AT362379B - Verfahren zur herstellung von neuen trisubsti- tuierten 1-phenyl-2,3,4,5-tetrahydro-1h-3- -benzazepinen und ihren salzen - Google Patents

Verfahren zur herstellung von neuen trisubsti- tuierten 1-phenyl-2,3,4,5-tetrahydro-1h-3- -benzazepinen und ihren salzen

Info

Publication number
AT362379B
AT362379B AT816377A AT816377A AT362379B AT 362379 B AT362379 B AT 362379B AT 816377 A AT816377 A AT 816377A AT 816377 A AT816377 A AT 816377A AT 362379 B AT362379 B AT 362379B
Authority
AT
Austria
Prior art keywords
benzazepines
tetrahydro
phenyl
salts
producing new
Prior art date
Application number
AT816377A
Other languages
English (en)
Other versions
ATA816377A (de
Original Assignee
Smithkline Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Corp filed Critical Smithkline Corp
Publication of ATA816377A publication Critical patent/ATA816377A/de
Application granted granted Critical
Publication of AT362379B publication Critical patent/AT362379B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT816377A 1976-11-17 1977-11-15 Verfahren zur herstellung von neuen trisubsti- tuierten 1-phenyl-2,3,4,5-tetrahydro-1h-3- -benzazepinen und ihren salzen AT362379B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/742,965 US4160765A (en) 1976-11-17 1976-11-17 Method for 6-bromination of 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds

Publications (2)

Publication Number Publication Date
ATA816377A ATA816377A (de) 1980-10-15
AT362379B true AT362379B (de) 1981-05-11

Family

ID=24986959

Family Applications (1)

Application Number Title Priority Date Filing Date
AT816377A AT362379B (de) 1976-11-17 1977-11-15 Verfahren zur herstellung von neuen trisubsti- tuierten 1-phenyl-2,3,4,5-tetrahydro-1h-3- -benzazepinen und ihren salzen

Country Status (37)

Country Link
US (1) US4160765A (de)
JP (3) JPS5363335A (de)
AR (1) AR224495A1 (de)
AT (1) AT362379B (de)
AU (1) AU509754B2 (de)
BE (1) BE860774A (de)
BG (1) BG30019A3 (de)
CA (1) CA1092107A (de)
CH (1) CH635079A5 (de)
CS (1) CS219333B2 (de)
CY (1) CY1246A (de)
DD (1) DD133563A5 (de)
DE (1) DE2751258A1 (de)
DK (1) DK156057C (de)
ES (1) ES464044A1 (de)
FI (1) FI67374C (de)
FR (1) FR2371430A1 (de)
GB (1) GB1595502A (de)
HU (1) HU176709B (de)
IE (1) IE46087B1 (de)
IL (1) IL53377A (de)
IN (1) IN150172B (de)
IT (1) IT1126216B (de)
LU (1) LU78513A1 (de)
MX (1) MX4682E (de)
MY (1) MY8500382A (de)
NL (2) NL185563C (de)
NO (1) NO147029C (de)
PH (2) PH13611A (de)
PL (1) PL109672B1 (de)
PT (1) PT67260B (de)
RO (1) RO72905A (de)
SE (1) SE436646B (de)
SG (1) SG31784G (de)
SU (1) SU976847A3 (de)
YU (1) YU40490B (de)
ZA (1) ZA775910B (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4197297A (en) * 1976-11-17 1980-04-08 Smithkline Corporation 6-Halo-7,8-dihydroxy-1-(hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepines
JPS5481290A (en) * 1977-11-17 1979-06-28 Smithkline Corp Benzazepin compound
US4171359A (en) * 1978-04-12 1979-10-16 Smithkline Corporation Benz-tetrasubstituted 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
ZA792043B (en) * 1978-05-08 1980-05-28 Scherico Ltd Esters of substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines,process for the preparation thereof and pharmaceutical compositions containing them
US4251525A (en) * 1979-05-25 1981-02-17 Smithkline Corporation 3-Allyl-7,8-dihydroxy-6-halo-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives
EP0022330B1 (de) * 1979-07-10 1983-12-21 Smithkline Beckman Corporation Synergistische blutdrucksenkende Zusammensetzungen
US4285938A (en) * 1979-10-11 1981-08-25 Smithkline Corporation 7,8-Dihydroxy-1-(sulfamylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives
US4284556A (en) * 1980-01-31 1981-08-18 Smithkline Corporation 7,8-Amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
US4328153A (en) * 1980-07-17 1982-05-04 Smith Kline Corporation Dopaminergic benzazepines
DE3172458D1 (en) * 1981-12-08 1985-10-31 Smithkline Beckman Corp Pharmaceutical compositions comprising 7,8-dihydroxy-1(hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine derivatives and a beta-adrenergic blocking compound
US4705862A (en) * 1984-10-05 1987-11-10 Smithkline Beckman Corporation Chemical processes for 2-(2-halo-3,4-dimethoxybenzyl)-5-(4-methoxyphenyl)oxazolidines
US4782163A (en) * 1984-10-05 1988-11-01 Smithkline Beckman Corporation 2-(2-halo-3,4-dimethoxybenzyl)-5-(4-methoxyphenyl)-oxazolidines
US5068326A (en) * 1989-04-03 1991-11-26 Kung Hank F Dopamine receptor ligands and imaging agents
KR20010113006A (ko) * 2000-06-15 2001-12-24 주정호 항암제로서 유용한 ｎ-치환된 벤즈아제피닐우레아 유도체및 그의 제조방법
US7585493B2 (en) 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US7766013B2 (en) 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
US7090830B2 (en) 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
WO2004104490A1 (en) 2003-05-21 2004-12-02 Alexza Pharmaceuticals, Inc. Self-contained heating unit and drug-supply unit employing same
GB0412314D0 (en) * 2004-06-02 2004-07-07 Glaxo Group Ltd Compounds
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
WO2006022714A1 (en) 2004-08-12 2006-03-02 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heat packages
MX2007008849A (es) * 2005-01-24 2007-08-21 Sicor Inc Proceso para la preparacion de mesilato de fenoldopam.
WO2008112661A2 (en) 2007-03-09 2008-09-18 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
CN104876869B (zh) * 2011-12-22 2017-06-30 四川科伦药物研究院有限公司 一种手性菲诺多泮的拆分方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3393192A (en) * 1965-04-26 1968-07-16 Schering Corp Novel benzazepines
CH555831A (de) * 1967-02-17 1974-11-15 Scherico Ltd Verfahren zur herstellung von neuen benzazepinen.
GB1118688A (en) * 1967-02-17 1968-07-03 Scherico Ltd Novel benzazepines and process for making same
CH498122A (de) * 1968-02-09 1970-10-31 Geigy Ag J R Verfahren zur Herstellung eines neuen Tetrahydroazepinderivates
DE1695844C3 (de) * 1967-02-21 1980-01-17 Scherico Ltd., Luzern (Schweiz) l-Phenyl-23,43-tetrahydro-lH^benzazepin-Derivate und sie enthaltende pharmazeutische Zusammensetzungen
US3609138A (en) * 1967-12-22 1971-09-28 Ciba Geigy Corp 1-aryl-3-benzazepines
US4011319A (en) * 1975-07-02 1977-03-08 Smithkline Corporation Pharmaceutical compositions and methods involving benzazepine derivatives

