US20040158101A1 - Methods for preparing O-desmethylvenlafaxine - Google Patents
Methods for preparing O-desmethylvenlafaxine Download PDFInfo
- Publication number
- US20040158101A1 US20040158101A1 US10/750,196 US75019603A US2004158101A1 US 20040158101 A1 US20040158101 A1 US 20040158101A1 US 75019603 A US75019603 A US 75019603A US 2004158101 A1 US2004158101 A1 US 2004158101A1
- Authority
- US
- United States
- Prior art keywords
- desmethylvenlafaxine
- venlafaxine
- ethylene glycol
- sodium
- arom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- PZSHCGSAQAAGCU-UHFFFAOYSA-N CN(C)CC(C1=CC=C(O)C=C1)C1(O)CCCCC1.COC1=CC=C(C(CN(C)C)C2(O)CCCCC2)C=C1 Chemical compound CN(C)CC(C1=CC=C(O)C=C1)C1(O)CCCCC1.COC1=CC=C(C(CN(C)C)C2(O)CCCCC2)C=C1 PZSHCGSAQAAGCU-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Definitions
- O-desmethylvenlafaxine is a major metabolite of venlafaxine.
- Methods to make O-desmethylvenlafaxine are described in U.S. Pat. No. 4,535,186. This method uses benzyl blocking groups leading to relatively low throughput.
- a process of making O-desmethylvenlafaxine is also described in WO 00/59851 in which venlafaxine is allowed to react with diphenyl phosphide in THF (generated by adding n-butyl lithium in THF to diphenylphosphine in THF below 0° C.) at reflux for an overnight period.
- the yield was reported to be 73.8%.
- the method involved extraction steps involving large volumes of solvent.
- the present invention provides a process of making O-desmethylvenlafaxine which is both time and material efficient.
- Venlafaxine As described in Scheme I the starting material, venlafaxine (Formula I), is demethylated. Venlafaxine may be prepared in accordance with procedures known in the art such as described in U.S. Pat. No. 4,535,186.
- demethylation is performed using a high molecular weight alkane, arene, or arylalkyl thiolate anion, such as straight or branched chain alkane thiolate anions having 8 to 20 carbon atoms, mono or bicyclic arene thiolate anions having 6 to 10 carbon atoms, or mono or bicyclic arylalkyl thiolate anions having 7 to 12 carbon atoms in the presence of a protic or aprotic solvent.
- a base such as an alkoxide comprised of a straight or branched chain alkyl group of from 1 to 6 carbon atoms may be present to generate the thiolate anion.
- the aliphatic thiol has from 10 to 20 carbon atoms and most preferably the aliphatic thiol is dodecanethiol.
- the aromatic thiol is preferably benzenethiol.
- the arylalkyl thiolate anion is preferably toluenethiol or naphthylmethanethiol.
- the alkoxide is preferably a lower alkoxide (methoxide, ethoxide and the like) such as sodium methoxide (sodium methylate, sodium methanolate).
- the solvent is preferably a hydroxylic or ethereal solvent, and more preferably an alcohol, ethylene glycol or ether of ethylene glycol.
- Ethers of ethylene glycol include, but are not limited to, ethylene glycol monoethyl ether, triethylene glycol dimethyl ether and polyethylene glycol.
- the solvent is an inert, polar, high boiling point ether of ethylene glycol such as polyethylene glycol and most preferably PEG 400 (polyethylene glycol having a molecular weight range of from about 380-420).
- the reaction is performed at a temperature of from about 150° C. to about 220° C., more preferably from about 170° C. to about 220° C., and most preferably from about 180° C. to about 200° C.
- the reaction is generally allowed to progress until, ideally, not more than 1% venlafaxine remains.
- the reaction is complete in from about 2 hours to about 5 hours and more preferably in from about 2 to about 3.5 hours.
- the thiolate anion can be prepared separately or in situ.
- venlafaxine base is dissolved in polyethylene glycol 400 containing dodecanethiol and sodium methylate as a solution in methanol as the temperature is increased to from about 180° C. to about 200° C., with stirring for about 2 to about 3.5 hours.
- venlafaxine base is dissolved in polyethylene glycol containing dodecanethiolate and stirred for about 2 to about 3.5 hours at from about 180° C. to about 200° C. with stirring.
