KR900001693A - 아자사이클릭 화합물, 이의 제조방법 및 이의 용도 - Google Patents

아자사이클릭 화합물, 이의 제조방법 및 이의 용도 Download PDF

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Publication number
KR900001693A
KR900001693A KR1019890009461A KR890009461A KR900001693A KR 900001693 A KR900001693 A KR 900001693A KR 1019890009461 A KR1019890009461 A KR 1019890009461A KR 890009461 A KR890009461 A KR 890009461A KR 900001693 A KR900001693 A KR 900001693A
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KR
South Korea
Prior art keywords
compound
formula
methyl
alkyl
paradine
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KR1019890009461A
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English (en)
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사우에르베르그 페르
Original Assignee
타게 호노레
에이/에스 페로산
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Publication of KR900001693A publication Critical patent/KR900001693A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

아자사이클릭 화합물, 이의 제조방법 및 이의 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 일반식(I)의 아자사이클릭 화합물.
    상기식에서, R1은 수소 또는 C1-6-알킬이고; R3는이고; R′은 수소, C1-6-알킬, C3-8-사이클로 알킬, C1-4-알콕시, C1-6-알케닐, C1-6-알키닐, 할로겐 또는 아미노이다.
  2. 제 1 항에 있어서, 1,2,5,6-테트라하이드로-1-메틸-3-(3-메틸-1,2,4-티아디아졸-5-일)파라딘, 1,2,5,6-테트라하이드로-1-메틸-3-(1,2,4-티아디아졸-5-일)파라딘 및 3-(3-아미노-1,2,4-티아디아졸-5-일)파라딘,1,2,5,6-테트라하이드로-1-메틸)피라딘중에서 선택된 화합물.
  3. a) 일반식(II)화합물의 반응성 유도체를 일반식(III)의 화합물과 반응시켜 일반식(I)의 화합물을 생성시키거나; b)일반식(IV)의 화합물을 알킬 힐라이드로 알킬화하고, 수득된 화합물을 하이드라이드 이온에 의해 환원시켜 일반식(V)의 화합물을 생성시킴을 특징으로 하여, 제 1 항에 따른 일반식(I)의 화합물을 제조하는 방법.
    상기식에서, R1, R3및 R′는 제 1 항에서 정의한 바와 같다.
  4. 약제학적으로 허용되는 담체 또는 희석제와 함께 포유동물의 전뇌 및 해마를 자극시키거나 알쯔하이머 질병르 치료하기에 유용한 양의 제 1 항의 일반식(I)화합물을 함유함을 특징으로 하여, 인간을 포함한 포유동물의 전뇌 및 해마다 인지 기능을 자극하고 알쯔하이머 질병을 치료하는데 사용하기에 적합한 약제학적 조성물.
  5. 제 4 항에 있어서, 활성 화합물 1 내지 100㎎을 함유하는 경구 투여 단위 형태인 약제학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890009461A 1988-07-04 1989-07-04 아자사이클릭 화합물, 이의 제조방법 및 이의 용도 KR900001693A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK371088A DK162892C (da) 1988-07-04 1988-07-04 1,2,5,6-tetrahydropyridinforbindelser, deres fremstilling og farmaceutiske praeparater indeholdende disse
DK3710/88 1988-07-04

Publications (1)

Publication Number Publication Date
KR900001693A true KR900001693A (ko) 1990-02-27

Family

ID=8125926

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890009461A KR900001693A (ko) 1988-07-04 1989-07-04 아자사이클릭 화합물, 이의 제조방법 및 이의 용도

Country Status (11)

Country Link
EP (1) EP0349956A1 (ko)
JP (1) JPH0256482A (ko)
KR (1) KR900001693A (ko)
AU (1) AU3729789A (ko)
DK (1) DK162892C (ko)
FI (1) FI893249A (ko)
IL (1) IL90753A0 (ko)
NO (1) NO892753L (ko)
PH (1) PH26396A (ko)
PT (1) PT91056A (ko)
ZA (1) ZA895005B (ko)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5043345A (en) * 1989-02-22 1991-08-27 Novo Nordisk A/S Piperidine compounds and their preparation and use
IE911994A1 (en) * 1990-07-03 1992-01-15 Akzo Nv 5-isothiazolamine derivatives
DK198590D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
DK198390D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
DK198490D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
US5418240A (en) * 1990-08-21 1995-05-23 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
USRE35822E (en) * 1990-08-21 1998-06-09 Novo Nordisk A/S Heterocyclic compounds
US5527813A (en) * 1990-08-21 1996-06-18 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
US5376668A (en) * 1990-08-21 1994-12-27 Novo Nordisk A/S Heterocyclic compounds
US5641791A (en) * 1991-08-13 1997-06-24 Novo Nordisk A.S Heterocyclic compounds and their preparation and use
WO1993014089A1 (en) * 1992-01-13 1993-07-22 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
DE4414569A1 (de) * 1994-04-27 1995-11-02 Bayer Ag Verwendung von substituierten Aminen zur Behandlung von Hirnleistungsstörungen
US5612351A (en) * 1994-11-08 1997-03-18 Novo Nordisk A/S Method of treating urinary bladder dysfunctions
US20110294835A1 (en) 2008-05-15 2011-12-01 The Board Of Trustees Of The University Of Illinois Muscarinic Agonists as Cognitive Enhancers
US9549928B2 (en) 2011-04-29 2017-01-24 The University Of Toledo Muscarinic agonists as enhancers of cognitive flexibility

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650805A (en) * 1985-12-02 1987-03-17 Warner-Lambert Company 4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines and 4-(hexahydro-1-alkyl-3-pyridinyl)-2-thiazolamines having anti-psychotic activity
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
GB8610432D0 (en) * 1986-04-29 1986-06-04 Akzo Nv Amino-thiazole & oxazole derivatives
IL83275A (en) * 1986-09-08 1994-02-27 Novo Nordisk As Compounds 1,2, 4-Oxadiazolyl Pipridine Transformed, their preparation and pharmaceutical preparations containing them
GB8714789D0 (en) * 1987-06-24 1987-07-29 Lundbeck & Co As H Heterocyclic compounds

Also Published As

Publication number Publication date
DK162892B (da) 1991-12-23
FI893249A (fi) 1990-01-05
DK162892C (da) 1992-05-11
PT91056A (pt) 1990-02-08
IL90753A0 (en) 1990-01-18
PH26396A (en) 1992-07-02
FI893249A0 (fi) 1989-07-04
EP0349956A1 (en) 1990-01-10
ZA895005B (en) 1990-04-25
AU3729789A (en) 1990-01-04
DK371088A (da) 1990-01-05
JPH0256482A (ja) 1990-02-26
NO892753L (no) 1990-01-05
DK371088D0 (da) 1988-07-04
NO892753D0 (no) 1989-07-03

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