DE2408804C2 - 1-(2-Methoxyphenyl)-4-[3-(naphth-1-yl-oxy)-2-hydroxy-propyl]-piperazin, dessen Salze, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten - Google Patents

1-(2-Methoxyphenyl)-4-[3-(naphth-1-yl-oxy)-2-hydroxy-propyl]-piperazin, dessen Salze, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten

Info

Publication number
DE2408804C2
DE2408804C2 DE2408804A DE2408804A DE2408804C2 DE 2408804 C2 DE2408804 C2 DE 2408804C2 DE 2408804 A DE2408804 A DE 2408804A DE 2408804 A DE2408804 A DE 2408804A DE 2408804 C2 DE2408804 C2 DE 2408804C2
Authority
DE
Germany
Prior art keywords
oxy
naphth
hydroxypropyl
methoxyphenyl
piperazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2408804A
Other languages
German (de)
English (en)
Other versions
DE2408804A1 (de
Inventor
Egon Dr.Med. 6840 Lampertheim Roesch
Gisbert Dr.Med.Vet. 6944 Hemsbach Sponer
Kurt Dr.-Ing. Stach
Max Dr.Rer.Nat. 6800 Mannheim Thiel
Ernst-Christian Dr.Rer.Nat. Witte
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to NLAANVRAGE7501877,A priority Critical patent/NL175059C/xx
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Priority to DE2408804A priority patent/DE2408804C2/de
Priority to AR257639A priority patent/AR206339A1/es
Priority to US05/544,719 priority patent/US3997666A/en
Priority to CA219,883A priority patent/CA1039282A/en
Priority to AU78268/75A priority patent/AU486489B2/en
Priority to GB656975A priority patent/GB1445548A/en
Priority to YU0382/75A priority patent/YU37156B/xx
Priority to DK58175A priority patent/DK135124C/da
Priority to NLAANVRAGE7501877,A priority patent/NL175059B/xx
Priority to ES434829A priority patent/ES434829A1/es
Priority to FI750449A priority patent/FI59248C/fi
Priority to ZA00751031A priority patent/ZA751031B/xx
Priority to MX511375U priority patent/MX3750E/es
Priority to BE153540A priority patent/BE825755A/xx
Priority to JP50021386A priority patent/JPS6029712B2/ja
Priority to SE7501911A priority patent/SE405601B/xx
Priority to CH218575A priority patent/CH609342A5/xx
Priority to SU2112509A priority patent/SU549085A3/ru
Priority to FR7505511A priority patent/FR2261770B1/fr
Priority to PL1975178230A priority patent/PL92131B1/pl
Priority to IE359/75A priority patent/IE40678B1/xx
Priority to AT132375A priority patent/AT340937B/de
Priority to CH1023478A priority patent/CH612958A5/xx
Publication of DE2408804A1 publication Critical patent/DE2408804A1/de
Priority to SU2308659A priority patent/SU561514A3/ru
Priority to AT26277A priority patent/AT340940B/de
Priority to YU1044/81A priority patent/YU37157B/xx
Application granted granted Critical
Publication of DE2408804C2 publication Critical patent/DE2408804C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE2408804A 1974-02-23 1974-02-23 1-(2-Methoxyphenyl)-4-[3-(naphth-1-yl-oxy)-2-hydroxy-propyl]-piperazin, dessen Salze, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten Expired DE2408804C2 (de)

Priority Applications (27)