- reaction mixture is cooled to between about 65° C. and about 75° C. and an alcohol may be added as a diluent before neutralization to the isoelectric point (about pH9.5 to about pH10.0) with an appropriate neutralization agent such as hydrochloric acid.
- an appropriate neutralization agent such as hydrochloric acid.
- the alcoholic medium may also aid in the crystallization of the product as neutralization is initiated.
- the alcohol comprises a straight or branched chain alkyl group of 1 to 6 carbon atoms, such as methanol, ethanol, isopropanol, butanol, and the like, and mixtures thereof.
- the alcohol is isopropanol.
- Yields of the present invention are greater than about 75% and generally from about 85% to greater than 90%.
- Dodecanethiol (122 g), venlafaxine (111 g), and a methanolic solution of sodium methanolate (30%, 90 g) and PEG 400 are heated to 190° C.
- the methanol is distilled off and the solution is stirred 2 h at 190° C.
- 2-propanol (450 g) is added and the pH is adjusted to 9.5 with aqueous HCl.
- the precipitate is collected by suction filtration, and the cake is washed with 2-propanol, toluene, 2-propanol and water.
- the wet O-desmethylvenlafaxine is dried in vacuo.
- Venlafaxine (5.6 g) and benzenethiol sodium salt(6.9 g) are charged to PEG 400 (25 g).
- the reaction mixture is heated to 160° C. for 5 h. Then the temperature is lowered and water is added (60 g).
- the pH is adjusted to 3.5 with H 3 PO 4 .
- the organic by-products are removed by extraction with heptanes (25 g).
- the pH of the aqueous layer is then adjusted to 9.5 with aqueous ammonia.
- the precipitate is collected by suction filtration, re-slurried in water (100 g), isolated by suction filtration and dried in vacuo.
- Step a Formation of the Reagent Sodium Dodecanethiolate.
- a mixture of sodium dodecanethiolate (272 g) venlafaxine (256 g) and PEG 400 (185 g) is stirred 3 h at 190° C. Then the temperature is lowered and 2-propanol (915 g) is added and the pH is adjusted to 9.5 with aqueous HCl. The precipitate is collected by suction filtration, and the cake is washed with 2-propanol and water. The wet O-desmethylvenlafaxine is dried in vacuo. Yield: 200 g.
Abstract
The present invention provides an efficient method of making O-desmethylvenlafaxine.
Description
- This application is a continuation of application Ser. No. 10/304,871, filed on Nov. 26, 2002, which claims priority from co-pending provisional application serial No. 60/334,953, filed on Dec. 4, 2001, the entire disclosure of which is hereby incorporated by reference.
- O-desmethylvenlafaxine is a major metabolite of venlafaxine. Methods to make O-desmethylvenlafaxine are described in U.S. Pat. No. 4,535,186. This method uses benzyl blocking groups leading to relatively low throughput.
- A process of making O-desmethylvenlafaxine is also described in WO 00/59851 in which venlafaxine is allowed to react with diphenyl phosphide in THF (generated by adding n-butyl lithium in THF to diphenylphosphine in THF below 0° C.) at reflux for an overnight period. The yield was reported to be 73.8%. Furthermore, the method involved extraction steps involving large volumes of solvent.
- The present invention provides a process of making O-desmethylvenlafaxine which is both time and material efficient.
-
- As described in Scheme I the starting material, venlafaxine (Formula I), is demethylated. Venlafaxine may be prepared in accordance with procedures known in the art such as described in U.S. Pat. No. 4,535,186.
- In accordance with the present invention, demethylation is performed using a high molecular weight alkane, arene, or arylalkyl thiolate anion, such as straight or branched chain alkane thiolate anions having 8 to 20 carbon atoms, mono or bicyclic arene thiolate anions having 6 to 10 carbon atoms, or mono or bicyclic arylalkyl thiolate anions having 7 to 12 carbon atoms in the presence of a protic or aprotic solvent. Optionally, a base such as an alkoxide comprised of a straight or branched chain alkyl group of from 1 to 6 carbon atoms may be present to generate the thiolate anion.
