GR65703B - Method for the preparation of 5-substituted-10,11-dihydro-5h-dibenzo(a,d)cycloepten-5,10-imines - Google Patents

Method for the preparation of 5-substituted-10,11-dihydro-5h-dibenzo(a,d)cycloepten-5,10-imines

Info

Publication number
GR65703B
GR65703B GR57185A GR780157185A GR65703B GR 65703 B GR65703 B GR 65703B GR 57185 A GR57185 A GR 57185A GR 780157185 A GR780157185 A GR 780157185A GR 65703 B GR65703 B GR 65703B
Authority
GR
Greece
Prior art keywords
cycloepten
dibenzo
imines
dihydro
substituted
Prior art date
Application number
GR57185A
Other languages
English (en)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of GR65703B publication Critical patent/GR65703B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
GR57185A 1977-09-19 1978-09-08 Method for the preparation of 5-substituted-10,11-dihydro-5h-dibenzo(a,d)cycloepten-5,10-imines GR65703B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83463977A 1977-09-19 1977-09-19

Publications (1)

Publication Number Publication Date
GR65703B true GR65703B (en) 1980-10-22

Family

ID=25267426

Family Applications (1)

Application Number Title Priority Date Filing Date
GR57185A GR65703B (en) 1977-09-19 1978-09-08 Method for the preparation of 5-substituted-10,11-dihydro-5h-dibenzo(a,d)cycloepten-5,10-imines

Country Status (33)

Country Link
JP (1) JPS5463100A (el)
AR (1) AR231544A1 (el)
AT (1) AT370103B (el)
AU (1) AU520178B2 (el)
BE (1) BE870562A (el)
CA (1) CA1129850A (el)
CH (1) CH637954A5 (el)
CY (1) CY1283A (el)
DE (1) DE2840786A1 (el)
DK (1) DK153843C (el)
ES (7) ES473492A1 (el)
FI (1) FI65618C (el)
FR (1) FR2403334A1 (el)
GB (2) GB2061947B (el)
GR (1) GR65703B (el)
HK (1) HK30885A (el)
HU (1) HU180868B (el)
IE (1) IE47355B1 (el)
IL (1) IL55521A0 (el)
IT (1) IT1113279B (el)
KE (1) KE3501A (el)
LU (1) LU80262A1 (el)
NL (1) NL191488C (el)
NO (1) NO151861C (el)
NZ (1) NZ188361A (el)
PH (1) PH15920A (el)
PL (3) PL118478B1 (el)
PT (1) PT68544A (el)
SE (1) SE437520B (el)
SG (1) SG9585G (el)
SU (2) SU895288A3 (el)
YU (1) YU41432B (el)
ZA (1) ZA785291B (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232158A (en) * 1979-06-04 1980-11-04 Merck & Co., Inc. 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines
US4477668A (en) * 1982-04-07 1984-10-16 Merck & Co., Inc. Process for 5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine
GB8719199D0 (en) * 1987-08-13 1987-09-23 Merck Sharp & Dohme Chemical compounds
US5686614A (en) * 1995-04-11 1997-11-11 Neurogen Corporation Preparation of chiral 5-aminocarbonyl-5H-dibenzo a,d!cyclohepten-5,10-imines by optical resolution
US5739337A (en) * 1996-03-08 1998-04-14 Neurogen Corporation Process for preparing dibenzo-1-carboxamido-1,4-azabicyclo 3.2.1!octanes
US10583171B2 (en) 2015-11-30 2020-03-10 INSERM (Institut National de la Santé et de la Recherche Médicale) NMDAR antagonists for the treatment of diseases associated with angiogenesis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE794904A (fr) * 1972-02-04 1973-08-02 Roussel Uclaf Nouveaux derives du dibenzocycloheptene et leur preparation
BE829075A (fr) * 1974-05-15 1975-11-14 9,10-dihydroanthracen-9,10-imines substituees et leurs analogues heterocycliques (aza)

