SU561514A3 - Способ получени производных 1-/3-(нафт-1-илокси)-2-оксипропил/-пиперазина или их солей - Google Patents
Способ получени производных 1-/3-(нафт-1-илокси)-2-оксипропил/-пиперазина или их солейInfo
- Publication number
- SU561514A3 SU561514A3 SU2308659A SU2308659A SU561514A3 SU 561514 A3 SU561514 A3 SU 561514A3 SU 2308659 A SU2308659 A SU 2308659A SU 2308659 A SU2308659 A SU 2308659A SU 561514 A3 SU561514 A3 SU 561514A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- hydroxypropyl
- piperazine
- naphth
- derivatives
- water
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (1)
- (54) СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ (НАФТ-1-ИЛОКСИ )-2-ОКСИПРОПИЛ -ПИПЕРАЗИНА ИЛИ ИХ СОЛЕЙ сколько раз перемеил1вают с водой, раствор ют в хлороформе, фильтруют, промывают раствор последовательно 2 н. едким натром, водой, 1 н.сол;-ной кислотой и водой, сушат сульфатом натри , насыщают хлористым водородом, добавл ют эфир, отсасывают дитидрохлорид 1-{4- метоксифенил) (нафт-1-илокси)-2- оксипропил - пиперазина н несколько раз перекристаллизовывают из метанола с добавкой активированного угл . Выход 13,4 г (29%), т. пл. 235-237°С. Целевое соединение получают также, когда исходные вещества вьщерживают 1-2 суток при комнатной температуре. Аналогичным образом получают 1 . - (2- метоксифенил )-4- 3- (нафт-1-нлокси)-2- оксипропил - пиперазин, т. пл. 125-126°С (изопропанол). Формула изобретени Способ получени производных (нафтСпособ получени производных (нафтилокси )-2-оксипропил -пиперазина формулы ОСН2-СН-ОН2-1( if онООН: иди их солей, отличающийс тем, что нафтол-1 подвергают взаимодействию с соединением общей формулы R2-CH2-CH-(3H2 - :N-OEi где RI - водород и Rj - галоген или Rj и R вместе означают валентную св зь, с выделением целевых продуктов в виде основани или соли. Источники информадии, прин тые во внимание при экспертизе: 1. Бюлер К., Пирсон Д., Органические син1 . Бюлер К., Пирсон Д., Органическ тезы, .Мнр, М., 1973, стр. 327.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2408804A DE2408804C2 (de) | 1974-02-23 | 1974-02-23 | 1-(2-Methoxyphenyl)-4-[3-(naphth-1-yl-oxy)-2-hydroxy-propyl]-piperazin, dessen Salze, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten |
Publications (1)
Publication Number | Publication Date |
---|---|
SU561514A3 true SU561514A3 (ru) | 1977-06-05 |
Family
ID=5908286
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU2112509A SU549085A3 (ru) | 1974-02-23 | 1975-02-21 | Способ получени 1-(3-(нафт-1-илокси)2-оксипропил)-пиперазина или их солей |
SU2308659A SU561514A3 (ru) | 1974-02-23 | 1976-01-07 | Способ получени производных 1-/3-(нафт-1-илокси)-2-оксипропил/-пиперазина или их солей |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU2112509A SU549085A3 (ru) | 1974-02-23 | 1975-02-21 | Способ получени 1-(3-(нафт-1-илокси)2-оксипропил)-пиперазина или их солей |
Country Status (20)
Country | Link |
---|---|
US (1) | US3997666A (ru) |
JP (1) | JPS6029712B2 (ru) |
AR (1) | AR206339A1 (ru) |
AT (1) | AT340937B (ru) |
BE (1) | BE825755A (ru) |
CA (1) | CA1039282A (ru) |
CH (2) | CH612958A5 (ru) |
