YU48030B - Postupak za dobijanje supstituisanih piperidina i supstituisani piperidini - Google Patents

Postupak za dobijanje supstituisanih piperidina i supstituisani piperidini

Info

Publication number
YU48030B
YU48030B YU96291A YU96291A YU48030B YU 48030 B YU48030 B YU 48030B YU 96291 A YU96291 A YU 96291A YU 96291 A YU96291 A YU 96291A YU 48030 B YU48030 B YU 48030B
Authority
YU
Yugoslavia
Prior art keywords
substituted piperidine
procedure
obtaining
processes
piperidine
Prior art date
Application number
YU96291A
Other languages
English (en)
Other versions
YU96291A (sh
Inventor
D. Godek
T. Rosen
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of YU96291A publication Critical patent/YU96291A/sh
Publication of YU48030B publication Critical patent/YU48030B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

POSTUPAK ZA DOBIJANJE SUPSTITUISANIH PIPERIDINA I SUPSTITUISANI PIPERIDINI, formule u kojima R1 je aril odabran iz grupe koju sacinjavaju indanil, fenil i naftil; heteroaril odabran iz grupe koju sacinjavaju tienil, furil, piridil i hinolil; i cikloalkil koji ima 3-7 ugljenikovih atoma, gde jedan od pomenutih ugljenikovih atoma moze opciono biti zamenjen sa azotom, kiseonikom ili sumporom; gde svaka od pomenutih aril i heteroaril grupa moze opciono biti supstituisana sa jednim ili vise supstituenata, i pomenuti (C3-C7) cikloalkil moze opciono biti supstituisan sa jednim ili dva supstituenta, pri cemu pomenuti supstituenti su nezavisno odabrani iz grupe koju sacinjavaju halo, nitro, (C1-C10) alkil, (C1-C10) alkoksi, trifluorometil, amino, cijano, hidroksil, (C1-C6) alkilamino, (C1-C6) dialkilamino, O O -NHCH i -NHC-(C1-C6)alkil, gde atomi azota u pomenutim amino i (C1-C6) alkilamino grupama mogu opciono biti zasticeni sa odgovarajucom zastitnom grupom; i R2 je tienil, benzhidril, naftil ili fenil supstituisan sa od jedan do tri supstituenta koji su nezavisno odabrani iz grupe koju sacin-javaju hloro, bromo, fluoro, jodo, (C1-C10)-alkil, (C1-C10)alkoksi i trifluorometil; naznacen time, sto obuhvata (a) reakciju jedinjenje formule: u kojoj R2 je kao sto je gore definisano, sa ili (i) jedinjenjem O R1CX, u kome R1 je kao sto je gore definisano i X je lako odlazeca grupa, posle cega se vrsi tretiranje dobijenog amida sa reduk-cionim sredstvom, (ii) jedinjenjem formule R1CHO, gde R1 je kao sto je gore definisano, u prisustvu redukcionog sredstva, ili (iii) jedinjenjem formule R1CH2X, gde R1 je kao sto je gore definisano i X je lako odlazeca grupa, radi dobijanja jedinjenja formule u kome R1 i R2 su kao sto je gore definisano; i (b) redukciju pomenutog jedinjenja formule II. Prijava sadrzi jos 1 nezavisan i 9 zavisnih zahteva.
YU96291A 1990-05-31 1991-05-30 Postupak za dobijanje supstituisanih piperidina i supstituisani piperidini YU48030B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53126590A 1990-05-31 1990-05-31

Publications (2)

Publication Number Publication Date
YU96291A YU96291A (sh) 1994-06-10
YU48030B true YU48030B (sh) 1996-10-09

Family

ID=24116944

Family Applications (1)

Application Number Title Priority Date Filing Date
YU96291A YU48030B (sh) 1990-05-31 1991-05-30 Postupak za dobijanje supstituisanih piperidina i supstituisani piperidini

Country Status (26)

