2009-10-14
CA2466779A1 (en) 2003-06-12
EP1451143A1 (en) 2004-09-01
RU2317286C2 (ru) 2008-02-20
US6689912B2 (en) 2004-02-10
DK1451143T3 (da) 2008-11-10
CA2466779C (en) 2013-11-19

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Legal Events

Date Code Title Description
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INT.CL: C07C 213/00, C07C 213/08, C07C 211/27, C07C 211/28, C07C 215/64, A61P 25/24

Ipc: C07C 213/00 (2006.01), C07C 215/64 (2006.01)

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.