DE3750198T3 - Hybridisierungssonden. - Google Patents

Hybridisierungssonden. Download PDF

Info

Publication number
DE3750198T3
DE3750198T3 DE3750198T DE3750198T DE3750198T3 DE 3750198 T3 DE3750198 T3 DE 3750198T3 DE 3750198 T DE3750198 T DE 3750198T DE 3750198 T DE3750198 T DE 3750198T DE 3750198 T3 DE3750198 T3 DE 3750198T3
Authority
DE
Germany
Prior art keywords
probe
nucleotide
nucleotide probe
detectable
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3750198T
Other languages
German (de)
English (en)
Other versions
DE3750198D1 (de
DE3750198T2 (de
Inventor
Francis Joseph Carr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bio Rad Laboratories Inc
Original Assignee
Bio Rad Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10598059&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3750198(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bio Rad Laboratories Inc filed Critical Bio Rad Laboratories Inc
Publication of DE3750198D1 publication Critical patent/DE3750198D1/de
Application granted granted Critical
Publication of DE3750198T2 publication Critical patent/DE3750198T2/de
Anticipated expiration legal-status Critical
Publication of DE3750198T3 publication Critical patent/DE3750198T3/de
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Surgical Instruments (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
DE3750198T 1986-05-19 1987-05-19 Hybridisierungssonden. Expired - Lifetime DE3750198T3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8612087 1986-05-19
GB868612087A GB8612087D0 (en) 1986-05-19 1986-05-19 Hybridisation probes

Publications (3)

Publication Number Publication Date
DE3750198D1 DE3750198D1 (de) 1994-08-18
DE3750198T2 DE3750198T2 (de) 1995-01-26
DE3750198T3 true DE3750198T3 (de) 2008-01-03

Family

ID=10598059

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3750198T Expired - Lifetime DE3750198T3 (de) 1986-05-19 1987-05-19 Hybridisierungssonden.

Country Status (7)

