DE60218840D1 - Nicht legierende Core-Shell-Nanopartikel - Google Patents

Nicht legierende Core-Shell-Nanopartikel

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Publication number
DE60218840D1
DE60218840D1 DE60218840T DE60218840T DE60218840D1 DE 60218840 D1 DE60218840 D1 DE 60218840D1 DE 60218840 T DE60218840 T DE 60218840T DE 60218840 T DE60218840 T DE 60218840T DE 60218840 D1 DE60218840 D1 DE 60218840D1
Authority
DE
Germany
Prior art keywords
core
shell nanoparticles
alloyed core
relates
shell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60218840T
Other languages
English (en)
Other versions
DE60218840T2 (de
Inventor
Chad A Mirkin
Yun-Wei Cao
Rongchao Jin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Northwestern University
Original Assignee
Northwestern University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Northwestern University filed Critical Northwestern University
Publication of DE60218840D1 publication Critical patent/DE60218840D1/de
Application granted granted Critical
Publication of DE60218840T2 publication Critical patent/DE60218840T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
    • B22F1/10—Metallic powder containing lubricating or binding agents; Metallic powder containing organic material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
    • B22F1/10—Metallic powder containing lubricating or binding agents; Metallic powder containing organic material
    • B22F1/102—Metallic powder coated with organic material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
    • B22F1/17—Metallic particles coated with metal
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F1/00—Metallic powder; Treatment of metallic powder, e.g. to facilitate working or to improve properties
    • B22F1/18—Non-metallic particles coated with metal
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
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    • B22F9/00—Making metallic powder or suspensions thereof
    • B22F9/16—Making metallic powder or suspensions thereof using chemical processes
    • B22F9/18—Making metallic powder or suspensions thereof using chemical processes with reduction of metal compounds
    • B22F9/24—Making metallic powder or suspensions thereof using chemical processes with reduction of metal compounds starting from liquid metal compounds, e.g. solutions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B19/00—Selenium; Tellurium; Compounds thereof
    • C01B19/007—Tellurides or selenides of metals
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G11/00—Compounds of cadmium
    • C01G11/02—Sulfides
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G49/00—Compounds of iron
    • C01G49/02—Oxides; Hydroxides
    • C01G49/08—Ferroso-ferric oxide (Fe3O4)
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G7/00—Compounds of gold
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/5434—Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
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    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/0036—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties showing low dimensional magnetism, i.e. spin rearrangements due to a restriction of dimensions, e.g. showing giant magnetoresistivity
    • H01F1/0045—Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/0036—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties showing low dimensional magnetism, i.e. spin rearrangements due to a restriction of dimensions, e.g. showing giant magnetoresistivity
    • H01F1/0045—Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use
    • H01F1/0054—Coated nanoparticles, e.g. nanoparticles coated with organic surfactant
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L29/00—Semiconductor devices adapted for rectifying, amplifying, oscillating or switching, or capacitors or resistors with at least one potential-jump barrier or surface barrier, e.g. PN junction depletion layer or carrier concentration layer; Details of semiconductor bodies or of electrodes thereof  ; Multistep manufacturing processes therefor
    • H01L29/02—Semiconductor bodies ; Multistep manufacturing processes therefor
    • H01L29/12—Semiconductor bodies ; Multistep manufacturing processes therefor characterised by the materials of which they are formed
    • H01L29/122—Single quantum well structures
    • H01L29/127—Quantum box structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B22F2998/00—Supplementary information concerning processes or compositions relating to powder metallurgy
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2002/00—Crystal-structural characteristics
    • C01P2002/80—Crystal-structural characteristics defined by measured data other than those specified in group C01P2002/70
    • C01P2002/82—Crystal-structural characteristics defined by measured data other than those specified in group C01P2002/70 by IR- or Raman-data
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
    • C01P2004/01—Particle morphology depicted by an image
    • C01P2004/04—Particle morphology depicted by an image obtained by TEM, STEM, STM or AFM
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
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    • C01P2004/60—Particles characterised by their size
    • C01P2004/64—Nanometer sized, i.e. from 1-100 nanometer