Application Number Priority Date Filing Date Title
NLAANVRAGE7501877,A NL175059C (nl) 1974-02-23 Bereiding van bloeddrukverlagende stoffen en van preparaten die ze bevatten.
DE2408804A DE2408804C2 (de) 1974-02-23 1974-02-23 1-(2-Methoxyphenyl)-4-[3-(naphth-1-yl-oxy)-2-hydroxy-propyl]-piperazin, dessen Salze, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten
AR257639A AR206339A1 (es) 1974-02-23 1975-01-01 Procedimiento para la preparacion de derivados de 1-(metoxifenil)-4-(3-(naft-1-il-oxi)-2-hidroxi-propil)-piperazina
US05/544,719 US3997666A (en) 1974-02-23 1975-01-28 1-[3-(Naphth-1-yloxy)-2-hydroxypropvl]-piperazine compounds and therapeutic compositions
CA219,883A CA1039282A (en) 1974-02-23 1975-02-12 1-(3-(naphth-1-yloxy)-2-hydroxy-propyl)-piperazine derivatives
AU78268/75A AU486489B2 (en) 1974-02-23 1975-02-17 1-[3-(naphth-1-yloxyo-2-hydroxypropyl] piperazine derivatives
GB656975A GB1445548A (en) 1974-02-23 1975-02-17 1-3-naphth-1-yloxy-2-hydroxypropyl-piperazine derivatives
YU0382/75A YU37156B (en) 1974-02-23 1975-02-18 Process for preparing 1-z3-(naphthyl-1-yloxy)-2-hydroxy-propylc-piperazine derivatives
DK58175A DK135124C (da) 1974-02-23 1975-02-18 Analogifremgangsmade til fremstilling af 1-(3-(naphth-1-yl-oxy)-2-hydroxypropyl)-piperazinderivater eller syreadditionssalte heraf
NLAANVRAGE7501877,A NL175059B (nl) 1974-02-23 1975-02-18 Bereiding van bloeddrukverlagende stoffen en van preparaten die ze bevatten.
ES434829A ES434829A1 (es) 1974-02-23 1975-02-18 Procedimiento para la preparacion de derivados de 1-(3-( naft-1-il-oxi)2-hidroxipropil)-piperazina.
FI750449A FI59248C (fi) 1974-02-23 1975-02-18 Foerfarande foer framstaellning av blodtrycksaenkande 1-(3-(naft-1-yl-oxi)-2-hydroxi-propyl)-piperazinderivat
ZA00751031A ZA751031B (en) 1974-02-23 1975-02-19 1 - <3 - naphth - 1 - yloxy) - 2 - hydroxypropyl> - piperazine derivatives and the preparation thereof
JP50021386A JPS6029712B2 (ja) 1974-02-23 1975-02-20 １−〔３−（ナフト−１−イル−オキシ）−２−ヒドロキシ−プロピル〕−ピペラジン−誘導体の製法
MX511375U MX3750E (es) 1974-02-23 1975-02-20 Procedimiento para la preparacion de derivados de piperazina
SE7501911A SE405601B (sv) 1974-02-23 1975-02-20 Forfarande for framstellning av 1-(3-(naft-1-yl-oxi)-2-hydroxipropyl)-piperazinderivat
BE153540A BE825755A (fr) 1974-02-23 1975-02-20 Nouvelles 1-(3-(naphtyl-1-oxy)-2-hydroxy-propyl)-piperazines et procedes pour leur preparation
AT132375A AT340937B (de) 1974-02-23 1975-02-21 Verfahren zur herstellung von neuen 1- (3-(naphth-1-yl-oxy)-2-hydroxy-propyl)-piperazin-derivaten sowie deren salzen
FR7505511A FR2261770B1 (en, 2012) 1974-02-23 1975-02-21
PL1975178230A PL92131B1 (en, 2012) 1974-02-23 1975-02-21
IE359/75A IE40678B1 (en) 1974-02-23 1975-02-21 1-(3-(naphth-1-yloxy)-2-hydroxypropyl)piperazine derivatives
CH218575A CH609342A5 (en, 2012) 1974-02-23 1975-02-21
CH1023478A CH612958A5 (en, 2012) 1974-02-23 1975-02-21
SU2112509A SU549085A3 (ru) 1974-02-23 1975-02-21 Способ получени 1-(3-(нафт-1-илокси)2-оксипропил)-пиперазина или их солей
SU2308659A SU561514A3 (ru) 1974-02-23 1976-01-07 Способ получени производных 1-/3-(нафт-1-илокси)-2-оксипропил/-пиперазина или их солей
AT26277A AT340940B (de) 1974-02-23 1977-01-18 Verfahren zur herstellung von neuen 1- (3-(naphth-1-yl-oxy)-2-hydroxy-propyl)-piperazin-derivaten sowie deren salzen
YU1044/81A YU37157B (en) 1974-02-23 1981-04-21 Process for preparing 1-z3-(naphth-1-yloxy)-2-hydroxy-propylc-piperazine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2408804A DE2408804C2 (de) 1974-02-23 1974-02-23 1-(2-Methoxyphenyl)-4-[3-(naphth-1-yl-oxy)-2-hydroxy-propyl]-piperazin, dessen Salze, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten

Publications (2)

Publication Number Publication Date
DE2408804A1 DE2408804A1 (de) 1975-09-04
DE2408804C2 true DE2408804C2 (de) 1983-09-22

Family

ID=5908286

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2408804A Expired DE2408804C2 (de) 1974-02-23 1974-02-23 1-(2-Methoxyphenyl)-4-[3-(naphth-1-yl-oxy)-2-hydroxy-propyl]-piperazin, dessen Salze, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten

Country Status (20)