- Preferably the aliphatic thiol has from 10 to 20 carbon atoms and most preferably the aliphatic thiol is dodecanethiol. The aromatic thiol is preferably benzenethiol. The arylalkyl thiolate anion is preferably toluenethiol or naphthylmethanethiol.
- When present, the alkoxide is preferably a lower alkoxide (methoxide, ethoxide and the like) such as sodium methoxide (sodium methylate, sodium methanolate).
- The solvent is preferably a hydroxylic or ethereal solvent, and more preferably an alcohol, ethylene glycol or ether of ethylene glycol. Ethers of ethylene glycol include, but are not limited to, ethylene glycol monoethyl ether, triethylene glycol dimethyl ether and polyethylene glycol. Preferably, the solvent is an inert, polar, high boiling point ether of ethylene glycol such as polyethylene glycol and most preferably PEG 400 (polyethylene glycol having a molecular weight range of from about 380-420).
- The reaction is performed at a temperature of from about 150° C. to about 220° C., more preferably from about 170° C. to about 220° C., and most preferably from about 180° C. to about 200° C. The reaction is generally allowed to progress until, ideally, not more than 1% venlafaxine remains. In some aspects of the invention the reaction is complete in from about 2 hours to about 5 hours and more preferably in from about 2 to about 3.5 hours.
- The thiolate anion can be prepared separately or in situ. In some preferred embodiments of the present invention, venlafaxine base is dissolved in polyethylene glycol 400 containing dodecanethiol and sodium methylate as a solution in methanol as the temperature is increased to from about 180° C. to about 200° C., with stirring for about 2 to about 3.5 hours. In other preferred embodiments of the present invention, venlafaxine base is dissolved in polyethylene glycol containing dodecanethiolate and stirred for about 2 to about 3.5 hours at from about 180° C. to about 200° C. with stirring.
- Thereafter the reaction mixture is cooled to between about 65° C. and about 75° C. and an alcohol may be added as a diluent before neutralization to the isoelectric point (about pH9.5 to about pH10.0) with an appropriate neutralization agent such as hydrochloric acid. The alcoholic medium may also aid in the crystallization of the product as neutralization is initiated.
- Preferably the alcohol comprises a straight or branched chain alkyl group of 1 to 6 carbon atoms, such as methanol, ethanol, isopropanol, butanol, and the like, and mixtures thereof. In some preferred embodiments of the invention, the alcohol is isopropanol.
- Yields of the present invention are greater than about 75% and generally from about 85% to greater than 90%.
- The following Examples are illustrative but are not meant to be limiting of the present invention.
- Dodecanethiol (122 g), venlafaxine (111 g), and a methanolic solution of sodium methanolate (30%, 90 g) and PEG 400 are heated to 190° C. The methanol is distilled off and the solution is stirred 2 h at 190° C. Then the temperature is lowered, 2-propanol (450 g) is added and the pH is adjusted to 9.5 with aqueous HCl. The precipitate is collected by suction filtration, and the cake is washed with 2-propanol, toluene, 2-propanol and water. The wet O-desmethylvenlafaxine is dried in vacuo.
- Yield: 87 g.
-
- Venlafaxine (5.6 g) and benzenethiol sodium salt(6.9 g) are charged to PEG 400 (25 g). The reaction mixture is heated to 160° C. for 5 h. Then the temperature is lowered and water is added (60 g). The pH is adjusted to 3.5 with H3PO4. The organic by-products are removed by extraction with heptanes (25 g). The pH of the aqueous layer is then adjusted to 9.5 with aqueous ammonia. The precipitate is collected by suction filtration, re-slurried in water (100 g), isolated by suction filtration and dried in vacuo.
- Yield 1 g.
-
- Dodecanethiol (69 g) venlafaxine (55 g) and an ethanolic solution of sodium ethanolate (21%, 82 g) are charged to a pressure vessel. The temperature is raised to 150° C. and the reaction mixture is stirred for 2 days. Then the temperature is lowered and the solution is filtered. The pH of the filtrate is adjusted to 9.5 with aqueous hydrogen chloride. The crystals are collected by suction filtration. The cake is washed with ethanol and dried in vacuo.
- Yield: 42 g
-
- Step a—Formation of the Reagent Sodium Dodecanethiolate.
