FR2387971A1 - Nouvelles trimethoxy cinnamoyles piperazines, leur procede de preparation et leur application en therapeutique - Google Patents

Nouvelles trimethoxy cinnamoyles piperazines, leur procede de preparation et leur application en therapeutique

Info

Publication number
FR2387971A1
FR2387971A1 FR7711707A FR7711707A FR2387971A1 FR 2387971 A1 FR2387971 A1 FR 2387971A1 FR 7711707 A FR7711707 A FR 7711707A FR 7711707 A FR7711707 A FR 7711707A FR 2387971 A1 FR2387971 A1 FR 2387971A1
Authority
FR
France
Prior art keywords
cinnamoyles
piperazines
trimethoxy
new
preparation process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7711707A
Other languages
English (en)
Other versions
FR2387971B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR7711707A priority Critical patent/FR2387971A1/fr
Priority to US05/894,965 priority patent/US4178442A/en
Priority to GB14171/78A priority patent/GB1603521A/en
Priority to GB9850/79A priority patent/GB1603522A/en
Priority to GR55951A priority patent/GR63200B/el
Priority to SE7804067A priority patent/SE436876B/sv
Priority to CH392878A priority patent/CH633783A5/fr
Priority to BE186795A priority patent/BE865990A/fr
Priority to ES468869A priority patent/ES468869A1/es
Priority to LU79448A priority patent/LU79448A1/fr
Priority to AU35142/78A priority patent/AU517029B2/en
Priority to JP4584578A priority patent/JPS53132581A/ja
Priority to NL7804137A priority patent/NL7804137A/xx
Priority to DE19782816785 priority patent/DE2816785A1/de
Priority to IT22434/78A priority patent/IT1094434B/it
Priority to ZA00782201A priority patent/ZA782201B/xx
Publication of FR2387971A1 publication Critical patent/FR2387971A1/fr
Priority to ES476525A priority patent/ES476525A1/es
Priority to ES476524A priority patent/ES476524A1/es
Priority to ES476526A priority patent/ES476526A1/es
Priority to CH62879A priority patent/CH633287A5/fr
Priority to US06/029,653 priority patent/US4248788A/en
Priority to NL7903035A priority patent/NL7903035A/xx
Priority to IT23763/80A priority patent/IT1219979B/it
Application granted granted Critical
Publication of FR2387971B1 publication Critical patent/FR2387971B1/fr
Priority to FR8111646A priority patent/FR2507604A2/fr
Priority to JP58016320A priority patent/JPS58150586A/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C07C273/1827—X being H
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/54—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/66—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C07D321/02—Seven-membered rings
    • C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems

Abstract

a. Nouvelles triméthoxy-3, 4, 5 cinnamoyles pipérazines. b. Ces composés répondent plus précisément à la formule générale :
FR7711707A 1977-04-19 1977-04-19 Nouvelles trimethoxy cinnamoyles piperazines, leur procede de preparation et leur application en therapeutique Granted FR2387971A1 (fr)

Priority Applications (25)