DE (1) | DE2408804C2 (ru) |
DK (1) | DK135124C (ru) |
ES (1) | ES434829A1 (ru) |
FI (1) | FI59248C (ru) |
FR (1) | FR2261770B1 (ru) |
GB (1) | GB1445548A (ru) |
IE (1) | IE40678B1 (ru) |
NL (2) | NL175059B (ru) |
PL (1) | PL92131B1 (ru) |
SE (1) | SE405601B (ru) |
SU (2) | SU549085A3 (ru) |
YU (2) | YU37156B (ru) |
ZA (1) | ZA751031B (ru) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2387971A1 (fr) * | 1977-04-19 | 1978-11-17 | Delalande Sa | Nouvelles trimethoxy cinnamoyles piperazines, leur procede de preparation et leur application en therapeutique |
US4882330A (en) * | 1986-11-21 | 1989-11-21 | A. H. Robins Company, Incorporated | 1-aryloxy-4-[((4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents |
JPS63141967A (ja) * | 1986-11-21 | 1988-06-14 | エイ・エッチ・ロビンス・カンパニー・インコーポレーテッド | 抗アレルギー薬として有用な1−アリールオキシー4−[(4−アリール)−1−ピペラジニル]−2−ブタノール |
DE3918543A1 (de) * | 1989-06-07 | 1990-12-13 | Boehringer Mannheim Gmbh | Verwendung von naftopidil zur therapie der dysurie bei benigner prostata-hypertrophie |
DE3918542A1 (de) * | 1989-06-07 | 1990-12-13 | Boehringer Mannheim Gmbh | Hydroxylierte 1-phenyl-4-(3-(napthth-1-yl-oxy)-2-hydroxy -propyl)-piperazine, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
US5932538A (en) * | 1996-02-02 | 1999-08-03 | Nitromed, Inc. | Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses |
US20050065161A1 (en) * | 1996-02-02 | 2005-03-24 | Nitromed, Inc. | Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses |
US20020143007A1 (en) * | 1996-02-02 | 2002-10-03 | Garvey David S. | Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use |
CA2278660A1 (en) | 1997-01-30 | 1998-08-06 | Kazumi Ogata | Hydroquinone derivatives |
EP1891954A3 (en) | 1998-09-30 | 2009-01-14 | Takeda Pharmaceutical Company Limited | Acetylcholinesterase inhibitors for improving excretory potency of urinary bladder |
US20020065286A1 (en) * | 2000-08-21 | 2002-05-30 | Davies Michael John | Treatment of wounds |
US20020091129A1 (en) * | 2000-11-20 | 2002-07-11 | Mitradev Boolell | Treatment of premature ejaculation |
US20030229001A1 (en) * | 2002-01-31 | 2003-12-11 | Pfizer Inc. | Treatment of male sexual dysfunction |
CN1681495B (zh) | 2002-08-19 | 2010-05-12 | 辉瑞产品公司 | 用于治疗过度增生性疾病的组合物 |
GB0219961D0 (en) | 2002-08-28 | 2002-10-02 | Pfizer Ltd | Oxytocin inhibitors |
US7323462B2 (en) * | 2002-12-10 | 2008-01-29 | Pfizer Inc. | Morpholine dopamine agonists |
CA2451267A1 (en) * | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Pharmaceutical uses for alpha2delta ligands |
CA2509605C (en) | 2002-12-13 | 2010-10-05 | Warner-Lambert Company Llc | Alpha-2-delta ligand to treat lower urinary tract symptoms |
PA8597401A1 (es) * | 2003-03-14 | 2005-05-24 | Pfizer | Derivados del acido 3-(1-[3-(1,3-benzotiazol-6-il) propilcarbamoil] cicloalquil) propanoico como inhibidores de nep |
US20040220186A1 (en) * | 2003-04-30 | 2004-11-04 | Pfizer Inc. | PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease |
WO2004106299A2 (en) | 2003-05-30 | 2004-12-09 | Ranbaxy Laboratories Limited | Substituted pyrrole derivatives and their use as hmg-co inhibitors |
US20050065158A1 (en) * | 2003-07-16 | 2005-03-24 | Pfizer Inc. | Treatment of sexual dysfunction |
US7291640B2 (en) * | 2003-09-22 | 2007-11-06 | Pfizer Inc. | Substituted triazole derivatives as oxytocin antagonists |
JP2008533192A (ja) | 2005-03-21 | 2008-08-21 | ファイザー・リミテッド | オキシトシンアンタゴニストとしての置換されたトリアゾール誘導体 |
CA2618103A1 (en) * | 2005-08-10 | 2007-02-15 | Pfizer Limited | Substituted triazole derivatives as oxytocin antagonists |
GT200600381A (es) | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
KR101329112B1 (ko) | 2005-11-08 | 2013-11-14 | 랜박시 래보러터리스 리미티드 | (3r,5r)-7-〔2-(4-플루오로페닐)-5-이소프로필-3-페닐-4-〔(4-히드록시 메틸 페닐 아미노)카르보닐〕-피롤-1-일〕-3,5-디히드록시 헵탄산 헤미 칼슘염의 제조 방법 |
US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
US7919506B2 (en) | 2006-03-10 | 2011-04-05 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
US8383660B2 (en) | 2006-03-10 | 2013-02-26 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
US8470859B2 (en) * | 2006-10-23 | 2013-06-25 | Takeda Pharmaceutical Company Limited | Iminopyridine derivative and use thereof |
CN101663262B (zh) | 2006-12-01 | 2014-03-26 | 百时美施贵宝公司 | 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物 |
US8481569B2 (en) * | 2008-04-23 | 2013-07-09 | Takeda Pharmaceutical Company Limited | Iminopyridine derivatives and use thereof |
US20110039892A1 (en) | 2008-04-23 | 2011-02-17 | Takeda Pharmaceutical Company Limited | Iminopyridine derivative and use thereof |
CN101671317B (zh) * | 2009-10-09 | 2011-04-27 | 蚌埠丰原涂山制药有限公司 | 一种萘哌地尔的制备方法 |
CN101747293B (zh) * | 2009-12-29 | 2011-12-07 | 蚌埠丰原涂山制药有限公司 | 萘哌地尔的制备方法 |
JP5807423B2 (ja) * | 2011-07-21 | 2015-11-10 | 大日本印刷株式会社 | ナフトピジルの製造方法 |
CN102816136A (zh) * | 2012-09-18 | 2012-12-12 | 通化吉通药业有限公司 | 萘哌地尔制备方法 |
WO2014170786A1 (en) | 2013-04-17 | 2014-10-23 | Pfizer Inc. | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
US9272980B2 (en) | 2014-06-06 | 2016-03-01 | Ktn Biotec, Inc. | Anticancer agent |
WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
CN113574055A (zh) | 2019-01-18 | 2021-10-29 | 阿斯利康(瑞典)有限公司 | Pcsk9抑制剂及其使用方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA967965A (en) * | 1968-12-24 | 1975-05-20 | Hoffmann-La Roche Limited | Aromatic ethers and process for the manufacture thereof |
GB1317479A (en) * | 1970-11-10 | 1973-05-16 | Pfizer Ltd | 1-2-hydroxy-3-phenoxy or phenylthiopropyl-4-phenyl-piperazine derivatives |
DE2235597A1 (de) * | 1972-07-20 | 1974-01-31 | Boehringer Mannheim Gmbh | 1-eckige klammer auf 3-(5,6,7,8tetrahydronaphth-1-yl-oxy) -propyl eckige klammer zu -piperazin-derivate und verfahren zu ihrer herstellung |
-
0
- NL NLAANVRAGE7501877,A patent/NL175059C/xx active
-
1974
- 1974-02-23 DE DE2408804A patent/DE2408804C2/de not_active Expired
-
1975
- 1975-01-01 AR AR257639A patent/AR206339A1/es active
- 1975-01-28 US US05/544,719 patent/US3997666A/en not_active Expired - Lifetime
- 1975-02-12 CA CA219,883A patent/CA1039282A/en not_active Expired
- 1975-02-17 GB GB656975A patent/GB1445548A/en not_active Expired
- 1975-02-18 NL NLAANVRAGE7501877,A patent/NL175059B/xx not_active IP Right Cessation
- 1975-02-18 FI FI750449A patent/FI59248C/fi not_active IP Right Cessation
- 1975-02-18 YU YU0382/75A patent/YU37156B/xx unknown
- 1975-02-18 ES ES434829A patent/ES434829A1/es not_active Expired
- 1975-02-18 DK DK58175A patent/DK135124C/da not_active IP Right Cessation
- 1975-02-19 ZA ZA00751031A patent/ZA751031B/xx unknown
- 1975-02-20 BE BE153540A patent/BE825755A/xx not_active IP Right Cessation
- 1975-02-20 JP JP50021386A patent/JPS6029712B2/ja not_active Expired
- 1975-02-20 SE SE7501911A patent/SE405601B/xx not_active IP Right Cessation
- 1975-02-21 CH CH1023478A patent/CH612958A5/xx not_active IP Right Cessation
- 1975-02-21 SU SU2112509A patent/SU549085A3/ru active
- 1975-02-21 FR FR7505511A patent/FR2261770B1/fr not_active Expired
- 1975-02-21 CH CH218575A patent/CH609342A5/xx not_active IP Right Cessation
- 1975-02-21 PL PL1975178230A patent/PL92131B1/pl unknown
- 1975-02-21 IE IE359/75A patent/IE40678B1/xx unknown
- 1975-02-21 AT AT132375A patent/AT340937B/de not_active IP Right Cessation
-
1976
- 1976-01-07 SU SU2308659A patent/SU561514A3/ru active
-
1981
- 1981-04-21 YU YU1044/81A patent/YU37157B/xx unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SU561514A3 (ru) | Способ получени производных 1-/3-(нафт-1-илокси)-2-оксипропил/-пиперазина или их солей | |
SU648103A3 (ru) | Способ получени тетразол - (1,5-а) хинолинов или их солей | |
SU503521A3 (ru) | Способ получени производных морфолина | |
ES320295A1 (es) | Procedimiento para la preparacion de nuevos derivados del indol. | |
ES417333A1 (es) | Procedimiento de preparacion de nuevos derivados de (4'- (3''-indolil)piperidino)alcohil-arilcetonas. | |
SU679135A3 (ru) | Способ получени производных аминопропанола или их солей | |
NO131056B (ru) | ||
CN112694398A (zh) | 重氮化合物和α-Br酮类化合物为原料在制备草酸酯中的应用 | |
US2996506A (en) | Hcxchb | |
CN110386911A (zh) | 二氟烷基取代的亚胺异苯并呋喃类化合物及其合成方法 | |
US3141893A (en) | 4-amino-coumarins | |
SU414787A3 (ru) | Способ получения замещенных бис-(бензилиденамино)-гуанидинов | |
SU649710A1 (ru) | Способ получени 4,4-бис-4-хлорфенилтио-дифенилсульфона | |
SU436493A3 (ru) | ||
SU713861A1 (ru) | Производные 3,4-эпокси-8-гидрокситрицикло/5.2.1.0 / децил-9-меркурофталата в качестве термостабилизаторов поливинилхлорида | |
SU562553A1 (ru) | Способ получени 0-бензоильных производных 3-окси(2-окси)-1,2,3,4-тетрагидрохинолинов | |
SU290700A1 (ru) | Способ получени 2,2,6,6-тетраметил-4( -аминофенилсульфамидопиперидил-1-оксила) | |
SU465786A3 (ru) | Способ получени соли 4-хлор-м-толуол или 3,4-дихлорбензолсульфокислоты и -форм пропоксифена | |
SU388553A1 (ru) | Способ получени производных изоидолина | |
ES429247A1 (es) | Procedimiento para la preparacion de derivados de halogeno-pirazol y sus sales con bases organicas o inorganicas. | |
ES421792A1 (es) | Procedimiento de preparacion de derivados de tieno-benzaze-pinas. | |
SU367095A1 (ru) | Всесоюзная i | |
SU691090A3 (ru) | Способ получени производных бензимидазола | |
JPS62273264A (ja) | フルオラン化合物の製造法 | |
SU625604A3 (ru) | Способ получени гидрохлорида 3,4,5-триметоксифенил(3,4-диметил-2-пиридил) этоксиметана |