- Dodecanethiol (246 g) and sodium methylate in methanol 30% (216 g) are charged to a rotary evaporator. Vacuum is applied and the solvent is abstracted completely using a bath temperature up to 90° C. The remaining sodium dodecanethiolate (272 g) is used without further purification in the subsequent step.
- Step b—Demethylation
- A mixture of sodium dodecanethiolate (272 g) venlafaxine (256 g) and PEG 400 (185 g) is stirred 3 h at 190° C. Then the temperature is lowered and 2-propanol (915 g) is added and the pH is adjusted to 9.5 with aqueous HCl. The precipitate is collected by suction filtration, and the cake is washed with 2-propanol and water. The wet O-desmethylvenlafaxine is dried in vacuo. Yield: 200 g.
-
Claims (2)
1. O-desmethylvenlafaxine prepared by reacting venlafaxine with a high molecular weight alkane or arene thiolate anion in an alcohol, ethylene glycol, ether of ethylene glycol, or mixture thereof, wherein the O-desmethylvenlafaxine contains no more than about 1% venlafaxine as an impurity.
2. O-desmethylvenlafaxine prepared by demethylating venlafaxine with dodecyl thiolate and polyethylene glycol 400 in the presence of sodium methylate in methanol at about 180 C to about 200 C for about 2 to about 5 hours and neutralizing the product to about pH 9.5 in the presence of isopropanol, wherein the O-desmethylvenlafaxine contains no more than about 1% venlafaxine as an impurity.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/750,196 US20040158101A1 (en) | 2001-12-04 | 2003-12-31 | Methods for preparing O-desmethylvenlafaxine |
US11/756,772 US7435854B2 (en) | 2001-12-04 | 2007-06-01 | Methods for preparing O-desmethylvenlafaxine |
US12/208,990 US20090018365A1 (en) | 2001-12-04 | 2008-09-11 | Methods for Preparing O-Desmethylvenlafaxine |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33495301P | 2001-12-04 | 2001-12-04 | |
US10/304,871 US6689912B2 (en) | 2001-12-04 | 2002-11-26 | Methods for preparing O-desmethylvenlafaxine |
US10/750,196 US20040158101A1 (en) | 2001-12-04 | 2003-12-31 | Methods for preparing O-desmethylvenlafaxine |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/304,871 Continuation US6689912B2 (en) | 2001-12-04 | 2002-11-26 | Methods for preparing O-desmethylvenlafaxine |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/756,772 Continuation US7435854B2 (en) | 2001-12-04 | 2007-06-01 | Methods for preparing O-desmethylvenlafaxine |
Publications (1)
Publication Number | Publication Date |
---|---|
US20040158101A1 true US20040158101A1 (en) | 2004-08-12 |
Family
ID=23309595
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/304,871 Expired - Fee Related US6689912B2 (en) | 2001-12-04 | 2002-11-26 | Methods for preparing O-desmethylvenlafaxine |
US10/750,196 Abandoned US20040158101A1 (en) | 2001-12-04 | 2003-12-31 | Methods for preparing O-desmethylvenlafaxine |
US11/756,772 Expired - Fee Related US7435854B2 (en) | 2001-12-04 | 2007-06-01 | Methods for preparing O-desmethylvenlafaxine |
US12/208,990 Abandoned US20090018365A1 (en) | 2001-12-04 | 2008-09-11 | Methods for Preparing O-Desmethylvenlafaxine |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/304,871 Expired - Fee Related US6689912B2 (en) | 2001-12-04 | 2002-11-26 | Methods for preparing O-desmethylvenlafaxine |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/756,772 Expired - Fee Related US7435854B2 (en) | 2001-12-04 | 2007-06-01 | Methods for preparing O-desmethylvenlafaxine |
