DE2953723C2 - Neue carbostyrilderivate, verfahren zu deren herstellung und diese enthaltende mittel - Google Patents

Neue carbostyrilderivate, verfahren zu deren herstellung und diese enthaltende mittel

Info

Publication number
DE2953723C2
DE2953723C2 DE2953723A DE2953723A DE2953723C2 DE 2953723 C2 DE2953723 C2 DE 2953723C2 DE 2953723 A DE2953723 A DE 2953723A DE 2953723 A DE2953723 A DE 2953723A DE 2953723 C2 DE2953723 C2 DE 2953723C2
Authority
DE
Germany
Prior art keywords
dihydrocarbostyril
propoxy
group
dehydro compound
phenylpiperazinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2953723A
Other languages
German (de)
English (en)
Inventor
Kazuo Tokushima Banno
Takafumi Itano Tokushima Fujioka
Kazuyuki Tokushima Nakagawa
Yasuo Oshiro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE2953723C2 publication Critical patent/DE2953723C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C07D215/28—Alcohols; Ethers thereof with halogen atoms or nitro radicals in positions 5, 6 or 7

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE2953723A 1978-03-30 1979-03-27 Neue carbostyrilderivate, verfahren zu deren herstellung und diese enthaltende mittel Expired DE2953723C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3778378A JPS54130587A (en) 1978-03-30 1978-03-30 Carbostyryl derivative

Publications (1)

Publication Number Publication Date
DE2953723C2 true DE2953723C2 (de) 1989-01-12

Family

ID=12507080

Family Applications (2)

Application Number Title Priority Date Filing Date
DE2953723A Expired DE2953723C2 (de) 1978-03-30 1979-03-27 Neue carbostyrilderivate, verfahren zu deren herstellung und diese enthaltende mittel
DE2912105A Expired DE2912105C2 (de) 1978-03-30 1979-03-27 Neue carbostyrilderivate, verfahren zu deren herstellung und diese enthaltende mittel

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE2912105A Expired DE2912105C2 (de) 1978-03-30 1979-03-27 Neue carbostyrilderivate, verfahren zu deren herstellung und diese enthaltende mittel

Country Status (21)

Country Link
US (2) US4734416A (cs)
JP (1) JPS54130587A (cs)
AT (1) AT376432B (cs)
AU (1) AU515531B2 (cs)
BE (1) BE875174A (cs)
CA (1) CA1117110A (cs)
CH (2) CH641455A5 (cs)
DE (2) DE2953723C2 (cs)
DK (1) DK158225C (cs)
ES (4) ES479134A1 (cs)
FI (1) FI70704C (cs)
FR (1) FR2421174A1 (cs)
GB (1) GB2017701B (cs)
IT (1) IT1119284B (cs)
MX (1) MX5862E (cs)
NL (1) NL183189C (cs)
NO (1) NO151321C (cs)
PT (1) PT69422A (cs)
SE (1) SE434945B (cs)
SU (2) SU1140687A3 (cs)
ZA (1) ZA791516B (cs)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9089567B2 (en) 2001-01-29 2015-07-28 Otsuka Pharmaceutical Co., Ltd. Method of treating cognitive impairments and schizophrenias
US9359302B2 (en) 2001-09-25 2016-06-07 Otsuka Pharmaceutical Co., Ltd. Low hygroscopic aripiprazole drug substance and processes for the preparation thereof

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KR940000785B1 (ko) * 1986-04-02 1994-01-31 오오쓰까세이야꾸 가부시끼가이샤 카르보스티릴 유도체 및 그의 염의 제조 방법
DK167187A (da) * 1986-04-02 1987-10-03 Otsuka Pharma Co Ltd Carbostyrilderivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse
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JPS63141967A (ja) * 1986-11-21 1988-06-14 エイ・エッチ・ロビンス・カンパニー・インコーポレーテッド 抗アレルギー薬として有用な１−アリールオキシー４−［（４−アリール）−１−ピペラジニル］−２−ブタノール
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US9089567B2 (en) 2001-01-29 2015-07-28 Otsuka Pharmaceutical Co., Ltd. Method of treating cognitive impairments and schizophrenias
US9387207B2 (en) 2001-01-29 2016-07-12 Otsuka Pharmaceutical Co., Ltd. 5-HT1A receptor subtype agonist
US9359302B2 (en) 2001-09-25 2016-06-07 Otsuka Pharmaceutical Co., Ltd. Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
US10150735B2 (en) 2001-09-25 2018-12-11 Otsuka Pharmaceutical Co., Ltd. Low hygroscopic aripiprazole drug substance and processes for the preparation thereof

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FR2421174A1 (fr) 1979-10-26
SU1140687A3 (ru) 1985-02-15
NO151321C (no) 1985-03-20
JPS6223750B2 (cs) 1987-05-25
ES486991A1 (es) 1980-10-01
FI791034A7 (fi) 1979-10-01
ES486992A1 (es) 1980-10-01
AT376432B (de) 1984-11-26
ZA791516B (en) 1980-04-30
BE875174A (fr) 1979-10-01
SU1232144A3 (ru) 1986-05-15
IT7967674A0 (it) 1979-03-30
US4734416A (en) 1988-03-29
JPS54130587A (en) 1979-10-09
DK128679A (da) 1979-10-26
NO791049L (no) 1979-10-02
DK158225C (da) 1990-09-17
ES479134A1 (es) 1980-06-16
IT1119284B (it) 1986-03-10
NL7902514A (nl) 1979-10-02
FI70704B (fi) 1986-06-26
ATA235179A (de) 1984-04-15
US4824840A (en) 1989-04-25
GB2017701A (en) 1979-10-10
AU4548079A (en) 1979-10-04
AU515531B2 (en) 1981-04-09
NO151321B (no) 1984-12-10
CA1117110A (en) 1982-01-26
DK158225B (da) 1990-04-16
NL183189C (nl) 1988-08-16
GB2017701B (en) 1983-03-16
SE434945B (sv) 1984-08-27
MX5862E (es) 1984-08-13
SE7902794L (sv) 1979-10-01
CH641350A5 (de) 1984-02-29
PT69422A (en) 1979-04-01
FR2421174B1 (cs) 1982-11-19
FI70704C (fi) 1986-10-06
DE2912105C2 (de) 1985-08-29
DE2912105A1 (de) 1979-10-11
CH641455A5 (de) 1984-02-29
ES486990A1 (es) 1980-10-01

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