DE2840786A1 - 5-substituierte 10,11-dihydro-5h- dibenzo eckige klammer auf a,d eckige klammer zu cyclohepten-5,10-imine - Google Patents

5-substituierte 10,11-dihydro-5h- dibenzo eckige klammer auf a,d eckige klammer zu cyclohepten-5,10-imine

Info

Publication number
DE2840786A1
DE2840786A1 DE19782840786 DE2840786A DE2840786A1 DE 2840786 A1 DE2840786 A1 DE 2840786A1 DE 19782840786 DE19782840786 DE 19782840786 DE 2840786 A DE2840786 A DE 2840786A DE 2840786 A1 DE2840786 A1 DE 2840786A1
Authority
DE
Germany
Prior art keywords
alkyl
hydrogen
cycloalkyl
dihydro
dibenzo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19782840786
Other languages
German (de)
English (en)
Other versions
DE2840786C2 (show.php
Inventor
Paul Stanley Anderson
Marcia Elizabeth Christy
Ben Edward Evans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE2840786A1 publication Critical patent/DE2840786A1/de
Application granted granted Critical
Publication of DE2840786C2 publication Critical patent/DE2840786C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE19782840786 1977-09-19 1978-09-19 5-substituierte 10,11-dihydro-5h- dibenzo eckige klammer auf a,d eckige klammer zu cyclohepten-5,10-imine Granted DE2840786A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83463977A 1977-09-19 1977-09-19

Publications (2)

Publication Number Publication Date
DE2840786A1 true DE2840786A1 (de) 1979-03-22
DE2840786C2 DE2840786C2 (show.php) 1987-05-21

Family

ID=25267426

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19782840786 Granted DE2840786A1 (de) 1977-09-19 1978-09-19 5-substituierte 10,11-dihydro-5h- dibenzo eckige klammer auf a,d eckige klammer zu cyclohepten-5,10-imine

Country Status (33)

Country Link
JP (1) JPS5463100A (show.php)
AR (1) AR231544A1 (show.php)
AT (1) AT370103B (show.php)
AU (1) AU520178B2 (show.php)
BE (1) BE870562A (show.php)
CA (1) CA1129850A (show.php)
CH (1) CH637954A5 (show.php)
CY (1) CY1283A (show.php)
DE (1) DE2840786A1 (show.php)
DK (1) DK153843C (show.php)
ES (7) ES473492A1 (show.php)
FI (1) FI65618C (show.php)
FR (1) FR2403334A1 (show.php)
GB (2) GB2061947B (show.php)
GR (1) GR65703B (show.php)
HK (1) HK30885A (show.php)
HU (1) HU180868B (show.php)
IE (1) IE47355B1 (show.php)
IL (1) IL55521A0 (show.php)
IT (1) IT1113279B (show.php)
KE (1) KE3501A (show.php)
LU (1) LU80262A1 (show.php)
NL (1) NL191488C (show.php)
NO (1) NO151861C (show.php)
NZ (1) NZ188361A (show.php)
PH (1) PH15920A (show.php)
PL (3) PL121605B1 (show.php)
PT (1) PT68544A (show.php)
SE (1) SE437520B (show.php)
SG (1) SG9585G (show.php)
SU (2) SU895288A3 (show.php)
YU (1) YU41432B (show.php)
ZA (1) ZA785291B (show.php)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0091071A1 (en) * 1982-04-07 1983-10-12 Merck & Co. Inc. Process for the preparation of 5-methyl-10,11-dihydro-5H-dibenzo(a,d)-cyclohepten-5,10-imine and its salts

