ATE438410T1 - Verfahren zur herstellung von immunogenen konjugaten - Google Patents

Verfahren zur herstellung von immunogenen konjugaten

Info

Publication number
ATE438410T1
ATE438410T1 AT05758048T AT05758048T ATE438410T1 AT E438410 T1 ATE438410 T1 AT E438410T1 AT 05758048 T AT05758048 T AT 05758048T AT 05758048 T AT05758048 T AT 05758048T AT E438410 T1 ATE438410 T1 AT E438410T1
Authority
AT
Austria
Prior art keywords
agent
carrier
hapten
modified
antigen
Prior art date
Application number
AT05758048T
Other languages
English (en)
Inventor
Rachel Schneerson
Joanna Kubler-Kielb
Fathy Majadly
Stephen Leppla
John Robbins
Darrell Liu
Joseph Shiloach
Original Assignee
Us Gov Health & Human Serv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2004/017736 external-priority patent/WO2005000884A1/en
Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv
Priority claimed from PCT/US2005/019678 external-priority patent/WO2005117965A1/en
Application granted granted Critical
Publication of ATE438410T1 publication Critical patent/ATE438410T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
AT05758048T 2004-06-04 2005-06-03 Verfahren zur herstellung von immunogenen konjugaten ATE438410T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US2004/017736 WO2005000884A1 (en) 2003-06-05 2004-06-04 Poly-gamma-glutamic conjugates for eliciting immune responses directed against bacilli
US11/005,851 US7625736B2 (en) 2004-06-04 2004-12-06 Methods for preparing immunogenic conjugates
PCT/US2005/019678 WO2005117965A1 (en) 2004-06-04 2005-06-03 Methods for preparing immunogenic conjugates

Publications (1)

Publication Number Publication Date
ATE438410T1 true ATE438410T1 (de) 2009-08-15

Family

ID=35449202

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05758048T ATE438410T1 (de) 2004-06-04 2005-06-03 Verfahren zur herstellung von immunogenen konjugaten

Country Status (3)

Country Link
US (2) US7625736B2 (de)
AT (1) ATE438410T1 (de)
DE (1) DE602005015855D1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6248334B1 (en) * 1997-01-08 2001-06-19 Henry M. Jackson Foundation For The Advancement Of Military Medicine Process for preparing conjugate vaccines including free protein and the conjugate vaccines, immunogens, and immunogenic reagents produced by this process
US6858211B1 (en) 1998-07-20 2005-02-22 The United States Of America As Represented By The Department Of Health And Human Services Vaccines against Escherichia coli O157 infection
WO2002020059A2 (en) * 2000-09-01 2002-03-14 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Vibrio cholerae o139 conjugate vaccines
CA2528067C (en) * 2003-06-05 2015-08-04 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Poly-gamma-glutamic acid conjugates for eliciting immune responses directed against bacilli
AU2007259329A1 (en) 2006-05-12 2007-12-21 Farris, Darise Anthrax compositions and methods of use and production
KR102125600B1 (ko) * 2013-06-04 2020-06-23 페트르 젠나디에비치 아파린 개질된 내독성 세균 지질다당류(변형체), 개질된 지질다당류들(변형체들)의 조합물, 및 이를 함유한 백신(변형체) 및 약제 조성물(변형체)
US11052142B2 (en) 2013-06-04 2021-07-06 Petr G. Aparin Modified endotoxic bacteria lipopolysaccharide (variants), combination of modified lipopolysaccharides (variants) and, containing same, a vaccine (variants) and a pharmaceutical composition (variants)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4496538A (en) 1982-07-06 1985-01-29 Connaught Laboratories, Inc. Haemophilus influenzae b polysaccharide-diphtheria toxoid conjugate vaccine
DK163176C (da) * 1985-09-27 1992-06-22 Schweiz Serum & Impfinst Ugiftig konjugatvaccine mod infektioner af pseudomonas aeruginosa- og escherichia coli- bakterier, fremgangsmaade til fremstilling heraf og anvendelse af vaccinen
US5066789A (en) * 1988-09-30 1991-11-19 Neorx Corporation Targeting substance-diagnostic/therapeutic agent conjugates having Schiff base linkages
FR2639559B1 (fr) * 1988-11-29 1991-01-11 Bull Sa Appareil pour separer et recuperer des particules solides de revelateur transportees par un flux gazeux
AU2001238346A1 (en) 2000-02-15 2001-08-27 Genzyme Corporation Modification of biopolymers for improved drug delivery
US6911535B2 (en) * 2000-03-22 2005-06-28 Solvlink Biosciences Biomolecule/polymer conjugates
CA2528067C (en) 2003-06-05 2015-08-04 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Poly-gamma-glutamic acid conjugates for eliciting immune responses directed against bacilli

Also Published As

Publication number Publication date
US20050271675A1 (en) 2005-12-08
US7625736B2 (en) 2009-12-01
US8481048B2 (en) 2013-07-09
US20100040644A1 (en) 2010-02-18
DE602005015855D1 (de) 2009-09-17

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties