DK135124C - Analogifremgangsmade til fremstilling af 1-(3-(naphth-1-yl-oxy)-2-hydroxypropyl)-piperazinderivater eller syreadditionssalte heraf - Google Patents

Analogifremgangsmade til fremstilling af 1-(3-(naphth-1-yl-oxy)-2-hydroxypropyl)-piperazinderivater eller syreadditionssalte heraf

Info

Publication number
DK135124C
DK135124C DK58175A DK58175A DK135124C DK 135124 C DK135124 C DK 135124C DK 58175 A DK58175 A DK 58175A DK 58175 A DK58175 A DK 58175A DK 135124 C DK135124 C DK 135124C
Authority
DK
Denmark
Prior art keywords
naphth
oxy
hydroxypropyl
preparation
acid addition
Prior art date
Application number
DK58175A
Other languages
English (en)
Other versions
DK135124B (da
DK58175A (da
Inventor
E C Witte
K Stach
M Thiel
G Sponer
E Roesch
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of DK58175A publication Critical patent/DK58175A/da
Publication of DK135124B publication Critical patent/DK135124B/da
Application granted granted Critical
Publication of DK135124C publication Critical patent/DK135124C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK58175A 1974-02-23 1975-02-18 Analogifremgangsmade til fremstilling af 1-(3-(naphth-1-yl-oxy)-2-hydroxypropyl)-piperazinderivater eller syreadditionssalte heraf DK135124C (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2408804A DE2408804C2 (de) 1974-02-23 1974-02-23 1-(2-Methoxyphenyl)-4-[3-(naphth-1-yl-oxy)-2-hydroxy-propyl]-piperazin, dessen Salze, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten

Publications (3)

Publication Number Publication Date
DK58175A DK58175A (da) 1975-10-20
DK135124B DK135124B (da) 1977-03-07
DK135124C true DK135124C (da) 1977-08-15

Family

ID=5908286

Family Applications (1)

Application Number Title Priority Date Filing Date
DK58175A DK135124C (da) 1974-02-23 1975-02-18 Analogifremgangsmade til fremstilling af 1-(3-(naphth-1-yl-oxy)-2-hydroxypropyl)-piperazinderivater eller syreadditionssalte heraf

Country Status (20)