    • C—CHEMISTRY; METALLURGY
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    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00—Particle morphology
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    • C01P2004/82—Particles consisting of a mixture of two or more inorganic phases two phases having the same anion, e.g. both oxidic phases
    • C01P2004/84—Particles consisting of a mixture of two or more inorganic phases two phases having the same anion, e.g. both oxidic phases one phase coated with the other
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2006/00—Physical properties of inorganic compounds
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y10S977/701—Integrated with dissimilar structures on a common substrate
    • Y10S977/702—Integrated with dissimilar structures on a common substrate having biological material component
    • Y10S977/704—Nucleic acids, e.g. DNA or RNA
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10S977/81—Of specified metal or metal alloy composition
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/12—All metal or with adjacent metals
    • Y10T428/12014—All metal or with adjacent metals having metal particles
DE60218840T 2001-05-25 2002-05-22 Nicht legierende Core-Shell-Nanopartikel Expired - Lifetime DE60218840T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US29386101P 2001-05-25 2001-05-25
US293861P 2001-05-25
WOPCT/US01/50825 2001-12-28
PCT/US2001/050825 WO2002096262A2 (en) 2001-05-25 2001-12-28 Non-alloying core shell nanoparticles
US10/034,451 US7238472B2 (en) 2001-05-25 2001-12-28 Non-alloying core shell nanoparticles
US34451 2001-12-28
PCT/US2002/016382 WO2003008539A2 (en) 2001-05-25 2002-05-22 Non-alloying core shell nanoparticles

Publications (2)

Publication Number Publication Date
DE60218840D1 true DE60218840D1 (de) 2007-04-26
DE60218840T2 DE60218840T2 (de) 2007-11-29

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DE60218840T Expired - Lifetime DE60218840T2 (de) 2001-05-25 2002-05-22 Nicht legierende Core-Shell-Nanopartikel

Country Status (7)

Country Link
US (2) US7238472B2 (de)
EP (1) EP1392872B1 (de)
JP (1) JP3885054B2 (de)
AT (1) ATE356826T1 (de)
AU (2) AU2002239726A1 (de)
DE (1) DE60218840T2 (de)
WO (2) WO2002096262A2 (de)

Families Citing this family (175)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7169556B2 (en) * 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6506564B1 (en) * 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6750016B2 (en) * 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7098320B1 (en) 1996-07-29 2006-08-29 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6984491B2 (en) * 1996-07-29 2006-01-10 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US6974669B2 (en) * 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
US20050037397A1 (en) * 2001-03-28 2005-02-17 Nanosphere, Inc. Bio-barcode based detection of target analytes
US20030096321A1 (en) * 1999-05-19 2003-05-22 Jose Remacle Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips
WO2001051665A2 (en) * 2000-01-13 2001-07-19 Nanosphere Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6743395B2 (en) * 2000-03-22 2004-06-01 Ebara Corporation Composite metallic ultrafine particles and process for producing the same
AU2001276870B2 (en) * 2000-07-11 2006-07-20 Northwestern University Method of detection by enhancement of silver staining
US20060040286A1 (en) * 2001-03-28 2006-02-23 Nanosphere, Inc. Bio-barcode based detection of target analytes
US20030113740A1 (en) * 2001-04-26 2003-06-19 Mirkin Chad A. Oligonucleotide-modified ROMP polymers and co-polymers
US7147687B2 (en) * 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
AU2002239726A1 (en) * 2001-05-25 2002-12-09 Northwestern University Non-alloying core shell nanoparticles
AU2002367817B2 (en) 2001-11-09 2008-05-29 Nanosphere, Inc. Bioconjugate-nanoparticle probes
GR1004178B (el) * 2001-11-29 2003-03-05 "����������" Ολοκληρωμενος οπτοηλεκτρονικος βιοαισθητηρας πυριτιου για ανιχνευση βιομοριων επισημασμενων με χρωμοφορες ομαδες ή νανοσωματιδια
US7282710B1 (en) * 2002-01-02 2007-10-16 International Business Machines Corporation Scanning probe microscopy tips composed of nanoparticles and methods to form same
WO2003072830A1 (en) * 2002-02-22 2003-09-04 Purdue Research Foundation Magnetic nanomaterials and methods for detection of biological materials
WO2003086660A1 (en) * 2002-04-09 2003-10-23 The Government Of The United States Of America As Represented By The Secretary Of The Navy Magnetic nanoparticles having passivated metallic cores
US20030211488A1 (en) 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
EP1532274A4 (de) * 2002-06-28 2006-09-27 Purdue Research Foundation Magnetische nanomaterialien und verfahren zum nachweis biologischer materialien
ATE420357T1 (de) * 2002-07-02 2009-01-15 Nanosphere Inc Nanopartikel-polyanion-konjugate sowie verfahren zur verwendung davon beim nachweis von analyten
TWI242478B (en) * 2002-08-01 2005-11-01 Masami Nakamoto Metal nanoparticle and process for producing the same
US20040156846A1 (en) * 2003-02-06 2004-08-12 Triton Biosystems, Inc. Therapy via targeted delivery of nanoscale particles using L6 antibodies
EP1597399A2 (de) * 2003-02-27 2005-11-23 Nanosphere, Inc. Markierungsfreie erstellung von genexpressionsprofilen mittels universeller nanopartikelsonden im mikroarray-testformat
