DE3783588T2 - Neue verbindungen dc-88a und dc-89a1 und deren herstellungsverfahren. - Google Patents

Neue verbindungen dc-88a und dc-89a1 und deren herstellungsverfahren.

Info

Publication number
DE3783588T2
DE3783588T2 DE8787902737T DE3783588T DE3783588T2 DE 3783588 T2 DE3783588 T2 DE 3783588T2 DE 8787902737 T DE8787902737 T DE 8787902737T DE 3783588 T DE3783588 T DE 3783588T DE 3783588 T2 DE3783588 T2 DE 3783588T2
Authority
DE
Germany
Prior art keywords
measured
broad
spectrum
streptomyces
ppm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8787902737T
Other languages
German (de)
English (en)
Other versions
DE3783588D1 (de
Inventor
Kozo Asano
Kazuhisa Fujimoto
Michio Ichimura
Isao Kawamoto
Makoto Morimoto
Hirofumi Nakano
Hiroshi Sano
Isami Takahashi
Fusao Tomita
Toru Yasuzawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Application granted granted Critical
Publication of DE3783588D1 publication Critical patent/DE3783588D1/de
Publication of DE3783588T2 publication Critical patent/DE3783588T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
DE8787902737T 1986-04-17 1987-04-17 Neue verbindungen dc-88a und dc-89a1 und deren herstellungsverfahren. Expired - Lifetime DE3783588T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP8903186 1986-04-17
JP9564986 1986-04-24
PCT/JP1987/000247 WO1987006265A1 (fr) 1986-04-17 1987-04-17 Nouveaux composes dc-88a et dc-89a1, et procede pour leur preparation

Publications (2)

Publication Number Publication Date
DE3783588D1 DE3783588D1 (de) 1993-02-25
DE3783588T2 true DE3783588T2 (de) 1993-06-09

Family

ID=26430476

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787902737T Expired - Lifetime DE3783588T2 (de) 1986-04-17 1987-04-17 Neue verbindungen dc-88a und dc-89a1 und deren herstellungsverfahren.

Country Status (5)

Country Link
US (1) US4923990A (enExample)
EP (1) EP0271581B1 (enExample)
JP (1) JPH0684377B2 (enExample)
DE (1) DE3783588T2 (enExample)
WO (1) WO1987006265A1 (enExample)

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US5187186A (en) * 1989-07-03 1993-02-16 Kyowa Hakko Kogyo Co., Ltd. Pyrroloindole derivatives
US5214065A (en) * 1990-06-11 1993-05-25 Kyowa Hakko Kogyo Co., Ltd. Dc-89 derivatives
US5248692A (en) * 1990-06-11 1993-09-28 Kyowa Hakko Kogyo Co., Ltd. DC-89 derivatives as anti-tumor agents
DE69121334T2 (de) * 1990-07-26 1997-03-20 Kyowa Hakko Kogyo Kk DC-89-Derivate als Antitumor-Wirkstoffe
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Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
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US4423230A (en) * 1980-11-18 1983-12-27 The Upjohn Company Preparation of an intermediate for N-(methylsulfonyl)-1,2,8,8a-cyclopropa[c][1,2-b:-4,3-b']dipyrol-4(5H)-one
US4413132A (en) * 1980-11-18 1983-11-01 The Upjohn Company Antibiotic CC-1065 indoline intermediates
US4423228A (en) * 1980-11-18 1983-12-27 The Upjohn Company Process for preparing N-(methyl-sulfonyl)-1,2,8,8a-cyclopropa[c]benzo[1,2-b:4,3-b']dipyrrol-4(5H)-one
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US4400518A (en) * 1980-11-18 1983-08-23 The Upjohn Company Composition of matter and process
CA1238907A (en) * 1984-02-21 1988-07-05 Robert C. Kelly 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
AU617304B2 (en) * 1986-12-19 1991-11-28 Pharmacia & Upjohn Company Novel cc-1065 analogs

Also Published As

Publication number Publication date
US4923990A (en) 1990-05-08
EP0271581A1 (en) 1988-06-22
JPH0684377B2 (ja) 1994-10-26
JPH0684377B1 (enExample) 1994-10-26
WO1987006265A1 (fr) 1987-10-22
EP0271581A4 (en) 1989-06-26
EP0271581B1 (en) 1993-01-13
DE3783588D1 (de) 1993-02-25

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