US12/208,990 Abandoned US20090018365A1 (en) | 2001-12-04 | 2008-09-11 | Methods for Preparing O-Desmethylvenlafaxine |
Country Status (29)
Country | Link |
---|---|
US (4) | US6689912B2 (en) |
EP (1) | EP1451143B9 (en) |
JP (1) | JP4342312B2 (en) |
KR (1) | KR100939650B1 (en) |
CN (1) | CN1319934C (en) |
AR (1) | AR037622A1 (en) |
AT (1) | ATE403641T1 (en) |
AU (1) | AU2002357049B2 (en) |
BR (1) | BR0214701A (en) |
CA (1) | CA2466779C (en) |
CO (1) | CO5580816A2 (en) |
DE (1) | DE60228118D1 (en) |
DK (1) | DK1451143T3 (en) |
EC (1) | ECSP045135A (en) |
ES (1) | ES2311647T4 (en) |
HK (1) | HK1065778A1 (en) |
HU (1) | HUP0402269A3 (en) |
IL (3) | IL162253A0 (en) |
MX (1) | MXPA04005309A (en) |
NO (1) | NO20042680L (en) |
NZ (1) | NZ533316A (en) |
PL (1) | PL369299A1 (en) |
PT (1) | PT1451143E (en) |
RU (1) | RU2317286C2 (en) |
SI (1) | SI1451143T1 (en) |
TW (1) | TWI260982B (en) |
UA (1) | UA80543C2 (en) |
WO (1) | WO2003048104A1 (en) |
ZA (1) | ZA200405250B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7435854B2 (en) | 2001-12-04 | 2008-10-14 | Wyeth | Methods for preparing O-desmethylvenlafaxine |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6342533B1 (en) | 1998-12-01 | 2002-01-29 | Sepracor, Inc. | Derivatives of (−)-venlafaxine and methods of preparing and using the same |
PT1466889E (en) * | 1999-04-06 | 2008-07-02 | Sepracor Inc | O-desmethylvenlafaxine succinate |
AU2002250058B2 (en) * | 2001-02-12 | 2007-08-16 | Wyeth Llc | Novel succinate salt of O-desmethyl-venlafaxine |
AU2006265008A1 (en) * | 2005-07-06 | 2007-01-11 | Sepracor Inc. | Combinations of eszopiclone and O-desmethylvenlafaxine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders |
WO2007067501A1 (en) * | 2005-12-05 | 2007-06-14 | Wyeth | Process for selective synthesis of enantiomers of substituted 1-(2-amino-1-phenyl-ethyl)-cyclohexanols |
WO2007071404A1 (en) * | 2005-12-20 | 2007-06-28 | Synthon B.V. | Process for making desvenlafaxine |
MX2007016179A (en) * | 2006-04-17 | 2008-03-11 | Teva Pharma | Polymorphic forms of tegaserod maleate. |
MX2007016172A (en) * | 2006-04-17 | 2008-03-10 | Teva Pharma | Substantially pure o-desmethylvenlafaxine and processes for preparing it. |
WO2008035369A2 (en) * | 2006-06-30 | 2008-03-27 | Alembic Limited | Novel form of o-desmethyl venlafaxine |
CA2656167A1 (en) | 2006-07-26 | 2008-01-31 | Teva Pharmaceutical Industries Ltd. | Processes for the synthesis of o-desmethylvenlafaxine |
CA2656285A1 (en) * | 2006-07-26 | 2008-01-31 | Teva Pharmaceutical Industries Ltd. | Processes for the synthesis of o-desmethylvenlafaxine |
CA2656166A1 (en) * | 2006-07-26 | 2008-01-31 | Teva Pharmaceutical Industries Ltd. | Processes for the synthesis of o-desmethylvenlafaxine |
US20090137846A1 (en) * | 2006-07-26 | 2009-05-28 | Valerie Niddam-Hildesheim | Processes for the synthesis of O-Desmethylvenlafaxine |
US20080221356A1 (en) * | 2006-07-26 | 2008-09-11 | Valerie Niddam-Hildesheim | Processes for the synthesis of O-desmethylvenlafaxine |
US20090069601A1 (en) * | 2006-07-26 | 2009-03-12 | Valerie Niddam-Hildesheim | Processes for the synthesis of O-desmethylvenlafaxine |
EP2046725A2 (en) * | 2006-07-26 | 2009-04-15 | Teva Pharmaceutical Industries Ltd. | Processes for the synthesis of o-desmethylvenlafaxine |
