IE810698L - Pyranone derivatives - Google Patents
Pyranone derivativesInfo
- Publication number
- IE810698L IE810698L IE810698A IE69881A IE810698L IE 810698 L IE810698 L IE 810698L IE 810698 A IE810698 A IE 810698A IE 69881 A IE69881 A IE 69881A IE 810698 L IE810698 L IE 810698L
- Authority
- IE
- Ireland
- Prior art keywords
- hydrogen atom
- compounds
- prepared
- group
- pyranone derivatives
- Prior art date
Links
- ZPSJGADGUYYRKE-UHFFFAOYSA-N 2H-pyran-2-one Chemical class O=C1C=CC=CO1 ZPSJGADGUYYRKE-UHFFFAOYSA-N 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 241000228347 Monascus <ascomycete fungus> Species 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Compounds of formula (I): (in which R<1> and R<2>, which may be the same or different, each represents a hydrogen atom or an acyl group and R<3> represents a hydrogen atom or a methyl group, provided that, where R<1> represents a hydrogen atom, R<2> and R<3> cannot simultaneously be hydrogen atoms and R<2> cannot be a a- methylbutyryl group) inhibit the biosynthesis of cholesterol and hence can be used for the treatment of disorders resulting from high cholesterol levels. The compounds of the invention can be prepared by acylation of corresponding compounds where one or both of R<1> and R<2> represents a hydrogen atom and these may, in turn, be prepared by cultivation of microoorganisms of the genus Monascus.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55041292A JPH0692381B2 (en) | 1980-03-31 | 1980-03-31 | MB-530A derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE810698L true IE810698L (en) | 1981-09-30 |
| IE52367B1 IE52367B1 (en) | 1987-09-30 |
Family
ID=12604367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE698/81A IE52367B1 (en) | 1980-03-31 | 1981-03-27 | Inhibitors of cholesterol biosynthesis,their preparation and use |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPH0692381B2 (en) |
| AT (1) | ATA150781A (en) |
| AU (1) | AU6893281A (en) |
| BE (1) | BE888214A (en) |
| CH (1) | CH646966A5 (en) |
| DE (2) | DE3112566A1 (en) |
| DK (3) | DK151273C (en) |
| FI (1) | FI810991L (en) |
| FR (1) | FR2479222A1 (en) |
| GB (1) | GB2073193A (en) |
| IE (1) | IE52367B1 (en) |
| IT (1) | IT1144325B (en) |
| MX (1) | MX9203567A (en) |
| NL (1) | NL8101592A (en) |
| SE (1) | SE461590B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4472426A (en) * | 1982-12-22 | 1984-09-18 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| EP0215665B1 (en) * | 1985-09-13 | 1991-11-21 | Sankyo Company Limited | Hydroxy-ml-236b derivatives, their preparation and use |
| US4997848A (en) * | 1987-10-27 | 1991-03-05 | Sankyo Company, Limited | Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition |
| US5075327A (en) * | 1988-08-10 | 1991-12-24 | Hoffmann-La Roche Inc. | Antipsoriatic agents |
| US5021451A (en) * | 1988-11-14 | 1991-06-04 | Hoffman-La Roche Inc. | Method for inhibiting hyperproliferative diseases |
| US5073568A (en) * | 1988-11-14 | 1991-12-17 | Hoffmann-La Roche Inc. | Antipsoriatic agents |
| US5200549A (en) * | 1988-11-14 | 1993-04-06 | Hoffman-La Roche Inc. | Antipsoriatic agents |
| US5159104A (en) * | 1991-05-01 | 1992-10-27 | Merck & Co., Inc. | Process to simvastatin ester |
| FR2937537A1 (en) | 2008-10-29 | 2010-04-30 | Centre Nat Rech Scient | NANOPARTICLES OF STATIN |
| KR101820099B1 (en) | 2013-01-18 | 2018-01-18 | 에스프린팅솔루션 주식회사 | resistive heat generating material, heating member and fusing device adopting the same |
