JPS56138181A - Ml-236a and mb-530a derivative - Google Patents

Ml-236a and mb-530a derivative

Info

Publication number
JPS56138181A
JPS56138181A JP4129280A JP4129280A JPS56138181A JP S56138181 A JPS56138181 A JP S56138181A JP 4129280 A JP4129280 A JP 4129280A JP 4129280 A JP4129280 A JP 4129280A JP S56138181 A JPS56138181 A JP S56138181A
Authority
JP
Japan
Prior art keywords
formula
ferm
compound
sank18174
sank15177
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP4129280A
Other languages
Japanese (ja)
Other versions
JPH0692381B2 (en
Inventor
Aiya Satou
Akira Terahara
Yoshio Tsujita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=12604367&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPS56138181(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP55041292A priority Critical patent/JPH0692381B2/en
Priority to IE698/81A priority patent/IE52367B1/en
Priority to DE3153666A priority patent/DE3153666C2/en
Priority to DE19813112566 priority patent/DE3112566A1/en
Priority to CH215381A priority patent/CH646966A5/en
Priority to IT67438/81A priority patent/IT1144325B/en
Priority to AU68932/81A priority patent/AU6893281A/en
Priority to NL8101592A priority patent/NL8101592A/en
Priority to DK145481A priority patent/DK151273C/en
Priority to FR8106403A priority patent/FR2479222A1/en
Priority to KR1019810001067A priority patent/KR840001958B1/en
Priority to AT0150781A priority patent/ATA150781A/en
Priority to FI810991A priority patent/FI810991L/en
Priority to SE8102047A priority patent/SE461590B/en
Priority to GB8110075A priority patent/GB2073193A/en
Priority to BE0/204328A priority patent/BE888214A/en
Publication of JPS56138181A publication Critical patent/JPS56138181A/en
Priority to DK542085A priority patent/DK159439C/en
Priority to DK032290A priority patent/DK32290D0/en
Priority to DK032190A priority patent/DK167805B1/en
Priority to MX9203567A priority patent/MX9203567A/en
Publication of JPH0692381B2 publication Critical patent/JPH0692381B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Abstract