Country Link
US (1) US3997666A (en, 2012)
JP (1) JPS6029712B2 (en, 2012)
AR (1) AR206339A1 (en, 2012)
AT (1) AT340937B (en, 2012)
BE (1) BE825755A (en, 2012)
CA (1) CA1039282A (en, 2012)
CH (2) CH609342A5 (en, 2012)
DE (1) DE2408804C2 (en, 2012)
DK (1) DK135124C (en, 2012)
ES (1) ES434829A1 (en, 2012)
FI (1) FI59248C (en, 2012)
FR (1) FR2261770B1 (en, 2012)
GB (1) GB1445548A (en, 2012)
IE (1) IE40678B1 (en, 2012)
NL (2) NL175059B (en, 2012)
PL (1) PL92131B1 (en, 2012)
SE (1) SE405601B (en, 2012)
SU (2) SU549085A3 (en, 2012)
YU (2) YU37156B (en, 2012)
ZA (1) ZA751031B (en, 2012)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2387971A1 (fr) * 1977-04-19 1978-11-17 Delalande Sa Nouvelles trimethoxy cinnamoyles piperazines, leur procede de preparation et leur application en therapeutique
US4882330A (en) * 1986-11-21 1989-11-21 A. H. Robins Company, Incorporated 1-aryloxy-4-[((4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents
EP0269383A3 (en) * 1986-11-21 1990-05-02 A.H. Robins Company, Incorporated 1-Aryloxy-4-[(4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents
DE3918543A1 (de) * 1989-06-07 1990-12-13 Boehringer Mannheim Gmbh Verwendung von naftopidil zur therapie der dysurie bei benigner prostata-hypertrophie
DE3918542A1 (de) * 1989-06-07 1990-12-13 Boehringer Mannheim Gmbh Hydroxylierte 1-phenyl-4-(3-(napthth-1-yl-oxy)-2-hydroxy -propyl)-piperazine, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
US20020143007A1 (en) * 1996-02-02 2002-10-03 Garvey David S. Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use
US5932538A (en) * 1996-02-02 1999-08-03 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses
US20050065161A1 (en) * 1996-02-02 2005-03-24 Nitromed, Inc. Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
WO1998033771A1 (fr) 1997-01-30 1998-08-06 Senju Pharmaceutical Co., Ltd. Derives d'hydroquinone
EP1118322A4 (en) 1998-09-30 2004-10-20 Takeda Chemical Industries Ltd MEDICINES THAT IMPROVE BLADDER DRAINING POWER
US20020065286A1 (en) * 2000-08-21 2002-05-30 Davies Michael John Treatment of wounds
US20020091129A1 (en) * 2000-11-20 2002-07-11 Mitradev Boolell Treatment of premature ejaculation
US20030229001A1 (en) * 2002-01-31 2003-12-11 Pfizer Inc. Treatment of male sexual dysfunction
DE60336485D1 (de) 2002-08-19 2011-05-05 Pfizer Kombinationstherapie gegen hyperproliferative erkrankungen
GB0219961D0 (en) 2002-08-28 2002-10-02 Pfizer Ltd Oxytocin inhibitors
US7323462B2 (en) * 2002-12-10 2008-01-29 Pfizer Inc. Morpholine dopamine agonists
KR20050085563A (ko) 2002-12-13 2005-08-29 워너-램버트 캄파니 엘엘씨 하부요로증상을 치료하기 위한 알파-2-델타 리간드
CA2451267A1 (en) * 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
PA8597401A1 (es) * 2003-03-14 2005-05-24 Pfizer Derivados del acido 3-(1-[3-(1,3-benzotiazol-6-il) propilcarbamoil] cicloalquil) propanoico como inhibidores de nep
US20040220186A1 (en) * 2003-04-30 2004-11-04 Pfizer Inc. PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
US7923467B2 (en) 2003-05-30 2011-04-12 Ranbaxy Laboratories, Inc. Substituted pyrrole derivatives and their use as HMG-CO inhibitors
US20050065158A1 (en) * 2003-07-16 2005-03-24 Pfizer Inc. Treatment of sexual dysfunction
US7291640B2 (en) * 2003-09-22 2007-11-06 Pfizer Inc. Substituted triazole derivatives as oxytocin antagonists
US7618972B2 (en) 2005-03-21 2009-11-17 Pfizer Inc Substituted triazole derivatives as oxytocin antagonists
WO2007017752A1 (en) * 2005-08-10 2007-02-15 Pfizer Limited Substituted triazole derivatives as oxytocin antagonists