| JP2021509907A (en) * | 2018-01-09 | 2021-04-08 | リガンド・ファーマシューティカルズ・インコーポレイテッド | Acetal compounds and their therapeutic use |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5612114B2 (en) * | 1974-06-07 | 1981-03-18 | ||
| JPS5925599B2 (en) * | 1979-02-20 | 1984-06-19 | 三共株式会社 | New physiologically active substance monacolin K and its production method |
| AU535944B2 (en) * | 1979-06-15 | 1984-04-12 | Merck & Co., Inc. | Hypocholestermic fermentation products from aspergillus |
| US4231938A (en) * | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| US4282155A (en) * | 1980-02-04 | 1981-08-04 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| ZA81703B (en) * | 1980-02-04 | 1982-09-29 | Merck & Co Inc | New antihypercholesterolemic compounds,intermediates and processes |
| AU548996B2 (en) * | 1980-02-04 | 1986-01-09 | Merck & Co., Inc. | Tetrahydro-2h-pyran-2-one derivatives |
| PT72394B (en) * | 1980-02-04 | 1982-09-06 | Merck & Co Inc | Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics |
-
1980
- 1980-03-31 JP JP55041292A patent/JPH0692381B2/en not_active Expired - Lifetime
-
1981
- 1981-03-27 IE IE698/81A patent/IE52367B1/en not_active IP Right Cessation
- 1981-03-30 CH CH215381A patent/CH646966A5/en not_active IP Right Cessation
- 1981-03-30 DE DE19813112566 patent/DE3112566A1/en active Granted
- 1981-03-30 DE DE3153666A patent/DE3153666C2/en not_active Expired - Lifetime
- 1981-03-30 IT IT67438/81A patent/IT1144325B/en active
- 1981-03-31 NL NL8101592A patent/NL8101592A/en not_active Application Discontinuation
- 1981-03-31 AT AT0150781A patent/ATA150781A/en not_active IP Right Cessation
- 1981-03-31 SE SE8102047A patent/SE461590B/en not_active Application Discontinuation
- 1981-03-31 FI FI810991A patent/FI810991L/en not_active Application Discontinuation
- 1981-03-31 FR FR8106403A patent/FR2479222A1/en active Granted
- 1981-03-31 BE BE0/204328A patent/BE888214A/en not_active IP Right Cessation
- 1981-03-31 DK DK145481A patent/DK151273C/en not_active IP Right Cessation
- 1981-03-31 AU AU68932/81A patent/AU6893281A/en not_active Abandoned
- 1981-03-31 GB GB8110075A patent/GB2073193A/en not_active Withdrawn
-
1990
- 1990-02-07 DK DK032290A patent/DK32290A/en not_active Application Discontinuation
- 1990-02-07 DK DK032190A patent/DK167805B1/en not_active IP Right Cessation
-
1992
- 1992-06-26 MX MX9203567A patent/MX9203567A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IT1144325B (en) | 1986-10-29 |
| JPS56138181A (en) | 1981-10-28 |
| ATA150781A (en) | 1983-03-15 |
| MX9203567A (en) | 1992-09-01 |
| DE3112566A1 (en) | 1982-03-11 |
| DE3112566C2 (en) | 1990-04-05 |
| NL8101592A (en) | 1981-10-16 |
| FI810991L (en) | 1981-10-01 |
| FR2479222A1 (en) | 1981-10-02 |
| SE461590B (en) | 1990-03-05 |
| JPH0692381B2 (en) | 1994-11-16 |
| IE52367B1 (en) | 1987-09-30 |
| DK145481A (en) | 1981-10-01 |
| SE8102047L (en) | 1981-10-01 |
| DK32190A (en) | 1990-02-07 |
| DK151273C (en) | 1988-07-04 |
| BE888214A (en) | 1981-09-30 |
| GB2073193A (en) | 1981-10-14 |
| IT8167438A0 (en) | 1981-03-30 |
| DK167805B1 (en) | 1993-12-20 |
| DK32290D0 (en) | 1990-02-07 |
| AU6893281A (en) | 1981-10-08 |
| DE3153666C2 (en) | 1993-11-11 |
| DK151273B (en) | 1987-11-16 |
| DK32190D0 (en) | 1990-02-07 |
| FR2479222B1 (en) | 1983-08-26 |
| DK32290A (en) | 1990-02-07 |
| CH646966A5 (en) | 1984-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK9A | Patent expired |