EP1606610A2 (de) * 2003-03-12 2005-12-21 Intel Corporation Chemische verstärkung bei oberflächenverstärkter raman-streuung unter verwendung von lithiumchlorid
WO2004083290A2 (en) * 2003-03-17 2004-09-30 University Of Rochester Core-shell magnetic nanoparticles and nanocomposite materials formed therefrom
US20050250094A1 (en) * 2003-05-30 2005-11-10 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes
CA2473429A1 (en) * 2003-07-09 2005-01-09 National Research Council Of Canada Process for producing gold nanoparticles
JP5082187B2 (ja) * 2003-10-06 2012-11-28 日産自動車株式会社 固体高分子型燃料電池用電極触媒粒子の製造方法
JP4207754B2 (ja) * 2003-10-31 2009-01-14 和光純薬工業株式会社 磁性体を用いた免疫学的測定方法
US20050191665A1 (en) * 2003-12-29 2005-09-01 Xing Su Composite organic-inorganic nanoclusters
JP3912391B2 (ja) * 2004-05-26 2007-05-09 ソニー株式会社 金属磁性ナノ粒子群及びその製造方法
US7718094B2 (en) * 2004-06-18 2010-05-18 The Research Foundation Of State University Of New York Preparation of metallic nanoparticles
JP2008507296A (ja) * 2004-07-26 2008-03-13 ナノスフェアー　インコーポレイテッド 混合培養物中でメチシリン耐性黄色ブドウ球菌とメチシリン感受性黄色ブドウ球菌とを区別する方法
US9494581B2 (en) 2004-08-24 2016-11-15 University Of Wyoming System and method for Raman spectroscopy assay using paramagnetic particles
US7776547B2 (en) * 2004-08-26 2010-08-17 Intel Corporation Cellular analysis using Raman surface scanning
WO2007018562A2 (en) * 2004-09-22 2007-02-15 Nanolab, Inc. Nanospearing for molecular transportation into cells
BRPI0516227A (pt) 2004-10-21 2008-08-26 Englebienne & Associates colóides compósitos de metal/polìmero condutor estáveis e métodos para fabricar e usar os mesmos
US7485471B1 (en) 2004-12-17 2009-02-03 Intel Corporation Detection of enhanced multiplex signals by surface enhanced Raman spectroscopy
US7855021B2 (en) * 2004-12-22 2010-12-21 Brookhaven Science Associates, Llc Electrocatalysts having platium monolayers on palladium, palladium alloy, and gold alloy core-shell nanoparticles, and uses thereof
US8084275B2 (en) * 2005-02-08 2011-12-27 Fujifilm Corporation Magnetic composite body, production method thereof, method for removing substance with mannose on its surface, and method for concentrating substance with mannose on its surface
JP4665144B2 (ja) * 2005-03-31 2011-04-06 独立行政法人物質・材料研究機構 高分子膜の体積膨張に伴うストレス変化を利用した湿度センサー
JP4791867B2 (ja) * 2005-03-31 2011-10-12 日立マクセル株式会社 貴金属コート磁性粒子を用いた被検物質の検出方法
US7700193B2 (en) * 2005-04-08 2010-04-20 Industrial Technology Research Institute Core-shell structure with magnetic, thermal, and optical characteristics and manufacturing method thereof
US20060281076A1 (en) * 2005-05-18 2006-12-14 Nanosphere, Inc. Substrate functionalization method for high sensitivity applications
US8062552B2 (en) * 2005-05-19 2011-11-22 Brookhaven Science Associates, Llc Electrocatalyst for oxygen reduction with reduced platinum oxidation and dissolution rates
WO2006138145A1 (en) 2005-06-14 2006-12-28 Northwestern University Nucleic acid functionalized nanoparticles for therapeutic applications
US20070154903A1 (en) * 2005-06-23 2007-07-05 Nanosphere, Inc. Selective isolation and concentration of nucleic acids from complex samples
JP2007040978A (ja) * 2005-06-30 2007-02-15 Fujifilm Corp 磁性体ナノ粒子を用いた目的成分の分離方法
US7704919B2 (en) * 2005-08-01 2010-04-27 Brookhaven Science Associates, Llc Electrocatalysts having gold monolayers on platinum nanoparticle cores, and uses thereof
SG183720A1 (en) 2005-08-12 2012-09-27 Cambrios Technologies Corp Nanowires-based transparent conductors
DE602006018477D1 (de) * 2005-08-19 2011-01-05 Nanosphere Inc Dna und antikörpern sowie verwendungen davon
US7736910B2 (en) * 2005-10-04 2010-06-15 Calypte Biomedical Corporation One-step production of gold sols
US20070098640A1 (en) * 2005-11-02 2007-05-03 General Electric Company Nanoparticle-based imaging agents for X-ray/computed tomography
WO2007059630A1 (en) * 2005-11-28 2007-05-31 National Research Council Of Canada Multifunctional nanostructure and method
US20070166730A1 (en) * 2006-01-19 2007-07-19 Menon & Associates, Inc. Magnetic resonance system and method to detect and confirm analytes
JP2007205911A (ja) * 2006-02-02 2007-08-16 Sekisui Chem Co Ltd 金酸化鉄複合磁性粒子、免疫測定用磁性粒子及び免疫測定法
US7790066B2 (en) * 2006-03-03 2010-09-07 William Marsh Rice University Nanorice particles: hybrid plasmonic nanostructures
CA2643691A1 (en) * 2006-03-08 2007-09-13 Northwestern University Photoinduced phase separation of gold in two-component nanoparticles to form nanoprisms
US7864322B2 (en) 2006-03-23 2011-01-04 The Research Foundation Of State University Of New York Optical methods and systems for detecting a constituent in a gas containing oxygen in harsh environments
GB0605965D0 (en) * 2006-03-24 2006-05-03 Univ East Anglia Fluorescence based detection of substances
US20080085508A1 (en) * 2006-05-11 2008-04-10 Nanosphere, Inc. Non-nucleic acid based biobarcode assay for detection of biological materials
US7625637B2 (en) * 2006-05-31 2009-12-01 Cabot Corporation Production of metal nanoparticles from precursors having low reduction potentials
US20100035243A1 (en) * 2006-07-10 2010-02-11 Nanosphere, Inc. Ultra-sensitive detection of analytes
ITFI20060180A1 (it) * 2006-07-20 2008-01-21 Acta Spa Catalizzatori anodici costituiti da metalli nobili depositati spontaneamente su catalizzatori nanostrutturati a base di metalli di transizione, loro preparazione ed uso e celle a combustibile che li contengono.
