ES483288A1 - Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas sustituidas - Google Patents

Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas sustituidas

Info

Publication number
ES483288A1
ES483288A1 ES483288A ES483288A ES483288A1 ES 483288 A1 ES483288 A1 ES 483288A1 ES 483288 A ES483288 A ES 483288A ES 483288 A ES483288 A ES 483288A ES 483288 A1 ES483288 A1 ES 483288A1
Authority
ES
Spain
Prior art keywords
phenylalkyl
cycloalkylalkyl
alkenyl
alkyl
dialkylaminoalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES483288A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES483288A1 publication Critical patent/ES483288A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Nuevas 10,11-dihidro-5H-dibenzo [a,d] ciclohepten-5,10-iminas 5-sustituidas, derivados, isómeros ópticos y sales farmacéuticamente aceptables de las mismas, que son útiles como ansiolíticos, antidepresivos, anticonvulsivos y relajantes musculares, así como en el tratamiento de trastornos combinados de ansiedad y depresión, irregularidades funcionales menores del cerebro y desórdenes extrapiramidales tales como la enfermedad de Párkinson.
ES483288A 1977-09-19 1979-08-09 Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas sustituidas Expired ES483288A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83463977A 1977-09-19 1977-09-19

Publications (1)

Publication Number Publication Date
ES483288A1 true ES483288A1 (es) 1980-04-16

Family

ID=25267426

Family Applications (7)

Application Number Title Priority Date Filing Date
ES473492A Expired ES473492A1 (es) 1977-09-19 1978-09-19 Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas.sustituidas.
ES483284A Expired ES483284A1 (es) 1977-09-19 1979-08-09 Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas sustituidas
ES483287A Expired ES483287A1 (es) 1977-09-19 1979-08-09 Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas sustituidas
ES483286A Expired ES483286A1 (es) 1977-09-19 1979-08-09 Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas sustituidas
ES483288A Expired ES483288A1 (es) 1977-09-19 1979-08-09 Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas sustituidas
ES483285A Expired ES483285A1 (es) 1977-09-19 1979-08-09 Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas sustituidas
ES483283A Expired ES483283A1 (es) 1977-09-19 1979-08-09 Un procedimiento para la preparacion de nuevas (a,d) ciclo- hepten-5,10, sustituidas.

Family Applications Before (4)

Application Number Title Priority Date Filing Date
ES473492A Expired ES473492A1 (es) 1977-09-19 1978-09-19 Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas.sustituidas.
ES483284A Expired ES483284A1 (es) 1977-09-19 1979-08-09 Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas sustituidas
ES483287A Expired ES483287A1 (es) 1977-09-19 1979-08-09 Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas sustituidas
ES483286A Expired ES483286A1 (es) 1977-09-19 1979-08-09 Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas sustituidas

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES483285A Expired ES483285A1 (es) 1977-09-19 1979-08-09 Un procedimiento para la preparacion de nuevas dibenzo (a,d)ciclohepten-5,10-iminas sustituidas
ES483283A Expired ES483283A1 (es) 1977-09-19 1979-08-09 Un procedimiento para la preparacion de nuevas (a,d) ciclo- hepten-5,10, sustituidas.

Country Status (33)