Country Link
EP (1) EP0246864B2 (es)
JP (2) JP2622255B2 (es)
AT (1) ATE108490T1 (es)
DE (1) DE3750198T3 (es)
ES (1) ES2058112T3 (es)
GB (1) GB8612087D0 (es)
HK (1) HK125195A (es)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU622426B2 (en) * 1987-12-11 1992-04-09 Abbott Laboratories Assay using template-dependent nucleic acid probe reorganization
US5449602A (en) * 1988-01-13 1995-09-12 Amoco Corporation Template-directed photoligation
US5093245A (en) * 1988-01-26 1992-03-03 Applied Biosystems Labeling by simultaneous ligation and restriction
IE61148B1 (en) * 1988-03-10 1994-10-05 Ici Plc Method of detecting nucleotide sequences
DE68911648T2 (de) * 1988-03-24 1994-06-23 Univ Iowa Res Found Katalytische hybridisierungs-systeme zum nachweis von nukleinsäuresequenzen, die auf deren aktivität als kofaktoren in katalytischen reaktionen basieren in denen eine komplementäre, markierte nukleinsäureprobe gespalten wird.
US4988617A (en) * 1988-03-25 1991-01-29 California Institute Of Technology Method of detecting a nucleotide change in nucleic acids
US8148065B1 (en) * 1988-04-06 2012-04-03 City Of Hope Ligation amplification of nucleic acid sequences
CA1341584C (en) * 1988-04-06 2008-11-18 Bruce Wallace Method of amplifying and detecting nucleic acid sequences
AU634969B2 (en) * 1988-06-24 1993-03-11 Amgen, Inc. Method and reagents for detecting nucleic acid sequences
EP0425563B1 (en) * 1988-07-20 1996-05-15 David Segev Process for amplifying and detecting nucleic acid sequences
US6004826A (en) * 1988-07-20 1999-12-21 David Segev Repair-mediated process for amplifying and detecting nucleic acid sequences
US5382511A (en) * 1988-08-02 1995-01-17 Gene Tec Corporation Method for studying nucleic acids within immobilized specimens
US5185243A (en) * 1988-08-25 1993-02-09 Syntex (U.S.A.) Inc. Method for detection of specific nucleic acid sequences
GB2225112A (en) * 1988-11-22 1990-05-23 Ici Plc Hybridisation probes
GR1000347B (el) * 1988-12-21 1992-06-25 Ortho Diagnostic Systems Inc Μεθοδος παραγωγης νουκλεοτιδικων ανιχνευτων χρησιμοποιωντας ενα συμπληρωμα γεφυρωσεως.
ATE142272T1 (de) * 1989-01-19 1996-09-15 Behringwerke Ag Nukleinsäure-amplifikation unter verwendung eines einzelprimers
ATE143696T1 (de) * 1989-02-28 1996-10-15 Canon Kk Partiell doppelsträngiges oligonukleotid und verfahren zu seiner bildung
CA2012983A1 (en) * 1989-03-27 1990-09-27 Sydney Brenner Process for nucleic acid detection by binary amplification
US5091302A (en) * 1989-04-27 1992-02-25 The Blood Center Of Southeastern Wisconsin, Inc. Polymorphism of human platelet membrane glycoprotein iiia and diagnostic and therapeutic applications thereof
US5516663A (en) * 1990-01-26 1996-05-14 Abbott Laboratories Ligase chain reaction with endonuclease IV correction and contamination control
US5427930A (en) * 1990-01-26 1995-06-27 Abbott Laboratories Amplification of target nucleic acids using gap filling ligase chain reaction
ES2089038T3 (es) * 1990-01-26 1996-10-01 Abbott Lab Procedimiento mejorado para amplificar acidos nucleicos blanco aplicable para la reaccion en cadena de polimerasa y ligasa.
US5573907A (en) * 1990-01-26 1996-11-12 Abbott Laboratories Detecting and amplifying target nucleic acids using exonucleolytic activity
US6013431A (en) 1990-02-16 2000-01-11 Molecular Tool, Inc. Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators
CA2040896C (en) * 1990-04-20 2002-01-29 Edwin F. Ullman Double receptor polynucleotide assay method
US5494810A (en) * 1990-05-03 1996-02-27 Cornell Research Foundation, Inc. Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5846710A (en) * 1990-11-02 1998-12-08 St. Louis University Method for the detection of genetic diseases and gene sequence variations by single nucleotide primer extension
US6004744A (en) 1991-03-05 1999-12-21 Molecular Tool, Inc. Method for determining nucleotide identity through extension of immobilized primer
US5981176A (en) * 1992-06-17 1999-11-09 City Of Hope Method of detecting and discriminating between nucleic acid sequences
US5695933A (en) * 1993-05-28 1997-12-09 Massachusetts Institute Of Technology Direct detection of expanded nucleotide repeats in the human genome
DE69434314T2 (de) * 1993-11-03 2006-03-30 Orchid Biosciences, Inc. Polymorphismus von mononukleotiden und ihre verwendung in der genanalyse
EP0734457A1 (en) * 1994-01-26 1996-10-02 HYBRIDON, Inc. Method of detecting sub-ppb levels of oligonucleotides in biological fluids
EP0754240B1 (en) * 1994-02-07 2003-08-20 Beckman Coulter, Inc. Ligase/polymerase-mediated genetic bit analysis of single nucleotide polymorphisms and its use in genetic analysis
US5552278A (en) * 1994-04-04 1996-09-03 Spectragen, Inc. DNA sequencing by stepwise ligation and cleavage
US5714330A (en) * 1994-04-04 1998-02-03 Lynx Therapeutics, Inc. DNA sequencing by stepwise ligation and cleavage
US5831065A (en) * 1994-04-04 1998-11-03 Lynx Therapeutics, Inc. Kits for DNA sequencing by stepwise ligation and cleavage
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US6013445A (en) * 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
