DE2649925C2 - 5,5-Dimethyl-3-[4-nitro-3-(trifluormethyl)-phenyl]-2-imidazolidinone, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Mittel - Google Patents

5,5-Dimethyl-3-[4-nitro-3-(trifluormethyl)-phenyl]-2-imidazolidinone, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Mittel

Info

Publication number
DE2649925C2
DE2649925C2 DE2649925A DE2649925A DE2649925C2 DE 2649925 C2 DE2649925 C2 DE 2649925C2 DE 2649925 A DE2649925 A DE 2649925A DE 2649925 A DE2649925 A DE 2649925A DE 2649925 C2 DE2649925 C2 DE 2649925C2
Authority
DE
Germany
Prior art keywords
nitro
phenyl
trifluoromethyl
dimethyl
imidazolidinones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2649925A
Other languages
German (de)
English (en)
Other versions
DE2649925A1 (de
Inventor
Claude Bry-Sur-Marne Bonne
Pierre Paris Girault
Jacques Perronnet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of DE2649925A1 publication Critical patent/DE2649925A1/de
Application granted granted Critical
Publication of DE2649925C2 publication Critical patent/DE2649925C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Electromechanical Clocks (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE2649925A 1975-10-29 1976-10-29 5,5-Dimethyl-3-[4-nitro-3-(trifluormethyl)-phenyl]-2-imidazolidinone, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Mittel Expired DE2649925C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7533084A FR2329276A1 (fr) 1975-10-29 1975-10-29 Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant

Publications (2)

Publication Number Publication Date
DE2649925A1 DE2649925A1 (de) 1977-05-12
DE2649925C2 true DE2649925C2 (de) 1986-08-28

Family

ID=9161795

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2649925A Expired DE2649925C2 (de) 1975-10-29 1976-10-29 5,5-Dimethyl-3-[4-nitro-3-(trifluormethyl)-phenyl]-2-imidazolidinone, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Mittel

Country Status (18)

Country Link
US (1) US4097578A (enExample)
JP (1) JPS6011701B2 (enExample)
AU (1) AU500542B2 (enExample)
BE (1) BE847742A (enExample)
BG (1) BG60533B2 (enExample)
CA (1) CA1086751A (enExample)
CH (1) CH599164A5 (enExample)
DE (1) DE2649925C2 (enExample)
DK (1) DK152125C (enExample)
ES (1) ES452746A1 (enExample)
FR (1) FR2329276A1 (enExample)
GB (1) GB1518444A (enExample)
GE (1) GEP19970948B (enExample)
IE (1) IE43875B1 (enExample)
LU (2) LU76085A1 (enExample)
NL (2) NL187102C (enExample)
SE (1) SE430502B (enExample)
SU (1) SU596165A3 (enExample)