Also Published As

Publication number Publication date
IT1126216B (it) 1986-05-14
BE860774A (fr) 1978-05-16
FI67374C (fi) 1985-03-11
NL185563C (nl) 1990-05-16
JPS6366808B2 (de) 1988-12-22
NO147029C (no) 1983-01-19
YU270777A (en) 1983-02-28
JPS6125697B2 (de) 1986-06-17
SU976847A3 (ru) 1982-11-23
DE2751258C2 (de) 1990-01-04
JPS62155218A (ja) 1987-07-10
YU40490B (en) 1986-02-28
JPS5363335A (en) 1978-06-06
SG31784G (en) 1985-03-08
BG30019A3 (en) 1981-03-16
HU176709B (en) 1981-04-28
AU3062677A (en) 1979-05-24
JPS6225658B2 (de) 1987-06-04
FR2371430B1 (de) 1980-06-27
ES464044A1 (es) 1978-08-01
IE46087B1 (en) 1983-02-23
DE2751258A1 (de) 1978-06-01
IE46087L (en) 1978-05-17
PH13611A (en) 1980-08-05
SE436646B (sv) 1985-01-14
ATA816377A (de) 1980-10-15
NL7712567A (nl) 1978-05-19
DK156057C (da) 1989-11-13
NO147029B (no) 1982-10-11
PT67260A (en) 1977-12-01
PH14740A (en) 1981-11-20
DD133563A5 (de) 1979-01-10
CS219333B2 (en) 1983-03-25
CY1246A (en) 1984-08-31
US4160765A (en) 1979-07-10
MX4682E (es) 1982-07-28
NL185563B (nl) 1989-12-18
GB1595502A (en) 1981-08-12
DK156057B (da) 1989-06-19
IL53377A (en) 1982-09-30
AR224495A1 (es) 1981-12-15
RO72905A (ro) 1981-11-04
NL930026I2 (nl) 1993-11-01
MY8500382A (en) 1985-12-31
ZA775910B (en) 1978-05-30
CH635079A5 (de) 1983-03-15
FR2371430A1 (fr) 1978-06-16
PL109672B1 (en) 1980-06-30
SE7712944L (sv) 1978-05-18
NL930026I1 (nl) 1993-06-01
LU78513A1 (de) 1978-03-20
PT67260B (en) 1979-04-18
FI67374B (fi) 1984-11-30
PL202177A1 (pl) 1978-09-25
IN150172B (de) 1982-04-07
NO773901L (no) 1978-05-19
IL53377A0 (en) 1978-01-31
FI773448A (fi) 1978-05-18
DK500477A (da) 1978-05-18
AU509754B2 (en) 1980-05-22
JPS58113153A (ja) 1983-07-05
CA1092107A (en) 1980-12-23

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