Country Link
US (1) US3997666A (da)
JP (1) JPS6029712B2 (da)
AR (1) AR206339A1 (da)
AT (1) AT340937B (da)
BE (1) BE825755A (da)
CA (1) CA1039282A (da)
CH (2) CH609342A5 (da)
DE (1) DE2408804C2 (da)
DK (1) DK135124C (da)
ES (1) ES434829A1 (da)
FI (1) FI59248C (da)
FR (1) FR2261770B1 (da)
GB (1) GB1445548A (da)
IE (1) IE40678B1 (da)
NL (2) NL175059B (da)
PL (1) PL92131B1 (da)
SE (1) SE405601B (da)
SU (2) SU549085A3 (da)
YU (2) YU37156B (da)
ZA (1) ZA751031B (da)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2387971A1 (fr) * 1977-04-19 1978-11-17 Delalande Sa Nouvelles trimethoxy cinnamoyles piperazines, leur procede de preparation et leur application en therapeutique
US4882330A (en) * 1986-11-21 1989-11-21 A. H. Robins Company, Incorporated 1-aryloxy-4-[((4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents
EP0269383A3 (en) * 1986-11-21 1990-05-02 A.H. Robins Company, Incorporated 1-Aryloxy-4-[(4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents
DE3918542A1 (de) * 1989-06-07 1990-12-13 Boehringer Mannheim Gmbh Hydroxylierte 1-phenyl-4-(3-(napthth-1-yl-oxy)-2-hydroxy -propyl)-piperazine, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
DE3918543A1 (de) * 1989-06-07 1990-12-13 Boehringer Mannheim Gmbh Verwendung von naftopidil zur therapie der dysurie bei benigner prostata-hypertrophie
US20020143007A1 (en) * 1996-02-02 2002-10-03 Garvey David S. Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use
US20050065161A1 (en) * 1996-02-02 2005-03-24 Nitromed, Inc. Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
US5932538A (en) * 1996-02-02 1999-08-03 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses
CA2278660A1 (en) 1997-01-30 1998-08-06 Kazumi Ogata Hydroquinone derivatives
KR100639543B1 (ko) 1998-09-30 2006-10-31 다케다 야쿠힌 고교 가부시키가이샤 방광 배출력 개선제
US20020065286A1 (en) * 2000-08-21 2002-05-30 Davies Michael John Treatment of wounds
US20020091129A1 (en) * 2000-11-20 2002-07-11 Mitradev Boolell Treatment of premature ejaculation
US20030229001A1 (en) * 2002-01-31 2003-12-11 Pfizer Inc. Treatment of male sexual dysfunction
CN1681495B (zh) 2002-08-19 2010-05-12 辉瑞产品公司 用于治疗过度增生性疾病的组合物
GB0219961D0 (en) 2002-08-28 2002-10-02 Pfizer Ltd Oxytocin inhibitors
US7323462B2 (en) * 2002-12-10 2008-01-29 Pfizer Inc. Morpholine dopamine agonists
CA2509605C (en) 2002-12-13 2010-10-05 Warner-Lambert Company Llc Alpha-2-delta ligand to treat lower urinary tract symptoms
CA2451267A1 (en) * 2002-12-13 2004-06-13 Warner-Lambert Company Llc Pharmaceutical uses for alpha2delta ligands
PA8597401A1 (es) * 2003-03-14 2005-05-24 Pfizer Derivados del acido 3-(1-[3-(1,3-benzotiazol-6-il) propilcarbamoil] cicloalquil) propanoico como inhibidores de nep
US20040220186A1 (en) * 2003-04-30 2004-11-04 Pfizer Inc. PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease
CA2526730A1 (en) 2003-05-30 2004-12-09 Ranbaxy Laboratories Limited Substituted pyrrole derivatives
US20050065158A1 (en) * 2003-07-16 2005-03-24 Pfizer Inc. Treatment of sexual dysfunction
US7291640B2 (en) * 2003-09-22 2007-11-06 Pfizer Inc. Substituted triazole derivatives as oxytocin antagonists
ES2313626T3 (es) 2005-03-21 2009-03-01 Pfizer Limited Derivados de triazol sustituidos como antagonistas de oxitocina.
CA2618103A1 (en) * 2005-08-10 2007-02-15 Pfizer Limited Substituted triazole derivatives as oxytocin antagonists
GT200600381A (es) 2005-08-25 2007-03-28 Compuestos organicos
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
SG166829A1 (en) 2005-11-08 2010-12-29 Ranbaxy Lab Ltd Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
US8383660B2 (en) 2006-03-10 2013-02-26 Pfizer Inc. Dibenzyl amine compounds and derivatives
WO2008050732A1 (fr) 2006-10-23 2008-05-02 Takeda Pharmaceutical Company Limited Dérivé de l'iminopyridine et son utilisation
ES2382009T3 (es) 2006-12-01 2012-06-04 Bristol-Myers Squibb Company Derivados de N-((3-bencil)-2,2-(bis-fenil-)-propan-1-amina como inhibidores de CETP para el tratamiento de aterosclerosis y enfermedades cardiovasculares
US20110039892A1 (en) 2008-04-23 2011-02-17 Takeda Pharmaceutical Company Limited Iminopyridine derivative and use thereof
US8481569B2 (en) * 2008-04-23 2013-07-09 Takeda Pharmaceutical Company Limited Iminopyridine derivatives and use thereof
CN101671317B (zh) * 2009-10-09 2011-04-27 蚌埠丰原涂山制药有限公司 一种萘哌地尔的制备方法
CN101747293B (zh) * 2009-12-29 2011-12-07 蚌埠丰原涂山制药有限公司 萘哌地尔的制备方法
JP5807423B2 (ja) * 2011-07-21 2015-11-10 大日本印刷株式会社 ナフトピジルの製造方法
CN102816136A (zh) * 2012-09-18 2012-12-12 通化吉通药业有限公司 萘哌地尔制备方法
JP2016516804A (ja) 2013-04-17 2016-06-09 ファイザー・インク 心血管疾患を治療するためのｎ−ピペリジン−３−イルベンズアミド誘導体
US9272980B2 (en) 2014-06-06 2016-03-01 Ktn Biotec, Inc. Anticancer agent
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
EP3911648A4 (en) 2019-01-18 2022-10-26 Astrazeneca AB PCSK9 INHIBITORS AND METHODS OF USE THEREOF

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA967965A (en) * 1968-12-24 1975-05-20 Hoffmann-La Roche Limited Aromatic ethers and process for the manufacture thereof
GB1317479A (en) * 1970-11-10 1973-05-16 Pfizer Ltd 1-2-hydroxy-3-phenoxy or phenylthiopropyl-4-phenyl-piperazine derivatives
DE2235597A1 (de) * 1972-07-20 1974-01-31 Boehringer Mannheim Gmbh 1-eckige klammer auf 3-(5,6,7,8tetrahydronaphth-1-yl-oxy) -propyl eckige klammer zu -piperazin-derivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
FI59248B (fi) 1981-03-31
FR2261770B1 (da) 1978-08-04
NL175059B (nl) 1984-04-16
SU561514A3 (ru) 1977-06-05
FI750449A (da) 1975-08-24
IE40678B1 (en) 1979-08-01
BE825755A (fr) 1975-08-20
NL7501877A (nl) 1975-08-26
AU7826875A (en) 1976-08-19
DK135124B (da) 1977-03-07
CH612958A5 (da) 1979-08-31
FI59248C (fi) 1981-07-10
PL92131B1 (da) 1977-03-31
ZA751031B (en) 1976-02-25
JPS6029712B2 (ja) 1985-07-12
ATA132375A (de) 1977-05-15
YU38275A (en) 1983-04-27
AR206339A1 (es) 1976-07-15
YU37156B (en) 1984-08-31
SE405601B (sv) 1978-12-18
YU37157B (en) 1984-08-31
JPS50121286A (da) 1975-09-23
AT340937B (de) 1978-01-10
YU104481A (en) 1983-04-27
DE2408804C2 (de) 1983-09-22
GB1445548A (en) 1976-08-11
NL175059C (nl)
SU549085A3 (ru) 1977-02-28
DE2408804A1 (de) 1975-09-04
ES434829A1 (es) 1976-12-01
FR2261770A1 (da) 1975-09-19
CH609342A5 (da) 1979-02-28
US3997666A (en) 1976-12-14
DK58175A (da) 1975-10-20
IE40678L (en) 1975-08-23
CA1039282A (en) 1978-09-26
SE7501911L (da) 1975-08-24