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232158A (en) * 1979-06-04 1980-11-04 Merck & Co., Inc. 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines
GB8719199D0 (en) * 1987-08-13 1987-09-23 Merck Sharp & Dohme Chemical compounds
US5686614A (en) * 1995-04-11 1997-11-11 Neurogen Corporation Preparation of chiral 5-aminocarbonyl-5H-dibenzo a,d!cyclohepten-5,10-imines by optical resolution
US5739337A (en) * 1996-03-08 1998-04-14 Neurogen Corporation Process for preparing dibenzo-1-carboxamido-1,4-azabicyclo 3.2.1!octanes
WO2017093354A1 (en) 2015-11-30 2017-06-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Nmdar antagonists for the treatment of diseases associated with angiogenesis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3892756A (en) * 1972-02-04 1975-07-01 Roussel Uclaf Novel dibenzocycloheptenes
BE829075A (fr) * 1974-05-15 1975-11-14 9,10-dihydroanthracen-9,10-imines substituees et leurs analogues heterocycliques (aza)

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3892756A (en) * 1972-02-04 1975-07-01 Roussel Uclaf Novel dibenzocycloheptenes
BE829075A (fr) * 1974-05-15 1975-11-14 9,10-dihydroanthracen-9,10-imines substituees et leurs analogues heterocycliques (aza)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0091071A1 (en) * 1982-04-07 1983-10-12 Merck & Co. Inc. Process for the preparation of 5-methyl-10,11-dihydro-5H-dibenzo(a,d)-cyclohepten-5,10-imine and its salts

Also Published As

Publication number Publication date
ATA669778A (de) 1982-07-15
DK153843C (da) 1989-01-23
HU180868B (en) 1983-04-29
GR65703B (en) 1980-10-22
BE870562A (fr) 1979-03-19
FR2403334A1 (fr) 1979-04-13
NL191488B (nl) 1995-04-03
DK153843B (da) 1988-09-12
NZ188361A (en) 1982-06-29
ES483284A1 (es) 1980-09-01
FR2403334B1 (show.php) 1982-11-19
ES483286A1 (es) 1980-04-16
SG9585G (en) 1985-08-08
PH15920A (en) 1983-04-22
ES483287A1 (es) 1980-04-16
JPS5639315B2 (show.php) 1981-09-11
NL191488C (nl) 1995-08-04
ZA785291B (en) 1980-04-30
IE47355B1 (en) 1984-02-22
CH637954A5 (de) 1983-08-31
DK389978A (da) 1979-03-20
PL118478B1 (en) 1981-10-31
AU3966878A (en) 1980-03-13
GB2061947A (en) 1981-05-20
SU895288A3 (ru) 1981-12-30
PL209632A1 (pl) 1979-06-04
SU915800A3 (en) 1982-03-23
AR231544A1 (es) 1984-12-28
KE3501A (en) 1985-02-22
ES483288A1 (es) 1980-04-16
IE781866L (en) 1979-03-19
NO151861B (no) 1985-03-11
PL112834B1 (en) 1980-11-29
FI65618B (fi) 1984-02-29
HK30885A (en) 1985-04-26
IT7851126A0 (it) 1978-09-18
JPS5463100A (en) 1979-05-21
SE7809187L (sv) 1979-03-20
NO783017L (no) 1979-03-20
CA1129850A (en) 1982-08-17
AU520178B2 (en) 1982-01-21
GB2004872B (en) 1982-04-15
GB2061947B (en) 1982-08-04
YU41432B (en) 1987-06-30
DE2840786C2 (show.php) 1987-05-21
GB2004872A (en) 1979-04-11
CY1283A (en) 1985-07-05
NL7808847A (nl) 1979-03-21
IL55521A0 (en) 1978-12-17
IT1113279B (it) 1986-01-20
AT370103B (de) 1983-03-10
PL121605B1 (en) 1982-05-31
SE437520B (sv) 1985-03-04
ES483285A1 (es) 1980-09-01
FI65618C (fi) 1984-06-11
LU80262A1 (fr) 1979-06-01
ES483283A1 (es) 1980-04-16
YU219678A (en) 1983-02-28
NO151861C (no) 1985-06-19
ES473492A1 (es) 1980-07-16
FI782680A7 (fi) 1979-03-20
PT68544A (en) 1978-10-01

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Legal Events

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OAP Request for examination filed
OD Request for examination
D2 Grant after examination
8364 No opposition during term of opposition