US7502106B2 (en) * 2006-09-21 2009-03-10 Honeywell International Inc. SERS analyzer
SG10201502808UA (en) 2006-10-12 2015-05-28 Cambrios Technologies Corp Nanowire-Based Transparent Conductors And Applications Thereof
US8018568B2 (en) 2006-10-12 2011-09-13 Cambrios Technologies Corporation Nanowire-based transparent conductors and applications thereof
US7727776B2 (en) * 2006-10-24 2010-06-01 Honeywell International Inc. Core-shell nanoparticles for detection based on SERS
WO2008127414A2 (en) * 2006-11-08 2008-10-23 Northwestern University Colorimetric detection of metallic ions in aqueous media using functionlized nanoparticles
WO2008098248A2 (en) 2007-02-09 2008-08-14 Northwestern University Particles for detecting intracellular targets
JP2008196927A (ja) * 2007-02-13 2008-08-28 Fujifilm Corp プローブの脱着を伴う対象物質の検出方法
JP2010520749A (ja) * 2007-02-27 2010-06-17 ノースウェスタン ユニバーシティ ナノ粒子への分子の結合
JP4854547B2 (ja) * 2007-03-09 2012-01-18 独立行政法人科学技術振興機構 銀微粒子と核酸の複合体及びその製造方法
JP6098860B2 (ja) 2007-04-20 2017-03-22 シーエーエム ホールディング コーポレーション 複合透明導電体、及び機器
US20100215851A1 (en) * 2007-04-25 2010-08-26 Tetsuya Shoji Method of producing core/shell composite nano-particles
US20080293588A1 (en) * 2007-05-11 2008-11-27 Northwestern University Nanodisk codes
EP2160464B1 (de) 2007-05-30 2014-05-21 Northwestern University Nukleinsäure-funktionalisierte nanopartikel für therapeutische anwendungen
US7807372B2 (en) 2007-06-04 2010-10-05 Northwestern University Screening sequence selectivity of oligonucleotide-binding molecules using nanoparticle based colorimetric assay
DE08780145T1 (de) 2007-07-11 2011-04-28 Gr Intellectual Reserve, Llc Kontinuierliche verfahren zur behandlung von flüssigkeiten und herstellung von bestimmten bestandteilen (z.b. nanopartikeln) in flüssigkeiten, vorrichtungen und sich daraus ergebende nanopartikel und nanopartikel/flüssigkeit-lösung(en)
JP5686598B2 (ja) * 2007-09-27 2015-03-18 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ 分離可能な及び再分散可能な遷移金属ナノ粒子、それらの製造方法、並びにｉｒ吸収体としての使用
US7829735B2 (en) * 2007-10-26 2010-11-09 Northwestern University Universal phosphoramidite for preparation of modified biomolecules and surfaces
US8679458B2 (en) 2007-11-07 2014-03-25 Battelle Memorial Institute Functionalized magnetic nanoparticle analyte sensor
US20090181361A1 (en) * 2008-01-14 2009-07-16 Weidong Xu Rapid test for detecting infection
US20100105024A1 (en) * 2008-01-14 2010-04-29 Transgenex Nanobiotech, Inc. Rapid test including genetic sequence probe
WO2009090748A1 (ja) * 2008-01-17 2009-07-23 Applied Nanoparticle Laboratory Corporation 複合銀ナノ粒子、その製法及び製造装置
DK2288336T3 (en) 2008-04-25 2017-03-13 Univ Northwestern NANOSTRUCTURES SUITABLE FOR COMPLEXATION OF CHOLESTEROL
WO2011071343A2 (ko) * 2009-12-11 2011-06-16 한국화학연구원 라만 활성분자가 나노입자 이합체의 접합부에 위치한 이합체 코어쉘 나노 입자, 이의 용도 및 이의 제조방법
KR101153748B1 (ko) * 2008-05-07 2012-06-14 재단법인서울대학교산학협력재단 바이오센서로 유용한 새로운 형태의 금／은 코어쉘 복합체
WO2009139747A1 (en) * 2008-05-16 2009-11-19 Utc Power Corporation A stabilized platinum catalyst
US8389175B2 (en) * 2008-05-16 2013-03-05 Utc Power Corporation Fuel cell having a stabilized cathode catalyst
US9833836B2 (en) 2008-06-23 2017-12-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Core-shell metallic nanoparticles, methods of production thereof, and ink compositions containing same
WO2010016798A1 (en) * 2008-08-06 2010-02-11 Agency For Science, Technology And Research Nanocomposites
EP3335705A1 (de) 2008-11-24 2018-06-20 Northwestern University Polyvalente rna-nanopartikelzusammensetzungen
US7879625B1 (en) 2008-12-03 2011-02-01 The United States Of America As Represented By The Secretary Of The Navy Preparation of SERS substrates on silica-coated magnetic microspheres
US20100233270A1 (en) 2009-01-08 2010-09-16 Northwestern University Delivery of Oligonucleotide-Functionalized Nanoparticles
US9387452B2 (en) 2009-01-14 2016-07-12 Gr Intellectual Reserve, Llc. Continuous methods for treating liquids and manufacturing certain constituents (e.g., nanoparticles) in liquids, apparatuses and nanoparticles and nanoparticle/liquid solution(s) resulting therefrom
AU2010271298B2 (en) 2009-07-08 2015-12-17 Clene Nanomedicine, Inc. Novel gold-based nanocrystals for medical treatments and electrochemical manufacturing processes therefor