Country Link
JP (1) JPS5463100A (es)
AR (1) AR231544A1 (es)
AT (1) AT370103B (es)
AU (1) AU520178B2 (es)
BE (1) BE870562A (es)
CA (1) CA1129850A (es)
CH (1) CH637954A5 (es)
CY (1) CY1283A (es)
DE (1) DE2840786A1 (es)
DK (1) DK153843C (es)
ES (7) ES473492A1 (es)
FI (1) FI65618C (es)
FR (1) FR2403334A1 (es)
GB (2) GB2004872B (es)
GR (1) GR65703B (es)
HK (1) HK30885A (es)
HU (1) HU180868B (es)
IE (1) IE47355B1 (es)
IL (1) IL55521A0 (es)
IT (1) IT1113279B (es)
KE (1) KE3501A (es)
LU (1) LU80262A1 (es)
NL (1) NL191488C (es)
NO (1) NO151861C (es)
NZ (1) NZ188361A (es)
PH (1) PH15920A (es)
PL (3) PL121605B1 (es)
PT (1) PT68544A (es)
SE (1) SE437520B (es)
SG (1) SG9585G (es)
SU (2) SU895288A3 (es)
YU (1) YU41432B (es)
ZA (1) ZA785291B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232158A (en) * 1979-06-04 1980-11-04 Merck & Co., Inc. 10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines
US4477668A (en) * 1982-04-07 1984-10-16 Merck & Co., Inc. Process for 5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine
GB8719199D0 (en) * 1987-08-13 1987-09-23 Merck Sharp & Dohme Chemical compounds
US5686614A (en) * 1995-04-11 1997-11-11 Neurogen Corporation Preparation of chiral 5-aminocarbonyl-5H-dibenzo a,d!cyclohepten-5,10-imines by optical resolution
US5739337A (en) * 1996-03-08 1998-04-14 Neurogen Corporation Process for preparing dibenzo-1-carboxamido-1,4-azabicyclo 3.2.1!octanes
US10583171B2 (en) 2015-11-30 2020-03-10 INSERM (Institut National de la Santé et de la Recherche Médicale) NMDAR antagonists for the treatment of diseases associated with angiogenesis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE794904A (fr) * 1972-02-04 1973-08-02 Roussel Uclaf Nouveaux derives du dibenzocycloheptene et leur preparation
BE829075A (fr) * 1974-05-15 1975-11-14 9,10-dihydroanthracen-9,10-imines substituees et leurs analogues heterocycliques (aza)

Also Published As

Publication number Publication date
JPS5639315B2 (es) 1981-09-11
AR231544A1 (es) 1984-12-28
YU41432B (en) 1987-06-30
ES483283A1 (es) 1980-04-16
CH637954A5 (de) 1983-08-31
IT1113279B (it) 1986-01-20
FI65618B (fi) 1984-02-29
SE437520B (sv) 1985-03-04
AU520178B2 (en) 1982-01-21
ZA785291B (en) 1980-04-30
HU180868B (en) 1983-04-29
FI782680A (fi) 1979-03-20
GB2004872B (en) 1982-04-15
PH15920A (en) 1983-04-22
IL55521A0 (en) 1978-12-17
NO783017L (no) 1979-03-20
PL121605B1 (en) 1982-05-31
BE870562A (fr) 1979-03-19
PL209632A1 (pl) 1979-06-04
IE781866L (en) 1979-03-19
FR2403334A1 (fr) 1979-04-13
ES483285A1 (es) 1980-09-01
NO151861B (no) 1985-03-11
JPS5463100A (en) 1979-05-21
DE2840786A1 (de) 1979-03-22
GB2004872A (en) 1979-04-11
ES473492A1 (es) 1980-07-16
ES483287A1 (es) 1980-04-16
NL191488B (nl) 1995-04-03
SE7809187L (sv) 1979-03-20
NO151861C (no) 1985-06-19
IE47355B1 (en) 1984-02-22
LU80262A1 (fr) 1979-06-01
IT7851126A0 (it) 1978-09-18
DK389978A (da) 1979-03-20
CY1283A (en) 1985-07-05
ATA669778A (de) 1982-07-15
SG9585G (en) 1985-08-08
PL118478B1 (en) 1981-10-31
PT68544A (en) 1978-10-01
DE2840786C2 (es) 1987-05-21
DK153843B (da) 1988-09-12
CA1129850A (en) 1982-08-17
ES483284A1 (es) 1980-09-01
GR65703B (en) 1980-10-22
FI65618C (fi) 1984-06-11
ES483286A1 (es) 1980-04-16
YU219678A (en) 1983-02-28
AU3966878A (en) 1980-03-13
FR2403334B1 (es) 1982-11-19
AT370103B (de) 1983-03-10
DK153843C (da) 1989-01-23
SU895288A3 (ru) 1981-12-30
NL7808847A (nl) 1979-03-21
SU915800A3 (en) 1982-03-23
GB2061947A (en) 1981-05-20
NZ188361A (en) 1982-06-29
HK30885A (en) 1985-04-26
KE3501A (en) 1985-02-22
GB2061947B (en) 1982-08-04
NL191488C (nl) 1995-08-04
PL112834B1 (en) 1980-11-29

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