GB9507238D0 (en) 1995-04-07 1995-05-31 Isis Innovation Detecting dna sequence variations
US5728526A (en) * 1995-06-07 1998-03-17 Oncor, Inc. Method for analyzing a nucleotide sequence
EP0832287B1 (en) * 1995-06-07 2007-10-10 Solexa, Inc Oligonucleotide tags for sorting and identification
DE19610255B4 (de) * 1996-03-15 2004-11-04 Universität Heidelberg Verfahren zur Herstellung von Nukleinsäuresequenzen und Verfahren zum Nachweis von Translokationen zwischen Chromosomen
AU2320597A (en) 1996-03-19 1997-10-10 Molecular Tool, Inc. Method for determining the nucleotide sequence of a polynucleotide
ES2288760T3 (es) 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
ATE245194T1 (de) 1996-10-01 2003-08-15 Geron Corp Katalytische untereinheit der menschlichen telomerase
DE69840439D1 (de) 1997-04-24 2009-02-26 Univ Washington Zielgerichtete genveraenderung mit parvoviralen vektoren
US6960457B1 (en) 1997-09-04 2005-11-01 Stanford University Reversible immobilization of arginine-tagged moieties on a silicate surface
WO2000031302A1 (en) * 1998-11-25 2000-06-02 Isis Pharmaceuticals, Inc. In situ binary synthesis of biologically effective molecules
US6492111B1 (en) * 1998-11-25 2002-12-10 Isis Pharmaceuticals, Inc. In situ binary synthesis of biologically effective molecules
US7014994B1 (en) 1999-03-19 2006-03-21 Cornell Research Foundation,Inc. Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process
WO2000062036A1 (en) * 1999-04-12 2000-10-19 Nanogen/Becton Dickinson Partnership Amplification and separation of nucleic acid sequences using strand displacement amplification and bioelectronic microchip technology
WO2001025481A1 (fr) 1999-10-04 2001-04-12 Olympus Optical Co., Ltd. Procede de detection d'acide nucleique
JP4598338B2 (ja) * 1999-10-04 2010-12-15 オリンパス株式会社 核酸検出方法
JP3668075B2 (ja) 1999-10-12 2005-07-06 光夫 板倉 遺伝物質シーケンス決定用懸濁系、その懸濁系を用いた遺伝物質シーケンス決定方法およびその懸濁系を用いたＳＮＰｓ高速スコアリング方法
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US8076063B2 (en) 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
AU2003303395A1 (en) 2001-05-22 2004-07-22 Dahl, Gary, A. Target-dependent transcription using deletion mutants of n4 rna polymerase
US7291490B2 (en) 2001-06-11 2007-11-06 Ecopia Biosciences Inc. Nucleic acid fragment encoding an NRPS for the biosynthesis of anthramycin
WO2002101051A2 (en) 2001-06-11 2002-12-19 Ecopia Biosciences Inc. Genes and proteins for the biosynthesis of anthramycin
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
ES2661167T3 (es) 2001-10-15 2018-03-27 Bioarray Solutions Ltd. Análisis multiplexado de loci polimórficos mediante consulta simultánea y detección mediada por enzimas
EP1860200A1 (en) * 2001-12-03 2007-11-28 Illumina, Inc. Multiplexed methylation detection methods
JP4694201B2 (ja) 2002-09-20 2011-06-08 インテグレイテッド ディーエヌエイ テクノロジーズ インコーポレイテッド アントラキノン消光色素、それらの製造方法及び使用
WO2004044242A1 (en) * 2002-11-14 2004-05-27 John Nicholas Housby Polymorphism assay
US7526114B2 (en) 2002-11-15 2009-04-28 Bioarray Solutions Ltd. Analysis, secure access to, and transmission of array images
US7595279B2 (en) 2003-09-22 2009-09-29 Bioarray Solutions Ltd. Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
CA2544041C (en) 2003-10-28 2015-12-08 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
US7439341B2 (en) 2003-11-14 2008-10-21 Integrated Dna Technologies, Inc. Fluorescence quenching azo dyes, their methods of preparation and use
JP4892358B2 (ja) 2004-02-04 2012-03-07 ノヴォ ノルディスク アー／エス 哺乳動物グリコシルトランスフェラーゼをリフォールディングする方法
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
CA2601554A1 (en) 2005-05-20 2006-11-30 Integrated Dna Technologies, Inc. Compounds and methods for labeling oligonucleotides
EP2172563A1 (en) * 2008-09-24 2010-04-07 bioMérieux S.A. Method for lowering the dependency towards sequence variation of a nucleic acid target in a diagnostic hybridization assay
JP5886828B2 (ja) 2010-03-26 2016-03-16 インテグレイテッド ディーエヌエイ テクノロジーズ インコーポレイテッド 核酸のハイブリダイゼーションを強化する方法
US9506057B2 (en) 2010-03-26 2016-11-29 Integrated Dna Technologies, Inc. Modifications for antisense compounds
WO2012033848A1 (en) 2010-09-07 2012-03-15 Integrated Dna Technologies, Inc. Modifications for antisense compounds
WO2012058073A2 (en) 2010-10-27 2012-05-03 Harrisvaccines, Inc. Methods and compositions to protect aquatic invertebrates from disease
CN103635584B (zh) 2011-04-12 2017-10-27 冈戈根股份有限公司 嵌合抗菌多肽
JP6028025B2 (ja) 2011-07-08 2016-11-16 キージーン・エン・フェー オリゴヌクレオチド・ライゲーション・アッセイに基づく配列ベースの遺伝子型決定
WO2013103434A1 (en) 2011-10-19 2013-07-11 Harrisvaccines, Inc. Methods and compositions to protect aquatic invertebrates from disease
US9791445B2 (en) 2013-01-28 2017-10-17 Kansas State University Research Foundation Rift Valley Fever Virus glycoproteins, Gn and Gc, and their use
US20170136102A1 (en) 2014-03-27 2017-05-18 Umender Kumar SHARMA Phage-derived compositions for improved mycobacterial therapy
EP3807420A1 (en) 2018-06-12 2021-04-21 Keygene N.V. Nucleic acid amplification method
CA3127572A1 (en) 2019-02-21 2020-08-27 Keygene N.V. Genotyping of polyploids
KR20240034182A (ko) 2021-06-03 2024-03-13 마젠 애니멀 헬스 인코포레이티드 사이토카인 수준을 변경하고 갓 태어난 돼지에게 수동 면역을 제공하기 위한 코로나바이러스 스파이크 단백질의 경구 투여