Country Link
EP (1) EP0532515B1 (sh)
JP (2) JPH0794439B2 (sh)
KR (1) KR0160142B1 (sh)
CN (2) CN1037768C (sh)
AT (1) ATE144498T1 (sh)
AU (1) AU648558B2 (sh)
BR (1) BR9106518A (sh)
CA (1) CA2080249C (sh)
CZ (1) CZ284663B6 (sh)
DE (1) DE69122866T2 (sh)
DK (1) DK0532515T3 (sh)
ES (1) ES2093099T3 (sh)
FI (1) FI101376B (sh)
GR (1) GR3022079T3 (sh)
HU (1) HU226529B1 (sh)
IE (1) IE911841A1 (sh)
IL (3) IL98256A (sh)
MY (1) MY107819A (sh)
NO (1) NO180083C (sh)
NZ (2) NZ250217A (sh)
PL (2) PL168236B1 (sh)
PT (1) PT97796B (sh)
RU (1) RU2077531C1 (sh)
WO (1) WO1991018878A1 (sh)
YU (1) YU48030B (sh)
ZA (1) ZA914133B (sh)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5332817A (en) * 1990-01-04 1994-07-26 Pfizer Inc. 3-aminopiperidine derivatives and related nitrogen containing heterocycles
UA41251C2 (uk) * 1990-01-04 2001-09-17 Пфайзер, Інк. Гідровані азотвмісні гетероциклічні сполуки, похідні піперидину, фармацевтична композиція та спосіб пригнічення активності речовини р в організмі
US5364943A (en) * 1991-11-27 1994-11-15 Pfizer Inc. Preparation of substituted piperidines
EP0581777A1 (en) * 1991-03-26 1994-02-09 Pfizer Inc. Stereoselective preparation of substituted piperidines
MY110227A (en) * 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
ATE161821T1 (de) * 1991-11-12 1998-01-15 Pfizer Azyklische ethylendiaminderivate als 'substance p rezeptor' antagonisten
ATE194340T1 (de) * 1992-12-10 2000-07-15 Pfizer Aminomethylen substituierte heterocyclische verbindungen und ihre verwendung alssubstanz p antagonisten
DK0700384T3 (da) 1993-05-28 1997-12-08 Pfizer fremgangsmåde til fremstilling og opløsning af 2-phenyl-3-aminopiperidin
TW397825B (en) * 1994-10-14 2000-07-11 Novartis Ag Aroyl-piperidine derivatives
FR2728166A1 (fr) 1994-12-19 1996-06-21 Oreal Composition topique contenant un antagoniste de substance p
FR2728165A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
FR2728169A1 (fr) 1994-12-19 1996-06-21 Oreal Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
FR2741262B1 (fr) 1995-11-20 1999-03-05 Oreal Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
CA2291734A1 (en) * 1997-06-27 1999-01-07 Merck Sharp & Dohme Limited Substituted 3-(benzylamino)piperidine derivatives and their use as therapeutic agents
WO2000005212A1 (en) * 1998-07-21 2000-02-03 Syngenta Participations Ag 3-substituted pyridine compounds and related synthesis
JP2011016751A (ja) * 2009-07-08 2011-01-27 Sumitomo Chemical Co Ltd 光学活性３−アミノピペリジン−１−カルボキシレート化合物の製造方法およびその製造方法に用いられる中間体
CN111808017B (zh) * 2020-08-05 2023-11-28 国家纳米科学中心 一种含氮杂环化合物及其制备方法和应用
CN116162055B (zh) * 2023-03-10 2023-09-12 山东汇智药物研究有限公司 一种用n-氧化吡啶衍生物制备哌啶衍生物的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52125170A (en) * 1976-04-12 1977-10-20 Yoshitomi Pharmaceut Ind Ltd Pyridine derivatives
CA1160229A (en) * 1979-03-13 1984-01-10 Pieter T. Haken Pyridyliminomethylbenzene derivatives
CA1231710A (en) * 1979-07-19 1988-01-19 Haken Pieter Ten Heterocyclic compounds having fungicidal, herbicidal and plant-growth regulating properties
GB2056974B (en) * 1979-07-19 1984-02-29 Shell Int Research Heterocyclic acylamino compounds having fungicidal herbicidal and plant-growth regulating properties
EP0100158A3 (en) * 1982-07-28 1985-03-27 The Upjohn Company (3-pyridinyl)heteroalkarylalkanols, alkanoic acids and esters
US4552960A (en) * 1983-06-20 1985-11-12 Eli Lilly And Company Fungicidal amines
FR2662696A2 (fr) * 1989-12-13 1991-12-06 Rhone Poulenc Sante Antagonistes de la serotonine, leur preparation et medicaments les contenant.
UA41251C2 (uk) * 1990-01-04 2001-09-17 Пфайзер, Інк. Гідровані азотвмісні гетероциклічні сполуки, похідні піперидину, фармацевтична композиція та спосіб пригнічення активності речовини р в організмі

Also Published As

Publication number Publication date
PT97796A (pt) 1992-02-28
FI925415A (fi) 1992-11-27
HU226529B1 (en) 2009-03-30
IL98256A (en) 1995-11-27
AU7770391A (en) 1991-12-31
DE69122866T2 (de) 1997-02-20
JPH07206819A (ja) 1995-08-08
GR3022079T3 (en) 1997-03-31
DE69122866D1 (de) 1996-11-28
EP0532515A1 (en) 1993-03-24
DK0532515T3 (da) 1997-04-21
FI925415A0 (fi) 1992-11-27
HU9203761D0 (en) 1993-03-29
MY107819A (en) 1996-06-29
IL113011A0 (en) 1995-06-29
NO924598D0 (no) 1992-11-27
NZ238340A (en) 1994-06-27
WO1991018878A1 (en) 1991-12-12
KR0160142B1 (ko) 1998-12-01
NO924598L (no) 1992-11-27
YU96291A (sh) 1994-06-10
FI101376B1 (fi) 1998-06-15
RU2077531C1 (ru) 1997-04-20
CN1056876A (zh) 1991-12-11
PL168236B1 (pl) 1996-01-31
CN1154636C (zh) 2004-06-23
IE911841A1 (en) 1991-12-04
CS162391A3 (en) 1992-02-19
IL98256A0 (en) 1992-06-21
JP2549609B2 (ja) 1996-10-30
ZA914133B (en) 1993-01-27
JPH0794439B2 (ja) 1995-10-11
NO180083C (no) 1997-02-12
ES2093099T3 (es) 1996-12-16
FI101376B (fi) 1998-06-15
KR930700443A (ko) 1993-03-15
BR9106518A (pt) 1993-05-25
CN1037768C (zh) 1998-03-18
NO180083B (no) 1996-11-04
AU648558B2 (en) 1994-04-28
CN1183408A (zh) 1998-06-03
EP0532515B1 (en) 1996-10-23
IL113011A (en) 1999-09-22
JPH05502238A (ja) 1993-04-22
CZ284663B6 (cs) 1999-01-13
PT97796B (pt) 1998-10-30
CA2080249A1 (en) 1991-12-01
HUT68166A (en) 1995-05-29
PL169187B1 (pl) 1996-06-28
CA2080249C (en) 1996-11-19
ATE144498T1 (de) 1996-11-15
NZ250217A (en) 1995-05-26

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