IT1144325B - Inibitori della biosintesi del colesterolo loro preparazione ed impiego - Google Patents
Inibitori della biosintesi del colesterolo loro preparazione ed impiegoInfo
- Publication number
- IT1144325B IT1144325B IT67438/81A IT6743881A IT1144325B IT 1144325 B IT1144325 B IT 1144325B IT 67438/81 A IT67438/81 A IT 67438/81A IT 6743881 A IT6743881 A IT 6743881A IT 1144325 B IT1144325 B IT 1144325B
- Authority
- IT
- Italy
- Prior art keywords
- hydrogen atom
- preparation
- compounds
- biosynthesis inhibitors
- cholesterol biosynthesis
- Prior art date
Links
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 235000012000 cholesterol Nutrition 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 241000228347 Monascus <ascomycete fungus> Species 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55041292A JPH0692381B2 (ja) | 1980-03-31 | 1980-03-31 | Ｍｂ−５３０ａ誘導体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8167438A0 IT8167438A0 (it) | 1981-03-30 |
| IT1144325B true IT1144325B (it) | 1986-10-29 |
Family
ID=12604367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT67438/81A IT1144325B (it) | 1980-03-31 | 1981-03-30 | Inibitori della biosintesi del colesterolo loro preparazione ed impiego |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPH0692381B2 (ja) |
| AT (1) | ATA150781A (ja) |
| AU (1) | AU6893281A (ja) |
| BE (1) | BE888214A (ja) |
| CH (1) | CH646966A5 (ja) |
| DE (2) | DE3112566A1 (ja) |
| DK (3) | DK151273C (ja) |
| FI (1) | FI810991L (ja) |
| FR (1) | FR2479222A1 (ja) |
| GB (1) | GB2073193A (ja) |
| IE (1) | IE52367B1 (ja) |
| IT (1) | IT1144325B (ja) |
| MX (1) | MX9203567A (ja) |
| NL (1) | NL8101592A (ja) |
| SE (1) | SE461590B (ja) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4472426A (en) * | 1982-12-22 | 1984-09-18 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| DE3682557D1 (de) * | 1985-09-13 | 1992-01-02 | Sankyo Co | Hydroxy-ml-236b-derivate, deren herstellung und anwendung. |
| US4997848A (en) * | 1987-10-27 | 1991-03-05 | Sankyo Company, Limited | Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition |
| US5075327A (en) * | 1988-08-10 | 1991-12-24 | Hoffmann-La Roche Inc. | Antipsoriatic agents |
| US5021451A (en) * | 1988-11-14 | 1991-06-04 | Hoffman-La Roche Inc. | Method for inhibiting hyperproliferative diseases |
| US5200549A (en) * | 1988-11-14 | 1993-04-06 | Hoffman-La Roche Inc. | Antipsoriatic agents |
| US5073568A (en) * | 1988-11-14 | 1991-12-17 | Hoffmann-La Roche Inc. | Antipsoriatic agents |
| US5159104A (en) * | 1991-05-01 | 1992-10-27 | Merck & Co., Inc. | Process to simvastatin ester |
| FR2937537A1 (fr) * | 2008-10-29 | 2010-04-30 | Centre Nat Rech Scient | Nanoparticules de statine |
| KR101820099B1 (ko) | 2013-01-18 | 2018-01-18 | 에스프린팅솔루션 주식회사 | 저항 발열체, 이를 채용한 가열 부재, 및 정착 장치 |
| RU2020126177A (ru) | 2018-01-09 | 2022-02-10 | Лиганд Фармасьютикалз, Инк. | Ацетальные соединения и их терапевтическое применение |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5612114B2 (ja) * | 1974-06-07 | 1981-03-18 | ||
| JPS5925599B2 (ja) * | 1979-02-20 | 1984-06-19 | 三共株式会社 | 新生理活性物質モナコリンｋおよびその製造法 |
| US4231938A (en) * | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| AU535944B2 (en) * | 1979-06-15 | 1984-04-12 | Merck & Co., Inc. | Hypocholestermic fermentation products from aspergillus |
| PT72394B (en) * | 1980-02-04 | 1982-09-06 | Merck & Co Inc | Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics |
| US4282155A (en) * | 1980-02-04 | 1981-08-04 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| AU548996B2 (en) * | 1980-02-04 | 1986-01-09 | Merck & Co., Inc. | Tetrahydro-2h-pyran-2-one derivatives |
| ZA81703B (en) * | 1980-02-04 | 1982-09-29 | Merck & Co Inc | New antihypercholesterolemic compounds,intermediates and processes |
-
1980
- 1980-03-31 JP JP55041292A patent/JPH0692381B2/ja not_active Expired - Lifetime
-
1981
- 1981-03-27 IE IE698/81A patent/IE52367B1/en not_active IP Right Cessation
- 1981-03-30 DE DE19813112566 patent/DE3112566A1/de active Granted
- 1981-03-30 CH CH215381A patent/CH646966A5/de not_active IP Right Cessation
- 1981-03-30 IT IT67438/81A patent/IT1144325B/it active
- 1981-03-30 DE DE3153666A patent/DE3153666C2/de not_active Expired - Lifetime
- 1981-03-31 BE BE0/204328A patent/BE888214A/fr not_active IP Right Cessation
- 1981-03-31 AT AT0150781A patent/ATA150781A/de not_active IP Right Cessation
- 1981-03-31 FI FI810991A patent/FI810991L/fi not_active Application Discontinuation
- 1981-03-31 GB GB8110075A patent/GB2073193A/en not_active Withdrawn
- 1981-03-31 NL NL8101592A patent/NL8101592A/nl not_active Application Discontinuation
- 1981-03-31 DK DK145481A patent/DK151273C/da not_active IP Right Cessation
- 1981-03-31 FR FR8106403A patent/FR2479222A1/fr active Granted
- 1981-03-31 AU AU68932/81A patent/AU6893281A/en not_active Abandoned
- 1981-03-31 SE SE8102047A patent/SE461590B/sv not_active Application Discontinuation
-
1990
- 1990-02-07 DK DK032290A patent/DK32290A/da not_active Application Discontinuation
- 1990-02-07 DK DK032190A patent/DK167805B1/da not_active IP Right Cessation
-
1992
- 1992-06-26 MX MX9203567A patent/MX9203567A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU6893281A (en) | 1981-10-08 |
| SE8102047L (sv) | 1981-10-01 |
| DK145481A (da) | 1981-10-01 |
| DE3112566A1 (de) | 1982-03-11 |
| BE888214A (fr) | 1981-09-30 |
| ATA150781A (de) | 1983-03-15 |
| DK32290D0 (da) | 1990-02-07 |
| DK32290A (da) | 1990-02-07 |
| DK167805B1 (da) | 1993-12-20 |
| FR2479222B1 (ja) | 1983-08-26 |
| MX9203567A (es) | 1992-09-01 |
| DK32190D0 (da) | 1990-02-07 |
| GB2073193A (en) | 1981-10-14 |
| JPS56138181A (en) | 1981-10-28 |
| FR2479222A1 (fr) | 1981-10-02 |
| CH646966A5 (de) | 1984-12-28 |
| DK32190A (da) | 1990-02-07 |
| SE461590B (sv) | 1990-03-05 |
| DK151273C (da) | 1988-07-04 |
| IT8167438A0 (it) | 1981-03-30 |
| IE810698L (en) | 1981-09-30 |
| DE3153666C2 (de) | 1993-11-11 |
| DK151273B (da) | 1987-11-16 |
| FI810991L (fi) | 1981-10-01 |
| JPH0692381B2 (ja) | 1994-11-16 |
| DE3112566C2 (ja) | 1990-04-05 |
| NL8101592A (nl) | 1981-10-16 |
| IE52367B1 (en) | 1987-09-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS5412381A (en) | N-alkylpiperidine derivative | |
| MX9204661A (es) | Compuestos intermedios derivados de eter y procedimiento para su preparacion. | |
| ES2067314T3 (es) | 3-benzacepin-zonas sustituidas por un grupo benzociclobutilo o indanil-alquil-amino-alquilo, utiles en el tratamiento de las afecciones cardiovasculares. | |
| IT1144325B (it) | Inibitori della biosintesi del colesterolo loro preparazione ed impiego | |
| DE69022368T2 (de) | Quinolin-3-carboxanilid-derivate. | |
| IT8068211A0 (it) | Composti utilizzabili come agenti inibitori della biosintesi del colesterolo e procedimento per la loro preparazione | |
| YU96291A (sh) | Postupak za dobijanje supstituisanih piperidina i supstituisani piperidini | |
| FR2656609B1 (fr) | Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique. | |
| IT7825074A0 (it) | Procedimento per l'eliminazione di impurita' di carbonile da idrocarburi. | |
| IT7822832A0 (it) | Composizioni contenenti ditranolper il trattamento della psoriasi. | |
| NO891703L (no) | Farmasoeytiske sammensetninger for behandling av psoriasis. | |
| ES516158A0 (es) | Procedimiento de preparacion de nuevos derivados del adamantano. | |
| NO820820L (no) | Fremgangsmaate ved fremstilling av 2,9-dioxatricyclo (4,3,1,0 3,7)decaner | |
| IT8020763A0 (it) | Procedimento per il trattamento d'olio greggio. | |
| IT7819527A0 (it) | Appararecchiatura per il trattamento di articoli. | |
| ZA887158B (en) | Azachromane derivatives | |
| FI934665A (fi) | Aryliden-1-azacykloalkaner och arylalkyl-1-azacyckloalkaner, deras salter, dessa foereningar innehaollande laekemedel och deras anvaendning och framstaellning | |
| NO880405D0 (no) | Fremgangsmaate til fremstilling av 3-fenyl-7h-tiazolo-/3,2-b//1,2,4/-tiazine-7-oner. | |
| FR2389627A1 (ja) | ||
| IT8322692A0 (it) | Composizioni per il trattamento della ruggine. | |
| PH15932A (en) | Method for treating inflammation | |
| SU677071A1 (ru) | Формирователь импульсов | |
| FR2360576A1 (fr) | Derives de 4-arylpiperidine et procedes pour leur production | |
| IT1130297B (it) | Procedimento per il trattamento di acque di scarico solforate mediante perossido di idrogeno | |
| IT7848486A0 (it) | Composizioni per il trattamento di infezioni da elminti |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970329 |