Also Published As

Publication number Publication date
FI782680A (fi) 1979-03-20
IL55521A0 (en) 1978-12-17
AU3966878A (en) 1980-03-13
YU219678A (en) 1983-02-28
IE781866L (en) 1979-03-19
NZ188361A (en) 1982-06-29
ES483287A1 (es) 1980-04-16
YU41432B (en) 1987-06-30
HK30885A (en) 1985-04-26
PL121605B1 (en) 1982-05-31
NL7808847A (nl) 1979-03-21
SE7809187L (sv) 1979-03-20
NO151861C (no) 1985-06-19
PH15920A (en) 1983-04-22
ES483288A1 (es) 1980-04-16
GB2004872A (en) 1979-04-11
GB2061947B (en) 1982-08-04
SG9585G (en) 1985-08-08
FR2403334A1 (fr) 1979-04-13
DK389978A (da) 1979-03-20
IT1113279B (it) 1986-01-20
JPS5463100A (en) 1979-05-21
CA1129850A (en) 1982-08-17
ES473492A1 (es) 1980-07-16
PL118478B1 (en) 1981-10-31
SE437520B (sv) 1985-03-04
FI65618C (fi) 1984-06-11
SU915800A3 (en) 1982-03-23
FR2403334B1 (el) 1982-11-19
CH637954A5 (de) 1983-08-31
ES483283A1 (es) 1980-04-16
SU895288A3 (ru) 1981-12-30
ES483286A1 (es) 1980-04-16
ZA785291B (en) 1980-04-30
IT7851126A0 (it) 1978-09-18
NO783017L (no) 1979-03-20
CY1283A (en) 1985-07-05
ATA669778A (de) 1982-07-15
ES483285A1 (es) 1980-09-01
DE2840786A1 (de) 1979-03-22
LU80262A1 (fr) 1979-06-01
AU520178B2 (en) 1982-01-21
NL191488B (nl) 1995-04-03
KE3501A (en) 1985-02-22
GB2004872B (en) 1982-04-15
FI65618B (fi) 1984-02-29
DE2840786C2 (el) 1987-05-21
IE47355B1 (en) 1984-02-22
DK153843C (da) 1989-01-23
ES483284A1 (es) 1980-09-01
PL209632A1 (pl) 1979-06-04
BE870562A (fr) 1979-03-19
GB2061947A (en) 1981-05-20
NO151861B (no) 1985-03-11
AR231544A1 (es) 1984-12-28
PL112834B1 (en) 1980-11-29
JPS5639315B2 (el) 1981-09-11
NL191488C (nl) 1995-08-04
PT68544A (en) 1978-10-01
DK153843B (da) 1988-09-12
AT370103B (de) 1983-03-10
HU180868B (en) 1983-04-29

Similar Documents

Publication Publication Date Title
EG13530A (en) A process for preparing imidazolderivates
JPS53124585A (en) Method for forming nonnwoven
AU519107B2 (en) Process for making polyamide
GR65234B (en) Method for the preparation new cefalosporimical derivatives
PT67884A (en) Process for the preparation of a n-acethyl-dehydro- hienamycin antibiotic.
IL53587A (en) Process for the preparation of 2,5-dichlorophenol
YU41015B (en) Process for obtainig 2-formqequinoxaline -1,4-dioxyde cyanoacetylhydrazone
GR65350B (en) Method for the preparation of 2,6-diaminonouoularins
YU221682A (en) Process for obtaining a 4a, 9b-transhexahydro-gamma-carboline compound
CU21388A3 (en) A method for the preparation of vinyl clorides polimers
GR64892B (en) Method for the preparation of new derivatives of 1,3 diphenoxypropan-2-on
GB2000775B (en) Method for the preparation of -tetralone
GB2000158B (en) Method for the preparation of a plated product
GR65189B (en) Method for the preparation of 2-deoxyfortionicin a,4-n-alkyl and 4-n-acyl-2-deoxyfortionicin b derivatives and intermediates therefor
GR65703B (en) Method for the preparation of 5-substituted-10,11-dihydro-5h-dibenzo(a,d)cycloepten-5,10-imines
DE2861204D1 (en) Process for the preparation of halogenovinyl-substituted 2-tetrahydrofuranones, selected halogenovinyl-substituted 2-tetrahydrofuranones
DE2860211D1 (en) Process for the preparation of alpha-hydroxy-beta,beta-dimethyl-gamma-butyrolactone
PH15353A (en) A process for 2-chlorosulfinylazetidin-4-ones
PT67703B (en) A new pyridil-piperazine derivative and a process for the preparation thereof
IL56090A0 (en) A two stage process for preparing 2,6 pyridine-dicarboxlicacid
IL54521A0 (en) A process for preparing thiopheols
GR65322B (en) Method for the preparation of d,1-b-benzoylaminoisobutyrate acid
GR65022B (en) Method for the preparation of new substituted i-piperazinylo-triazolo-thieno-1,4-diazepines
PT68805A (en) Process for preparing anthracene-9,10-bis-carbonyl-hydrazones
GB1518784A (en) Preparation of a 4,6-diamino-5-arylazo-pyrimidine