Similar Documents

Publication Publication Date Title
DK135124C (da) Analogifremgangsmade til fremstilling af 1-(3-(naphth-1-yl-oxy)-2-hydroxypropyl)-piperazinderivater eller syreadditionssalte heraf
DK143275C (da) Analogifremgangsmaade til fremstilling af 1-(3-dimethylaminopropyl)-phthalanderivater eller syreadditionssalte deraf
DK56077A (da) Fremgangsmade til fremstilling af 3-quinolincarboxylsyrederivater eller additionssalte deraf
DK178379A (da) Fremgangsmaade til fremstilling af n-substituerede moranolinderivater eller syreadditionssalte deraf
DK139387C (da) Analogifremgangsmaade til fremstilling af apovincaminsyrederivater eller syreadditionssalte deraf
DK557277A (da) Fremgangsmaade til fremstilling af piperazinderivater eller syreaddttionssalte eller kvarternaere ammoniumsalte deraf
DK137188C (da) Analogifremgangsmaade til fremstilling af 2-tetrahydrofurfuryl-6,7-benzomorphaner eller syreadditionssalte heraf
DK138992C (da) Analogifremgangsmaade til fremstilling af 5,9beta-disubstituerede 2-tetrahydrofurfuryl-6,7-benzomorphaner eller syreadditionssalte heraf
DK137990C (da) Analogifremgangsmaade til fremstilling af racemiske eller optisk aktive 1-arylpropyl-(2)-piperazinderivater eller syreadditionssalte deraf
DK135842B (da) Analogifremgangsmade til fremstilling af 7-methoxy-6-thiatetracycliner eller syreadditionssalte deraf
DK149230C (da) Analogifremgangsmaade til fremstilling af 5-benzoyl-6-hydroxy-indan-1-carboxylsyrederivater eller farmaceutisk acceptable salte deraf
DK441875A (da) Fremgangsmade til fremstilling af 2-phenyliminoimidazolidiner eller syreadditionssalte deraf
DK149077C (da) Analogifremgangsmaade til fremstilling af encephalin-analoge pentapeptidamidderivater eller farmaceutisk acceptable syreadditionssalte deraf
DK137677C (da) Analogifremgangsmaade til fremstilling af basisk substitueredexanthinderivater eller syreadditionssalte heraf
DK139522C (da) Analogifremgangsmaade til fremstilling af 9-iminoalkylamino-erythromyciner eller syreadditionssalte deraf
DK446978A (da) Fremgangsmaade til fremstilling af cephalosporansyrederivater
DK137606C (da) Analogifremgangsmaade til fremstilling af substituerede 2-phenylamino-imidazoliner-(2) eller syreadditionssalte deraf
DK532176A (da) Fremgangsmade til fremstilling af tetradydropyridin-og piperidinderivater eller syreadditionssalte deraf
DK139517C (da) Analogifremgangsmaade til fremstilling af substituerede thiazol-2-carboxamider eller syreadditionssalte deraf
DK131857C (da) Analogifremgangsmade til fremstilling af 4-hydroxymethyl-1-phthalazonderivater eller syreadditionssalte deraf
DK135125C (da) Analogifremgangsmade til fremstilling af 1-(3-(naphth-1-yl-oxy)-propyl)-piperazinderivater eller deres syreadditionssalte
DK446575A (da) Fremgangsmade til fremstilling af cephalosporansyrederivater
DK255976A (da) Fremgangsmade til fremstilling af substituerede 4-phenylimidazoliner eller syreadditionssalte heraf
DK138848B (da) Analogifremgangsmaade til fremstilling af phenylpropanolaminderivater eller syreadditionssalte deraf
DK132622C (da) Analogifremgangsmade til fremstilling af n-substituerede eller n,n-disubstituerede 2-aminoisoquinolinderivater eller syreadditionssalte deraf

Legal Events

Date Code Title Description
PUP Patent expired