KR101546673B1 (ko) * 2009-01-15 2015-08-25 삼성전자주식회사 전자 사진용 토너 및 그의 제조방법
AU2010204991B2 (en) 2009-01-15 2016-01-14 Clene Nanomedicine, Inc. Continuous semicontinuous and batch methods for treating liquids and manufacturing certain constituents (e.g., nanoparticles) in liquids, apparatuses and nanoparticles and nanoparticle/liquid solution(s) and colloids resulting therefrom
US20110033940A1 (en) * 2009-01-30 2011-02-10 Northwestern University Click chemistry, molecular transport junctions, and colorimetric detection of copper
WO2010109268A1 (en) * 2009-03-23 2010-09-30 Yeditepe Universitesi Synthesis of oligonucleotide mediated gold core- silver shell nanoparticles
CN108451968A (zh) 2009-04-15 2018-08-28 西北大学 寡核苷酸功能化的纳米颗粒的递送
KR101040903B1 (ko) 2009-06-24 2011-06-16 성균관대학교산학협력단 금 나노입자가 코팅된 백금촉매 및 이의 제조 방법
WO2011031999A2 (en) * 2009-09-10 2011-03-17 Purdue Research Foundation Multi-component nanoparticle structure having detectable magnetic resonance properties
DK2494075T3 (en) 2009-10-30 2018-07-23 Univ Northwestern TABLE-MANAGED NANOCONJUGATES
AU2011207563B2 (en) 2010-01-19 2016-03-10 Northwestern University Synthetic nanostructures including nucleic acids and/or other entities
CN102834472B (zh) 2010-02-05 2015-04-22 凯博瑞奥斯技术公司 光敏墨组合物和透明导体以及它们的使用方法
US20130101512A1 (en) 2010-03-12 2013-04-25 Chad A. Mirkin Crosslinked polynucleotide structure
JP5543021B2 (ja) * 2010-06-13 2014-07-09 オーシャンズ キング ライティング サイエンスアンドテクノロジー カンパニー リミテッド コアシェル型磁性合金ナノ粒子の調製方法
FR2965719B1 (fr) * 2010-10-07 2014-05-23 Oreal Particule comportant deux metaux plasmoniques
CN102554252A (zh) * 2010-12-17 2012-07-11 中国科学技术大学 一种多孔双金属纳米结构的合成方法
EP2670549A4 (de) * 2011-02-03 2017-10-25 Metallo Therapy Ltd Oberflächenmodifizierte schwermetallnanopartikel, zusammensetzungen und verwendungen davon
CN102672167B (zh) * 2011-03-16 2014-04-02 首都师范大学 一种新型三角形银－硫化银纳米复合颗粒的制备及其应用
CN102407340B (zh) * 2011-04-18 2013-06-12 中国人民解放军总后勤部军需装备研究所 一种银/碳核壳结构微粉的制备方法
US9605304B2 (en) * 2011-07-20 2017-03-28 The Hong Kong Polytechnic University Ultra-stable oligonucleotide-gold and-silver nanoparticle conjugates and method of their preparation
CN102298055B (zh) * 2011-07-21 2013-12-11 南京博天科智生物技术有限公司 一种人血液h-fabp纳米金标检测试纸条及其制备方法
WO2013036974A1 (en) 2011-09-11 2013-03-14 Aurasense, Llc Cellular uptake control systems
ES2856091T3 (es) 2011-09-14 2021-09-27 Univ Northwestern Nanoconjugados capaces de atravesar la barrera hematoencefálica
CN102380335B (zh) * 2011-09-15 2014-03-12 东南大学 核壳型水凝胶胶体晶体微球及其制备方法和用途
US9079249B2 (en) * 2011-09-30 2015-07-14 Uchicago Argonne, Llc Intermetallic nanoparticles
CN102519948B (zh) * 2011-11-24 2014-05-07 中国科学院宁波材料技术与工程研究所 一种六价铬离子的检测方法
WO2013170229A1 (en) * 2012-05-11 2013-11-14 Vanderbilt University Detecting antigens such as bacterial quorum sensing proteins
WO2014010012A1 (ja) * 2012-07-09 2014-01-16 トヨタ自動車株式会社 排ガス浄化用触媒及びその製造方法
US9512468B2 (en) 2012-11-06 2016-12-06 Industrial Technology Research Institute Detection method uses magnetic and detectable nanoparticles with oligonucleotides attached thereto
CN102962474B (zh) * 2012-12-13 2014-10-22 北京航空航天大学 一种乙二醇体系制备金镍核壳纳米结构的可控合成方法
KR102310098B1 (ko) * 2013-02-19 2021-10-06 삼성전자주식회사 금속 나노입자와 발광물질의 접합체
CN103159771B (zh) * 2013-03-29 2015-04-08 山东科技大学 一步法合成卟啉功能化的四氧化三钴纳米粒子的工艺
CN103265950B (zh) * 2013-06-09 2015-09-02 南京大学 氮化硼纳米片/金纳米簇复合材料及其制法和在生物分析中的应用
US20160194642A1 (en) 2013-07-25 2016-07-07 Exicure, Inc Spherical nucleic acid-based constructs as immunoregulatory agents
JP6697384B2 (ja) 2013-07-25 2020-05-20 イグジキュア, インコーポレーテッドExicure, Inc. 予防的および治療的使用のための免疫刺激剤としての球状の核酸ベース構築物
WO2015023797A1 (en) 2013-08-13 2015-02-19 Northwestern University Lipophilic nanoparticles for drug delivery
CN103447547B (zh) * 2013-08-28 2015-06-24 同济大学 微乳中制备星状结构四氧化三铁/金纳米复合粒子的方法
WO2015066708A1 (en) 2013-11-04 2015-05-07 Northwestern University Quantification and spatio-temporal tracking of a target using a spherical nucleic acid (sna)
KR101427146B1 (ko) 2013-11-13 2014-08-07 단국대학교 산학협력단 생체 분자 분석 키트 및 이를 이용한 생체 분자 분석 방법
US20170199185A1 (en) * 2014-05-30 2017-07-13 Dai Nippon Toryo Co., Ltd. Suspension of Gold-Coated Silver Nanoplates
TR201908550T4 (tr) 2014-06-04 2019-07-22 Exicure Inc Profilaktik veya terapötik uygulamalar için lipozomal sferik nükleik asitler tarafından immün modülatörlerin çok değerlikli teslimi.
