DE2751258A1 - Trisubstituierte 1-phenyl-2,3,4,5- tetrahydro-1h-3-benzazepine und deren salze, verfahren zu ihrer herstellung und ihre verwendung als arzneistoffe - Google Patents
Trisubstituierte 1-phenyl-2,3,4,5- tetrahydro-1h-3-benzazepine und deren salze, verfahren zu ihrer herstellung und ihre verwendung als arzneistoffeInfo
- Publication number
- DE2751258A1 DE2751258A1 DE19772751258 DE2751258A DE2751258A1 DE 2751258 A1 DE2751258 A1 DE 2751258A1 DE 19772751258 DE19772751258 DE 19772751258 DE 2751258 A DE2751258 A DE 2751258A DE 2751258 A1 DE2751258 A1 DE 2751258A1
- Authority
- DE
- Germany
- Prior art keywords
- tetrahydro
- benzazepine
- group
- phenyl
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/742,965 US4160765A (en) | 1976-11-17 | 1976-11-17 | Method for 6-bromination of 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2751258A1 true DE2751258A1 (de) | 1978-06-01 |
| DE2751258C2 DE2751258C2 (US20080293856A1-20081127-C00150.png) | 1990-01-04 |
Family
ID=24986959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19772751258 Granted DE2751258A1 (de) | 1976-11-17 | 1977-11-16 | Trisubstituierte 1-phenyl-2,3,4,5- tetrahydro-1h-3-benzazepine und deren salze, verfahren zu ihrer herstellung und ihre verwendung als arzneistoffe |
Country Status (37)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0022330A2 (en) * | 1979-07-10 | 1981-01-14 | Smithkline Beckman Corporation | Synergistic antihypertensive compositions |
| WO2005118549A2 (en) * | 2004-06-02 | 2005-12-15 | Glaxo Group Limited | Compounds having affinity for dopamine d3 receptor and uses thereof |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4197297A (en) * | 1976-11-17 | 1980-04-08 | Smithkline Corporation | 6-Halo-7,8-dihydroxy-1-(hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepines |
| JPS5481290A (en) * | 1977-11-17 | 1979-06-28 | Smithkline Corp | Benzazepin compound |
| US4171359A (en) * | 1978-04-12 | 1979-10-16 | Smithkline Corporation | Benz-tetrasubstituted 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines |
| ZA792043B (en) * | 1978-05-08 | 1980-05-28 | Scherico Ltd | Esters of substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines,process for the preparation thereof and pharmaceutical compositions containing them |
| US4251525A (en) * | 1979-05-25 | 1981-02-17 | Smithkline Corporation | 3-Allyl-7,8-dihydroxy-6-halo-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives |
| US4285938A (en) * | 1979-10-11 | 1981-08-25 | Smithkline Corporation | 7,8-Dihydroxy-1-(sulfamylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives |
| US4284556A (en) * | 1980-01-31 | 1981-08-18 | Smithkline Corporation | 7,8-Amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines |
| US4328153A (en) * | 1980-07-17 | 1982-05-04 | Smith Kline Corporation | Dopaminergic benzazepines |
| ATE15762T1 (de) * | 1981-12-08 | 1985-10-15 | Smithkline Beckman Corp | Pharmazeutische zusammensetzungen mit gehalt an 7,8-dihydroxy-1-(hydroxy-phenyl)-2,3,4,5tetrahydro-1h-3-benzazepin-derivaten und an einem beta-adrenergischen blocker. |
| US4705862A (en) * | 1984-10-05 | 1987-11-10 | Smithkline Beckman Corporation | Chemical processes for 2-(2-halo-3,4-dimethoxybenzyl)-5-(4-methoxyphenyl)oxazolidines |
| US4782163A (en) * | 1984-10-05 | 1988-11-01 | Smithkline Beckman Corporation | 2-(2-halo-3,4-dimethoxybenzyl)-5-(4-methoxyphenyl)-oxazolidines |
| US5068326A (en) * | 1989-04-03 | 1991-11-26 | Kung Hank F | Dopamine receptor ligands and imaging agents |
| KR20010113006A (ko) * | 2000-06-15 | 2001-12-24 | 주정호 | 항암제로서 유용한 ｎ-치환된 벤즈아제피닐우레아 유도체및 그의 제조방법 |