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US8026377B2 (en) 2005-11-08 2011-09-27 Ranbaxy Laboratories, Limited Process for (3R, 5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid hemi calcium salt
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US8383660B2 (en) 2006-03-10 2013-02-26 Pfizer Inc. Dibenzyl amine compounds and derivatives
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
US8470859B2 (en) * 2006-10-23 2013-06-25 Takeda Pharmaceutical Company Limited Iminopyridine derivative and use thereof
WO2008070496A2 (en) 2006-12-01 2008-06-12 Bristol-Myers Squibb Company N- ( (3-benzyl) -2, 2- (bis-phenyl) -propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases
US20110039892A1 (en) 2008-04-23 2011-02-17 Takeda Pharmaceutical Company Limited Iminopyridine derivative and use thereof
US8481569B2 (en) * 2008-04-23 2013-07-09 Takeda Pharmaceutical Company Limited Iminopyridine derivatives and use thereof
CN101671317B (zh) * 2009-10-09 2011-04-27 蚌埠丰原涂山制药有限公司 一种萘哌地尔的制备方法
CN101747293B (zh) * 2009-12-29 2011-12-07 蚌埠丰原涂山制药有限公司 萘哌地尔的制备方法
JP5807423B2 (ja) * 2011-07-21 2015-11-10 大日本印刷株式会社 ナフトピジルの製造方法
CN102816136A (zh) * 2012-09-18 2012-12-12 通化吉通药业有限公司 萘哌地尔制备方法
AU2014255381A1 (en) 2013-04-17 2015-10-08 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
US9272980B2 (en) 2014-06-06 2016-03-01 Ktn Biotec, Inc. Anticancer agent
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
CN113574055B (zh) 2019-01-18 2024-07-23 阿斯利康(瑞典)有限公司 Pcsk9抑制剂及其使用方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA967965A (en) * 1968-12-24 1975-05-20 Hoffmann-La Roche Limited Aromatic ethers and process for the manufacture thereof
GB1317479A (en) * 1970-11-10 1973-05-16 Pfizer Ltd 1-2-hydroxy-3-phenoxy or phenylthiopropyl-4-phenyl-piperazine derivatives
DE2235597A1 (de) * 1972-07-20 1974-01-31 Boehringer Mannheim Gmbh 1-eckige klammer auf 3-(5,6,7,8tetrahydronaphth-1-yl-oxy) -propyl eckige klammer zu -piperazin-derivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
NL7501877A (nl) 1975-08-26
US3997666A (en) 1976-12-14
CH612958A5 (en, 2012) 1979-08-31
FI59248C (fi) 1981-07-10
YU37156B (en) 1984-08-31
ATA132375A (de) 1977-05-15
AU7826875A (en) 1976-08-19
FR2261770B1 (en, 2012) 1978-08-04
CH609342A5 (en, 2012) 1979-02-28
DK135124C (da) 1977-08-15
YU104481A (en) 1983-04-27
DK58175A (en, 2012) 1975-10-20
FR2261770A1 (en, 2012) 1975-09-19
YU38275A (en) 1983-04-27
IE40678L (en) 1975-08-23
JPS50121286A (en, 2012) 1975-09-23
JPS6029712B2 (ja) 1985-07-12
CA1039282A (en) 1978-09-26
DK135124B (da) 1977-03-07
AT340937B (de) 1978-01-10
FI59248B (fi) 1981-03-31
GB1445548A (en) 1976-08-11
DE2408804A1 (de) 1975-09-04
ES434829A1 (es) 1976-12-01
ZA751031B (en) 1976-02-25
IE40678B1 (en) 1979-08-01
NL175059B (nl) 1984-04-16
YU37157B (en) 1984-08-31
SU549085A3 (ru) 1977-02-28
BE825755A (fr) 1975-08-20
FI750449A7 (en, 2012) 1975-08-24
PL92131B1 (en, 2012) 1977-03-31
NL175059C (nl)
SE7501911L (en, 2012) 1975-08-25
SU561514A3 (ru) 1977-06-05
AR206339A1 (es) 1976-07-15
SE405601B (sv) 1978-12-18

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Legal Events

Date Code Title Description
OD Request for examination
8126 Change of the secondary classification

Ipc: A61K 31/495

8181 Inventor (new situation)

Free format text: WITTE, ERNST-CHRISTIAN, DR.RER.NAT. STACH, KURT, DR.-ING. THIEL, MAX, DR.RER.NAT., 6800 MANNHEIM, DE SPONER, GISBERT, DR.MED.VET., 6944 HEMSBACH, DE ROESCH, EGON, DR.MED., 6840 LAMPERTHEIM, DE

D2 Grant after examination
8364 No opposition during term of opposition