AR062266A1 (en) * | 2006-08-04 | 2008-10-29 | Medichem Sa | IMPROVED PROCESS TO SYNTHETIZE BASE FREE OF DEVENLAFAXINE AND ITS SALTS OR SOLVATES |
WO2008093142A1 (en) * | 2007-01-31 | 2008-08-07 | Generics [Uk] Limited | Process for the preparation of o-desmethyl venlafaxine |
EP2049465A2 (en) * | 2007-03-14 | 2009-04-22 | Teva Pharmaceutical Industries Ltd. | Processes for preparing solid states of o-desmethylvenlafaxine succinate |
IN2010CN00695A (en) * | 2007-07-12 | 2010-08-27 | Reddys Lab Ltd Dr | |
IN2007CH01519A (en) * | 2007-07-16 | 2009-09-11 | Matrix Lab Ltd | |
WO2009034434A2 (en) * | 2007-09-10 | 2009-03-19 | Cadila Pharmaceuticals Limited | An improved process for the preparation of o-desmethylvenlafaxine |
US20110118357A1 (en) * | 2007-10-26 | 2011-05-19 | Generics Limited | Process for preparing o-desmethylvenlafaxine |
WO2009070311A2 (en) * | 2007-11-26 | 2009-06-04 | Teva Pharmaceutical Industries Ltd. | Crystal forms of o-desmethylvenlafaxine fumarate |
WO2009084038A2 (en) * | 2007-12-28 | 2009-07-09 | Ind-Swift Laboratories Limited | Improved process for the preparation of 0-desmethyl-venlafaxine |
WO2009151494A1 (en) * | 2008-03-06 | 2009-12-17 | Teva Pharmaceutical Industries Ltd. | Processes for the preparation of o-desmethylvenlafaxine, free from its dimer impurities |
EP2119696A1 (en) | 2008-05-16 | 2009-11-18 | Krka | Preparation of O-desmethylvenlafaxine salts |
EP2119695A1 (en) | 2008-05-16 | 2009-11-18 | Krka | Preparation of O-desmethylvenlafaxine salts |
CA2720538A1 (en) * | 2008-06-16 | 2010-01-21 | Teva Pharmaceutical Industries Ltd. | Solid states of o-desmethylvenlafaxine salts |
US20100016638A1 (en) * | 2008-07-21 | 2010-01-21 | Zdenko Hamersak | Method for preparation of o-desmethylvenlafaxine using polythiolates |
JP2011529481A (en) * | 2008-07-30 | 2011-12-08 | ジェネリクス・(ユーケー)・リミテッド | Method for preparing O-desmethylvenlafaxine |
CZ301503B6 (en) | 2008-11-27 | 2010-03-24 | Zentiva, A. S. | Process for preparing desvenlafaxine and salts thereof |
CZ301820B6 (en) | 2009-02-06 | 2010-06-30 | Zentiva, K.S. | Novel salts of desvenlafaxine and process of their preparation |
CZ2009454A3 (en) | 2009-07-15 | 2010-11-10 | Zentiva, K. S. | Process for preparing desvenlafaxine and salts thereof |
EP2454228A2 (en) | 2009-07-16 | 2012-05-23 | Cipla Limited | Process for the preparation of o-desmethyl venlafaxine and intermediate for use therein |
US20110098506A1 (en) * | 2009-10-26 | 2011-04-28 | Intas Pharmaceuticals Limited | Method of preparing o-desmethylvenlafaxine |
US20110184067A1 (en) * | 2010-01-25 | 2011-07-28 | Intas Pharmaceuticals Ltd. | O-desmethylvenlafaxine succinate polymorph & process for preparing thereof |
CA2795023A1 (en) | 2010-03-29 | 2011-10-06 | Pliva Hrvatska D.O.O. | Crystal forms of o-desmethylvenlafaxine fumarate |
CZ303249B6 (en) | 2010-04-06 | 2012-06-20 | Zentiva, K.S. | Process for preparing 4-(2-(substituted)-1-(1-hydroxycyclohexyl)ethyl)phenols by O-demethylation of their methyl ethers using odor free aromatic thiols |
EP2394976A1 (en) | 2010-06-11 | 2011-12-14 | LEK Pharmaceuticals d.d. | Process for demethylating aromatic methyl ethers using 3-mercaptopropionic acid |
JP6751200B2 (en) | 2017-02-09 | 2020-09-02 | アール エル ファインケム プライベート リミテッド | Method for producing 1-[2-(dimethylamino)-1-(4-hydroxyphenyl)ethyl]-cyclohexanol and salts thereof |
CN109232189B (en) * | 2018-09-25 | 2021-10-08 | 杭州盛弗泰新材料科技有限公司 | Preparation method of high-purity 1-hydroxypyrene |