| US7645442B2 (en) | 2001-05-24 | 2010-01-12 | Alexza Pharmaceuticals, Inc. | Rapid-heating drug delivery article and method of use |
| US7090830B2 (en) | 2001-05-24 | 2006-08-15 | Alexza Pharmaceuticals, Inc. | Drug condensation aerosols and kits |
| US7458374B2 (en) | 2002-05-13 | 2008-12-02 | Alexza Pharmaceuticals, Inc. | Method and apparatus for vaporizing a compound |
| US7766013B2 (en) | 2001-06-05 | 2010-08-03 | Alexza Pharmaceuticals, Inc. | Aerosol generating method and device |
| US20070122353A1 (en) | 2001-05-24 | 2007-05-31 | Hale Ron L | Drug condensation aerosols and kits |
| US7585493B2 (en) | 2001-05-24 | 2009-09-08 | Alexza Pharmaceuticals, Inc. | Thin-film drug delivery article and method of use |
| US20040105818A1 (en) | 2002-11-26 | 2004-06-03 | Alexza Molecular Delivery Corporation | Diuretic aerosols and methods of making and using them |
| US7913688B2 (en) | 2002-11-27 | 2011-03-29 | Alexza Pharmaceuticals, Inc. | Inhalation device for producing a drug aerosol |
| JP2007516149A (ja) | 2003-05-21 | 2007-06-21 | アレックザ ファーマシューティカルズ， インコーポレイテッド | 基板温度の均一性を制御する方法、および、内蔵式加熱ユニットおよびそれを使用する薬剤供給ユニット |
| US7540286B2 (en) | 2004-06-03 | 2009-06-02 | Alexza Pharmaceuticals, Inc. | Multiple dose condensation aerosol devices and methods of forming condensation aerosols |
| AU2004322756B2 (en) | 2004-08-12 | 2011-04-14 | Alexza Pharmaceuticals, Inc. | Aerosol drug delivery device incorporating percussively activated heat packages |
| CA2593667A1 (en) * | 2005-01-24 | 2006-07-27 | Sicor Inc. | Process for the preparation of fenoldopam mesylate |
| US20080216828A1 (en) | 2007-03-09 | 2008-09-11 | Alexza Pharmaceuticals, Inc. | Heating unit for use in a drug delivery device |
| CN104876869B (zh) * | 2011-12-22 | 2017-06-30 | 四川科伦药物研究院有限公司 | 一种手性菲诺多泮的拆分方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1118688A (en) * | 1967-02-17 | 1968-07-03 | Scherico Ltd | Novel benzazepines and process for making same |
| US3393192A (en) * | 1965-04-26 | 1968-07-16 | Schering Corp | Novel benzazepines |
| DE1695844A1 (de) * | 1967-02-21 | 1972-01-20 | Scherico Ltd | Neue Benzazepine und Verfahren zu ihrer Herstellung |
| CH555831A (de) * | 1967-02-17 | 1974-11-15 | Scherico Ltd | Verfahren zur herstellung von neuen benzazepinen. |
| US4011319A (en) * | 1975-07-02 | 1977-03-08 | Smithkline Corporation | Pharmaceutical compositions and methods involving benzazepine derivatives |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH498122A (de) * | 1968-02-09 | 1970-10-31 | Geigy Ag J R | Verfahren zur Herstellung eines neuen Tetrahydroazepinderivates |
| US3609138A (en) * | 1967-12-22 | 1971-09-28 | Ciba Geigy Corp | 1-aryl-3-benzazepines |
-
1976
- 1976-11-17 US US05/742,965 patent/US4160765A/en not_active Expired - Lifetime
-
1977
- 1977-10-04 ZA ZA00775910A patent/ZA775910B/xx unknown
- 1977-11-07 GB GB46184/77A patent/GB1595502A/en not_active Expired
- 1977-11-07 CY CY1246A patent/CY1246A/xx unknown
- 1977-11-10 CA CA290,593A patent/CA1092107A/en not_active Expired
- 1977-11-11 PT PT67260A patent/PT67260B/pt unknown
- 1977-11-11 PH PH20427A patent/PH13611A/en unknown
- 1977-11-11 YU YU2707/77A patent/YU40490B/xx unknown
- 1977-11-11 DK DK500477A patent/DK156057C/da not_active IP Right Cessation
- 1977-11-11 RO RO7792097A patent/RO72905A/ro unknown
- 1977-11-11 ES ES464044A patent/ES464044A1/es not_active Expired
- 1977-11-14 BG BG7737779A patent/BG30019A3/xx unknown
- 1977-11-14 BE BE182575A patent/BE860774A/xx not_active IP Right Cessation
- 1977-11-14 NO NO773901A patent/NO147029C/no unknown
- 1977-11-14 IL IL53377A patent/IL53377A/xx unknown
- 1977-11-14 MX MX776556U patent/MX4682E/es unknown
- 1977-11-14 AU AU30626/77A patent/AU509754B2/en not_active Expired
- 1977-11-14 IE IE2311/77A patent/IE46087B1/en not_active IP Right Cessation
- 1977-11-14 LU LU78513A patent/LU78513A1/xx unknown
- 1977-11-15 AR AR269983A patent/AR224495A1/es active
- 1977-11-15 IT IT29708/77A patent/IT1126216B/it active Protection Beyond IP Right Term
- 1977-11-15 FR FR7734311A patent/FR2371430A1/fr active Granted
- 1977-11-15 FI FI773448A patent/FI67374C/fi not_active IP Right Cessation
- 1977-11-15 AT AT816377A patent/AT362379B/de active
- 1977-11-15 NL NLAANVRAGE7712567,A patent/NL185563C/xx not_active IP Right Cessation
- 1977-11-16 PL PL1977202177A patent/PL109672B1/pl unknown
- 1977-11-16 SE SE7712944A patent/SE436646B/sv not_active IP Right Cessation
- 1977-11-16 JP JP13841077A patent/JPS5363335A/ja active Granted
- 1977-11-16 DD DD7700202113A patent/DD133563A5/xx unknown
- 1977-11-16 DE DE19772751258 patent/DE2751258A1/de active Granted
- 1977-11-16 SU SU772544154A patent/SU976847A3/ru active
- 1977-11-17 CS CS777593A patent/CS219333B2/cs unknown
- 1977-11-17 HU HU77SI1605A patent/HU176709B/hu not_active IP Right Cessation
-
1978
- 1978-09-14 PH PH21605A patent/PH14740A/en unknown
- 1978-11-03 IN IN790/DEL/78A patent/IN150172B/en unknown
-
1982
- 1982-01-14 CH CH21082A patent/CH635079A5/de not_active IP Right Cessation
- 1982-12-18 JP JP57222834A patent/JPS58113153A/ja active Granted
-
1984
- 1984-04-19 SG SG317/84A patent/SG31784G/en unknown
-
1985
- 1985-12-30 MY MY382/85A patent/MY8500382A/xx unknown
-
1986
- 1986-08-25 JP JP61199885A patent/JPS62155218A/ja active Granted
-
1993
- 1993-04-14 NL NL930026C patent/NL930026I2/nl unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3393192A (en) * | 1965-04-26 | 1968-07-16 | Schering Corp | Novel benzazepines |
| GB1118688A (en) * | 1967-02-17 | 1968-07-03 | Scherico Ltd | Novel benzazepines and process for making same |
| CH555831A (de) * | 1967-02-17 | 1974-11-15 | Scherico Ltd | Verfahren zur herstellung von neuen benzazepinen. |
| DE1695844A1 (de) * | 1967-02-21 | 1972-01-20 | Scherico Ltd | Neue Benzazepine und Verfahren zu ihrer Herstellung |
| US4011319A (en) * | 1975-07-02 | 1977-03-08 | Smithkline Corporation | Pharmaceutical compositions and methods involving benzazepine derivatives |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0022330A2 (en) * | 1979-07-10 | 1981-01-14 | Smithkline Beckman Corporation | Synergistic antihypertensive compositions |
| EP0022330A3 (en) * | 1979-07-10 | 1981-01-21 | Smithkline Beckman Corporation | Synergistic antihypertensive compositions |
| WO2005118549A2 (en) * | 2004-06-02 | 2005-12-15 | Glaxo Group Limited | Compounds having affinity for dopamine d3 receptor and uses thereof |
| WO2005118549A3 (en) * | 2004-06-02 | 2006-04-13 | Glaxo Group Ltd | Compounds having affinity for dopamine d3 receptor and uses thereof |
| US7989444B2 (en) | 2004-06-02 | 2011-08-02 | Glaxo Group Limited | Compounds having affinity for dopamine D3 receptor and uses thereof |
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| 8127 | New person/name/address of the applicant |
Owner name: SMITHKLINE BECKMAN CORP., 19101 PHILADELPHIA, PA., |
|
| 8128 | New person/name/address of the agent |
Representative=s name: VOSSIUS, V., DIPL.-CHEM. DR.RER.NAT. VOSSIUS, D., |
|
| 8128 | New person/name/address of the agent |
Representative=s name: VOSSIUS, V., DIPL.-CHEM. DR.RER.NAT. TAUCHNER, P., |
|
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Free format text: TAUCHNER, P., DIPL.-CHEM. DR.RER.NAT., PAT.-ANW., 8000 MUENCHEN |