CN104096849B (zh) * 2014-07-15 2016-10-19 中国石油大学(华东) 金核银壳纳米探针的制备方法及其在氰根离子比色检测中的应用
SG11201702656WA (en) 2014-10-06 2017-04-27 Exicure Inc Anti-tnf compounds
US11213593B2 (en) 2014-11-21 2022-01-04 Northwestern University Sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
CN104439276B (zh) * 2014-11-30 2016-04-13 湖南科技大学 一种快速制备中空多孔二氧化硅/银纳米复合材料的方法及产品
US9821061B2 (en) 2015-03-03 2017-11-21 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Enhanced plasmonic nanoparticles for cancer therapy and diagnostics
CN104668580A (zh) * 2015-03-06 2015-06-03 天津大学 一种四氧化三铁/金纳米复合材料的制备及其快速检测罗丹明分子的方法
US10078092B2 (en) 2015-03-18 2018-09-18 Northwestern University Assays for measuring binding kinetics and binding capacity of acceptors for lipophilic or amphiphilic molecules
AU2016301375B2 (en) * 2015-08-04 2022-03-03 Zoetis Services Llc Signal amplification in solution-based plasmonic specific-binding partner assays
US9627115B2 (en) * 2015-09-14 2017-04-18 Elwha Llc Magnetic plasmonic nanoparticle dimer
US9627114B2 (en) * 2015-09-14 2017-04-18 Elwha Llc Magnetic plasmonic nanoparticle positioned on a magnetic plasmonic substrate
JP2017150865A (ja) * 2016-02-23 2017-08-31 コニカミノルタ株式会社 ガス検知方法及びガス検知装置
CN105598442B (zh) * 2016-02-25 2019-01-22 天津工业大学 一维链状Au-Ag核壳纳米结构、自组装制备方法及SERS应用
US11866700B2 (en) 2016-05-06 2024-01-09 Exicure Operating Company Liposomal spherical nucleic acid (SNA) constructs presenting antisense oligonucleotides (ASO) for specific knockdown of interleukin 17 receptor mRNA
CN105903979B (zh) * 2016-05-13 2017-12-26 吉林师范大学 一种Fe3O4@Au核壳功能材料的制备方法
CN106111974B (zh) * 2016-07-26 2017-11-28 江南大学 一种金银核壳粒子‑金纳米棒自组装结构的制备方法及应用
WO2018039629A2 (en) 2016-08-25 2018-03-01 Northwestern University Micellar spherical nucleic acids from thermoresponsive, traceless templates
CA3042036A1 (en) * 2016-10-26 2018-05-03 Integrated Nano-Technologies, Inc. Systems and methods for optical sensing of biomolecular targets
CN106735287B (zh) * 2016-11-28 2018-08-28 东北大学 一种单分散的FePt/Fe3O4混合纳米颗粒的制备方法
US11977072B2 (en) 2017-01-30 2024-05-07 Zoetis Services Llc Solution-based plasmonic specific-binding partner assays using metallic nanostructures
WO2018201090A1 (en) 2017-04-28 2018-11-01 Exicure, Inc. Synthesis of spherical nucleic acids using lipophilic moieties
US11433131B2 (en) 2017-05-11 2022-09-06 Northwestern University Adoptive cell therapy using spherical nucleic acids (SNAs)
US10178735B1 (en) 2017-08-22 2019-01-08 Northrop Grumman Systems Corporation Dynamically tunable materials for parity-time symmetric electro-optical devices
KR102064961B1 (ko) 2017-12-13 2020-01-10 주식회사 포스코 자성 나노입자 및 이를 이용한 측방유동 분석에서의 신호 증폭 방법
CN108097950A (zh) * 2017-12-25 2018-06-01 浙江理工大学 一种核壳结构Ag@Fe3O4复合微球、制备方法及其应用
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KR102357642B1 (ko) * 2019-11-12 2022-02-07 충남대학교산학협력단 자성 플라즈몬 입자
CN111266599B (zh) * 2020-01-21 2022-06-21 王海龙 一种多极子局域表面等离子体共振吸收体的制备方法及其应用
CN112062235B (zh) * 2020-09-09 2022-12-27 重庆科技学院 一种基于复合磁体的油水分离装置
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CN113984685B (zh) * 2021-09-30 2023-03-10 南京航空航天大学 一种银纳米结构生长机理的分析方法
CN116727678B (zh) * 2023-06-15 2024-03-12 东南大学 Yolk-Shell结构的金纳米粒子及其制备方法

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4193983A (en) * 1978-05-16 1980-03-18 Syva Company Labeled liposome particle compositions and immunoassays therewith
NL7807532A (nl) * 1978-07-13 1980-01-15 Akzo Nv Metaal-immunotest.
US4318707A (en) * 1978-11-24 1982-03-09 Syva Company Macromolecular fluorescent quencher particle in specific receptor assays
US4256834A (en) * 1979-04-09 1981-03-17 Syva Company Fluorescent scavenger particle immunoassay
US4261968A (en) * 1979-05-10 1981-04-14 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4650770A (en) * 1981-04-27 1987-03-17 Syntex (U.S.A.) Inc. Energy absorbing particle quenching in light emitting competitive protein binding assays
US4713348A (en) * 1983-04-05 1987-12-15 Syntex (U.S.A.) Inc. Fluorescent multiparameter particle analysis
US5288609A (en) * 1984-04-27 1994-02-22 Enzo Diagnostics, Inc. Capture sandwich hybridization method and composition
US4868104A (en) * 1985-09-06 1989-09-19 Syntex (U.S.A.) Inc. Homogeneous assay for specific polynucleotides
US4996143A (en) * 1985-12-23 1991-02-26 Syngene, Inc. Fluorescent stokes shift probes for polynucleotide hybridization
US5137827A (en) * 1986-03-25 1992-08-11 Midwest Research Technologies, Inc. Diagnostic element for electrical detection of a binding reaction
US5514602A (en) * 1986-06-09 1996-05-07 Ortho Diagnostic Systems, Inc. Method of producing a metal sol reagent containing colloidal metal particles
US5360895A (en) * 1987-04-22 1994-11-01 Associated Universities, Inc. Derivatized gold clusters and antibody-gold cluster conjugates
US4853335A (en) * 1987-09-28 1989-08-01 Olsen Duane A Colloidal gold particle concentration immunoassay
US5460831A (en) * 1990-06-22 1995-10-24 The Regents Of The University Of California Targeted transfection nanoparticles
AU8951191A (en) * 1990-10-29 1992-05-26 Dekalb Plant Genetics Isolation of biological materials using magnetic particles
US5665582A (en) * 1990-10-29 1997-09-09 Dekalb Genetics Corp. Isolation of biological materials
US5294369A (en) * 1990-12-05 1994-03-15 Akzo N.V. Ligand gold bonding
WO1993010564A1 (en) * 1991-11-22 1993-05-27 The Regents Of The University Of California Semiconductor nanocrystals covalently bound to solid inorganic surfaces using self-assembled monolayers
US5225064A (en) * 1992-01-15 1993-07-06 Enzyme Technology Research Group, Inc. Peroxidase colloidal gold oxidase biosensors for mediatorless glucose determination
US5472881A (en) * 1992-11-12 1995-12-05 University Of Utah Research Foundation Thiol labeling of DNA for attachment to gold surfaces
US5637508A (en) * 1993-03-26 1997-06-10 Geo-Centers, Inc. Biomolecules bound to polymer or copolymer coated catalytic inorganic particles, immunoassays using the same and kits containing the same
US5384265A (en) * 1993-03-26 1995-01-24 Geo-Centers, Inc. Biomolecules bound to catalytic inorganic particles, immunoassays using the same
US5681943A (en) * 1993-04-12 1997-10-28 Northwestern University Method for covalently linking adjacent oligonucleotides
US5543158A (en) * 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
DE4405156C1 (de) * 1994-02-18 1995-10-26 Univ Karlsruhe Verfahren zur Herstellung beschichteter polymerer Mikropartikel
US5521289A (en) * 1994-07-29 1996-05-28 Nanoprobes, Inc. Small organometallic probes
US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US6025202A (en) * 1995-02-09 2000-02-15 The Penn State Research Foundation Self-assembled metal colloid monolayers and detection methods therewith
US5609907A (en) * 1995-02-09 1997-03-11 The Penn State Research Foundation Self-assembled metal colloid monolayers
IL126544A (en) * 1996-04-25 2004-08-31 Genicon Sciences Inc Test for component detection using detectable particles in diffused light
US6984491B2 (en) 1996-07-29 2006-01-10 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US6750016B2 (en) * 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
EP1818417B1 (de) * 1996-07-29 2014-02-12 Nanosphere, Inc. Nanopartikel mit angehängten Oligonukleotiden und ihre Verwendungen
US6506564B1 (en) 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6361944B1 (en) * 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7169556B2 (en) 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US5830986A (en) * 1996-10-28 1998-11-03 Massachusetts Institute Of Technology Methods for the synthesis of functionalizable poly(ethylene oxide) star macromolecules
US5900481A (en) * 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
US5922537A (en) * 1996-11-08 1999-07-13 N.o slashed.AB Immunoassay, Inc. Nanoparticles biosensor
US5939021A (en) * 1997-01-23 1999-08-17 Hansen; W. Peter Homogeneous binding assay
US6180415B1 (en) 1997-02-20 2001-01-30 The Regents Of The University Of California Plasmon resonant particles, methods and apparatus