Application Number Priority Date Filing Date Title
FR7711707A FR2387971A1 (fr) 1977-04-19 1977-04-19 Nouvelles trimethoxy cinnamoyles piperazines, leur procede de preparation et leur application en therapeutique
US05/894,965 US4178442A (en) 1977-04-19 1978-04-10 Novel cinnamoyles piperazines and homopiperazines, the method of preparing them and their application in therapeutics
GB14171/78A GB1603521A (en) 1977-04-19 1978-04-11 Cinnamoyl piperazines and homopiperazines methods of preparing them and pharmaceutical compositions containing them
GB9850/79A GB1603522A (en) 1977-04-19 1978-04-11 Benzodioxole benzodioxepine-1,5 and benzodioxan derivatives
GR55951A GR63200B (en) 1977-04-19 1978-04-11 Preparation process of novel cinnamoyles piperazines and omopiperazines
SE7804067A SE436876B (sv) 1977-04-19 1978-04-11 Sett att framstella 3,4,5-trimetoxicinnamoylpiperaziner
CH392878A CH633783A5 (fr) 1977-04-19 1978-04-12 Cinnamoyles piperazines et homopiperazines, leurs procedes de preparation, et medicaments les contenant.
BE186795A BE865990A (fr) 1977-04-19 1978-04-14 Nouvelles cinnamoyles piperazines et homopiperazines, leur procede de preparation et leur application en therapeutique
LU79448A LU79448A1 (fr) 1977-04-19 1978-04-17 Procede de preparation des nouvelles trimethoxy cinnamoyles piperazines
AU35142/78A AU517029B2 (en) 1977-04-19 1978-04-17 Cinnamoyl piperazines and homopiperazines
ES468869A ES468869A1 (es) 1977-04-19 1978-04-17 Procedimiento de preparacion de nuevas cinamoilos-piperazi- nas y homopiperazinas
NL7804137A NL7804137A (nl) 1977-04-19 1978-04-18 Nieuwe cinnamoylpiperazinen homopiperazinen, werkwijze voor hun bereiding en hun toepassing voor de bereiding van geneesmiddelen.
JP4584578A JPS53132581A (en) 1977-04-19 1978-04-18 Novel cinnamoylpiperadine and homopiperadines and method for its production
DE19782816785 DE2816785A1 (de) 1977-04-19 1978-04-18 Neue cinnamoyl-piperazine und homo-piperazine, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
IT22434/78A IT1094434B (it) 1977-04-19 1978-04-18 Cinnamoil piperazione e cinnamoil omopiperazione,procedimento per la loro preparazione e loro applicazione in terapia
ZA00782201A ZA782201B (en) 1977-04-19 1978-04-18 Novel cinnamoyles piperazines and homopiperazines,the method of preparing them and their application in therapeutics
ES476525A ES476525A1 (es) 1977-04-19 1978-12-30 Procedimiento de preparacion dle nuevas cinamoil-piperazinas y homopiperazinas.
ES476524A ES476524A1 (es) 1977-04-19 1978-12-30 Procedimiento de preparacion de nuevas cinamoil-piperazinas y homopiperazinas.
ES476526A ES476526A1 (es) 1977-04-19 1978-12-30 Procedimiento de nuevas cinamoil-piperazinas y homopiperazi-nas.
CH62879A CH633287A5 (fr) 1977-04-19 1979-01-22 Diethers cycliques aromatiques.
US06/029,653 US4248788A (en) 1977-04-19 1979-04-13 Substituted benzodioxane, benzodioxole and benzodioxepine compounds
NL7903035A NL7903035A (nl) 1977-04-19 1979-04-18 Nieuwe benzodioxan- en benzodioxolanverbindingen.
IT23763/80A IT1219979B (it) 1977-04-19 1980-07-29 Derivati della 3,4,5-trimetossicinnamoil-piperazina,loro procedimento di preparazione e loro applicazione terapeutica
FR8111646A FR2507604A2 (fr) 1977-04-19 1981-06-12 Nouvelles trimethoxy-3,4,5 cinnamoyle piperazines, leur procede de preparation et leur application en therapeutique
JP58016320A JPS58150586A (ja) 1977-04-19 1983-02-04 新規なアルキレンジオキシフエニル誘導体

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7711707A FR2387971A1 (fr) 1977-04-19 1977-04-19 Nouvelles trimethoxy cinnamoyles piperazines, leur procede de preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2387971A1 true FR2387971A1 (fr) 1978-11-17
FR2387971B1 FR2387971B1 (fr) 1981-01-09

Family

ID=9189566

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7711707A Granted FR2387971A1 (fr) 1977-04-19 1977-04-19 Nouvelles trimethoxy cinnamoyles piperazines, leur procede de preparation et leur application en therapeutique

Country Status (15)