CN109665966A (en) * | 2018-11-01 | 2019-04-23 | 山东蒲济医药科技有限公司 | A kind of preparation method of succinic acid desmethylvenlafaxine compound |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4535186A (en) * | 1983-04-19 | 1985-08-13 | American Home Products Corporation | 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives |
US4729817A (en) * | 1984-08-01 | 1988-03-08 | Tenneco Canada Inc. (Erco Division) | Process for the oxidative delignification of demethylated chemical pulp |
US5043466A (en) * | 1989-02-01 | 1991-08-27 | John Wyeth & Bro., Limited | Preparation of cyclohexanol derivatives and novel thioamide intermediates |
US6441048B1 (en) * | 1998-12-01 | 2002-08-27 | Sepracor, Inc. | Methods of treating affective disorders using derivatives of (-)-venlafaxine |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2741009A1 (en) * | 1976-09-22 | 1978-03-23 | Sandoz Ag | 4-STYRYL-4-INDOLINOL DERIVATIVES, THEIR USE AND PRODUCTION |
US6197828B1 (en) * | 1998-12-01 | 2001-03-06 | Sepracor, Inc. | Derivatives of (+)-venlafaxine and methods of preparing and using the same |
PT1466889E (en) | 1999-04-06 | 2008-07-02 | Sepracor Inc | O-desmethylvenlafaxine succinate |
WO2000076955A1 (en) | 1999-06-15 | 2000-12-21 | American Home Products Corporation | Enantiomers of o-desmethyl venlafaxine |
JP2004504026A (en) | 2000-07-18 | 2004-02-12 | バイエル アクチェンゲゼルシャフト | Regulation of human DESC1-like serine protease |
AU2002250058B2 (en) * | 2001-02-12 | 2007-08-16 | Wyeth Llc | Novel succinate salt of O-desmethyl-venlafaxine |
UA80543C2 (en) | 2001-12-04 | 2007-10-10 | Wyeth Corp | Method for the preparation of o-desmethylvenlafaxine |
-
2002
- 2002-03-12 UA UA20040705306A patent/UA80543C2/en unknown
- 2002-11-26 US US10/304,871 patent/US6689912B2/en not_active Expired - Fee Related
- 2002-11-27 TW TW091134427A patent/TWI260982B/en not_active IP Right Cessation
- 2002-12-03 KR KR1020047008512A patent/KR100939650B1/en not_active IP Right Cessation
- 2002-12-03 AR ARP020104669A patent/AR037622A1/en unknown
- 2002-12-03 EP EP02804479A patent/EP1451143B9/en not_active Expired - Lifetime
- 2002-12-03 JP JP2003549297A patent/JP4342312B2/en not_active Expired - Fee Related
- 2002-12-03 DE DE60228118T patent/DE60228118D1/en not_active Expired - Lifetime
- 2002-12-03 DK DK02804479T patent/DK1451143T3/en active
- 2002-12-03 PT PT02804479T patent/PT1451143E/en unknown
- 2002-12-03 AU AU2002357049A patent/AU2002357049B2/en not_active Ceased
- 2002-12-03 CN CNB028242386A patent/CN1319934C/en not_active Expired - Fee Related
- 2002-12-03 MX MXPA04005309A patent/MXPA04005309A/en active IP Right Grant
- 2002-12-03 ES ES02804479T patent/ES2311647T4/en not_active Expired - Lifetime
- 2002-12-03 SI SI200230743T patent/SI1451143T1/en unknown
- 2002-12-03 NZ NZ533316A patent/NZ533316A/en unknown
- 2002-12-03 IL IL16225302A patent/IL162253A0/en active IP Right Grant
- 2002-12-03 WO PCT/US2002/038403 patent/WO2003048104A1/en active Application Filing
- 2002-12-03 PL PL02369299A patent/PL369299A1/en unknown
- 2002-12-03 AT AT02804479T patent/ATE403641T1/en not_active IP Right Cessation
- 2002-12-03 HU HU0402269A patent/HUP0402269A3/en active IP Right Revival
- 2002-12-03 RU RU2004120284/04A patent/RU2317286C2/en not_active IP Right Cessation
- 2002-12-03 BR BR0214701-7A patent/BR0214701A/en not_active Application Discontinuation
