BE888214A - Derives de composes du type monacoline k ayant une activite inhibitrice sur la biosynthese du cholesterol - Google Patents

Derives de composes du type monacoline k ayant une activite inhibitrice sur la biosynthese du cholesterol

Info

Publication number
BE888214A
BE888214A BE0/204328A BE204328A BE888214A BE 888214 A BE888214 A BE 888214A BE 0/204328 A BE0/204328 A BE 0/204328A BE 204328 A BE204328 A BE 204328A BE 888214 A BE888214 A BE 888214A
Authority
BE
Belgium
Prior art keywords
monacolin
biosynthesis
cholesterol
derivatives
inhibitory activity
Prior art date
Application number
BE0/204328A
Other languages
English (en)
French (fr)
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=12604367&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE888214(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of BE888214A publication Critical patent/BE888214A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BE0/204328A 1980-03-31 1981-03-31 Derives de composes du type monacoline k ayant une activite inhibitrice sur la biosynthese du cholesterol BE888214A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55041292A JPH0692381B2 (ja) 1980-03-31 1980-03-31 Ｍｂ−５３０ａ誘導体

Publications (1)

Publication Number Publication Date
BE888214A true BE888214A (fr) 1981-09-30

Family

ID=12604367

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/204328A BE888214A (fr) 1980-03-31 1981-03-31 Derives de composes du type monacoline k ayant une activite inhibitrice sur la biosynthese du cholesterol

Country Status (15)

Country Link
JP (1) JPH0692381B2 (ja)
AT (1) ATA150781A (ja)
AU (1) AU6893281A (ja)
BE (1) BE888214A (ja)
CH (1) CH646966A5 (ja)
DE (2) DE3112566A1 (ja)
DK (3) DK151273C (ja)
FI (1) FI810991L (ja)
FR (1) FR2479222A1 (ja)
GB (1) GB2073193A (ja)
IE (1) IE52367B1 (ja)
IT (1) IT1144325B (ja)
MX (1) MX9203567A (ja)
NL (1) NL8101592A (ja)
SE (1) SE461590B (ja)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4472426A (en) * 1982-12-22 1984-09-18 Merck & Co., Inc. Antihypercholesterolemic compounds
DE3682557D1 (de) * 1985-09-13 1992-01-02 Sankyo Co Hydroxy-ml-236b-derivate, deren herstellung und anwendung.
US4997848A (en) * 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
US5075327A (en) * 1988-08-10 1991-12-24 Hoffmann-La Roche Inc. Antipsoriatic agents
US5021451A (en) * 1988-11-14 1991-06-04 Hoffman-La Roche Inc. Method for inhibiting hyperproliferative diseases
US5200549A (en) * 1988-11-14 1993-04-06 Hoffman-La Roche Inc. Antipsoriatic agents
US5073568A (en) * 1988-11-14 1991-12-17 Hoffmann-La Roche Inc. Antipsoriatic agents
US5159104A (en) * 1991-05-01 1992-10-27 Merck & Co., Inc. Process to simvastatin ester
FR2937537A1 (fr) * 2008-10-29 2010-04-30 Centre Nat Rech Scient Nanoparticules de statine
KR101820099B1 (ko) 2013-01-18 2018-01-18 에스프린팅솔루션 주식회사 저항 발열체, 이를 채용한 가열 부재, 및 정착 장치
RU2020126177A (ru) 2018-01-09 2022-02-10 Лиганд Фармасьютикалз, Инк. Ацетальные соединения и их терапевтическое применение

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (ja) * 1974-06-07 1981-03-18
JPS5925599B2 (ja) * 1979-02-20 1984-06-19 三共株式会社 新生理活性物質モナコリンｋおよびその製造法
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
AU535944B2 (en) * 1979-06-15 1984-04-12 Merck & Co., Inc. Hypocholestermic fermentation products from aspergillus
PT72394B (en) * 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics
US4282155A (en) * 1980-02-04 1981-08-04 Merck & Co., Inc. Antihypercholesterolemic compounds
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
ZA81703B (en) * 1980-02-04 1982-09-29 Merck & Co Inc New antihypercholesterolemic compounds,intermediates and processes

Also Published As

Publication number Publication date
AU6893281A (en) 1981-10-08
SE8102047L (sv) 1981-10-01
DK145481A (da) 1981-10-01
DE3112566A1 (de) 1982-03-11
IT1144325B (it) 1986-10-29
ATA150781A (de) 1983-03-15
DK32290D0 (da) 1990-02-07
DK32290A (da) 1990-02-07
DK167805B1 (da) 1993-12-20
FR2479222B1 (ja) 1983-08-26
MX9203567A (es) 1992-09-01
DK32190D0 (da) 1990-02-07
GB2073193A (en) 1981-10-14
JPS56138181A (en) 1981-10-28
FR2479222A1 (fr) 1981-10-02
CH646966A5 (de) 1984-12-28
DK32190A (da) 1990-02-07
SE461590B (sv) 1990-03-05
DK151273C (da) 1988-07-04
IT8167438A0 (it) 1981-03-30
IE810698L (en) 1981-09-30
DE3153666C2 (de) 1993-11-11
DK151273B (da) 1987-11-16
FI810991L (fi) 1981-10-01
JPH0692381B2 (ja) 1994-11-16
DE3112566C2 (ja) 1990-04-05
NL8101592A (nl) 1981-10-16
IE52367B1 (en) 1987-09-30

Similar Documents

Publication Publication Date Title
FI864359A0 (fi) Gestaltande dopplerinterferometer.
FI862575A (fi) Paosar foersedda med en dragkedja och foerfarande och anordning foer manuellt fyllning och separering av dem.
FI870919A (fi) Anordning foer avsaltning av saltvatten med membrandestillation.
NO855163L (no) Fremgangsmaate for fremstilling av acylerte diketon-forbindelser.
BE888214A (fr) Derives de composes du type monacoline k ayant une activite inhibitrice sur la biosynthese du cholesterol
ES517862A0 (es) Derivados de alcanosulfonanilida.
IT1157304B (it) Determinazione di enzimi immunochimica
FR2543552B1 (fr) Derives de 3-isoxazolyl-2-imidazolidinone doues d'une activite herbicide
FI850438A0 (fi) Foerfarande och anordning foer detaktering av biologiskt aktiva aemnen.
MA21996A1 (fr) Composes ayant une activite fongicide .
DK134489A (da) Forbindelser, der inhiberer biosyntesen af lipoxygenaseafledte nedbrydningsprodukter af arachidonsyre
DE3785689D1 (de) Verwendung von prostaglandin-biosynthese-hemmer.
MX9249A (es) Derivados pesticidas de polihalogenoalqueno.
PT71888A (fr) Process de preparation de derives de la pyridine ayant notamment une activite antiarythmique et antiagregante plaquettaire
NO852857L (no) Fremgangsmaate for prosessering av signalopptak ved seismiske undersoekelser.
DE3672254D1 (de) Hemmung des wegs der 5-lipoxydase.
NO863598D0 (no) Oekning av utbyttet av forskjellige kornslag ved hjelp av brassinolidderivater.
DE3879792D1 (de) Gerichtete-biosynthese eines milbemycinanaloges.
MX9203229A (es) Derivados de lankacidina.
BE892147A (fr) Derives hydrosolubles de cholesterol
FI863883A0 (fi) Anordning foer tillslutning av flaskhals.
FI860911A0 (fi) Anordning foer reglering av roekgasernas utloppshastighet i en skorsten.
IT8719882A0 (it) Solfidril-composti per sopprimere gli effetti inibitori di prodotti di degradazione nad sull'attivita'ld-l.
FI853071L (fi) Foerfarande foer framstaellning av kationiska terpolymerer och produkt deriverad av dem.
NO162463C (no) Mellomprodukter for fremstilling av derivater av (okso-4-4h-(1)-benzopyran-8-yl)-eddiksyre.

Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: SANKYO CY LTD

Effective date: 20010331