Country Link
US (2) US4178442A (fr)
JP (2) JPS53132581A (fr)
AU (1) AU517029B2 (fr)
BE (1) BE865990A (fr)
CH (2) CH633783A5 (fr)
DE (1) DE2816785A1 (fr)
ES (4) ES468869A1 (fr)
FR (1) FR2387971A1 (fr)
GB (2) GB1603521A (fr)
GR (1) GR63200B (fr)
IT (1) IT1094434B (fr)
LU (1) LU79448A1 (fr)
NL (2) NL7804137A (fr)
SE (1) SE436876B (fr)
ZA (1) ZA782201B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2507604A2 (fr) * 1977-04-19 1982-12-17 Delalande Sa Nouvelles trimethoxy-3,4,5 cinnamoyle piperazines, leur procede de preparation et leur application en therapeutique

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2462432A2 (fr) 1979-08-03 1981-02-13 Delalande Sa Nouveaux derives de la 3,4,5 trimethoxy cinnamoyle piperazine, leur procede de preparation et leur application en therapeutique
FR2456738A2 (fr) * 1978-04-10 1980-12-12 Delalande Sa Nouvelles cinnamoyles piperazines et homopiperazines, leur procede de preparation et leur application en therapeutique
CH641468A5 (de) * 1978-05-30 1984-02-29 Hoffmann La Roche Cephemderivate.
US4368199A (en) * 1980-01-21 1983-01-11 Delalande S.A. Novel derivatives of 3,4,5-trimethoxy cinnamoyl piperazine, their salts, the process for preparing the same and their application in therapeutics
FR2474031A1 (fr) * 1980-01-21 1981-07-24 Delalande Sa Nouveaux derives de la trimethoxy-3,4,5 cinnamoyle piperazine, leurs sels, leur procede de preparation et leur application en therapeutique
JPS5888370A (ja) * 1981-11-19 1983-05-26 Hokuriku Seiyaku Co Ltd １−（３，４，５−トリメトキシシンナモイル）−４−アミノカルボニルエチル置換ピペラジン及びホモピペラジン誘導体、及びその製造方法
US4567264A (en) * 1983-05-18 1986-01-28 Syntex (U.S.A.) Inc. Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry
IT1207990B (it) * 1983-11-15 1989-06-01 Euroresearch Srl Attivita' analgesica, processo per derivati metil-piperazinici edla loro preparazione e composizioni terapeutiche che li contengono.
DE3407695A1 (de) * 1984-03-02 1985-09-12 Röhm Pharma GmbH, 6108 Weiterstadt Pteridinverbindungen mit pharmazeutischer wirksamkeit
JPS6360749U (fr) * 1986-10-09 1988-04-22
JPH01121755U (fr) * 1988-02-15 1989-08-17
US4997836A (en) * 1988-11-11 1991-03-05 Takeda Chemical Industries, Ltd. Trisubstituted piperazine compounds, their production and use
DE19536378A1 (de) * 1995-09-29 1997-04-03 Bayer Ag Heterocyclische Aryl-, Alkyl- und Cycloalkylessigsäureamide
AU4967697A (en) * 1996-11-19 1998-06-10 Kyowa Hakko Kogyo Co. Ltd. Oxygenic heterocyclic compounds
US6673122B1 (en) 1997-02-26 2004-01-06 L'oréal Compositions for dyeing keratin fibers containing para-aminophenols, dyeing process, novel para-aminophenols and process for their preparation
FR2760012B1 (fr) * 1997-02-26 2000-08-18 Oreal Compositions pour la teinture des fibres keratiniques contenant des para-aminophenols, procede de teinture, nouveaux para-aminophenols et leur procede de prepraration
CN1315781C (zh) * 2001-08-31 2007-05-16 拜尔化学品股份公司 制备4－氨基－1－萘酚醚类化合物的方法
US7078407B2 (en) * 2001-11-23 2006-07-18 Korea Research Institute Of Chemical Technology 4-hydroxycinnamamide derivatives as antioxidants and pharmaceutical compositions containing them
FR3000742B1 (fr) * 2013-01-08 2015-08-21 Pharmasynthese Nouveaux derives de l’acide sinapinique
CN115991683B (zh) * 2022-12-08 2024-05-07 贵州大学 一种含异丙醇胺结构的肉桂酸类化合物、制备方法及其应用

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Publication number Priority date Publication date Assignee Title
US2699438A (en) * 1952-04-19 1955-01-11 Rayonier Inc Linear polyesters of carboxy-2-hydroxymethyl benzodioxane
US3268407A (en) * 1963-10-04 1966-08-23 American Cyanamid Co Tranquilizing compositions and method of inducing a state of tranquility
DE1670482A1 (de) * 1967-01-07 1971-03-18 Cassella Farbwerke Mainkur Ag Verfahren zur Herstellung von Derivaten des Cumarins
GB1168108A (en) * 1967-09-29 1969-10-22 Delalande Sa Amide Derivatives of 1-Piperazine Acetic Acid and Process for their Preparation
US3753984A (en) * 1971-05-26 1973-08-21 Delalande Sa Amides derived from the esters of 1-piperazine propionic acid, their method of preparation and their application to therapeutics
US4038279A (en) * 1972-12-23 1977-07-26 Boehringer Ingelheim Gmbh N-aryl-n'-(phenyl-or phenoxy-alkyl)-piperazines and salts thereof
CH585209A5 (fr) * 1973-06-29 1977-02-28 Cermol Sa
FR2244475B1 (fr) * 1973-07-24 1977-11-10 Centre Etd Ind Pharma
NL175059C (nl) * 1974-02-23 Boehringer Mannheim Gmbh Bereiding van bloeddrukverlagende stoffen en van preparaten die ze bevatten.
FR2278340A1 (fr) * 1974-07-17 1976-02-13 Delalande Sa Nouveau derive de la n-(trimethoxy-3,4,5 cinnamoyl) piperazine, ses sels d'addition d'acides, son procede de preparation et son application en therapeutique
GB1473262A (en) * 1974-11-20 1977-05-11 Delalande Sa Derivatives of n-3,4,5-trimethoxy cinnamoyl-piperazine their process of preparation and their therapeutic application

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2507604A2 (fr) * 1977-04-19 1982-12-17 Delalande Sa Nouvelles trimethoxy-3,4,5 cinnamoyle piperazines, leur procede de preparation et leur application en therapeutique

Also Published As

Publication number Publication date
GB1603521A (en) 1981-11-25
JPS58150586A (ja) 1983-09-07
JPS6240358B2 (fr) 1987-08-27
CH633783A5 (fr) 1982-12-31
NL7903035A (nl) 1979-09-28
JPS53132581A (en) 1978-11-18
BE865990A (fr) 1978-10-16
FR2387971B1 (fr) 1981-01-09
GB1603522A (en) 1981-11-25
NL7804137A (nl) 1978-10-23
DE2816785C2 (fr) 1991-04-25
ES476524A1 (es) 1979-10-16
IT7822434A0 (it) 1978-04-18
ES468869A1 (es) 1979-08-16
ZA782201B (en) 1979-03-28
SE7804067L (sv) 1978-10-20
AU3514278A (en) 1979-10-25
US4178442A (en) 1979-12-11
DE2816785A1 (de) 1978-10-26
ES476526A1 (es) 1979-11-01
SE436876B (sv) 1985-01-28
IT1094434B (it) 1985-08-02
ES476525A1 (es) 1979-10-16
GR63200B (en) 1979-10-04
US4248788A (en) 1981-02-03
CH633287A5 (fr) 1982-11-30
JPS6250468B2 (fr) 1987-10-24
LU79448A1 (fr) 1978-11-28
AU517029B2 (en) 1981-07-02

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