NEW MATERIAL:A compound of formula I (R1 and R2 are H or acyl; R3 is H or methyl, except when R1, R2 and R3 are all H or when R1 is H and R2 is α-methylbutyryl).
EXAMPLE: ML-236A-3,8'-diformate.
USE: Useful as an antilipemic agent and a preventing agent against antiarteriosclerosis having an action on lowering the lipoid cocn, in blood by inhibiting the biosynthesis of the cholesterol.
PROCESS: ML-236A of formula II, ML-236B of formula III, ML-530A of formula IV or ML-530B of formula V is reacted with an acid chloride in the presence of an organic amine in an inert solvent to give the compound of formula I. The ML-530A and B are novel substances and the ML-530A or B is obtained by cultivating Monascus ruber SANK15177 (FERM-P No.4965) or SANK18174 (FERM-P No. 4957).
COPYRIGHT: (C)1981,JPO&Japio
JP55041292A 1980-03-31 1980-03-31 MB-530A derivative Expired - Lifetime JPH0692381B2 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
JP55041292A JPH0692381B2 (en) 1980-03-31 1980-03-31 MB-530A derivative
IE698/81A IE52367B1 (en) 1980-03-31 1981-03-27 Inhibitors of cholesterol biosynthesis,their preparation and use
DE3153666A DE3153666C2 (en) 1980-03-31 1981-03-30 Monacoline derivatives, processes for their preparation and medicinal products containing them
DE19813112566 DE3112566A1 (en) 1980-03-31 1981-03-30 MONACOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE DERIVATIVES
CH215381A CH646966A5 (en) 1980-03-31 1981-03-30 CHOLESTERIN BIOSYNTHESIS INHIBITING COMPOUNDS, THEIR PRODUCTION AND USE.
IT67438/81A IT1144325B (en) 1980-03-31 1981-03-30 CHOLESTEROL BIOSYNTHESIS INHIBITORS THEIR PREPARATION AND USE
BE0/204328A BE888214A (en) 1980-03-31 1981-03-31 DERIVATIVES OF MONACOLIN K TYPE COMPOUNDS HAVING INHIBITORY ACTIVITY ON THE BIOSYNTHESIS OF CHOLESTEROL
KR1019810001067A KR840001958B1 (en) 1980-03-31 1981-03-31 Process for preparing compounds having inhibitory activity against the biosyn-thesis of cholesterol
NL8101592A NL8101592A (en) 1980-03-31 1981-03-31 CHOLESTEROL BIOSYNTHESIS BRAKES, THEIR PREPARATION AND USE.
DK145481A DK151273C (en) 1980-03-31 1981-03-31 PROCEDURE FOR THE PREPARATION OF THE CHOLESTEROL BIOSYNTHESE INHIBITOR MB-530A.
FR8106403A FR2479222A1 (en) 1980-03-31 1981-03-31 COMPOUND DERIVATIVES OF MONACOLIN K TYPE HAVING INHIBITORY ACTIVITY ON CHOLESTEROL BIOSYNTHESIS, PREPARATION METHOD AND THERAPEUTIC USE THEREOF
AU68932/81A AU6893281A (en) 1980-03-31 1981-03-31 4,6-disubstituted tetrahydropyran-2-one derivatives
AT0150781A ATA150781A (en) 1980-03-31 1981-03-31 METHOD FOR PRODUCING NEW CHOLESTERINE BIOSYNTHESIS INHIBITORS
FI810991A FI810991L (en) 1980-03-31 1981-03-31 INHIBITOR AV CHOLESTEROLS BIOSYNTES DERAS FRAMSTAELLNING OCH ANVAENDNING
SE8102047A SE461590B (en) 1980-03-31 1981-03-31 DERIVATIVES OF 6-HEXAHYDRONAFTYLETHYL-4-HYDROXY-TETRAHYDROPYRENE-2-ON, PROCEDURES FOR PREPARING THESE AND A PHARMACEUTICAL COMPOSITION FOR USE FOR INHIBITION OF CHOLESTEROL
GB8110075A GB2073193A (en) 1980-03-31 1981-03-31 Inhibitors of Cholesterol Biosynthesis, their Preparation and Use
DK542085A DK159439C (en) 1980-03-31 1985-11-22 ANALOGY PROCEDURE FOR PREPARING CHOLESTEROL SYNTHESIS INHIBITORS
DK032190A DK167805B1 (en) 1980-03-31 1990-02-07 INTERMEDIATE FOR THE PREPARATION OF CHOLESTEROL SYNTHESIS INHIBITORS
DK032290A DK32290D0 (en) 1980-03-31 1990-02-07 APPLICATION OF 8'-ACYLED DERIVATIVES OF THE INTERMEDIATE COMPOUND MB-530A FOR THE PREPARATION OF A MEDICINE FOR TREATING HYPERCHOLESTEROLAEMIA
MX9203567A MX9203567A (en) 1980-03-31 1992-06-26 MONOCOLIN DERIVATIVE, PROCEDURE FOR ITS PREPARATION AND MEDICATION CONTAINED IN THIS DERIVATIVE.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55041292A JPH0692381B2 (en) 1980-03-31 1980-03-31 MB-530A derivative

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP11356790A Division JPH0334975A (en) 1990-04-27 1990-04-27 Ml-236a and mb-530a derivative

Publications (2)

Publication Number Publication Date
JPS56138181A true JPS56138181A (en) 1981-10-28
JPH0692381B2 JPH0692381B2 (en) 1994-11-16

Family

ID=12604367

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55041292A Expired - Lifetime JPH0692381B2 (en) 1980-03-31 1980-03-31 MB-530A derivative

Country Status (15)

Country Link
JP (1) JPH0692381B2 (en)
AT (1) ATA150781A (en)
AU (1) AU6893281A (en)
BE (1) BE888214A (en)
CH (1) CH646966A5 (en)
DE (2) DE3112566A1 (en)
DK (3) DK151273C (en)
FI (1) FI810991L (en)
FR (1) FR2479222A1 (en)
GB (1) GB2073193A (en)
IE (1) IE52367B1 (en)
IT (1) IT1144325B (en)
MX (1) MX9203567A (en)
NL (1) NL8101592A (en)
SE (1) SE461590B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021509907A (en) * 2018-01-09 2021-04-08 リガンド・ファーマシューティカルズ・インコーポレイテッド Acetal compounds and their therapeutic use
US11970482B2 (en) 2019-01-08 2024-04-30 Ligand Pharmaceuticals Inc. Acetal compounds and therapeutic uses thereof

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4472426A (en) * 1982-12-22 1984-09-18 Merck & Co., Inc. Antihypercholesterolemic compounds
DE3682557D1 (en) * 1985-09-13 1992-01-02 Sankyo Co HYDROXY-ML-236B DERIVATIVES, THEIR PRODUCTION AND USE.
US4997848A (en) 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
US5075327A (en) * 1988-08-10 1991-12-24 Hoffmann-La Roche Inc. Antipsoriatic agents
US5021451A (en) * 1988-11-14 1991-06-04 Hoffman-La Roche Inc. Method for inhibiting hyperproliferative diseases
US5073568A (en) * 1988-11-14 1991-12-17 Hoffmann-La Roche Inc. Antipsoriatic agents
US5200549A (en) * 1988-11-14 1993-04-06 Hoffman-La Roche Inc. Antipsoriatic agents
US5159104A (en) * 1991-05-01 1992-10-27 Merck & Co., Inc. Process to simvastatin ester
FR2937537A1 (en) * 2008-10-29 2010-04-30 Centre Nat Rech Scient NANOPARTICLES OF STATIN
KR101820099B1 (en) 2013-01-18 2018-01-18 에스프린팅솔루션 주식회사 resistive heat generating material, heating member and fusing device adopting the same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56122375A (en) * 1980-02-04 1981-09-25 Merck & Co Inc Novel antihypercholesteremic compound* its intermediate and its manufacture

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (en) * 1974-06-07 1981-03-18
JPS5925599B2 (en) * 1979-02-20 1984-06-19 三共株式会社 New physiologically active substance monacolin K and its production method
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
IL60219A (en) * 1979-06-15 1985-05-31 Merck & Co Inc Hypocholesteremic fermentation products of the hmg-coa reductase inhibitor type,their preparation and pharmaceutical compositions containing them
PT72394B (en) * 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics
US4282155A (en) * 1980-02-04 1981-08-04 Merck & Co., Inc. Antihypercholesterolemic compounds
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56122375A (en) * 1980-02-04 1981-09-25 Merck & Co Inc Novel antihypercholesteremic compound* its intermediate and its manufacture

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021509907A (en) * 2018-01-09 2021-04-08 リガンド・ファーマシューティカルズ・インコーポレイテッド Acetal compounds and their therapeutic use
US11970482B2 (en) 2019-01-08 2024-04-30 Ligand Pharmaceuticals Inc. Acetal compounds and therapeutic uses thereof

Also Published As

Publication number Publication date
DE3112566C2 (en) 1990-04-05
DE3112566A1 (en) 1982-03-11
IE810698L (en) 1981-09-30
AU6893281A (en) 1981-10-08
DK167805B1 (en) 1993-12-20
IT1144325B (en) 1986-10-29
DK32290A (en) 1990-02-07
GB2073193A (en) 1981-10-14
DK151273C (en) 1988-07-04
DE3153666C2 (en) 1993-11-11
DK32290D0 (en) 1990-02-07
MX9203567A (en) 1992-09-01
IT8167438A0 (en) 1981-03-30
SE8102047L (en) 1981-10-01
BE888214A (en) 1981-09-30
FR2479222A1 (en) 1981-10-02
DK145481A (en) 1981-10-01
DK32190A (en) 1990-02-07
NL8101592A (en) 1981-10-16
CH646966A5 (en) 1984-12-28
DK151273B (en) 1987-11-16
DK32190D0 (en) 1990-02-07
FR2479222B1 (en) 1983-08-26
SE461590B (en) 1990-03-05
IE52367B1 (en) 1987-09-30
ATA150781A (en) 1983-03-15
JPH0692381B2 (en) 1994-11-16
FI810991L (en) 1981-10-01

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