US6852252B2 (en) * 1997-03-12 2005-02-08 William Marsh Rice University Use of metalnanoshells to impede the photo-oxidation of conjugated polymer
US6344272B1 (en) * 1997-03-12 2002-02-05 Wm. Marsh Rice University Metal nanoshells
US6974669B2 (en) 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
US6149868A (en) * 1997-10-28 2000-11-21 The Penn State Research Foundation Surface enhanced raman scattering from metal nanoparticle-analyte-noble metal substrate sandwiches
US5990479A (en) * 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
US5972615A (en) * 1998-01-21 1999-10-26 Urocor, Inc. Biomarkers and targets for diagnosis, prognosis and management of prostate disease
US6699724B1 (en) * 1998-03-11 2004-03-02 Wm. Marsh Rice University Metal nanoshells for biosensing applications
US6428811B1 (en) * 1998-03-11 2002-08-06 Wm. Marsh Rice University Temperature-sensitive polymer/nanoshell composites for photothermally modulated drug delivery
DE19822996C1 (de) * 1998-05-22 1999-04-22 Siemens Ag Abscheidevorrichtung für langgestreckte Feststoffteile
US6290839B1 (en) * 1998-06-23 2001-09-18 Clinical Micro Sensors, Inc. Systems for electrophoretic transport and detection of analytes
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6738163B2 (en) * 1998-07-17 2004-05-18 Gary Hochman Method for transmission of facsimile image data
US6306610B1 (en) * 1998-09-18 2001-10-23 Massachusetts Institute Of Technology Biological applications of quantum dots
US6251303B1 (en) * 1998-09-18 2001-06-26 Massachusetts Institute Of Technology Water-soluble fluorescent nanocrystals
US6203989B1 (en) * 1998-09-30 2001-03-20 Affymetrix, Inc. Methods and compositions for amplifying detectable signals in specific binding assays
EP1135682B1 (de) * 1998-11-30 2007-07-11 Nanosphere, Inc. Nanopartikel mit polymerschalen
US6277489B1 (en) * 1998-12-04 2001-08-21 The Regents Of The University Of California Support for high performance affinity chromatography and other uses
US6159378A (en) * 1999-02-23 2000-12-12 Battelle Memorial Institute Apparatus and method for handling magnetic particles in a fluid
ATE324587T1 (de) * 1999-07-16 2006-05-15 Univ Wm Marsh Rice Verfahren zum nachweis von bioanalyten mittels metallische nanohüllen
US6579726B1 (en) * 1999-07-30 2003-06-17 Surromed, Inc. Instruments, methods and reagents for surface plasmon resonance
WO2001051665A2 (en) * 2000-01-13 2001-07-19 Nanosphere Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6530944B2 (en) * 2000-02-08 2003-03-11 Rice University Optically-active nanoparticles for use in therapeutic and diagnostic methods
US6773823B2 (en) * 2000-04-07 2004-08-10 University Of New Orleans Research And Technology Foundation, Inc. Sequential synthesis of core-shell nanoparticles using reverse micelles
AU2001276870B2 (en) * 2000-07-11 2006-07-20 Northwestern University Method of detection by enhancement of silver staining
US6660381B2 (en) * 2000-11-03 2003-12-09 William Marsh Rice University Partial coverage metal nanoshells and method of making same
WO2002046483A2 (en) * 2000-12-06 2002-06-13 Northwestern University Silver stain removal from dna detection chips by cyanide etching or sonication
US20030113740A1 (en) 2001-04-26 2003-06-19 Mirkin Chad A. Oligonucleotide-modified ROMP polymers and co-polymers
US7147687B2 (en) 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
AU2002239726A1 (en) 2001-05-25 2002-12-09 Northwestern University Non-alloying core shell nanoparticles
JP4347053B2 (ja) 2001-08-03 2009-10-21 ナノスフェアー インコーポレイテッド ナノ粒子撮像システムおよび方法
KR100438408B1 (ko) * 2001-08-16 2004-07-02 한국과학기술원 금속간의 치환 반응을 이용한 코어-쉘 구조 및 혼합된합금 구조의 금속 나노 입자의 제조 방법과 그 응용
ATE519438T1 (de) * 2001-09-26 2011-08-15 Rice University Optisch absorbierende nanopartikel für die verbesserte gewebereparatur
US6778316B2 (en) * 2001-10-24 2004-08-17 William Marsh Rice University Nanoparticle-based all-optical sensors
AU2002367817B2 (en) 2001-11-09 2008-05-29 Nanosphere, Inc. Bioconjugate-nanoparticle probes
US6875475B2 (en) * 2002-04-01 2005-04-05 William Marsh Rice University Methods for producing submicron metal line and island arrays
US20030211488A1 (en) * 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
ATE420357T1 (de) 2002-07-02 2009-01-15 Nanosphere Inc Nanopartikel-polyanion-konjugate sowie verfahren zur verwendung davon beim nachweis von analyten

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JP3885054B2 (ja) 2007-02-21
WO2002096262A2 (en) 2002-12-05
US20040038255A1 (en) 2004-02-26
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