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US4775660A (en) * 1984-08-02 1988-10-04 Fernand Labrie Treatment of breast cancer by combination therapy
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FR2619381B1 (fr) * 1987-08-13 1989-12-08 Roussel Uclaf Nouvelles imidazolidines substituees par un radical hydroxymethyle et un radical phenyl substitue, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant et un intermediaire pour leur preparation
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FR2656302B1 (fr) * 1989-12-22 1992-05-07 Roussel Uclaf Nouveau procede de preparation de l'anandron et derives de l'anandron.
FR2671348B1 (fr) * 1991-01-09 1993-03-26 Roussel Uclaf Nouvelles phenylimidazolidines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant.
FR2693461B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
US5411981A (en) * 1991-01-09 1995-05-02 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
USRE35956E (en) * 1991-01-09 1998-11-10 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
US6002016A (en) * 1991-12-20 1999-12-14 Rhone-Poulenc Agrochimie Fungicidal 2-imidazolin-5-ones and 2-imidazoline-5-thiones
FR2685328B1 (fr) * 1991-12-20 1995-12-01 Rhone Poulenc Agrochimie Derives de 2-imidazoline-5-ones et 2-imidazoline-5-thiones fongicides.
FR2706456B1 (fr) 1993-06-18 1996-06-28 Rhone Poulenc Agrochimie Dérivés optiquement actifs de 2-imidazoline-5-ones et 2-imidazoline-5-thiones fongicides.
FR2694290B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
US6008370A (en) * 1992-11-25 1999-12-28 Rhone-Poulenc Agrochimie Fungicidal-2-alkoxy/haloalkoxy-1-(mono- or disubstituted)amino-4,4-disubstituted-2-imidazolin-5-ones
FR2724169B1 (fr) * 1994-09-06 1997-01-03 Roussel Uclaf Nouvelles phenylimidazolidines eventuellement substituees, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
TW521073B (en) * 1994-01-05 2003-02-21 Hoechst Marion Roussel Inc New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them
FR2715402B1 (fr) * 1994-01-05 1996-10-04 Roussel Uclaf Nouvelles phénylimidazolines éventuellement substituées, leur procédé et des intermédiaires de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
FR2725206B1 (fr) * 1994-09-29 1996-12-06 Roussel Uclaf Nouvelles imidazolidines substituees par un heterocycle, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
US5656651A (en) * 1995-06-16 1997-08-12 Biophysica Inc. Androgenic directed compositions
US6566372B1 (en) 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
US20040077605A1 (en) 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
HUP0303172A3 (en) * 2000-06-28 2006-05-29 Bristol Myers Squibb Co Selective androgen receptor modulators and methods for their identification, desing and use
US7001911B2 (en) 2000-06-28 2006-02-21 Bristol-Myers Squibb Company Fused cyclic modulators of nuclear hormone receptor function
US6953679B2 (en) 2000-09-19 2005-10-11 Bristol-Myers Squibb Company Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof
EP1854798A3 (en) 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
AU2002322493A1 (en) * 2001-07-10 2003-01-29 Ams Research Corporation Surgical kit for treating prostate tissue
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US7354933B2 (en) * 2003-01-31 2008-04-08 Aventis Pharma Sa Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
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EP2299266A1 (en) * 2003-12-19 2011-03-23 The Regents of the University of California Methods and materials for assessing prostate cancer therapies
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BRPI0709771B1 (pt) 2006-03-27 2022-01-25 The Regents Of The University Of California Composto e composição farmacêutica
NZ596260A (en) * 2006-03-29 2013-05-31 Univ California Diarylthiohydantoin compounds
ATE547394T1 (de) 2006-12-01 2012-03-15 Bristol Myers Squibb Co N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen
US9232959B2 (en) 2007-01-02 2016-01-12 Aquabeam, Llc Multi fluid tissue resection methods and devices
JP5369336B2 (ja) * 2007-01-02 2013-12-18 アクアビーム エルエルシー 前立腺の疾患を治療するための侵襲性が最小である方法及びデバイス
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GB997037A (en) * 1962-03-19 1965-06-30 Ici Ltd New hydrantoin derivatives
JPS4920973B1 (enExample) * 1970-05-28 1974-05-29
JPS5136332B1 (enExample) * 1970-12-09 1976-10-07
IL45459A (en) * 1973-09-03 1978-01-31 Ciba Geigy Ag 1-(dichlorofluoromethylthio)-3-phenyl-imidazolidine-2,4-dione derivatives their preparation and their use as bactericides and fungicides

Also Published As

Publication number Publication date
GEP19970948B (en) 1997-04-18
NL930079I2 (nl) 1993-10-01
NL930079I1 (nl) 1993-09-16
DE2649925A1 (de) 1977-05-12
SE430502B (sv) 1983-11-21
SE7610859L (sv) 1977-04-30
LU76085A1 (enExample) 1977-05-31
SU596165A3 (ru) 1978-02-28
LU88282I2 (fr) 1994-05-04
US4097578A (en) 1978-06-27
DK152125C (da) 1988-06-20
IE43875B1 (en) 1981-06-17
NL187102C (nl) 1991-06-03
JPS6011701B2 (ja) 1985-03-27
BE847742A (fr) 1977-04-28
DK487476A (da) 1977-04-30
ES452746A1 (es) 1977-10-01
JPS5257176A (en) 1977-05-11
NL187102B (nl) 1991-01-02
CH599164A5 (enExample) 1978-05-12
FR2329276B1 (enExample) 1979-09-14
AU1909576A (en) 1978-05-04
AU500542B2 (en) 1979-05-24
FR2329276A1 (fr) 1977-05-27
CA1086751A (fr) 1980-09-30
DK152125B (da) 1988-02-01
GB1518444A (en) 1978-07-19
BG60533B2 (bg) 1995-07-28
NL7611576A (nl) 1977-05-03
IE43875L (en) 1977-04-29

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Representative=s name: ASSMANN, E., DIPL.-CHEM. DR.RER.NAT. KLINGSEISEN,

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