DE3007498A1 - Neue piperidin-derivate mit antihistaminwirkung - Google Patents

Neue piperidin-derivate mit antihistaminwirkung

Info

Publication number
DE3007498A1
DE3007498A1 DE19803007498 DE3007498A DE3007498A1 DE 3007498 A1 DE3007498 A1 DE 3007498A1 DE 19803007498 DE19803007498 DE 19803007498 DE 3007498 A DE3007498 A DE 3007498A DE 3007498 A1 DE3007498 A1 DE 3007498A1
Authority
DE
Germany
Prior art keywords
hydrogen
acid
pharmaceutically acceptable
carbon atoms
hydroxyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19803007498
Other languages
German (de)
English (en)
Other versions
DE3007498C2 (enExample
Inventor
Albert A Carr
Ohio Cincinnati
Joseph E Dolfini
George J Wright
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21845568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3007498(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of DE3007498A1 publication Critical patent/DE3007498A1/de
Application granted granted Critical
Publication of DE3007498C2 publication Critical patent/DE3007498C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE19803007498 1979-04-10 1980-02-28 Neue piperidin-derivate mit antihistaminwirkung Granted DE3007498A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/028,813 US4254129A (en) 1979-04-10 1979-04-10 Piperidine derivatives

Publications (2)

Publication Number Publication Date
DE3007498A1 true DE3007498A1 (de) 1980-10-23
DE3007498C2 DE3007498C2 (enExample) 1989-09-07

Family

ID=21845568

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19803007498 Granted DE3007498A1 (de) 1979-04-10 1980-02-28 Neue piperidin-derivate mit antihistaminwirkung

Country Status (19)

Country Link
US (1) US4254129A (enExample)
JP (1) JPS55141469A (enExample)
AT (1) AT376208B (enExample)
AU (1) AU531146B2 (enExample)
BE (1) BE882703A (enExample)
CA (1) CA1123438A (enExample)
CH (1) CH643245A5 (enExample)
DE (1) DE3007498A1 (enExample)
DK (1) DK153709C (enExample)
ES (1) ES489934A0 (enExample)
FR (1) FR2453854A1 (enExample)
IL (1) IL59158A (enExample)
IT (1) IT1143960B (enExample)
NL (2) NL190580C (enExample)
NO (2) NO154521C (enExample)
NZ (1) NZ192653A (enExample)
PH (1) PH17023A (enExample)
SE (1) SE448726B (enExample)
ZA (1) ZA80332B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3917241A1 (de) * 1989-05-26 1990-11-29 Schaper & Bruemmer Gmbh 4-(hydroxydiphenylmethyl)-1-piperidyl-phenylalkan-derivate
WO1993021156A1 (en) * 1992-04-10 1993-10-28 Merrell Dow Pharmaceuticals Inc. 4-diphenylmethyl piperidine derivatives and process for their preparation

Families Citing this family (115)

* Cited by examiner, † Cited by third party
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AR240018A1 (es) * 1987-10-07 1990-01-31 Merrell Pharma Inc Procedimiento para preparar una composicion que comprende derivados de piperidinoalcanol.
CN1053570C (zh) 1987-10-07 2000-06-21 默尔多药物公司 哌啶子基链烷醇的药用组合物-减充血剂复方的制备方法
US4929605A (en) * 1987-10-07 1990-05-29 Merrell Dow Pharmaceuticals Inc. Pharmaceutical composition for piperidinoalkanol derivatives
US4908372A (en) * 1988-10-13 1990-03-13 Merrell Dow Pharmaceuticals Inc. Antihistaminic piperidinyl benzimidazoles
AR245888A1 (es) * 1989-01-23 1994-03-30 Merrell Pharma Inc Procedimiento para la preparacion de una composicion farmaceutica liquida de derivados de piperidinoalcanol.
US5190029A (en) * 1991-02-14 1993-03-02 Virginia Commonwealth University Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
US5182097A (en) * 1991-02-14 1993-01-26 Virginia Commonwealth University Formulations for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
TW198008B (enExample) * 1991-04-08 1993-01-11 Green Cross Corp
HU211019B (en) * 1991-12-02 1995-09-28 Richter Gedeon Vegyeszet Process for producing new 1,2,3,6-tetrahydropyridine and piperidine derivatives substituted with n-(hydroxylalkyl) group and compositions comprising such compounds
CA2129995C (en) * 1992-02-13 2000-04-11 Albert A. Carr Piperidinyl thiacyclic derivatives
US5631375A (en) * 1992-04-10 1997-05-20 Merrell Pharmaceuticals, Inc. Process for piperidine derivatives
EP0639976B1 (en) * 1992-05-11 2000-07-26 Merrell Pharmaceuticals Inc. Use of terfenadine derivatives as antihistaminics in a hepatically impaired patient
WO1994003170A1 (en) * 1992-08-03 1994-02-17 Sepracor Inc. Terfenadine metabolites and their optically pure isomers for treating allergic disorders
US5654433A (en) * 1993-01-26 1997-08-05 Merrell Pharmaceuticals Inc. Process for piperidine derivatives
DK1026147T3 (da) * 1993-06-24 2004-03-22 Albany Molecular Res Inc Forbindelser, der er anvendelige som mellemprodukter i fremstillingen af piperidinderivater
US20020007068A1 (en) * 1999-07-16 2002-01-17 D'ambra Thomas E. Piperidine derivatives and process for their production
US6147216A (en) * 1993-06-25 2000-11-14 Merrell Pharmaceuticals Inc. Intermediates useful for the preparation of antihistaminic piperidine derivatives
HU226037B1 (en) * 1993-06-25 2008-03-28 Aventis Inc Process for producing antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives and novel intermediates
WO1995010278A1 (en) * 1993-10-15 1995-04-20 Hoechst Marion Roussel, Inc. Treatment of allergic disorders with terfenadine carboxylate
US5691352A (en) * 1993-10-25 1997-11-25 Merrell Pharmaceuticals Inc. Stable pharmaceutical composition of terfenadine and ibuprofen
KR100387459B1 (ko) * 1994-05-16 2003-11-20 메렐 파마슈티칼스 인크. 라세미성a-[4-(1,1-디메틸에틸)페닐]-4-(하이드록시디페닐메틸)-1-피페리딘부탄올및이의유도체화합물의광학분할법및이에유용한부분입체이성체염
CA2585705C (en) * 1994-05-18 2012-04-17 Aventis Pharmaceuticals Inc. Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
US20030045722A1 (en) * 1994-05-18 2003-03-06 Henton Daniel R. Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
CN101337922A (zh) * 1994-05-18 2009-01-07 阿温蒂斯药物公司 抗组胺哌啶衍生物,其多晶形物和假同晶物的无水和水合物形式的制备方法
DE69508093T2 (de) 1994-08-25 1999-07-15 Merrell Pharmaceuticals Inc., Cincinnati, Ohio Substituierte piperidine für die behandlung von allergischen krankheiten
PT812195E (pt) * 1995-02-28 2003-03-31 Aventis Pharma Inc Composicao farmaceutica para compostos de piperidinoalcanol
JPH11504650A (ja) * 1995-05-08 1999-04-27 ヘキスト・マリオン・ルセル・インコーポレイテツド アルファ−（置換アルキルフェニル）−４−（ヒドロキシジフェニルメチル）−１−ピペリジンブタノール誘導体、その製造および抗ヒスタミン剤、抗アレルギー剤および気管支拡張剤としてのその使用
US5574045A (en) * 1995-06-06 1996-11-12 Hoechst Marion Roussel, Inc. Oral pharmaceutical composition of piperidinoalkanol compounds in solution form
US5906747A (en) * 1995-11-13 1999-05-25 Biosepra Inc. Separation of molecules from dilute solutions using composite chromatography media having high dynamic sorptive capacity at high flow rates
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US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
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ATE260983T1 (de) * 1997-03-11 2004-03-15 Aventis Pharma Inc Verfahren zur herstellung von 4-(4-(4- (hydroxydiphenyl)-1-piperidinyl)-1-hydroxybutyl - alpha,alpha-dimenthylphenylessigsäure und phosphorylierter derivate
ATE224721T1 (de) * 1997-08-14 2002-10-15 Aventis Pharma Inc Verfahren zur verbesserung der bioverfügbarkeit des fexofenadins und seiner derivate
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US5077301A (en) * 1989-05-26 1991-12-31 Schaper & Bruemmer Gmbh & Co. Kg 4-(hydroxydiphenylmethyl)-1-piperidylphenylalkane derivatives as antihistamines and methods of treatment of an allergic response
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Also Published As

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IT1143960B (it) 1986-10-29
CH643245A5 (de) 1984-05-30
NO1998017I1 (no) 1998-05-29
JPS55141469A (en) 1980-11-05
ES8103735A1 (es) 1981-03-16
NL980013I2 (nl) 1998-10-01
NL190580B (nl) 1993-12-01
NO801014L (no) 1980-10-13
US4254129A (en) 1981-03-03
SE448726B (sv) 1987-03-16
SE8002634L (sv) 1980-10-11
DK132980A (da) 1980-10-11
NL8000754A (nl) 1980-10-14
PH17023A (en) 1984-05-11
NZ192653A (en) 1982-03-16
AU531146B2 (en) 1983-08-11
CA1123438A (en) 1982-05-11
DK153709B (da) 1988-08-22
JPH0132823B2 (enExample) 1989-07-10
IT8048245A0 (it) 1980-03-24
NL190580C (nl) 1994-05-02
BE882703A (fr) 1980-07-31
NO154521B (no) 1986-06-30
ZA80332B (en) 1981-01-28
FR2453854A1 (fr) 1980-11-07
IL59158A0 (en) 1980-05-30
FR2453854B1 (enExample) 1983-06-24
AT376208B (de) 1984-10-25
ATA144880A (de) 1984-03-15
AU5501680A (en) 1980-10-16
DK153709C (da) 1988-12-27
ES489934A0 (es) 1981-03-16
IL59158A (en) 1984-04-30
NO154521C (no) 1986-10-08
NL980013I1 (nl) 1998-06-02
DE3007498C2 (enExample) 1989-09-07

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