JPH0684377B1 - - Google Patents

Info

Publication number
JPH0684377B1
JPH0684377B1 JP62502491A JP50249187A JPH0684377B1 JP H0684377 B1 JPH0684377 B1 JP H0684377B1 JP 62502491 A JP62502491 A JP 62502491A JP 50249187 A JP50249187 A JP 50249187A JP H0684377 B1 JPH0684377 B1 JP H0684377B1
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP62502491A
Other languages
Japanese (ja)
Other versions
JPH0684377B2 (ja
JPWO1987006265A1 (ja
Inventor
Hirofumi Nakano
Isami Takahashi
Michiaki Ichimura
Isao Kawamoto
Kozo Asano
Fusao Tomita
Hiroshi Sano
Tooru Yasuzawa
Makoto Morimoto
Kazuhisa Fujimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP62-502491A priority Critical patent/JPH0684377B2/ja
Publication of JPWO1987006265A1 publication Critical patent/JPWO1987006265A1/ja
Publication of JPH0684377B2 publication Critical patent/JPH0684377B2/ja
Publication of JPH0684377B1 publication Critical patent/JPH0684377B1/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
JP62-502491A 1986-04-17 1987-04-17 新規化合物ｄｃ―８８ａ及びｄｃ―８９ａ１ Expired - Lifetime JPH0684377B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62-502491A JPH0684377B2 (ja) 1986-04-17 1987-04-17 新規化合物ｄｃ―８８ａ及びｄｃ―８９ａ１

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP61-89031 1986-04-17
JP8903186 1986-04-17
JP61-95649 1986-04-24
JP9564986 1986-04-24
JP62-502491A JPH0684377B2 (ja) 1986-04-17 1987-04-17 新規化合物ｄｃ―８８ａ及びｄｃ―８９ａ１
PCT/JP1987/000247 WO1987006265A1 (fr) 1986-04-17 1987-04-17 Nouveaux composes dc-88a et dc-89a1, et procede pour leur preparation

Publications (3)

Publication Number Publication Date
JPWO1987006265A1 JPWO1987006265A1 (ja) 1988-03-03
JPH0684377B2 JPH0684377B2 (ja) 1994-10-26
JPH0684377B1 true JPH0684377B1 (enExample) 1994-10-26

Family

ID=26430476

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62-502491A Expired - Lifetime JPH0684377B2 (ja) 1986-04-17 1987-04-17 新規化合物ｄｃ―８８ａ及びｄｃ―８９ａ１

Country Status (5)

Country Link
US (1) US4923990A (enExample)
EP (1) EP0271581B1 (enExample)
JP (1) JPH0684377B2 (enExample)
DE (1) DE3783588T2 (enExample)
WO (1) WO1987006265A1 (enExample)

Families Citing this family (100)

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US5187186A (en) * 1989-07-03 1993-02-16 Kyowa Hakko Kogyo Co., Ltd. Pyrroloindole derivatives
US5214065A (en) * 1990-06-11 1993-05-25 Kyowa Hakko Kogyo Co., Ltd. Dc-89 derivatives
US5248692A (en) * 1990-06-11 1993-09-28 Kyowa Hakko Kogyo Co., Ltd. DC-89 derivatives as anti-tumor agents
DE69121334T2 (de) * 1990-07-26 1997-03-20 Kyowa Hakko Kogyo Kk DC-89-Derivate als Antitumor-Wirkstoffe
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EP2650306A1 (en) 2006-03-06 2013-10-16 Aeres Biomedical Limited Humanized Anti-CD22 antibodies and their use in treatment of oncology, transplantation and autoimmune disease
TWI412367B (zh) 2006-12-28 2013-10-21 梅達雷克斯有限責任公司 化學鏈接劑與可裂解基質以及其之綴合物
JP2010519310A (ja) * 2007-02-21 2010-06-03 メダレックス インコーポレイテッド 単一のアミノ酸を有する化学リンカーおよびその複合体
BRPI0811466A2 (pt) 2007-05-07 2014-10-14 Medimmune Llc Anticorpo anti-icos isolado, ácido nucleico, vetor, célula isolada, métodos para produzir um anticorpo, para tratar uma doença ou distúrbio, para tratar ou prevenir a rejeição em um paciente de transplante humano, para tratar uma malignidade de célula t em um ser humano, para esgotar células t que expressam icos em um paciente humano, para romper a arquitetura do centro germinal em um órgão linfóide secundário de um primata, para esgotar células b centrais germinais de órgão linfóide secundário de um primata, e para esgotar células b comutadas em classes circulantes em um primata, e, composição farmacêutica.
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CN102264763B (zh) 2008-09-19 2016-04-27 米迪缪尼有限公司 定向于dll4的抗体及其用途
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CA1238907A (en) * 1984-02-21 1988-07-05 Robert C. Kelly 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
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Also Published As

Publication number Publication date
US4923990A (en) 1990-05-08
EP0271581A1 (en) 1988-06-22
JPH0684377B2 (ja) 1994-10-26
WO1987006265A1 (fr) 1987-10-22
EP0271581A4 (en) 1989-06-26
DE3783588T2 (de) 1993-06-09
EP0271581B1 (en) 1993-01-13
DE3783588D1 (de) 1993-02-25

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