- 2002-12-03 CA CA2466779A patent/CA2466779C/en not_active Expired - Lifetime
-
2003
- 2003-12-31 US US10/750,196 patent/US20040158101A1/en not_active Abandoned
-
2004
- 2004-05-31 IL IL162253A patent/IL162253A/en not_active IP Right Cessation
- 2004-06-01 CO CO04050957A patent/CO5580816A2/en active IP Right Grant
- 2004-06-04 EC EC2004005135A patent/ECSP045135A/en unknown
- 2004-06-25 NO NO20042680A patent/NO20042680L/en not_active Application Discontinuation
- 2004-07-01 ZA ZA2004/05250A patent/ZA200405250B/en unknown
- 2004-11-01 HK HK04108589A patent/HK1065778A1/en not_active IP Right Cessation
-
2007
- 2007-06-01 US US11/756,772 patent/US7435854B2/en not_active Expired - Fee Related
-
2008
- 2008-09-11 IL IL194034A patent/IL194034A/en not_active IP Right Cessation
- 2008-09-11 US US12/208,990 patent/US20090018365A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4535186A (en) * | 1983-04-19 | 1985-08-13 | American Home Products Corporation | 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives |
US4729817A (en) * | 1984-08-01 | 1988-03-08 | Tenneco Canada Inc. (Erco Division) | Process for the oxidative delignification of demethylated chemical pulp |
US5043466A (en) * | 1989-02-01 | 1991-08-27 | John Wyeth & Bro., Limited | Preparation of cyclohexanol derivatives and novel thioamide intermediates |
US6441048B1 (en) * | 1998-12-01 | 2002-08-27 | Sepracor, Inc. | Methods of treating affective disorders using derivatives of (-)-venlafaxine |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7435854B2 (en) | 2001-12-04 | 2008-10-14 | Wyeth | Methods for preparing O-desmethylvenlafaxine |
US20090018365A1 (en) * | 2001-12-04 | 2009-01-15 | Wyeth | Methods for Preparing O-Desmethylvenlafaxine |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6689912B2 (en) | Methods for preparing O-desmethylvenlafaxine | |
EP2077996B1 (en) | Purification process of montelukast and its amine salts | |
US7399859B1 (en) | Method for catalytic preparation of hydromorphone and hydrocodone | |
EP2940001B1 (en) | Method for producing purified form of amine compound | |
US9938297B2 (en) | Process for the synthesis of everolimus and intermediates thereof | |
EP0909754A1 (en) | Process to make chiral compounds | |
US20170355688A1 (en) | Processes for the Preparation of Tasimelteon and Intermediates Thereof | |
KR101308258B1 (en) | A novel method of making Endoxifen | |
US7030276B2 (en) | Process for preparing 2-[(dimethylamino)-methyl]-1-(3-methoxyphenyl)cyclohexanol | |
US20170137377A1 (en) | Method for producing phenolic compound | |
US20080064905A1 (en) | Process for preparing 1,2-diols from carbonyl compounds | |
US6664421B2 (en) | Process for preparing zolpidem | |
US7345206B2 (en) | Process for the dimerisation of alkyl glyoxals | |
US20150274624A1 (en) | Process for the preparation of ospemifene | |
US20130060031A1 (en) | Process for the preparation of highly pure ambrisentan | |
EP0126470B1 (en) | Process for the preparation of tamoxifen | |
US11739055B2 (en) | Process for preparing diisocyanates based on lysine | |
US7002034B2 (en) | Method for the production of biphenyl-4-carbonitrile | |
US20220144864A1 (en) | Method for purifying phosphorus-containing olefin compound salt and method for producing olefin compound using purified product obtained thereby | |
JPH09110756A (en) | Production of bisphenol-type dimethylol compound |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |