YU96291A - Postupak za dobijanje supstituisanih piperidina i supstituisani piperidini - Google Patents

Postupak za dobijanje supstituisanih piperidina i supstituisani piperidini

Info

Publication number
YU96291A
YU96291A YU96291A YU96291A YU96291A YU 96291 A YU96291 A YU 96291A YU 96291 A YU96291 A YU 96291A YU 96291 A YU96291 A YU 96291A YU 96291 A YU96291 A YU 96291A
Authority
YU
Yugoslavia
Prior art keywords
substituted piperidines
procedure
obtaining
piperidines
substituted
Prior art date
Application number
YU96291A
Other languages
English (en)
Other versions
YU48030B (sh
Inventor
D.M. Godek
T.J. Rosen
Original Assignee
Pfizer Inc. New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. New York filed Critical Pfizer Inc. New York
Publication of YU96291A publication Critical patent/YU96291A/sh
Publication of YU48030B publication Critical patent/YU48030B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

POSTUPAK ZA DOBIJANJE SUPSTITUISANIH PIPERIDINA I SUPSTITUISANI PIPERIDINI, opisani su novi supstituisani piperidini formule i postupci za njihovo dobijanje korišćenjem jedinjenja formule koja reaguje sa jedinjenjem R1CX, gde je X lako odlazeća grupa, a zatim se redukuje do jedinjeaja formule (II) koja se dalje redukuje do jedinjenja formule (I). U gornjim formulama R1 R2 su isti ili različiti i predstavljaju fenil opciono supstituisan hlorom, fluorom, (C1-C6)alkil i (C1-C6)alkoksi grupom. U varijanti postupka koristi se jedinjenje formule (III) gde je R1 kao prethodno definisano, a Q je halogen, koji se prevodi do jedinjenja formule (II), koje se zatim redukuje do jedinjenja formule I. Takodje su opisani postupci za dobijanje korišćenih polaznih materija.
YU96291A 1990-05-31 1991-05-30 Postupak za dobijanje supstituisanih piperidina i supstituisani piperidini YU48030B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53126590A 1990-05-31 1990-05-31

Publications (2)

Publication Number Publication Date
YU96291A true YU96291A (sh) 1994-06-10
YU48030B YU48030B (sh) 1996-10-09

Family

ID=24116944

Family Applications (1)

Application Number Title Priority Date Filing Date
YU96291A YU48030B (sh) 1990-05-31 1991-05-30 Postupak za dobijanje supstituisanih piperidina i supstituisani piperidini

Country Status (26)

Country Link
EP (1) EP0532515B1 (sh)
JP (2) JPH0794439B2 (sh)
KR (1) KR0160142B1 (sh)
CN (2) CN1037768C (sh)
AT (1) ATE144498T1 (sh)
AU (1) AU648558B2 (sh)
BR (1) BR9106518A (sh)
CA (1) CA2080249C (sh)
CZ (1) CZ284663B6 (sh)
DE (1) DE69122866T2 (sh)
DK (1) DK0532515T3 (sh)
ES (1) ES2093099T3 (sh)
FI (1) FI101376B1 (sh)
GR (1) GR3022079T3 (sh)
HU (1) HU226529B1 (sh)
IE (1) IE911841A1 (sh)
IL (3) IL113011A (sh)
MY (1) MY107819A (sh)
NO (1) NO180083C (sh)
NZ (2) NZ238340A (sh)
PL (2) PL168236B1 (sh)
PT (1) PT97796B (sh)
RU (1) RU2077531C1 (sh)
WO (1) WO1991018878A1 (sh)
YU (1) YU48030B (sh)
ZA (1) ZA914133B (sh)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA41251C2 (uk) * 1990-01-04 2001-09-17 Пфайзер, Інк. Гідровані азотвмісні гетероциклічні сполуки, похідні піперидину, фармацевтична композиція та спосіб пригнічення активності речовини р в організмі
US5332817A (en) * 1990-01-04 1994-07-26 Pfizer Inc. 3-aminopiperidine derivatives and related nitrogen containing heterocycles
US5364943A (en) * 1991-11-27 1994-11-15 Pfizer Inc. Preparation of substituted piperidines
BR9205807A (pt) * 1991-03-26 1994-06-28 Pfizer Preparação estéreo-seletiva de piperidinas substituidas
MY110227A (en) * 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
ATE161821T1 (de) * 1991-11-12 1998-01-15 Pfizer Azyklische ethylendiaminderivate als 'substance p rezeptor' antagonisten
DE69328975T2 (de) * 1992-12-10 2000-11-09 Pfizer Inc., New York Aminomethylen substituierte heterocyclische verbindungen und ihre verwendung alssubstanz p antagonisten
DE69404306T2 (de) 1993-05-28 1997-10-30 Pfizer Verfahren zur herstellung und optischen auflösung von 2-phenyl-3-aminopiperidine
TW397825B (en) * 1994-10-14 2000-07-11 Novartis Ag Aroyl-piperidine derivatives
FR2728166A1 (fr) 1994-12-19 1996-06-21 Oreal Composition topique contenant un antagoniste de substance p
FR2728165A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
FR2728169A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
FR2741262B1 (fr) 1995-11-20 1999-03-05 Oreal Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
CA2291734A1 (en) 1997-06-27 1999-01-07 Merck Sharp & Dohme Limited Substituted 3-(benzylamino)piperidine derivatives and their use as therapeutic agents
EP1098881A1 (en) * 1998-07-21 2001-05-16 Syngenta Participations AG 3-substituted pyridine compounds and related synthesis
JP2011016751A (ja) * 2009-07-08 2011-01-27 Sumitomo Chemical Co Ltd 光学活性３−アミノピペリジン−１−カルボキシレート化合物の製造方法およびその製造方法に用いられる中間体
CN111808017B (zh) * 2020-08-05 2023-11-28 国家纳米科学中心 一种含氮杂环化合物及其制备方法和应用
CN116162055B (zh) * 2023-03-10 2023-09-12 山东汇智药物研究有限公司 一种用n-氧化吡啶衍生物制备哌啶衍生物的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52125170A (en) * 1976-04-12 1977-10-20 Yoshitomi Pharmaceut Ind Ltd Pyridine derivatives
CA1160229A (en) * 1979-03-13 1984-01-10 Pieter T. Haken Pyridyliminomethylbenzene derivatives
CA1231710A (en) * 1979-07-19 1988-01-19 Haken Pieter Ten Heterocyclic compounds having fungicidal, herbicidal and plant-growth regulating properties
GB2056974B (en) * 1979-07-19 1984-02-29 Shell Int Research Heterocyclic acylamino compounds having fungicidal herbicidal and plant-growth regulating properties
EP0100158A3 (en) * 1982-07-28 1985-03-27 The Upjohn Company (3-pyridinyl)heteroalkarylalkanols, alkanoic acids and esters
US4552960A (en) * 1983-06-20 1985-11-12 Eli Lilly And Company Fungicidal amines
FR2662696A2 (fr) * 1989-12-13 1991-12-06 Rhone Poulenc Sante Antagonistes de la serotonine, leur preparation et medicaments les contenant.
UA41251C2 (uk) * 1990-01-04 2001-09-17 Пфайзер, Інк. Гідровані азотвмісні гетероциклічні сполуки, похідні піперидину, фармацевтична композиція та спосіб пригнічення активності речовини р в організмі

Also Published As

Publication number Publication date
NO924598L (no) 1992-11-27
CS162391A3 (en) 1992-02-19
CZ284663B6 (cs) 1999-01-13
AU648558B2 (en) 1994-04-28
NZ250217A (en) 1995-05-26
IE911841A1 (en) 1991-12-04
DE69122866D1 (de) 1996-11-28
CN1056876A (zh) 1991-12-11
KR0160142B1 (ko) 1998-12-01
JPH07206819A (ja) 1995-08-08
HU9203761D0 (en) 1993-03-29
DK0532515T3 (da) 1997-04-21
HU226529B1 (en) 2009-03-30
HUT68166A (en) 1995-05-29
ZA914133B (en) 1993-01-27
IL113011A (en) 1999-09-22
FI101376B (fi) 1998-06-15
DE69122866T2 (de) 1997-02-20
MY107819A (en) 1996-06-29
ATE144498T1 (de) 1996-11-15
AU7770391A (en) 1991-12-31
CN1154636C (zh) 2004-06-23
CA2080249C (en) 1996-11-19
JPH0794439B2 (ja) 1995-10-11
FI101376B1 (fi) 1998-06-15
CA2080249A1 (en) 1991-12-01
FI925415A (fi) 1992-11-27
GR3022079T3 (en) 1997-03-31
FI925415A0 (fi) 1992-11-27
CN1037768C (zh) 1998-03-18
PL169187B1 (pl) 1996-06-28
WO1991018878A1 (en) 1991-12-12
PT97796B (pt) 1998-10-30
IL113011A0 (en) 1995-06-29
NO180083C (no) 1997-02-12
YU48030B (sh) 1996-10-09
NO924598D0 (no) 1992-11-27
PT97796A (pt) 1992-02-28
RU2077531C1 (ru) 1997-04-20
JPH05502238A (ja) 1993-04-22
EP0532515A1 (en) 1993-03-24
JP2549609B2 (ja) 1996-10-30
BR9106518A (pt) 1993-05-25
KR930700443A (ko) 1993-03-15
CN1183408A (zh) 1998-06-03
NO180083B (no) 1996-11-04
PL168236B1 (pl) 1996-01-31
ES2093099T3 (es) 1996-12-16
NZ238340A (en) 1994-06-27
IL98256A0 (en) 1992-06-21
IL98256A (en) 1995-11-27
EP0532515B1 (en) 1996-10-23

Similar Documents

Publication Publication Date Title
YU96291A (sh) Postupak za dobijanje supstituisanih piperidina i supstituisani piperidini
DK0563345T3 (da) Nye 4-arylpiperaziner og 4-arylpiperidiner
ES2081636T3 (es) Preparacion de piperidinas sustituidas.
DK0393424T3 (da) Fremgangsmåde til fremstilling af 2,7-diazabicyclo(3.3.0)octaner
DK0450420T3 (da) Heterocyclisk substituerede dihydropyridiner, fremgangsmåde til deres fremstilling og deres anvendelse i lægemidler
SE8601344D0 (sv) Derivat av 11-desoxi-17alfa-hydroxikortikosteron derivat av 11-desoxi-17alfa-hydroxikortikosteron
DK0427160T3 (da) Benzylselenobenzamid af aminopyridiner og picolylaminer
DE59002172D1 (de) Neue 1,3-oxazine.
DK0582977T3 (da) Fremgangsmåde til fremstilling af 1,3-dialkyl-5-hydroxyoxindoler og etherderivater deraf