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1190838A (en) * 1981-07-17 1985-07-23 Cavit Akin Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer
CA1222680A (en) * 1983-07-05 1987-06-09 Nanibhushan Dattagupta Testing dna samples for particular nucleotide sequences
US4883750A (en) * 1984-12-13 1989-11-28 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
EP0224126A3 (en) * 1985-11-25 1989-02-01 The University of Calgary Covalently linked complementary oligodeoxynucleotides as universal nucleic acid sequencing primer linkers
EP0245206A1 (en) * 1986-05-05 1987-11-11 IntraCel Corporation Analytical method for detecting and measuring specifically sequenced nucleic acid

Also Published As

Publication number Publication date
EP0246864B1 (en) 1994-07-13
JPH09182591A (ja) 1997-07-15
JP2683336B2 (ja) 1997-11-26
DE3750198D1 (de) 1994-08-18
EP0246864A2 (en) 1987-11-25
ATE108490T1 (de) 1994-07-15
ES2058112T3 (es) 1994-11-01
DE3750198T2 (de) 1995-01-26
JPS6322197A (ja) 1988-01-29
EP0246864B2 (en) 2007-05-23
EP0246864A3 (en) 1989-08-23
HK125195A (en) 1995-08-11
JP2622255B2 (ja) 1997-06-18
GB8612087D0 (en) 1986-06-25

Similar Documents

Publication Publication Date Title
DE3750198T3 (de) Hybridisierungssonden.
DE68926504T2 (de) Verfahren zur amplifizierung und zum nachweis von nukleinsäuresequenzen
DE68909266T2 (de) Markierung durch gleichzeitige Ligation und Restriktion.
DE3689954T2 (de) Amplifiziertes hybridisierungstestverfahren.
DE69219727T2 (de) Nukleinsäure Zielerzeugung
DE68925717T2 (de) Verfahren und Reagenzkombination zur Bestimmung von Nukleotidsequenzen
DE68927373T2 (de) Verfahren und mittel zum nachweis von nukleinsäuresequenzen
DE68915202T3 (de) Verfahren zur Vermehrung und zum Nachweis von Nukleinsäuresequenzen.
DE69205181T2 (de) Strangverdrängungsamplifikation.
DE2915082C3 (de) Verfahren und Verwendung eines Reagenzsatzes zum Nachweis und zur Charakterisierung von Nukleinsäuren und ihren Sequenzen
DE69029105T2 (de) Schnellverfahren zum Nachweis und/oder zur Identifizierung einer Einzelbase in einer Nukleinsäuresequenz und seine Verwendungen
DE69307317T2 (de) Verwendung von Nuklein-säure Analoge in der Inhibition von Nuklein-säure Amplifikation
DE69301570T2 (de) Verfahren für die sequenzierung von synthetischen oligonukleotiden, welche internukleotid-bindungen enthalten, die nicht vom phosphodiester-typ sind
DE69233458T2 (de) Nukleinsäuretypisierung durch polymeraseverlängerung von oligonukleotiden unter verwendung von terminator-mischungen
DE69233630T2 (de) Sätze von HIV-Sonden zur Verwendung in Sandwich-Hydridisierungsassays in Lösungsphase
DE3446635C2 (de) Synthese von Aminoderivaten von Oligonukleotiden
DE69034197T2 (de) Genomische Klonierung und Kartographie
EP0120376B1 (de) Verfahren zur Durchführung von Hybridisierungsreaktionen
DE69003477T2 (de) Verfahren zum Nachweis von Nucleinsäuren.
DE3629190A1 (de) Verfahren zum nachweis und zur reinigung einer einzelne basenfehlpaarungen aufweisenden dna
WO1991003573A1 (de) Verfahren zur vermehrung von nukleinsäuren
DE69029113T2 (de) Verfahren zur Bestimmung von Allelen für zystische Fibrose
DE3485834T2 (de) Verfahren zum bestimmen von nukleinsaeuresequenzen.
DE68923608T2 (de) Verfahren zur Vorbereitung von Nukleotid-Sonden unter Verwendung eines hybridizierbaren Komplementärelements.
DE3486290T2 (de) In vivo-Markierung von Polynucleotide-Sequenzen.

Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings