DE3112566A1 - Monacolin-derivate, verfahren zu ihrer herstellung und diese derivate enthaltende arzneimittel - Google Patents

Monacolin-derivate, verfahren zu ihrer herstellung und diese derivate enthaltende arzneimittel

Info

Publication number
DE3112566A1
DE3112566A1 DE19813112566 DE3112566A DE3112566A1 DE 3112566 A1 DE3112566 A1 DE 3112566A1 DE 19813112566 DE19813112566 DE 19813112566 DE 3112566 A DE3112566 A DE 3112566A DE 3112566 A1 DE3112566 A1 DE 3112566A1
Authority
DE
Germany
Prior art keywords
group
branched
bis
straight
chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19813112566
Other languages
German (de)
English (en)
Other versions
DE3112566C2 (ja
Inventor
Aiya Dr. Kawaguchi Saitama Sato
Akira Dr. Tokyo Terahara
Yoshio Dr. Ichikawa Chiba Tsujita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=12604367&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3112566(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of DE3112566A1 publication Critical patent/DE3112566A1/de
Application granted granted Critical
Publication of DE3112566C2 publication Critical patent/DE3112566C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE19813112566 1980-03-31 1981-03-30 Monacolin-derivate, verfahren zu ihrer herstellung und diese derivate enthaltende arzneimittel Granted DE3112566A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55041292A JPH0692381B2 (ja) 1980-03-31 1980-03-31 Ｍｂ−５３０ａ誘導体

Publications (2)

Publication Number Publication Date
DE3112566A1 true DE3112566A1 (de) 1982-03-11
DE3112566C2 DE3112566C2 (ja) 1990-04-05

Family

ID=12604367

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19813112566 Granted DE3112566A1 (de) 1980-03-31 1981-03-30 Monacolin-derivate, verfahren zu ihrer herstellung und diese derivate enthaltende arzneimittel
DE3153666A Expired - Lifetime DE3153666C2 (de) 1980-03-31 1981-03-30 Monacolinderivate, Verfahren zu ihrer Herstellung und diese Derivate enthaltende Arzneimittel

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE3153666A Expired - Lifetime DE3153666C2 (de) 1980-03-31 1981-03-30 Monacolinderivate, Verfahren zu ihrer Herstellung und diese Derivate enthaltende Arzneimittel

Country Status (15)

Country Link
JP (1) JPH0692381B2 (ja)
AT (1) ATA150781A (ja)
AU (1) AU6893281A (ja)
BE (1) BE888214A (ja)
CH (1) CH646966A5 (ja)
DE (2) DE3112566A1 (ja)
DK (3) DK151273C (ja)
FI (1) FI810991L (ja)
FR (1) FR2479222A1 (ja)
GB (1) GB2073193A (ja)
IE (1) IE52367B1 (ja)
IT (1) IT1144325B (ja)
MX (1) MX9203567A (ja)
NL (1) NL8101592A (ja)
SE (1) SE461590B (ja)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4472426A (en) * 1982-12-22 1984-09-18 Merck & Co., Inc. Antihypercholesterolemic compounds
DE3682557D1 (de) * 1985-09-13 1992-01-02 Sankyo Co Hydroxy-ml-236b-derivate, deren herstellung und anwendung.
US4997848A (en) * 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
US5075327A (en) * 1988-08-10 1991-12-24 Hoffmann-La Roche Inc. Antipsoriatic agents
US5021451A (en) * 1988-11-14 1991-06-04 Hoffman-La Roche Inc. Method for inhibiting hyperproliferative diseases
US5200549A (en) * 1988-11-14 1993-04-06 Hoffman-La Roche Inc. Antipsoriatic agents
US5073568A (en) * 1988-11-14 1991-12-17 Hoffmann-La Roche Inc. Antipsoriatic agents
US5159104A (en) * 1991-05-01 1992-10-27 Merck & Co., Inc. Process to simvastatin ester
FR2937537A1 (fr) * 2008-10-29 2010-04-30 Centre Nat Rech Scient Nanoparticules de statine
KR101820099B1 (ko) 2013-01-18 2018-01-18 에스프린팅솔루션 주식회사 저항 발열체, 이를 채용한 가열 부재, 및 정착 장치
RU2020126177A (ru) 2018-01-09 2022-02-10 Лиганд Фармасьютикалз, Инк. Ацетальные соединения и их терапевтическое применение

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3983140A (en) * 1974-06-07 1976-09-28 Sankyo Company Limited Physiologically active substances
DE3006216A1 (de) * 1979-02-20 1980-09-04 Sankyo Co Neue verbindung monacolin k, verfahren zu ihrer herstellung und diese verbindung enthaltende arzneimittel
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
EP0033536A2 (en) * 1980-02-04 1981-08-12 Merck & Co. Inc. 6(R)-(2-(8'-etherified-hydroxy-2',6'-dimethylpolyhydro-naphthyl-1')-ethyl)-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones, the hydroxy acid form of said pyranones, the salts of said acid form, process for preparing the same and an antihypercholesterolemic pharmaceutical composition containing the same
EP0033538A2 (en) * 1980-02-04 1981-08-12 Merck & Co. Inc. 6(R)-(2-(8'-acyloxy-2'-methyl-6'-methyl (or hydrogen)-polyhydronaphthyl-1')-ethyl)-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones, the hydroxy acid form of said pyranones, the pharmaceutically acceptable salts of said hydroxy acids, and the lower alkyl, and phenyl, dimethylamino or acetylamino substituted lower alkyl esters of said hydroxy acid, processes for preparing the same, and a pharmaceutical antihypercholesterolemic composition containing the same
EP0033537A2 (en) * 1980-02-04 1981-08-12 Merck & Co. Inc. Hydrogenation products of mevinolin and dihydromevinolin, a process for preparing the same and an antihypercholesterolemic pharmaceutical composition containing the same
EP0022478B1 (en) * 1979-06-15 1983-02-23 Merck & Co. Inc. Polyhydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl)-ethyl)-1-naphthylenyl-2-methylbutanoates, corresponding hydroxy acids, process for preparing and pharmaceutical compositions containing the same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA81703B (en) * 1980-02-04 1982-09-29 Merck & Co Inc New antihypercholesterolemic compounds,intermediates and processes

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3983140A (en) * 1974-06-07 1976-09-28 Sankyo Company Limited Physiologically active substances
DE3006216A1 (de) * 1979-02-20 1980-09-04 Sankyo Co Neue verbindung monacolin k, verfahren zu ihrer herstellung und diese verbindung enthaltende arzneimittel
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
EP0022478B1 (en) * 1979-06-15 1983-02-23 Merck & Co. Inc. Polyhydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl)-ethyl)-1-naphthylenyl-2-methylbutanoates, corresponding hydroxy acids, process for preparing and pharmaceutical compositions containing the same
EP0033536A2 (en) * 1980-02-04 1981-08-12 Merck & Co. Inc. 6(R)-(2-(8'-etherified-hydroxy-2',6'-dimethylpolyhydro-naphthyl-1')-ethyl)-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones, the hydroxy acid form of said pyranones, the salts of said acid form, process for preparing the same and an antihypercholesterolemic pharmaceutical composition containing the same
EP0033538A2 (en) * 1980-02-04 1981-08-12 Merck & Co. Inc. 6(R)-(2-(8'-acyloxy-2'-methyl-6'-methyl (or hydrogen)-polyhydronaphthyl-1')-ethyl)-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones, the hydroxy acid form of said pyranones, the pharmaceutically acceptable salts of said hydroxy acids, and the lower alkyl, and phenyl, dimethylamino or acetylamino substituted lower alkyl esters of said hydroxy acid, processes for preparing the same, and a pharmaceutical antihypercholesterolemic composition containing the same
EP0033537A2 (en) * 1980-02-04 1981-08-12 Merck & Co. Inc. Hydrogenation products of mevinolin and dihydromevinolin, a process for preparing the same and an antihypercholesterolemic pharmaceutical composition containing the same

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Atherosclerosis V, Proceedings of the fifth Internat. Symp., Springer Verlag, New York, 1980, Deckblatt, S. XIV, S. 152-155
Atherosclerosis V, Proceedings of the fifth Internat. Symp., Springer Verlag, New York, 1980, Deckblatt, S. XIV, S. 152-155, Hakko Kogaku (Ferment. Engin.) 64 (1986), S. 509-512 *
Atherosclerosis V, Springer-Verlag, 1980 *
Chem. Abstr. 93, 1980, 106594 *
Hakko Kogaku (Ferment. Engin.) 64 (1986), S. 509-512
J. Antibiotics XXXII, 1979, S. 852-854 *

Also Published As

Publication number Publication date
AU6893281A (en) 1981-10-08
SE8102047L (sv) 1981-10-01
DK145481A (da) 1981-10-01
IT1144325B (it) 1986-10-29
BE888214A (fr) 1981-09-30
ATA150781A (de) 1983-03-15
DK32290D0 (da) 1990-02-07
DK32290A (da) 1990-02-07
DK167805B1 (da) 1993-12-20
FR2479222B1 (ja) 1983-08-26
MX9203567A (es) 1992-09-01
DK32190D0 (da) 1990-02-07
GB2073193A (en) 1981-10-14
JPS56138181A (en) 1981-10-28
FR2479222A1 (fr) 1981-10-02
CH646966A5 (de) 1984-12-28
DK32190A (da) 1990-02-07
SE461590B (sv) 1990-03-05
DK151273C (da) 1988-07-04
IT8167438A0 (it) 1981-03-30
IE810698L (en) 1981-09-30
DE3153666C2 (de) 1993-11-11
DK151273B (da) 1987-11-16
FI810991L (fi) 1981-10-01
JPH0692381B2 (ja) 1994-11-16
DE3112566C2 (ja) 1990-04-05
NL8101592A (nl) 1981-10-16
IE52367B1 (en) 1987-09-30

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